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Enclomiphene Citrate May Treat Andropause More Effectively than Bio-Identical Testosterone

Bio-Identical Testosterone has been used for decades in order to treat Low-T caused by Hypogonadism and Andropause. There is a drug currently undergoing Clinical Evaluation which is likely to reach the open market in just a matter of years, known as Enclomiphene Citrate.

Medications similar to Enclomiphene Citrate have long been used as fertility treatments for women, but studies indicate that the treatment can also provide men with a potent boost of Testosterone without a risk of overdose.

Enclomiphene Citrate Affects Men and Women Differently

In women, Enclomiphene Citrate encourages the process of ovulation, but in men, it encourages the release of precursor hormones which stimulate the production of both natural, endogenous Testosterone and sperm.

In fact, these trials provide evidence that Enclomiphene Citrate is even better than Testosterone Injections and Creams at restoring natural Testosterone Levels, all the while promoting healthier hormone balance and circulation in other ways.

How Does Testosterone Replacement Treat Low-T?

Bio-Identical Testosterone Therapy simply replaces the Testosterone that the body no longer produces at sufficient concentrations to sustain male health. Testosterone Therapy can bring Testosterone Levels back to normal, but it comes with side-effects, both inherent in the treatment and related to accidental overdose. Because Testosterone Therapy provides an outside source of Testosterone, the treatment suppresses the body's production of Testosterone Precursors that are responsible for healthy testicles, which leads to fertility issues as well as Testicular shrinkage.

Enclomiphene Citrate is Cheaper than Testosterone

Enclomiphene Citrate is also cheaper than Testosterone, meaning that, if the treatment is found to be effective and gains FDA Approval, and it appears likely that this will be the case, countless men will flock from Bio-Identical Testosterone to Enclomiphene Citrate in order to get more cost effective care that is easier to administer. Unlike Testosterone, which is generally delivered via injection or topical formulation, Enclomiphene Citrate is a simple pill.

Enclomiphene Citrate Clinical Research Study

At this point, Enclomiphene Citrate for Men is in the second stage of its clinical trial, after showing incredible promise in the initial stage of research. The details regarding this second phase will be published in the academic publication Fertility and Sterility.

Of course, the process for FDA Approval is a four stage process, but, based on off-label usage of similar medications, and the effectiveness of the treatment in the first two stages, it seems clear that Enclomiphene Citrate for Andropause and Male Infertility will almost certainly obtain FDA Approval.

Testosterone Deficiency Prevalent in American Society

Low-T, also known as Andropause or Age-Related Hypogonadism, is a prevalent condition among men in the United States. Millions of American males suffer from the condition, and studies suggest that the condition is still under-diagnosed, due to a number of different factors.

Testosterone Deficiency is most well-known for its impact on sexual health, but Low-T affects male health and longevity in a number of different ways. Aside from Low Libido, Infertility, and Erectile Dysfunction, other symptoms of Andropause include depression, anxiety, changes in body composition, loss of Bone Mineral Density, muscle atrophy, and lack of energy.

Low-T is a natural aspect of the process of aging, but not everything that is natural is healthy. Study after study shows that men with naturally high Testosterone tend to be both healthier and more well-adjusted than their peers that have lower levels of Testosterone.

When Does Testosterone Production Peak?

Biologically, our Testosterone Levels peak while we are in our teens and twenties, and start to fall off beginning in the thirties. Every man is impacted by Low-T in their own way, and some experience symptoms more quickly and more severely than others. Testosterone Deficiency is associated with a number of chronic medical conditions, from cardiovascular disease to diabetes to obesity.

The State of Modern Testosterone Therapy

One issue with Testosterone Deficiency as it is treated today is that there are no definite thresholds regarding how low Testosterone Concentrations must fall before a patient is ultimately diagnosed. This is partially because there is still ongoing research regarding Testosterone for Andropause, but also because each patient has his own personal genetic profile as well as their own set of unique lifestyle choices.

This means that part of diagnosing Low-T is up to the discretion of the prescribing physician, because it is up to his or her expertise to determine if the severity of the symptoms and the underlying hormone levels warrant therapy.

This also means that Testosterone Therapy is prescribed to meet our standards for what healthy Testosterone Levels should be, rather than the body's natural processes to provide youthful Testosterone. This is where Enclomiphene Citrate can be both useful and perhaps even superior to Testosterone Therapy for many patients.

