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ANASTROZOLE RESEARCH STUDY


Written by Dr. Welsh, Published on 18 June 2014

Anastrozole Research Study

Anastrozole is what is known as an Estrogen-Blocker. Estrogen-Blockers are used to inhibit the production of Estrogen by the body and to prevent the conversion of Testosterone into Estrogen via biological mechanisms inside the body. For post-menopausal women, Anastrozole is commonly prescribed as part of breast cancer treatments, because the presence of Estrogen exacerbates breast cancer. The brand name form of Anastrozole, Arimadex, is produced and distributed by the pharmaceutical giant, AstraZenaca.

Among men, Anastrozole Therapy is commonly prescribed along with Testosterone Therapy in order to inhibit the body's natural propensity to convert excess Testosterone into Estrogen, especially among obese patients and patients taking forms of Testosterone Therapy prone to inducing spikes in Testosterone Production.

Also, bodybuilders, athletes, and weight-lifters commonly take Anastrozole in combination with high levels of Testosterone in order to abuse the Anabolic effects of Testosterone while mitigating the side-effects related to excess Estrogen and Testosterone, including Gynecomastia.

Anastrozole Clinical Study

In one particular study, published in 2009, researchers studied the impact of Anastrozole Treatment upon the production of Testosterone and other sex hormones among men. They also measured a number of other co-varying factors, including cholesterol levels, PSA Counts, Strength, and Body Composition. All patients in the study were individuals suffering from Low-T, and all patients were treated with Anastrozole Estrogen-Blocker for twelve months.

After a year of treatment, researchers found that the men experienced an increase in Testosterone of around fifty percent, and this increase was sufficient to put men right in the middle of a healthy, adult Testosterone Range. This was coupled with an average twenty percent decrease in Estradiol levels, although the average Estradiol levels were normal on average.

Anastrozole had a number of beneficial effects. The Estrogen-Blocking Treatment increased concentrations of Luteinizing Hormone, Dihydrotestosterone and Free Testosterone (also known as Bioavailable Testosterone). These effects were significant when compared to the placebo group.

Unfortunately, the increase in Androgen Production and decrease in Estradiol production did not lead to significantly enhanced strength or body composition, but it also did not have a negative impact on cholesterol balance, prostate health, and PSA Levels.

Andropause and Male Health - Testosterone and Estrogen

It has long been known that the male aging process is strongly correlated with a steady and constant drop in the production of male androgens such as Testosterone and Dihydrotestosterone. It is also known that Estrogen Production also drops at the same time as these male Androgens decline, albeit at a slower rate.

This transformation eventually leads to a condition known as Testosterone Deficiency, Andropause, or simply Low-T. At the same time, Estradiol ratios increase in relation to Testosterone Concentration as a result of their differing rates of decline. This is because, although there is less Testosterone, the body converts that Testosterone into Estradiol at a faster rate with age.

Researchers are still attempting to discover the full implications of this biological change, and how it effects male health. Hormone Scientists are also attempting to figure out exactly how this biological change occurs, as the mechanisms are not yet fully understood.

Why Do Testosterone Levels Drop Faster than Estrogen Levels in Men?

Endocrinologists do have some hypotheses however. Here are some of them:

  • Reduced production of Testosterone as a result of increased Estrogen synthesis.

  • Decrease in the mass of Leydig Cells, which are responsible for the production of Testosterone.

  • Leydig Cells may become increasingly insensitive to stimulation from the Pituitary, which could inhibit Testosterone Production.

  • As men grow older, they could be producing less Testosterone as a result of increased activity of Gonadostatin Hormones or other hormones which suppress the production of Testosterone as a factor of age.

How Does Anastrozole Increase Testosterone Levels?

Aromatase Inhibitors such as Anastrozole and Arimadex are able to enhance Testosterone production because they reduce the production of Estradiol. The presence of excess Estradiol produces a negative feedback mechanism which encourages the enhanced release of Gonadotropin-Releasing Hormone, Luteinizing Hormone, and Follicle Stimulating Hormone by the Hypothalamus (GRH) and the Pituitary (LH and FSH). All of this acts together in a way which stimulates the testes and adrenal glands to produce more Testosterone.

Why is Anastrozole Useful for Testosterone Replacement?

There are a number of reasons why it would be highly beneficial to use Anastrozole as a means to improve Testosterone Production, if it were effective:

  • Anastrozole is effective in pill form, making it very easy to take with minimal inconvenience.

