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Geneticists Discover a Way to Extend Lifespans to 800 Years

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There is now a way to extend the lifespan of organisms so that humans could conceivably live to be 800 years old. In an amazing development, scientists at the University of Southern California have announced that they've extended the lifespan of yeast bacteria tenfold -- and the recipe they used to do it might easily translate into humans. It involves tinkering with two genes, and cutting down your calorie intake. Tests have already started on people in Ecuador. Source: io9.com
12 September 2012

Theories on Aging


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Theories on Aging

Aging is a complex process which has a variety of working parts. Medical scientists and biological researchers continue to study aging in order to give humanity a more complete understanding of the mechanisms by which it occurs, and they also try to learn ways to slow down or even reverse some aspects of the aging process.


There are three primary mechanisms that control how we age: Genetic Aging, Biochemical Aging, and Physiological Aging.

Genetic Aging

One of the three mechanisms by which human beings age is genetic. There are many forms of genetic aging, but all revolve around the idea that genetic breakdown causes the body to age over time. As we grow older, the genes become more prone to mutate. These mutations can cause a variety of issues to occur, one of which is cancer.

If a gene alters in a way that encourages endless replication, this significantly increases mortality risk, for example. Genetic mutations can also lead to other, less severe, genetic issues which simply impede the body's ability to perform the functions necessary to maintain a healthy and optimally functional body.

Small formations on the ends of our genes known as Telomeres also have an impact on aging. Telomeres are sections of junk genes at the end of our chromosomes which keep the active genetic code intact. As we age, these Telomeres become shorter and shorter, increasing the risk of genetic malfunction and mutation.

Finally, there are certain genes that only seem to express themselves later in life or when certain negative pressures are applied. And these negative pressures cause the aging process to occur more quickly.

Biochemical Aging

Biochemical Aging is a precursor of many forms of Physiological Aging. Biochemical Aging refers to intracellular and extracellular processes which contribute to aging in some way. In some cases, this is the result of natural chemical processes which cause our body to slowly break down over time, such as the inevitable oxidization which occurs as a natural side-effect of the chemical processes which keep us alive.

Other symptoms of biological aging are the result of changes in the way that our body functions, often for reasons that we are just beginning to understand. The way that our bodies produce Human Growth Hormone and Testosterone are good examples of this form of Biochemical Aging.

When we are young, our bodies produce ample levels of these hormones, and it encourages growth during adolescence and supports good health during early adulthood. Around the age of thirty, however, these hormones start to decline because the brain sends fewer and fewer signals for them. Also, hormones which control stress are produced in lower concentrations with age, which can increase the influence of psychological and physiological stress, which can cause other issues related to aging to become much more dangerous and severe.

Physiological Aging

Physiological aging refers to the physical changes that take place as a result of aging. Our teeth represent one of the most noticeable markers of physiological aging. Our teeth grow into place after our baby teeth fall out when we are young. After your teeth fully develop, your body has no mechanism to rebuild them and they slowly degrade over time, at a rate dependent upon how well you take care of them.

Graying hair is another type of physiological aging. Hair color is actually produced by tiny cellular organs known as Melanocytes. The color of your hair is dependent upon the type of pigment that these cells create, as well as the quantity and concentration at which they are produced. The more melanin that the Melanocytes produce, the darker your hair will be.

People get gray hair because the older that they get, the less pigment that Melanocytes secrete over time. There are actually scientific studies being performed regarding how to influence these cells to continue producing pigment later in life, potentially allowing aging men and women to naturally maintain their natural hair color.

Other Physiological aging changes are more than cosmetic, however. There are certain processes that occur regardless of how you take care of yourself as you grow older. Your baseline blood pressure will slowly go up over time, and your heart muscles will slowly harden, a condition known as atherosclerosis. Many physiological signs of aging can be alleviated with medication or a healthy lifestyle, but the general trends will continue over time without particular forms of treatment (many of which don't exist today).

How We Age Does Not Explain Why We Age

These three concepts, Physiological Aging, Biochemical Aging, and Genetic Aging, only serve to explain the processes by which we age. These processes do not answer the ultimate question of Why We Age, however. There are a number of theories associated with answering the question of why we age, but all of these theories belong to two distinct classes: Program Theory and Error Theory.