Enclomiphene Citrate and Andropause

Andropause is a form of Secondary Hypogonadism, meaning that the testes are still fully capable of producing their own Testosterone, they just aren't receiving the same signals that they did when the patient was younger. Enclomiphene Citrate restores this youthful signaling, allowing the body to make just as much Testosterone as it needs to meet the needs of the body. Enclomiphene Citrate encourages youthful production of Testosterone, without the risk of overdose (or under-dose) that is sometimes associated with Testosterone Treatment.

Why is Enclomiphene Citrate Superior to Testosterone?

Bio-Identical Low-T Treatments restore Testosterone quite capably, but they do so without taking into account the other hormones and processes of the male body which depend upon Luteinizing Hormone, Follicle-Stimulating Hormone, and Gonadotropin-Releasing Hormone to take place.

When Bio-Identical Testosterone is administered, the body fully absorbs and utilizes the Testosterone, but the three precursors listed above, LH, FSH, and GnRH, no longer get produced in sufficient quantities. This condition does not have a significant impact on health and wellness, but it has a tremendous impact on both male fertility and the condition of the testes themselves.

Doctors Often Prescribe Testosterone to Men that Want Children

Many men take Testosterone without realizing the fertility risk associated with Standard Testosterone Therapy. This is because many general practitioners prescribe Testosterone for Low-T without fully recognizing the downsides associated with the treatment, and thus, they don't relay that information effectively to their patients.

Often, we think of Testosterone Treatment as a therapy for men in the latter stages of their life, but Age-Related Low-T can affect male health even as soon as the early thirties, and many men start taking Testosterone while they are still interested in having children, without recognizing the suppressive effect that the treatment has on a man's ability to produce sufficient sperm for conception.

This lack of knowledge on the part of many physicians is not anecdote, there are studies to back it up. A recent poll by the American Urological Association discovered that fully a quarter of urological specialists were not aware that Testosterone inhibited fertility, and would prescribe Bio-Identical Testosterone Treatments like Axiron to men that were vocally interested in having children in the near future.

Fertility Suppression Due to Low-T Treatment Temporary

Luckily, the fertility risks associated with Bio-Identical Testosterone are short-term, and fertility returns to pre-treatment levels after therapy is suspended, but this still means that many men that would greatly benefit from Testosterone Therapy don't get the opportunity for treatment because of their desire for children.

Clomid vs. Enclomiphene Citrate

In the very near future, there will be a new option available for these men, so they can protect their health and their sexual function while also promoting the healthy production of sperm. Enclomiphene Citrate is a component of a medical treatment that has long been on the market in generic form known as Clomiphene Citrate.

This treatment is also available under the brand name Clomid. The treatment was originally designed to improve fertility in women, but also shows some effectiveness at restoring Testosterone Levels in males. In women, Clomid and Enclomiphene encourage the production of female sex hormones, but in men, the medical treatments encourage the production of Testosterone and sperm.

Clomid is a combination of two active compounds, Enclomiphene Citrate and Zuclomiphene. The benefits of Clomid on Male Sexual Health are primarily the result of the Enclomiphene component of the medication.

The issue with Off-Label prescription of Clomid is that Zuclomiphene does increase the level of Estrogen in the body by a slight amount, meaning that the ideal form of the medication would omit Zuclomiphene entirely. Because of the Estrogenic effects of Zuclomiphene, Clomid is often prescribed in combination with Arimadex in order to counteract those effects and optimize treatment.

Enclomiphene Shown to Be Effective in Stage-2 FDA Trial

In the second stage of clinical research for Enclomiphene Citrate, medical specialists from the Houston campus of the Baylor College of Medicine and Repros Therapeutrics provided 73 male patients with Enclomiphene Citrate for the treatment of Low-T caused by inhibited stimulation of the testes. This is most commonly the result of natural aging, but there are other factors which can impede the release of precursors from the pituitary and hypothalamus as well.

The study went according to the hypotheses supported by Off-Label use of the medication. The researchers found that Enclomiphene Citrate was incredibly effective at increasing Free and Total Testosterone to youthful levels, as well as LH and FSH Levels, which are necessary for proper sexual function.

As a result, Enclomiphene Citrate had no inhibitive effect upon the production of sperm, and perhaps even improved fertility among patients, though this is unclear.