  • It can mitigate the side-effect of Gynecomastia related to Testosterone Therapy

  • Protects the cardiovascular system and the cognitive faculties from the negative effects of excess estrogen.

  • Anastrozole may be beneficial in lieu of Testosterone Therapy as a means to enhance Testosterone Production without the risk of Benign Prostatic Hyperplasia (as of yet unfounded)

Previous Research: Hypogonadism and Anastrozole

One of the inspirations that lead researchers to conduct this study regarding the impact of Anastrozole on Estrogen and Androgen Levels was another study which evaluated the effects of Anastrozole upon 37 geriatric patients suffering from hypogonadism. This study produced some very similar results with regard to how Anastrozole improved Testosterone Concentrations as well as normalized the ratio between Testosterone and Estradiol.

The original study was conducted over the course of three months, as opposed to the year-long study conducted in 2009. These results were corroborated in another study, although that study did not involve a control-placebo group.

The Testes May Lose Their Ability to Produce Testosterone as Men Grow Older

Because this study was over the course of a year, rather than only three months, it provided greater information with regard to how the human body responds to long-term treatment with Anastrozole. In this study, for example, results after three months were nearly identical to those in the other earlier three month studies, but then over the course of the next nine months, androgen concentrations dropped.

The researchers hypothesize that the decrease in Testosterone Concentration could be the result of increased resistance to the Estrogen-Blocking Medication. Researchers found that, although Testosterone Production dropped over the course of the last nine months, Luteinizing Hormone Levels remained at high levels. This suggests that although the Hypothalamus and Pituitary are sending sufficient signals to produce youthful levels of Testosterone, that the Leydig Cells in the testes, for unclear reasons, are no longer capable to meet the demands of the body.

It has been observed however, that Leydig Cells are less responsive to Luteinizing Hormone when there is a higher concentration of ligands. Because of the stable Estradiol Concentrations over the course of the nine months, as well as well-kept medication diaries and monitored pill-counts, the researchers are able to discount noncompliance as a contributing factor to reduced Testosterone Concentrations.

Effects of Anastrozole on Body Composition Differ from the Effects of Testosterone Therapy

The vast majority of studies on why men with Low-T Hypogonadism have been treated with Testosterone have shown that Andropause Therapy reduces body fat and increases muscle mass. Many studies also show that Testosterone Restoration has a positive impact on physical strength.

In this particular study, the same benefits do not appear to be apparent with regard to Anastrozole. After a year of medication with Anastrozole, there were no significant changes in muscle mass, strength, or body composition observed. These results are similar to those of other studies which utilized Estrogen-Blockers for a shorter period of time.

Why Is Anastrozole Alone Not as Effective as Testosterone Treatment?

It could be that the patients did not have Low-T of sufficient severity to produce positive biological changes in body composition. The researchers don't feel that this is the case, however, because there have been other studies in which men with the same degree of Low-T were able to experience significant gains in body composition directly from therapy.

A second potential explanation for this lack of change in fat and muscle mass is that Anastrozole alone, or at the dose administered, does not have the capability to produce the increase in Testosterone necessary to lead to significant gains with regard to body composition. Most studies which have led to increased Muscle Mass and Decreased Body Fat were the result of increasing Free Testosterone Levels to High-Normal, whereas this treatment only raised Testosterone Levels to Mid-Normal.

Another issue with Anastrozole Pills is that they, alone, don't produce the same increases as Bio-Identical Testosterone Formulations, because these treatments bypass the digestive system and deliver the dose directly to the blood stream. Testosterone Administered via Injection, Patch, or Cream, produce Testosterone Peaks which are higher than average.

Since this study only produced peak Testosterone Levels that were mid-normal, and concentrations dropped over the course of the year of therapy, this may have been the reason why Free Concentration did not produce significant Body Composition gains.

It is also possible that the reduced concentrations of Estradiol resulting from Anastrozole Treatment could have inhibited the gains that one would normally expect from treatment. In animal subjects, there is evidence that male mice increase body fat if aromatase genes are not activated. This is also true if Estrogen Receptor-α is not activated. Among rats that have been castrated, the administration of Estrogen actually protects against weight gain and has the ability to generate muscle mass.

In relationship to this animal study, men that have experienced Prostate Cancer are more resistant to weight gain when treated with an Androgen Blocker which increases Estradiol Levels known as Bicalutamide. These benefits were enhanced in relationship to Gonadotropin-Releasing Hormone, which simultaneously inhibits Estrogen and Androgen Production. Interestingly enough, it appears that Estradiol does play a particular role in protecting healthy body composition among male patients.

