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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 01 July 2021

I bet you werent expecting to read about sea cucumbers when clicking on a hormone blog, did you? Surprise! That is what this article is all about...sort of. Actually, well be exploring the ancient origins of our endocrine system and its evolutionary history which just so happens to be traced back to sea cucumbers. Neat, huh? Lets begin on our journey through time

Proteins Essential for Reproduction, Metabolism and Immunity Traced Back to Sea Cucumbers

We love to study evolution and understand how we got to where we are today in terms of our genetics, our technology, our cultural history, etc. Scientists from the Marine Science and Technology College in China decided to pursue a study investigating the evolutionary history of our endocrine (hormone) system. They found that a key set of proteins that aid in hormone regulation and are necessary for many, many essential functions in humans as well as other vertebrates have origins that can be traced back to more primitive creatures: sea cucumbers. Who would have thought?

The group of proteins that they focused on are part of a system called the kisspeptin system. The kisspeptin system controls hormones that are released by the three main endocrine glands of the human body: the hypothalamus, the pituitary gland and the sex organs of both men (testicles) and women (ovaries). These three endocrine glands regulate major processes including reproduction, the immune system, metabolism and more. Lets delve into these organs a bit further

The Basics of the Endocrine System

The endocrine, or hormone system, is a collection of glands or organs that produce hormones. There are other glands involved besides the three previously mentioned, including the thyroid gland and adrenal glands. The word endocrine is derived from the Greek words endo, which means within and crinis which means to secrete. Basically, a gland selectively uptakes materials from the blood, processes them and secretes a finished biochemical product (hormone, protein, enzyme) for use in other areas of the body. Our endocrine system is so important because it acts on almost every organ and cell in our bodies.

Each type of hormone, such as growth hormone or estrogen, circulates through the bloodstream to targeted organs and tissues. Once the hormone reaches its destination, it will begin a chain reaction within the cell such as the production of sperm or the breakdown of fat for energy use. Basically, hormones is what keeps our bodies running efficiently, or running at all, really.

Hypothalamus: The hypothalamus is a small section in the center of the brain with the main role of keeping the body and/or endocrine system in homeostasis (or balance) as much as possible. Quite the job!

The hypothalamus is basically the connector between the endocrine system and the nervous system. Because of this connection, it plays a part in functions such as body temperature, appetite/hunger, emotions, sleep, blood pressure, balance of bodily fluids, etc. As different parts of the body send signals to the brain, they are telling the hypothalamus about any unbalanced factors that need to be fixed. For example, if the internal temperature is too high, the hypothalamus tells the body to start sweating.

Pituitary Gland: The pituitary gland actually sits underneath the brain, at the base of the skull in a bony hollow, connected to the hypothalamus and is considered the master gland. Even though it is the master gland, regulates several vital functions and controls the activity of other glands, it is only the size of a pea. The anterior portion is connected to the brain by blood vessels and the posterior portion is actually a part of the brain and secretes hormones directly into the bloodstream.

Most of the time, the hypothalamus acts on the pituitary gland first and stimulates it to release the hormones that the body needs, but not with every hormone. The pituitary gland secretes a variety of hormones including prolactin (induces milk production in the breasts), growth hormone (regulates growth, metabolism and body composition), leuteinizing hormone (LH) and follicle-stimulating hormone (FSH for sex hormone production and other activities in the sex organs) and thyroid stimulating hormone (stimulates thyroid gland to secrete thyroid hormones).

Sex Organs The sex organs are comprised of the testicles in men and the ovaries in women. They both are able to secrete their own hormones, such as testosterone and estrogen. The secretion of these hormones stimulates processes such as puberty, egg maturation and sperm production.

Evolutionary Origins of Kisspeptin Proteins

Now that you know a bit more about the endocrine system and the major trio composing the kisspeptin system (hypothalamus, pituitary gland and sex organs) we can delve into the evolutionary origins of them.