Enclomiphene Works Better Than Clomid for Men

The lead researcher of the study, Dr. Ron Wiehle, explains that Enclomiphene Citrate works via the same mechanism as Clomid, which is prescribed Off-Label, but appears to do so with improved consistency. Further research could prove or disprove that notion, but because Clomid is no longer under patent, there is no financial incentive to study its effects.

On the other hand, Enclomiphene Citrate is still under patent, and is potentially effective for a greater subset of the male population, which provides the motivation for funding and research by private pharmaceutical manufacturers such as Repros Therapeutrics.

Enclomiphene Slightly Reduces IGF-1 Levels

Prior research shows that Enclomiphene Citrate does have a slight suppressive effect upon IGF-1 Production in men. This means that Enclomiphene is likely not a good option for men that simulataneously suffer from significant HGH Deficiency and Testosterone Deficiency simultaneously. This does mean, however, that Enclomiphene Citrate is safer for the prostate than Testosterone Therapy. Further study is needed to elucidate the impact of Enclomiphene upon IGF-1.

Enclomiphene to Be Marketed as Androxal

Although Enclomiphene Citrate is not available on the open market quite yet, the plans are to sell and distribute the medication under the brand name Androxal. Androxal will be specially formulated for male use, to provide the optimal amount of medication to restore the youthful cascade of male hormones necessary to restore vitality and sexual potency.

One reason why there is so much interest in Enclomiphene Citrate is that men in America are choosing to have children later and later in the lifespan, meaning that the segment of the population that experiences symptoms related to Low-T while also being interested in having children continues to grow.

Interested in Enclomiphene Now? Talk to Your Doctor About Clomid!

Although Enclomiphene Citrate is not currently on the market, you can still talk to your doctor about Clomid (Clomiphene Citrate), and find out if you are a candidate for treatment. Clomid is designed and certified for use by women, but there are many physicians all across the country that are highly experienced with the treatment regimen. Clomid may never gain enough traction for FDA-Approval, but the treatment has been used effectively for decades.


HIDDEN SOURCES OF SUGAR IN COMMON FOODS


Written by Dr. Welsh, Published on 07 August 2014

Hidden Sources of Sugar

As our knowledge of nutritional science continues to grow, it is becoming increasingly clear how devastating the excess consumption of sugar is for our health. It causes us to gain weight, it causes spikes in blood sugar, and it increases the body's resistance to insulin, just to name a few of the issues caused by our national love affair with sugar.

Now, as we become armed with this knowledge, many of us are choosing to take control of our health and our diet, to live a better life by controlling our consumption of sugar. This can be incredibly difficult, however, because we are surrounded by so many concentrated sources of sugar that we aren't even aware of!

The goal of this article is to help you control your consumption of sugar by informing you of a variety of foods which many people don't realize are loaded with sugar.

Pasta Sauces Sometimes Worse than Drinking Soda

Most of us remember when we were children, and spaghetti was a staple of the average American diet. Pasta sauce does provide the nutrient equivalent of multiple servings of vegetables, but it also contains a tremendous amount of sugar. In fact, most of these sauces contain between six and twelve grams of sugar for each serving. Each serving is only a half a cup, and most people end up having even more.

Twelve grams of sugar is like eating two chocolate chip cookies!

Based on current research, it is recommended that men have 150 calories from sugar at most, and only 100 for women. That means that most pasta sauces have way too much sugar for you to keep your consumption down to acceptable levels without diligence. White sauces are even worse than red sauces, because they contain high levels of fat in addition to calories from sugar. We recommend shopping around for pastas that are specially made for aware consumers, or to make your own sauce at home!

Granola Bars Often as Bad as Candy Bars

Many people think of granola bars as the ideal healthy snack. Unfortunately, most of the granola bars that you buy at the store are loaded with sugar and other ingredients designed to make you crave them. Many of them are even covered in chocolate or yogurt.

It's important to recognize that many of the granola bars sold at supermarkets are nothing more than candy bars given a new name to appeal to more health conscious consumers. Granola is still a fantastic snack, but we recommend buying loose granola, which often comes in cereal boxes, and snacking on it that way. You can cut your sugar consumption from your snack significantly by switching to regular granola (8-12 grams of sugar per ounce vs. 5 grams of sugar per ounce).

Yogurt Can Be a Deceiving Health Food

Like granola bars, yogurt is another food which is often advertised as a health food when it is manufactured like a desert. Among dairy products, Yogurt is among the most concentrated sources of protein and calcium per serving, but it is often heavily sweetened to appeal to the consumer while also meeting their latent desire to improve their eating habits.