Anastrozole Does Not Impact the Prostate Gland

All signs from this study show that Anastrozole and Arimadex have no impact upon the health of the prostate. In particular, Anastrozole does not lead to prostate enlargement, and it does not lead to increased PSA Counts. Researchers hypothesize that since Anastrozole decreased Estradiol Levels while increasing Testosterone Levels, it counteracted the effect upon the prostate that is often the result of Testosterone Therapy used alone.

The scientists that produced this study took the time to place special emphasis upon this connection between the Prostate and Estrogen. It may be that Testosterone Therapy combined with Anastrozole may have the ability to provide the normal benefits of Testosterone Restoration and Optimization while protecting the prostate from risk of the potential side-effect of Prostate Enlargement.

There is further biological evidence that this may be the case. Estradiol Levels are positively correlated with increased incidence and severity of Benign Prostatic Hyperplasia, and the body also becomes more sensitive to Aromatase as men grow older. Animal studies have also shown that Estrogen Injections enhance Prostate-Specific Antigen, and they also lead directly to the proliferation of stromal cells and prostatic epithelial cells which are associated with Benign Prostatic Hyperplasia. Animal studies have also shown that drugs which inhibit Estradiol actually have the ability to alleviate the effects of the condition.

Anastrozole Does Not Alter Cholesterol Balance or Increase Red Blood Cell Count

In this study, there is no evidence that Anastrozole Treatment negatively impacts cholesterol or causes polycythemia. Today, researchers are highly interested in figuring out how to provide Testosterone Therapy to patients with Low-T while preserving or enhancing cardiovascular health and cholesterol levels. Many studies clearly point out that healthy Testosterone Levels are associated with improved heart health and enhanced cholesterol balance.

Other studies regarding Testosterone Therapy, on the other hand, show that some forms of Testosterone Treatment can sometimes lead to negative consequences in regard to cholesterol. There is also evidence that oral Estrogens reduce LDL cholesterol levels and increase HDL cholesterol levels in both sexes. Estrogens administered via cream have a limited impact on cholesterol.

These positive changes in cholesterol associated with Estrogen pills do not seem to provide heart benefits. This provides even more evidence that Cardiovascular Risks are complex, and there are a number of factors which control heart health, not just cholesterol. Other issues that can affect Cardiovascular Health include endothelial function, coagulation, insulin resistance, and inflammation.

Anastrozole Study Limitations

There is one powerful issue which can impact the results of this study. There is no clearly delineated definition of what is considered Low-T among older men. Because there is no agreed-upon definition, it makes establishing clinical guidelines for Andropause and Low-T a difficult thing to do.

This study used a more common definition of Age-Related Low-T to choose its subjects, but other researchers have tighter guidelines for what patients are considered Andropause Sufferers. If the researchers would have used tighter guidelines for Testosterone Deficiency, they may have found positive effects upon muscle mass and body fat, but they argue that, had they used these more stringent guidelines, the study could not effectively be compared to the majority of other Low-T Studies.

Anastrozole Study Summary

To summarize the above study and its effects, researchers found that one year of Anastrozole Pill Treatment had the ability to suppress Estradiol Levels and enhance Testosterone Production among adult males over the age of sixty struggling with mild or moderate Low-T.

This treatment was able to restore Testosterone Concentrations associated with that of young and healthy males, but it did not have a positive impact upon strength and body composition. This outcome could have been the effect of inhibited Estradiol Production in relationship to increased Testosterone Levels, or it could have been the result of a developed resistance to the Estrogen-Blockers.

Future studies could monitor the effects of Anastrozole (Arimadex) Estrogen-Blockers upon other issues associated with Low-T, including reduced sexual function, quality of life, cognitive health, insulin sensitivity, and bone mineral density. Such studies would enhance our knowledge of how Estrodiol and other Estrogens impact the health of men, and how Estrogen interacts with Testosterone and Testosterone Restoration.

Anastrozole Information Source:

http://www.medscape.com/viewarticle/586804_4


SUPPLEMENTING TESTOSTERONE WITH HCG


Written by Dr. Welsh, Published on 18 June 2014

Supplementing Testosterone with HCG

Testosterone Restoration is a fantastic way to treat Low-T. Actually, as of today, it's the only real and effective way to return Testosterone Levels to normal after Andropause. There are a few issues related to Testosterone that could give you pause, however.