Lead author, Tianming Wang, stated, The origins of these proteins have previously been traced to very simple creatures with spinal cords, but it hadnt been traced back any further. This raises an important question: does the kisspeptin system have an ancient evolutionary origin, or did it first emerge in animals with spinal cords?

Wang and his team wanted to answer this question. To do so, they looked for kisspeptin system genes in the sea cucumber. Sea cucumbers are very simple creatures that have no spinal cord. The scientists actually were able to identify equivalents of the kisspeptin genes in the squishy little creatures.

Next on the scientists agenda was to administer kisspeptin-like cucumber proteins into mammal cells to see what would happen. This caused the mammal cells to secrete calcium, which is similar to how human versions of the protein would behave. These sea cucumber proteins were able to interact with receptors in human cells as well. This finding suggests that not much has changed in these proteins over the course of years of evolution.

The scientists final phase of experiments consisted of activating or blocking the signaling system in sea cucumbers. By blocking these proteins from being produced, it became clear that they are critical for such important functions as reproduction and metabolism in the sea cucumbers.

Endocrine System Predates Evolution of Spinal Cord

The senior author of the study, Naiming Zhou, says that their experiments suggest that the kisspeptin system actually predates the evolution of the spinal cord in animals and would also be present in other animals that are closely related to the sea cucumber.

Zhou states, Our findings indicate the existence of a kisspeptin signaling system in a very simple organism lacking a spinal cord. They provide new evidence to support the ancient evolutionary origin of the physiological functions in vertebrates that are controlled by the kisspeptin system.

There you have it, folks. Our hormones and endocrine system can be traced all the way back to primitive sea creatures. Fascinating, indeed. Continue to follow our blog for more interesting and up-to-date hormone news!


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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 26 June 2021

The benefits of exercise are tremendous. Adding a regular weight lifting or resistance training regimen to your weekly routine can boost Testosterone, help you lose weight, and more! Working out is about more than building strengthit's a powerful tool to help you live a healthier and happier life.

Aerobic exercise is important, but cardio alone will not fulfill all of your body's wellness needs. The ideal exercise regimen combines Aerobic exercise and weight training for maximum potential. Let's focus on some of the many health advantages associated with anaerobic exercise.

Burn Belly Fat With Resistance Training

Studies have shown that lifting weights is more effective than aerobic exercise as a means to reduce stubborn adipose belly fat. Muscles naturally burn calories even when at rest. This basal metabolic rate increases with overall muscle mass. This means that the more that you can lift the higher your fat-burning potential!

Improve Heart Health By Lifting Weights

The overabundance of adipose fat heavily impacts cardiovascular health. This fat is associated with inflammatory hormones and proteins. Losing belly fat has the added bonus of reducing the influence of these chemicals, which negatively affect blood pressure and harm blood vessels. Weight lifting lowers triglycerides, balances blood pressure, and increases HDL Cholesterol.

Get Blood Sugar Under Control With Anaerobic Exercise

When you work out, your body needs more energy. Your body responds by using available glucose reserves. This reduces the strain on the pancreas that contributes to insulin resistance and Type-2 Diabetes. Weight lifting also encourages increased HGH Production, which frees energy stored in fat cells for use once readily available blood sugar is used up. A regular workout program trains your muscles to absorb blood sugar more readily.

Lifting Weights Mitigates Cancer Risk

Cells in your body fat produce a growth factor known as FGF2 that can increase the risk of various cancers. Obese individuals tend to make way too much of this hormone. Losing weight with exercise and diet reduces the dangerous influence of FGF2.

Stronger Muscles Help Prevent Injury

Weak muscles put your body off balance and in danger. Your muscles help maintain coordination and balance. A sedentary lifestyle interferes with your body's stability and increases the risk of injury. Weight training also strengthens the tendons, reducing the risk of tears, sprains, and other injuries.

Pumping Iron Lets Off Steam, Builds Mental Fortitude

Mental health and physical health are tightly intertwined. Strength training helps relieve psychological stress by giving it an outlet. A structured workout program also gives you goals and provides structure. It bolsters your ability to meet and overcome mental roadblocks. Exercise is also known to release hormones associated with psychological wellness, such as endorphins, serotonin, HGH, and Testosterone.