An eight ounce cup of Low-Fat Yogurt can contain more than thirty grams of sugar...Fully 1/3 of the sugar a woman needs in a single day! That's like eating eight ounces of ice cream! Of course, Greek Yogurt and similar forms of yogurt aren't inundated with sugar in the same way, and there are plenty of types of yogurt on the market which are low-sugar or naturally flavored which can fulfill your desire for a high-protein snack without loading you up with unhealthy sugar. Another option is to buy plain yogurt and add your own healthy fruits to naturally sweeten your snack!


Packaged Flavored Oatmeal Much Unhealthier than Plain Oatmeal

Oatmeal is an awesome way to get a lot of fiber along with some complex carbs, but the prepackaged flavored oatmeal that you buy at the store is almost like eating a bowl of sugary cereal. One serving of instant oatmeal contains as much as fifteen grams of sugar, whereas low-sugar packages still contain five or six grams of sugar.

Oatmeal is quick enough to make on its own. Plain oatmeal takes just a couple of minutes and is way healthier than flavored oatmeal. Try adding cinnamon and chopped up banana to meet your breakfast needs more completely without resorting to processed sugar. Plain oatmeal has less than a single gram of sugar.

Be Careful with Salad Dressing

Most people think about fat when they think about salad dressing, but these products are also often a major source of sugar. Catalina, French, and sweet vinaigrettes are the worst offenders, with as much as seven grams of sugar in just two ounces of dressing.

When using dressings, think of them as a means by which to add a source of healthy fat to your meal, and don't go overboard. There are a number of awesome dressings that are low in sugar while also adding a lot to the flavor and texture profile of your salad, such as oil and vinegar.

Breakfast Cereals Often Infused with Excess Sugar

Most people are aware of the unhealthy cereal brands that are targeted to children, but many of the cereals marketed as healthy foods are also quite loaded with sugar as well. Many bran, corn, and oat cereals have ten, twenty, or even more grams of sugar per cup.

Never trust the advertising when it comes to breakfast cereals, always look at the spine of the box and check the sugar content, as well as the general nutrition content! Good breakfast cereals should be fortified and full of fiber and complex carbs.

Energy Drinks Frequently Loaded with Sugar

Energy drinks are often marketed as metabolism boosters that give you a shot in the arm when you need it most, but many rely on a heavy dose of sugar to provide the brunt of their energy. There are a number of energy drinks on the market that have as much as 25 grams of sugar in a small can.

If you are interested in the healthier ingredients contained within energy drinks, think about buying B-Complex or Vitamin C supplements from the grocery store and combine them with a nice, tall glass of water to simultaneously rehydrate you and supply you with healthy nutritional supplementation. Supplements containing Taurine or Guarine may also be an option, but do your research.

Packaged Fruits Contain Much More Sugar than Fresh Fruit

One of the biggest culprits for excess sugar is canned fruit. The so-called light syrup commonly advertised on the can isn't so light, and drastically increases the sugar content per serving. In fact, just draining the syrup from the can can decrease the sugar content by more than half.

Rather than turn to canned fruits, buy them fresh at the store, and eat them before they go bad. Also, it's important to note that frozen fruits have a higher nutrition content than even their fresh counterparts, as frozen fruits are usually frozen immediately after they are harvested, whereas fresh fruit loses some of its nutrition content during transport and delivery. Both are still quality sources of dense nutrition, however.

Cole Slaw is a Poor Alternative to Salad

It almost seems like a little salad, doesn't it? This side, which is commonly one of the healthier-sounding sides at many restaurants, is usually also loaded with sugar, as well as fat. This is true for coleslaw from fast food restaurants as well as that which is sold at supermarkets and served at most eating establishments. Generally, cole slaw contains around fifteen grams of sugar.

Before going to a restaurant, consider looking up their sides on the web in order to see if their cole slaw meets the grade. If you are a big fan of cole slaw, start making your own batches, designed to meet your personal needs.

Many Teas Loaded with Sugar

In the recent past, people consumed lots and lots of juice, without thinking about the tremendous amount of sugar that is contained in many popular fruit juices. As consumers have become more aware, many have changed to specialty teas. Unfortunately, many of these forms of tea are just as bad, or worse. For example, Sweetened tea with lemon can contain more than thirty grams of sugar per 16 ounce bottle, even more than some fruit juices, including apple juice.