Testosterone Supplementation Suppresses Natural Testosterone Production

For one, Testosterone Therapy reduces the body's ability to produce its own Testosterone. Now, this isn't necessarily a bad thing. If you are suffering from Low-T or Andropause, your body is no longer able to produce the amount of Testosterone needed to sustain optimal function, so you need to do something to get your Testosterone Levels back to normal, because no amount of diet or exercise is going to get you above a certain level of Androgen function beyond that which you are limited to by age and genetics.

So, men with Low-T turn to Testosterone Replacement with Gels, Patches, Creams, or Injections, and are able to enhance their health and body composition in a number of beneficial ways, but the natural hormone rhythms of the body do benefit from some level of natural Testosterone Production. So, what can you do?

How Does Testosterone With HCG Sustain Testosterone Production?

If you are interested in preserving your body's natural rhythms, you may be interested in combining Bio-Identical Human Chorionic Gonadotropin to your Testosterone Therapy. HCG is a natural hormone that is normally only produced by the female body during pregnancy. Interestingly enough, however, this hormone is responsible for some very masculine effects when applied to the male body. HCG is a functional analogue of a hormone produced by both sexes under normal circumstances known as Luteinizing Hormone.

In the female body, Luteinizing Hormone helps regulate the menstrual cycle, but in the male body, Luteinizing Hormone preserves the normal manufacture and secretion of Testosterone by the testes, and it also encourages the testes to produce sperm for fertility. By supplementing your Testosterone Therapy with HCG Injections, it is possible to maintain a baseline level of natural, endogenous Testosterone Production which preserves your physiological ability to produce Testosterone, while Testosterone Treatments raise your Testosterone Levels to their optimal state so that you can experience the benefits of both Prescription Testosterone and Natural Testosterone simultaneously.

Testosterone Therapy Inhibits Fertility

Another issue with Testosterone Optimization for Andropause is that it reduces your fertility. The body has various mechanisms through which it can monitor concentrations of Testosterone in the body, and if the body recognizes that there is an outside source of Testosterone providing the hormone to the body, it will send signals to the hypothalamus to reduce production. The body produces less Luteinizing Hormone and Follicle-Stimulating Hormone in response.

This has minimal effects upon the overall health of the body, because the body is still getting the Testosterone that it needs-it's actually getting more Testosterone than it was getting before! The main issue with regard to Testosterone Patches, Injections, and Gels is that the body no longer produces the signal for Luteinizing Hormone, which is responsible for the production and proliferation of healthy sperm cells.

As the body becomes accustomed to the influx of Real Bio-Identical Testosterone, it slowly drops its production of Testosterone Precursors, which slowly reduces fertility over time. If a patient uses Testosterone long enough, he will actually eventually become effectively infertile. Luckily, however, this infertility is only a temporary symptom of treatment, and if the patient stops taking Testosterone, fertility can slowly return to pre-treatment levels.

Taking Testosterone with HCG Can Protect Fertility, Even During Treatment

In relationship to its ability to sustain normal production of Testosterone, HCG also simulates Luteinizing Hormone and promotes the normal production of sperm by the testes. In doing so, it preserves fertility.

If you are looking to choose Testosterone Optimization to preserve and foster greater health and protect yourself against some of the most devastating effects of aging and premature aging, but you also want to preserve your fertility potential, the best course of action would be to take Subcutaneous HCG in combination with Testosterone in order to maximize your fertility potential during treatment.

Of course, another option you have available to you if you are not interested in HCG is that you can deposit your sperm at a sperm bank. In doing so, you don't have to worry about your physiological fertility.

Testosterone Replacement Therapy Can Impact the Size and Appearance of the Testicles

A third issue with Testosterone Treatment is cosmetic. As we mentioned earlier, Bio-Identical Testosterone Restoration limits the productive activity of the reproductive system both in regard to the production of Endogenous Testosterone as well as sperm.

Because the testes become less active over the course of Testosterone Therapy, they actually shrink and recede slightly, and this also causes the testicles to shrink and become less full. If you are interested in looking your best in the bedroom, you may become a bit embarrassed about this. Don't let this affect your interest in treatment, however!

Testosterone with HCG can Preserve the Aesthetic Appearance of Your Testicles

Because Human Chorionic Gonadtropin preserves a baseline production of Testosterone and Sperm by the Testes, this prevents the physical changes in appearance associated with Testosterone Restoration Treatment. In addition to enhancing your sexual, physical, and psychological health with Testosterone, you are also protecting yourself from changes in appearance associated with treatment!