Strength Training Enhances Mobility and Flexibility

Combining weights with stretches has major benefits for your ability to maximize your range of motion. While simple stretches are beneficial to flexibility, mixing those stretches with some resistance training amplifies the benefits. Furthermore, strength-building exercises which target neglected muscles and muscle groups add to these mobility gains. Extension exercises do the most for flexibility.

Resistance Training Makes Bones More Resilient

It's critical to remember that weight lifting works out way more than muscles. Your entire skeletal structure benefits from anaerobic exercise. Just as your tendons become stronger because they link muscle to bone, your bones get stronger as well. Resistance workouts encourage your bones to increase activity which reinforces their strength. This has lifelong benefits, reducing the risk of fractures and breaks associated with Osteoporosis. If you're worried about the biggest risks associated with Osteoporosis, lunges and squats are most effective at increasing the bone density of the femur and lower spine.

Lifting Heavy Things Improves Self Image

Body image is a huge part of overall happiness. To look in the mirror and be happy with what one sees is incredibly important to positive mental health. Exercise helps people put their body into their own hands. Being able to look at yourself and realize changes and progress being made is huge. On top of that, studies have shown that weight training helps improve body image even in the absence of notable change. Working out just tends to make you feel more attractive.

Cognitive Function and Memory Benefit from a Physical Workout

If you're concerned with protecting and preserving your mental acuity as you get older, resistance training has notably positive effects on long-term outcomes. Research demonstrates that weight training has a bigger impact on cognitive function among older, at-risk individuals than simple stretches. This is another example of how the brain and body are linked. It's hypothesized that increased blood flow to the brain due to weight lifting gives the brain more resources to perform its normal functions.

Live Longer With the Help of Anaerobic Training

All of these benefits add up to enhance your longevity. Resistance training leads to a stronger body and mind, and it reduces the risk of traumatic injury. There is a strong correlation between all-cause mortality risk and grip strength. It's even hypothesized that strength is way more important than BMI when it comes to assessing one's overall health.

Men's Clinics and Hormone Therapy Centers Help Promote Optimal Hormone Levels

Hormone Balance and physical health are intricately interrelated. HGH Deficiency and Low-T lead to many symptoms which make it harder to get the most out of exercise. If you've been struggling with lack of energy combined with increased body fat and reduced strength, you may be having issues related to Hormone Imbalance.

While exercise helps promote healthy Hormone Levels, Testosterone Deficiency and other hormonal issues also make it harder to commit to a healthy exercise program. If you feel that your hormones are getting in the way of your health goals, consider reaching out to a trained HRT Specialist.


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 24 June 2021

When you hear the word chia, you might just think of Chia Pets, those silly red clay pots that look like llamas or presidents who grow green fur after you water them for a while. Well, those joke presents (admit it, youve bought several) do indeed use chia seeds to grow the green hair. But did you know that chia seeds can do some really beneficial and important things for your health? Read on, pardner!

Chia seeds are the seeds of a Central American desert plant called Salvia hispanica (the green and more common kind) or of a North American variety called Salvia columbariae (the golden chia). The first time we hear of chia seeds in history is in records of European explorers who recorded the fact that they were a staple of the diet of the Aztecs. The plant is related to mint.

Chia Seeds are a GREAT Source of Omega-3s!

In more recent years, weve discovered that chia seeds are a very good source of omega-3 fatty acid, which plays an important role in our bodys metabolism and studies have also shown omega-3 has beneficial effects on our mental health, too. Chia seeds are a great source of dietary fiber as well, with some 10 grams of fiber for every ounce of seeds. They also contain significant amounts of zinc, calcium, magnesium, and iron.