Teas are a fantastic way to infuse your diet with flavonoids and other healthy ingredients, but go for unsweetened tea or lightly sweetened tea, or better yet, make your own and control the content! Also consider sweetening your tea with Stevia, a natural no-calorie sweetener that is far better for you than artificial sweeteners.

High Sugar Volume in Dried Fruit

Dried fruit is often a solid choice for an on-the-go snack, but it's important to recognize that dried fruit has a high concentration of sugar. The dehydration process actually means that there is more sugar per ounce in the product, meaning that you have to be much more conscientious, and because of the reduced water content, will perhaps not be filled up as easily. For example, half an ounce of raisins contains ten more grams of sugar than eight ounces of grapes.

Sugar Content in Ketchup

Ketchup is a heavily sweetened and processed product by the ounce, but luckily, most people don't drown their food in ketchup. A single tablespoon of ketchup contains around four grams of sugar. If you have your sugar under control, this isn't an issue, but if you are looking to reduce your sugar consumption by any means necessary, turn to other condiments such as mustard, which contains less than a quarter of the sugar contained in ketchup.

Limiting Sugar is a Constant Battle

In this world of High Fructose Corn Syrup and sugar-infusion, it can be very difficult to contain the level of sugar in one's diet. It takes a conscious effort, because everywhere in society, there are advertisers trying to sell you products that sate your desire for flavor as well as your conscience with intentionally misleading labels.

By taking your nutrition into your own hands, it is possible to overcome these societal norms and optimize your diet for a long and healthy life without giving up the wonderful tastes and flavors that make eating such a pleasure!


CLOMIPHENE CITRATE INFORMATION AND GUIDE


Written by Dr. Welsh, Published on 07 August 2014

Clomiphene Information Guide

What is Clomiphene?

Clomiphene is a synthetic medication which has the ability to imitate the function of hormones produced by the human body known as Selective Estrogen Receptor Modulators (SERMs). In short, Clomiphene impacts the way that the hypothalamus registers Estrogen, in order to encourage the body to produce hormones related to ovulation in women and the production of Testosterone and sperm in men. There are three forms of Clomiphene available in the pharmaceutical market: Omifin, Clomid, and Androxal. Clomiphene is also available in generic form.

In the United States, the drug is named Clomiphene, but based on international standards, it is named Clomifene. This drug is taken orally, and, dependent upon the formulation, is a light yellow or white tablet.

Clomiphene and Female Fertility

Clomiphene was first used as a fertility treatment for women. There are two forms of infertility for which Clomiphene has proven exceptionally useful—oligoovulation and anovulation.

What is Oligoovulation?

Oligoovulation refers to ovulation which occurs irregularly or infrequently during the menstrual cycle. Under normal circumstances, women ovulate about two weeks into their menstrual cycle, but certain circumstances can get this release off track. In some cases, women only ovulate around once every fifty days or more, and under other circumstances, ovulation can simply occur at the wrong time of the cycle.

As a result of this irregularity, it is difficult for women to know exactly when conception is most possible. Clomiphene can help regulate this process, making ovulation occur more regularly and predictably.

What is Anovulation?

Anovulation is a condition in which the menstrual cycle occurs, but ovulation does not happen, which prevents the possibility of conception. Clomiphene is often used to encourage ovulation to take place in a normal fashion.

Clomiphene for General Infertility

There are strong clinical results for the use of Clomiphene for these purposes, but for fertility without known causes, the body of evidence is incomplete with regard to the effectiveness of Clomiphene Fertility Treatment.

However, there is evidence that Clomiphene can boost fertility in patients with unknown causes of infertility. Clinical studies have varied with regard to Clomiphene for this purpose. Under these circumstances, Clomiphene is shown to increase fertility to around a 5.6% chance of conception per menstrual cycle, an increase in fertility of 1.4%-4.3% dependent upon the study.

Clomiphene for Multi-Modal Fertility Treatment

Clomiphene Citrate is often combined with other forms of fertility treatment in order to further increase the odds of conception.

How is Clomiphene Prescribed for Women?

Generally, for female fertility treatment, Clomiphene Therapy begins at fifty milligrams per day for five days, beginning in the third, fourth, or fifth day of the menstrual cycle. In doing so, it encourages ovulation at a normalized and stable point of the menstrual cycle. In the week prior to ovulation, which will occur between the 15th and 18th day of the cycle, the couple should copulate frequently in order to optimize the chance of fertility success.