If You Decide to Take a Break From or Discontinue Therapy, The Body Regains It's Natural Testosterone Production Slowly

A final major issue with how the human body reacts to Testosterone Therapy is that the body recovers relatively slowly from the end of treatment. If you have been taking Testosterone for six months to a year, your body's natural production of the hormone is very, very low, and it will take time for it to come back to normal.

HCG Can Be Used in Order to Restore Normal Testosterone Production Quickly After Therapy

If you choose to undergo Testosterone Therapy on its own, your Hormone Prescribing Specialist may recommend that you undergo occasional Testosterone Cycling. This means that you will take Testosterone alone for awhile, and then occasionally, you will take brief breaks from Testosterone in order to keep your on body's production at a certain capacity. In this case, your physician will prescribe you with HCG during the breaks so that your body will more quickly adapt to the absence of outside Testosterone.

In addition to this, if you ever choose to suspend Testosterone Treatments for an extended period of time, and would like to get your Endogenous Testosterone Production back up to normal more quickly, your Prescribing Hormone Physician can also prescribe you with HCG in order to get your Testosterone Levels back to normal for your Age and Genetics.

Are You Interested in Supplementing Testosterone Therapy with HCG?

If you are interested in Testosterone Creams, Patches, or any other form of Testosterone Optimization, our clinic offers high-quality, Physician-Monitored Hormone Therapy, and if you qualify, we can get you the treatment that you're looking for, for some of the best prices available in America today. We can also provide you with HCG if you are looking to supplement your therapy.

We are also happy to offer a wide variety of Hormone Replacement Products and Services, including Human Growth Hormone Injections, Injectable Sermorelin Acetate, and HCG Injections for Weight Loss. If you are interested in these or any other form of Hormone Treatment, we encourage you to contact us via the form on this page and fill out the simple medical questionnaire.

We can also take your call at the number above. One of our friendly and knowledgeable Board-Certified Hormone Therapy Specialists will be happy to take your call and answer any questions!


VITAMIN B6 PART OF THE B COMPLEX FAMILY


Written by Dr. Welsh, Published on 14 January 2016

Vitamin B6, Part of the B Complex Family: You Need It

by Don V. Richards

Vitamin B6, also known in its biologically active form as pyridoxal phospate (and also in the form of pyridoxine, pyridoxamine, pyridoxal, and several other variants) is naturally-occurring nutrient that is absolutely essential to human health. It's a water-soluble vitamin which means that it can't be stored in the fat tissues of the human body, and any excess beyond what the body can use right now is just flushed away in the urine. Furthermore, the body can't manufacture its own supply. Since we need Vitamin B6 to stay alive, that means that we need an external source of this nutrient, and we must consume B6 regularly and repeatedly.

Vitamin B6 is one of the eight "B complex" vitamins and, like all of them, it helps the body convert our food fats, proteins, and carbohydrates into the glucose which every cell in our body constantly needs as fuel. Also, without Vitamin B6, we would be unable to maintain proper, healthy functioning of our liver, our skin, our hair, and our eyes among other things. The nervous system also needs Vitamin B6 for the production of certain substances called neurotransmitters, which are essential for our nerve cells to communicate with each other which is what enables all our senses, our control over our muscles and other organs (both conscious and unconscious), and our very minds themselves.

Vitamin B6 is essential not only for healthy human brain function, but for proper brain development in children, too. B6 is also needed in order for the body to produce the hormones norepinephrine and serotonin, which regulate our moods, and melatonin, the "sleep hormone," which helps us maintain a normal, restful sleep cycle.

In combination with other members of the B complex family (specifically, Vitamins B12 and B9), Vitamin B6 helps the body reduce levels of an amino acid called homocysteine in our blood. High levels of homocysteine in the bloodstream are linked to heart disease. Studies have shown that people who don't get enough Vitamin B6 are more likely to suffer from diseases of the heart.

Vitamin B6 is also good for our circulatory system in that it is needed for the production of both our regular red blood cells and the white blood cells of our (extremely important) immune system. And, in one of many examples of synergy between members of the B complex family of vitamins, our bodies cannot absorb Vitamin B12 (which boosts blood health and prevents anemia) without an adequate intake of Vitamin B6.