Chia seeds are rich in antioxidants, which many anti-aging researchers credit with helping to prevent the damage caused by free radicals in our bodies, which many believe are a major factor in aging. Theres also evidence that a diet that includes chia seeds can reduce chronic inflammation in some sufferers, without harming the bodys ability to produce inflammation when it is really necessary to fight off microbial invaders.

You might be surprised to learn, too, that a one-ounce serving of chia seeds contains almost 6 grams of protein. That makes them around 14% protein, making them one of the most protein-rich plant foods out there.

Chia Seeds Have Tons of Vitamins and Minerals

That same one-ounce serving has zero sugar, more than 13 grams of complex carbohydrate, 8.5 grams of fat (more than half of which are omega-3s), and gives your body a little over 130 calories of energy. Trace elements abound in an ounce of chia seeds, as well: 27% of the recommended daily intake of phosphorus; 30% of the recommended daily intake of manganese; 30% of the recommended daily intake of magnesium; 18% of the recommended daily intake of of calcium. That calcium number is really impressive gram for gram, chia seeds contain  ore calcium than dairy products so! And each zippy little chia seed ounce also delivers significant amounts of vitamin B3 (niacin), potassium, vitamin B1 (thiamine) and vitamin B2 as well. Heres the takeaway message: Chia seeds give you a huge helping of nutrition with a proportionately small helping of calories, a combination that is very hard to beat!

Some research suggests that chia seeds, when added to a healthy diet, can reduce some factors for cardiovascular disease: lowering blood pressure, triglycerides, and bad cholesterol (while at the same time increasing your good cholesterol).

Chia seeds are also known to feed the friendly bacteria in your intestines, and maintaining healthy digestive flora is, as doctors increasingly acknowledge, very important for human health.

And get this studies have found that chia seeds improve insulin sensitivity and blood sugar control for some diabetics, tending to stabilize their blood sugar levels after eating; in addition several studies report that eating bread with chia seeds added to or baked int it lowers the rise in blood sugar after meals that is experience by many people, including diabetics.

Diversify Your Diet With Both Chia Seeds AND Sprouts

And you dont have to restrict yourself to eating the seeds alone, either: chia sprouts are edible and texture-rich additions to many dishes including sandwiches, soups, salads, and as a garnish to almost anything. They have essentially the same benefits and nutrients as the seeds.

Chia seeds and sprouts have a subtle flavor that many people like. But if youre the kind of person who likes bold tastes, you might want to add a little bit of spices in chia dishes so that the flavor better harmonizes with the already-rich texture for your palate.

Chia seeds can be popped into your mouth raw, just like candy and a whole lot better for you! Or try spreading the raw seeds on vegetable dishes, cereal, or oatmeal. Or mix a few in with your smoothies for an extra flavor and texture boost. Chia seeds absorb water and other liquids easily, and so can be made slightly or greatly softer, depending on how long theyre exposed to liquid and the thickness of the liquid itself. So experiment and find our what texture you prefer. In fact, unless the chia seeds are certified organic, its a good idea to soak or rinse them before eating to remove any traces of chemicals, fertilizers, or other non-chia material.

Chia Seeds: An Egg Replacement for Vegans

And heres a great cooking tip for vegans: Soak the seeds in water, then mix, until the resultant solution is semi-solid and gelatinous-looking then use the result as an egg substitute in most any recipe. Yum! (In fact, chia seeds with their high protein and calcium levels are particularly good for folks on a plant-based diet or health-conscious people who just want to rebalance their diets to decrease animal-based foods.)

Chia seeds do tend to absorb liquids easily, soaking up up to 12 times their weight, and will increase in size dramatically when they do so. So, if you are a person who has difficulty swallowing, or who has a narrow throat opening, avoid swallowing a lot of dry chia seeds and then drinking afterward. Pre-soaking the seeds for five or ten minutes avoids this risk.

Chia seeds are widely available in local grocery stores and online, and they are very easy to prepare if you decide to prepare them at all! With their high nutrient profile, and low-calorie/low-fat footprint, Chia seeds are truly a superfood, and theyre one that most of us would benefit from having in our diet, if were not eating them already.

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