In many cases of feminine infertility, the physician will perform tests to monitor for the surge in Luteinizing Hormone which encourages ovulation and is spurred by Clomiphene, and these tests generally take place beginning on the day that the fifth dose of Clomiphene is taken, and are administered daily until ovulation occurs, as shown by affirmative Luteinizing Hormone Testing. If ovulation does not occur by the 18th day, the fertility doctor may force ovulation through a 10,000 IU dose of Human Chorionic Gonadotropin, if there is a follicle of sufficient size for implantation.

Interestingly enough, HCG triggering is not as effective at inducing pregnancy as monitoring and waiting for the natural release of Luteinizing Hormone.

How Is Ovulation Monitored?

There are a number of ways to keep track of cycling induced by Clomiphene Citrate:

  • Vaginal Ultrasound – Using ultrasound, it is possible to monitor the development of Ovarian Follicles necessary for implantation and which form preceding the release of the egg. Evidence of ovulation can also be obtained via ultrasound.

  • Luteinizing Hormone Testing – Luteinizing Hormone Levels increase in the days preceding ovulation, or are artificially increased to induce ovulation.

  • Estradiol Levels – These levels are generally tested four to six days after the last Clomiphene Dose, and can also provide evidence of impending ovulation.

  • Progesterone Levels – Between seven and nine days past ovulation, Progesterone Levels should be a minimum of ten nanograms per milliliter for optimal chances of fertilization.

  • Testing for Active Sperm – Tests can be conducted in the days preceding ovulation to make sure there is sufficient active sperm present for a reasonable chance at successful conception.

  • By Inducing Consecutive Menstrual Cycles – By administering the Clomiphene monthly, this further encourages a healthy and normal menstrual cycle. Clomiphene treatment can be administered five of every thirty days, to produce a stable pattern. If ovulation does not occur in a cycle, the dose of Clomiphene administered is often increased by fifty milligrams per cycle over the course of six months. When used as a fertility treatment, Clomiphene is only recommended as a six month maximum course of treatment.

Side-Effects of Clomiphene for Female Fertility

Most women experience no significant side-effects resulting from Clomiphene Citrate Fertility Treatment. The most reported side-effect of Clomiphene is an enlargement of the ovaries. This occurs in less than ten percent of patients treated, and is completely reversible.

All other side effects occur in less than ten percent of patients. The most common among these side effects are:

  • Abdominal Discomfort

  • Abnormal Bleeding from the Uterus

  • Hot Flashes

  • Headaches

  • Temporary Changes in Vision, including Scotoma (blind spots), Photophobia (light sensitivity), Floaters, Diplopia (double vision), and Blurred Vision

A very small percentage of patients, less than one percent, experience the following symptoms:

  • Ovarian Hyperstimulation

  • Reversible Hair Loss (Alopecia)

  • Hepatitis

  • Hypertriglyceridemia (elevated triglyceride levels)

Like many other forms of fertilization treatment, Clomiphene increases the likelihood of triplets and twins resulting from the release of multiple eggs (ten percent of patients that conceive using Clomiphene have twins).

Potential Long Term Risks of Clomiphene Therapy for Women

There is limited research that provides inconclusive evidence that the use of clomiphene for more than twelve months can elevate the risk of Ovarian Cancer. It may be that long term use of Clomiphene only impacts patients that don't become pregnant over the course of a year, which is why the therapy is generally only recommended for six months for women.

There have been no studies that have reproduced these risks, so there are many that believe that Ovarian Cancer risk is not affected by Clomiphene.

Clomiphene Does Not Lead to Neonatal Complications

There are no signs that suggest that Clomiphene increases the risk of Genetic Abnormalities as compared to the normal process of conception. Clomiphene also does not lead to increased risk of spontaneous abortion.

How Does Clomiphene Work?

Clomiphene works by reducing the ability of Estrogen to activate receptor-sites on the Hypothalamus. When the Hypothalamus receives stimulus from circulating Estrogen, it reduces signals from the production of Luteinizing Hormone by the Pituitary Gland. There is a similar pharmaceutical, known as Zuclomifine that acts in the same manner, but for a long a longer period of time. Although Clomiphene affects the release of steroid hormones, Clomiphene is not itself a steroid.