Program Theory assumes that aging occurs for evolutionary reasons, as a means to improve the effective viability of the species. There are a number of means by which this can be true, and it assumes that from the day that we are born, we are designed to progress down a set path from birth to death which maximizes the long term survival of the species. These programmed theories can be considered like a series of stages of life that eventually leads to death.

Error Theory, on the other hand, assumes that we are not genetically designed to self-destruct, but it is the result of a potential multitude of malfunctions which slowly reduce the viability of an organism until it eventually dies. There are a wide variety of forces that pressure an organism to break down and reach the end of its lifespan. It is incredibly important to note that the reality is likely much messier than a single theory, and there are inevitably a multitude of pressures which lead to aging, which are likely related to hypotheses of both Program Theory and Error Theory.

Below is a collection of some of the theories associated with Why We Age:

Program Theories of Aging

Programmed Senescence

This theory behind aging centers around the idea that we are programmed to age from a genetic level. It assumes that there are certain genes that turn on at a certain stage of the lifespan which change the way that our body works at a cellular level. This creates a cascade of change which causes our bodies to slowly deteriorate over time.

There are a number of cellular processes in the human body that involve programmed cell death, which is also known as apoptosis. Advanced theories regarding Programmed Senescence hypothesize that the genetic code of all animal species induces aging as a form of organism-wide apoptosis which makes way for the newer, younger generations.

Endocrine Theory

This Programmed Aging Theory hypothesizes that the endocrine system has the ability to control the rate at which an organism ages based off of both a natural biological clock as well as outside influences which may induce or postpone aging. This theory is also known as the Hormone Theory of Aging.

There are many insects, for example, that have the ability to live much longer lives if the conditions are not ideal for reproduction and procreation. If it is excessively cold, there is not enough food, or there are not enough partners, many insect species will release hormones which halt or slow down aging until conditions are more ripe to create offspring.

In human beings and other mammals, Growth Hormone and Sex Hormone production declines around midlife until the end of the lifespan. There is powerful evidence that these hormones have a positive impact on health and longevity, and there are those that argue that the body reduces production of these Anti-Aging Hormones over time so that the older generation can make way for the new generation.

Immunological Theory

This aging theory makes the hypothesis that immune systems weaken over time as a result of evolutionary pressures to encourage the organism to eventually become ill and die. This theory is also known as Immunosenescence. When we are young we are incredibly resilient to disease, but the older that we get, the less able our bodies are to fend off illness.

There is some evidence that an organism's ability to fight disease drops over time without regard to external factors, which leads some to suggest that this is an evolutionary strategy to encourage the young and healthy to acquire dominance over time. This change isn't exclusively the result of exterior factors, but as a result of changes which are deeply embedded in our genetic code.

Error Theories of Aging

Wear and Tear

This theory is quite straight forward. Our bodies grow and develop through childhood and adolescence, but after our bodies reach a point of peak performance, certain parts of our body start to age and decline in function because they do not have the capacity to heal themselves or have a limited ability to heal themselves.

One example of wear and tear is the scarring deterioration of the skin. When you receive a cut, your body has the ability to seal itself up and maintain a closed system, but if scars don't heal properly they will remain on the skin the rest of your life, because the body does not have a means to make the marks associated with these old wounds disappear once they are fully healed.

Another example of wear and tear involves the liver. The liver is an organ that has a limited ability to heal itself. Liver damage can result from a number of different lifestyle choices, including alcoholism, obesity, and drug abuse. The liver expends a lot of energy filtering impurities out of the body, and if too much is consumed for too long, the liver starts to become overwhelmed by fat tissue and cirrhosis.

Rate of Living

This form of aging is based on the hypothesis that, regardless of any evolutionary benefit, animal organisms have a lifespan which is highly correlated with their metabolism throughout their lives.

For example, rabbits and other small animals with very fast heartbeats tend to have very short lifespans. Animals like turtles, whales, and elephants have slow metabolisms which are associated with very slow heart beats, and they tend to have very long lifespans.