Scientists are currently studying whether or not Vitamin B6 can fight "morning sickness" (nausea and vomiting) among pregnant women. Several studies including one that was a double-blind test of the nutrient against a placebo control group indicate that it can. But a few studies failed to reproduce these results, so research is ongoing.

Another possible Vitamin B6 benefit currently under review by science is its value in combating depression. Patients suffering from depression often have low levels of the hormone serotonin, and several anti-depressant drugs function by raising serotonin levels in the bloodstream. Vitamin B6 helps the body produce serotonin, so trials are underway to see if B6 supplementation can ameliorate the symptoms of this terrible malady.

One of the symptoms of the painful disease arthritis, which particularly affects older people, is inflammation of the joints. This inflammation is known to reduce the level of Vitamin B6 in the body, so it is thought that arthritis sufferers require more of this nutrient than other people, and supplementation may be in order.

One recent study indicated that direct injection of Vitamin B6 was helpful to women experiencing hair loss. According to a Polish medical study published on the National Institutes of Health Web site, Vitamin B6 injections generally improved the quality of the women's hair and reduced hair loss.

Vitamin B6 deficiency is rare, but it does happen among people who have extraordinarily poor diets and the processed food industry enables us all to eat poorly if we don't watch ourselves! That said, though, it should be easily possible to get all the Vitamin B6 you need for normal bodily health and functioning from the foods you eat as part of a healthy, balanced diet. Some of the foods rich in Vitamin B6 are brown rice; bran; sunflower seeds; wheat germ; whole-grain flour; meat, including salmon, shrimp, and beef liver; milk; cheese; beans; spinach; carrots; and lentils. Symptoms of Vitamin B6 deficiency include sores on the tongue and in the mouth, short-term memory loss, confusion, difficulty in concentrating, muscle weakness, nervousness, irritability, and depression.

If you think you can benefit from Vitamin B6 supplements, be aware of the guidelines for daily intake to maintain health and, if you do take in excess of these amounts, make sure you discuss it with your doctor or trusted health adviser beforehand. For adults, the recommended daily allowance (RDA) of Vitamin B6 varies from 1.3 to 2 mg. If you have a special need that requires supplementation at a higher level, don't ever exceed 100 mg daily: Very large doses of this nutrient have been known to cause nerve damage. Some symptoms that might indicate you're consuming too much B6 are numbness in the legs, loss of balance, allergic reactions of the skin, nausea, abdominal pain, loss of appetite, and sensitivity to sunlight. When the excess intake of Vitamin B6 is terminated, all symptoms usually disappear in less than six months.

When supplementing with Vitamin B6, it may be wise to take the vitamin as part of a B complex supplement instead of just B6 on its own. This is because the B vitamins often work in tandem with one another, and allowing a large imbalance between them inhibits the synergy they normally exhibit together, in which the total health effect is greater than the sum of the individual parts.

Whatever your age, health, or condition in life, the 21st century is the age of more widespread health knowledge and information than we've ever known before. Take advantage of this information and take charge of your diet your exercise the supplements you take and start living like you've never lived before!

REFERENCES

Erlich, Steven D., "Vitamin B6," University of Maryland Medical Center, http://umm.edu/health/medical/altmed/supplement/vitamin-b6-pyridoxine , accessed 17 June 2014

Schnyder, G., Roffi, M., Flammer, Y., Pin, R., Hess, O.M., "Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial," Journal of the American Medical Association, 2002 Aug 28; 288(8): 973-9

Woolf K., Manore M.M., "Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis," Journal of the American Diet Assoc., 2008;108(3):443-53

Alpert, J.E., Mischoulon, D., Nierenberg, A.A., Fava, M.. "Nutrition and depression: focus on folate," Nutrition, 2000;16:544-581

Booth, G.L., Wang, E.E., "Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events," The Canadian Task Force on Preventive Health Care, CMAJ, 2000;163(1):21-29

Jewell, D., Young, G., "Interventions for nausea and vomiting in early pregnancy," (Cochrane Review), Cochrane Database System Review, 2002;(1):CD000145

Wong, Kathy, ND, About.com Alternative Medicine: Supplements; Vitamin B5, http://altmedicine.about.com/od/herbsupplementguide/a/Vitamin-B6.htm , accessed 17 June, 2014

Uzoma, Kay, Live Strong, "What Are the Benefits of Vitamin B6 for Women?", http://www.livestrong.com/article/247054-what-are-the-benefits-of-vitamin-b6-for-women/ , accessed 17 June 2014


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Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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