How Do Normal Women Reach Ovulation?

When women experience normal menstrual cycles, Progesterone and Estrogen Levels increase significantly, as released by the Corpus Luteum. This inhibits the production of Luteinizing Hormone, Follicle-Stimulating Hormone, and Gonadotropin-Releasing Hormone from the anterior pituitary and the Hypothalamus.

It is during this period where fertilization occurs, and if the body doesn't experience fertilization in the days after ovulation takes place, the Corpus Luteum breaks down because it does not receive Human Chorionic Gonadotropin signaling. HCG is released after fertilization to encourage stable Estrogen and Progesterone levels.

When used as a fertility treatment, Clomiphene is administered orally in the early stage of the menstrual cycle. During this period, levels of Follicle Stimulating Hormone increase quickly, which leads to the production of follicles in the uterus. The follicles then produce Estrogen which circulates through the blood stream. Clomiphene increases the production of Follicle Stimulating Hormone by reducing the negative feedback mechanism caused by Estrogen upon the receptors on the Hypothalamus, causing the Hypothalamus to produce quick pulses of Gonadotropin-Releasing Hormone.

As Follicle-Stimulating Hormone Levels increase, this causes the ovaries to produce more follicles, which spurs ovulation as they rupture. When using Clomiphene, ovulation generally occurs six or seven days after the last dose of Clomiphene is taken.

Clomiphene Chemistry

Clomiphene is a combination of two isomers of the same compound, Zuclomiphene and Enclomiphene. These are the active ingredients, which both have the capability of encouraging the production of Estrogen while also inhibiting the activity of negative feedback mechanisms which discourage the production of Estrogen by the female body.

In men, Clomiphene encourages the production of Testosterone by inhibiting negative feedback mechanisms, because the precursor hormones which lead to the production of Estrogen in females lead to the production of Testosterone in males.

Clomiphene Off-Label Uses

Clomiphene has proven to be highly effective for males that are experiencing Andropause, or other forms of primary hypogonadism which slow down the production of Gonadotropin-Releasing Hormone, Luteinizing Hormone, and Follicle-Stimulating Hormone.

As a result of its high effectiveness and lower incidence of side-effects, many patients and physicians prefer Clomiphene to Bio-Identical Testosterone for many patients suffering from Low-T. This is primarily because Clomiphene is cheaper than Testosterone while also being easier to administer, since it is taken orally.

Another reason why many patients prefer Clomiphene is because Clomiphene Testosterone Restoration sustains fertility during treatment while also preserving the normal form and function of the testes. With Bio-Identical Testosterone Therapy, the testes slowly lose their ability to produce sufficient levels of sperm for fertility, although this can be prevented by combining HCG Injections with Testosterone to maintain the body's production of Luteinizing Hormone, necessary for natural Testosterone and Sperm Production.

It is important to note, however, that Clomiphene has not been approved by the FDA for male use. This is not because of any inherent issue with the therapy, but because there is no profit motive for pharmaceutical companies to lobby the FDA for approval, because Clomiphene is available in generic form, and most patients use Bio-Identical Testosterone in spite of its disadvantages, as a result of a number of factors, including branding distribution. Enclomiphene, one of the two isomers that comprise Clomiphene, is in the process of clinical testing for male patients, and is also known as Androxal.fffff

Use of Clomiphene as a Performance Enhancing Drug

Clomiphene is often used by men that abuse Testosterone in order to counteract the effects of the conversion of Testosterone into Estrogen. Steroid and Testosterone Abuse is generally conducted in cycles which last months, in which the user takes breaks to help encourage normal physiological function. Clomiphene is generally used between cycles in order to prevent gynecomastia and other side-effects of Steroid Abuse. This also simultaneously encourages the male body to produce its own Testosterone more quickly after a cycle.

Because of these uses, Clomiphene is included among Testosterone, Human Growth Hormone, and many other drugs on the list of banned PEDs in various international athletic leagues and competitions.

The History of Clomiphene

Clomiphene was first used in the 1960s as a medical treatment. At first it was used for women suffering from abnormal ovulation, and was later approved for use for women that had trouble ovulating at all.

In 1989, Clomiphene was also approved as a method to ascertain fertility in female patients. It was discovered that women that were capable of pregnancy would gain Bone Mineral Density via their use of the drug, while women that were unable to conceive and bear children would not experience this change in bone mass.

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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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