Although metabolism does seem to play a certain correlative factor with regard to the average lifespan of various species, it is not a hard rule, and evidence suggests that it does not apply effectively to humans. Low Metabolism in humans is associated with a shorter lifespan, and is correlated with health issues such as obesity and cardiovascular disease.

Crosslinking

Crosslinking is a theory of aging that assumes that the older that we get, the more links that the proteins in our body make, causing them to no longer function as effectively. One example of crosslinking which leads to physical aging is skin elasticity.

When we are born, our skin is soft and returns to position quickly if pulled or compressed. This is because the collagen in our skin is optimally linked. The older that we get, the more crosslinkages that are made among the collagen of our skin, which causes the skin to tighten and become less optimized. These links eventually start to cause skin cells to function ineffectively or even die off because the protein links are so tight that nutrients are not delivered efficiently.

Crosslinking is also one reason why the immune system loses its function over time. The body loses its ability to successfully process glucose from the blood. This causes blood sugar to increase which has a toxic effect on the cardiovascular system. Sugars in the blood react with protein, increasing the prevalence of free radicals which can do major damage to the body over time.

Free Radicals

Free Radicals are the result of the very chemical processes of the human body which sustain us. As our bodies react with oxygen to create energy, they release spare atoms which travel haphazardly through the body causing chemical reactions and reaction cascades that can do harm to the body.

One of the body's primary lines of defense against Free Radicals are nutrients known as Antioxidants. The human body has the ability to produce some forms of antioxidant naturally, but others must be consumed in the diet. Omega-Three Fatty Acids, L-Carnitine, and Vitamin-C are some examples of antioxidants.

Free Radicals cause aging because the incremental damage caused by these chemical reactions slowly degrades the body, causing organs and cells to lose their ability to properly function and this slowly leads to declining health and vastly increased mortality risk.

Error Catastrophe

This form of Error Theory is associated with the way that our bodies utilize proteins. As a result of various other interferences, the cellular organs which generate necessary proteins in our body can malfunction, causing them to produce damaged proteins which can negatively impact health and normal function.

One of the most well-known forms of Error Catastrophe is actually Alzheimer's Disease. Alzheimer's Disease is caused when our brains become overloaded with prions, which are proteins which the body has folded improperly. These prions have the ability to convert other healthy proteins into the same form, spreading damage throughout the brain, deteriorating normal function over time until eventually inevitably leading to death.

Error Catastrophe also refers to the point at which mutations in proteins or genes reach a point at which the cell can no longer survive and propagate under normal circumstances. Eventually, the organism dies because cellular function breaks down at organ level and finally at a universal level.

Somatic Mutation

This form of Error Theory is related to Error Catastrophe, but is explicitly related to genetic function. A number of different factors can eventually cause genetic function to alter, which causes aging and eventually can lead to death.

Cancer is often the result of Somatic Mutation. A gene can mutate, causing it to reproduce indefinitely. This genetic mutation alters the healthy function of the body, and over time, the cancer can spread to other areas of the body and flood the entire organism with replicating cancer cells, which will inevitably lead to death. Cancers can usually be treated effectively if caught early, but if allowed to spread, they often become almost universally lethal.

Somatic Mutations can occur at any time from conception to the end of the lifespan. Sometimes, these mutations lie dormant for many years, perhaps even through the entire lifespan, but other times, they eventually lead to cancer or other physiological malfunctions.

15 March 2014

Flax Seed Oil: Longevity and Anti-Aging Medicine

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Flax Seed Oil: Anti-Aging and Longevity Superfood

When flaxseed becomes a normal part of the diet, a culture will achieve greater health - Mahatma Gandhi


For hundreds of years, humanity has recognized the amazing health benefits of flaxseed, and its derivative, flaxseed oil. In the eighth century, Roman Emperor Charlemagne actually institutionalized its use as a health food throughout the Holy Roman Empire, and he enacted decrees which demanded that it be made part of the diet of all of his citizens. Flaxseed was one of the first medications, in use since at least the time of Ancient Greece. Hippocrates was among the many who utilized Flaxseed for its tremendous medicinal qualities.

Flaxseed is among the best available and natural sources to obtain Alph-linolenic acid. This acid is one of the primary Omega-Three Fatty Acids which are vital for a healthy body. Alpha-linolenic also belongs to a group of nutrients known as essential fatty acids. These nutrients cannot be naturally produced by humans and must be consumed in ones diet. Flaxseed oil has the capability to provide defence against a number of degenerative diseases associated with aging such as arthritis, cancer, and heart disease. Flaxseed oil can significantly increase the effectiveness of Human Growth Hormone Therapy, or other forms of regenerative Hormone Replacement Therapy, because of its amazing protective capabilities. Although Flaxseed is most well-known for containing Alpha-Linolenic Acid, it also contains a number of other fatty acids such as Omega-9s and Omega-6s. Flaxseed is among the heartiest sources for Essential Fatty Acids available from cultivation.

Not all Essential fatty acids can be acquired from flaxseed alone, however. Flaxseed only provides one of a trio of essential Omega Threes, and the other two are primarily acquired from proteins, especially fish like salmon which thrive in cold water. These other two Essential Omega-Three Acids are EPA and DHA, scientifically known as eicosapentaenoic acid and docosahexaenoic acid, respectively.

Although DHA and EPA have more profound health effects than ALA, that doesnt mean that one should ignore the benefits of Flaxseed altogether. Alpha-linolenic acid has a number of significant effects on its own. For example, ALA has been shown to produce significant anti-inflammatory effects when added to an individuals diet. Another benefit of ALA is that after it has been consumed by the body, humans have the capability to convert Alpha-linolenic acid into both DHA and EPA. The issue with this is that the conversion takes place at a very low rate. Only around five to ten percent of ALA is converted into long-chain protein-derived Essential Omega-Threes.

So what does this mean for the health-conscious man or woman? Flaxseed is completely essential for vegetarians. Although proteins are the ideal source for EPA and DHA, Flaxseed oil makes a fantastic substitution for individuals who choose not to eat fish. It is also a great option because it is easily available in supplemental forms which can be purchased from any grocery store. The body does not need a large amount of DHA and EPA in order to function optimally, and for this reason, it only takes about a single tablespoon of Flaxseed oil to produce all of the Omega-Three Acids that the body needs to maintain optimal health. One tablespoon of flaxseed oil will be converted into around one gram of the protein-derived essential fatty acids.


Flaxseed Superfood: More than Just Omegas

There are numerous other benefits that flaxseed and flaxseed oil provide besides simply the essential amino acids. The oil of flaxseedand the seeds in particularare rich in beneficial material known as lignans. This material contributes to a number of the positive benefits of flaxseed as well. Lignans have been proven to be highly effective in treating many forms of cancer. They have the most significant effect upon hormonal cancers such as prostate, uterine, and breast cancer and as a result is an effective part of a hormone cancer treatment. For this reason, flaxseed oil is an invaluable nutrition source for patients undergoing Hormone Replacement Therapy, because it has the ability to insulate the body from many problems that can slowly come forth as a result of a healthy and robustly active endocrine system.


A significant amount of research has been conducted regarding the effect of lignans upon breast cancer cells. These studies have borne very positive results. In one particular study, participants who were suffering from breast cancer were fed a muffin which contained twenty five grams of flaxseed. A second group of participants were fed a placebo muffin which they believed contained the same level of flaxseed. Patients who consumed this high dose of flaxseed showed markedly improved tumor progression outcomes compared to their cohorts on placebo.

Researchers came to the conclusion that consuming twenty five grams of flax seed each day has the ability to significantly drop the rate of cancer cell reproduction, and it also has the capability to actually encourage apoptosis (the degeneration of cancer cells). Flaxseed was also shown to reduce endogenous levels of a protein known as HER2, which has been shown to agitate and strengthen breast cancer cells.

In another study, scientists discovered that lignans found in flaxseed have the ability to inhibit the growth of prostate cancer cells in laboratory testing. Another medical research study at Duke University produced evidence that prostate cancer patients who combined a healthy low-fat diet with the consumption of three tablespoons of flaxseed each day had improved medical outcomes which featured a reduction in the growth of prostate tumors. After further study, researchers have concluded that lignans have the ability to inhibit the production of dihydrotestosterone, better known by its acronym, DHT. This testosterone derivative is partially responsible for inducing male pattern baldness, and elevated levels also lead to an enlarged prostate gland, which is the reason many older men have to wake up in the middle of the night to go to the restroom. The medical term for an enlarged prostate is benign prostate hyperplasia. In addition to this, elevated levels of DHT contribute to an increased risk of prostate cancer.

Flaxseed and flaxseed oil have a number of other positive effects as well. It promotes better colon and cardiovascular health. In addition to this, flaxseed has the ability to bolster the immune system and prevent illness. It also is highly beneficial for skin health and has the capability to maintain stable levels of blood sugar. For this reason, there is growing evidence that flaxseed can help individuals at risk of diabetes ward off the dreaded disease. The lignans that are present in flax may benefit women who are experiencing perimenopause or menopause as well. Flax lignans actually belong to a group of biological compounds known as phytoestrogens. Phytoestrogens have been scientifically shown to reduce the effects of menopause and help women make it through the physiological change as comfortably as possible. For patients who are only suffering from mild symptoms of menopause, flaxseed may confer all of the benefits necessary to manage the ordeal.

Although this benefit is not obtainable through the oil, flaxseeds are also amazing sources of soluble fiber. Although flaxseed oil is highly beneficial, the maximum level of benefit is provided by consuming the seeds themselves. They are fantastic to use when baking or making a healthy and delicious salad. In addition to this, they can be added to cereals or blended into smoothies. It is important to break the shells of flaxseed before consuming them, because the human body cant digest the entire seed. Flaxseed is an excellent addition to nearly any meal, and is incredibly versatile and easy to include into a healthy diet.

The most effective way to obtain Flaxseed and Flaxseed Oils

The most widely distributed producer of flax is Barleans Organic Oils. They produce more flaxseed products than any other corporation in the United States. Their flagship product is called Forti-Flax, which is pre-shelled and pre-ground for immediate consumption. Consuming four tablespoons of this flaxseed product will provide you with three grams of Omega-Three Essential Fatty Acids, six grams of fiber, and a number of other health-promoting phytochemicals and lignans. It is important to note that the amount of flaxseed provided in one serving of Forti-Flax is identical to the amount used in the majority of studies which prove the health benefits of flax. On top of this, flaxseed has antioxidant and anti-inflammatory benefits as well. Flaxseed is a simple and cheap addition to a healthy diet which confers amazing benefits for minimal cost, and every person in America should take advantage of this medicinal seed.

Most high-quality forms of flaxseed oil are processed cold in order to preserve their high lignin levels. Barleans produces a product known as Lignan Flax Oil that is manufactured in this way, and it can be found refrigerated in most general nutrition stores.


It is vitally important to note that Flaxseed Oil is not a cooking oil. Cooking with flaxseed oil deteriorates the delicate bonds of the essential fatty acids contained within, and in addition to this, the relatively low boiling point makes it a poor choice as a cooking oil. The best way to use flaxseed oil is to consume it alone as a nutritional supplement, or use it as topping for cooked veggies, grains, or fresh salads.

Flaxseed oil truly is one of the most uniquely nutritious foods in the world. The multitude of benefits that result from the consumption of this superfood make it a dietary must for any patient undergoing bioidentical Hormone Replacement Therapy. Flaxseed both amplified the effects of HGH and Testosterone Hormone Replacement Therapy while also protecting the body from potential side-effects that can result from elevated hormones. Before receiving your first Hormone Replacement Therapy HRT treatment in the mail, we encourage you to purchase this product and add it to your diet as soon as you can.

Information provided by Doctor Jonny Bowden, author of The Original Healing Food

Doctor Bowden is a professional expert on health, nutrition, and weight control. He is a certified specialist in the field of nutrition and he has a graduate degree in psychology. He has written five nutritional guides, including The Most Effective Cures on Earth and The 150 Healthiest Foods on Earth.

04 January 2013

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Diet Science
Why Is It So Hard To Lose Weight And Keep It Off?Why Is It So Hard to Lose Weight and Keep It Off?
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Restrict Your Calories 30% And Live 30% Longer?Restrict your calories 30% and live 30% longer?
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Knowing Two Languages Can Postpone DementiaKnowing two languages can postpone dementia
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