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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

Mark Cuban to Finance Medical Study to Prove Benefits of HGH for Rehabilitation

Medical researchers have long understood the potential benefits of HGH Hormone Replacement Therapy to patients suffering from Age-Related Human Growth Hormone Deficiency, but we are just beginning to learn about a wide variety of other potentially beneficial uses for HGH Shots.

There has been growing evidence that HGH Injection Therapy can be useful for rehabilitation, and Mark Cuban, the owner of the Dallas Mavericks, is interested in finding out the real benefits and drawbacks of HGH for Injury Rehabilitation, and is willing to contribute large sums of money to find out the truth of the matter.

Two Year Study Will Test the Effectiveness of HGH

Mark Cuban has already made a major financial contribution with the intention of funding a clinical study at a prominent university. According to his description, the medical study will be conducted over the course of two years and will evaluate the potential ability for Human Growth Hormone Injections to speed up the rate of rehabilitation after an injury. The study will monitor patients from before their operation until long into their recovery process.

Human Growth Hormone Has Long Been Used by Athletes

HGH Injection Therapy has long been used by athletes of all kinds for the purpose of performance enhancement, and there are even rumors abound that many athletes travel overseas to Europe, because medical facilities in Europe often utilize Subcutaneous HGH Therapy in their treatment processes, which many believe speed up the healing process.

HGH Injections Currently Only Legal for a Few Limited Treatments

In the United States, Recombinant HGH is a highly regulated form of medical treatment, and can only be used legally in the country for a few explicit purposes: Human Growth Hormone Deficiency, Idiopathic Short Stature in Children, and HIV/AIDS-Related Wasting. Overseas, some alternative uses for HGH are often encouraged, and off-label use of the medication is considered legal practice. Since HGH was lumped in with Anabolic Steroids in the late 1980s and early 1990s, HGH Prescriptions are highly limited.

With this medical study, Mark Cuban aims to discover the real potential benefit of Human Growth Hormone Injections. There is a large amount of anecdotal evidence regarding the use of HGH for Rehabilitation, but there has been inconclusive medical study to provide a definitive answer. Cuban looks to provide that answer once and for all.

Players Should Be Able to Use All Effective Medical Tools Available to Recover from Injury

Although Mark Cuban leaves no indication that he believes that Human Growth Hormone should be used as a Performance Enhancing Drug, he sees no reason to deny players that ability to use the treatment as a legitimate medical therapy, especially one that is highly useful and beneficial for athletes prone to muscle and joint injuries.

He believes that if Human Growth Hormone Injections can limit the muscle atrophy associated with medical surgery, it should be available to players that have their rehabilitation times lengthened by such atrophy. He believes that reduced recovery times are good both for the player and for professional basketball itself. Cuban feels that if there is no downside, the players should be afforded the opportunity to use the treatment.

What We Know About This Future Study

Cuban does not go into specific details about the study. He does not name the University, and he does not mention the specific injury, but he does explain that the injury affects well over one hundred thousand patients annually. He implies that both groups will go through the exact same treatment regimen, except one group of patients will undergo routine rehabilitation with HGH Injections, and the other group will undergo routine rehabilitation with placebo injections.

Besides the use of injections, the experiment will not negatively impact the normal rehabilitative process, and will provide a clear image of the effects of HGH on Injury Rehab. If the treatment does improve recovery times, it not only benefits NBA Players, it benefits millions of potential patients all across the United States.

Study Awaits DEA and FDA-Approval

Mark Cuban refused to release any overly-specific information regarding the medical study, because it still awaits FDA and DEA-Approval, although at this time he believes there are no roadblocks to approval.

Also, even though he did not mention the university in particular that would conduct the research, he did express that it was a very well-regarded medical institution. At this stage, Cuban is unsure when the study will actually start, because of the need for federal approval.

Mark Cuban Has Long Been an Advocate for Judicious Use of HGH If Deemed Beneficial

Today, Human Growth Hormone is fully banned as a Performance Enhancing Drug by the National Basketball Association. This means that the drug cannot be used by healthy players to attempt to improve their game, but it also means that injured players are not allowed to use the Bio-Identical Hormone as a medical treatment.

Cuban is interested in providing players this opportunity if research suggests that it is beneficial, and discussed this in a recent Board of Governors meeting. He believes that if HGH Injections prove beneficial for Injury Recovery, they should be allowed for use by injured players. After talking about the subject at the meeting, a number of universities contacted him to discuss potential research opportunities.

Motivations for Supporting HGH Research

Mark Cuban says that his main goal in financing this study is to uncover the truth about Human Growth Hormone. He believes that the NBA's current position toward Human Growth Hormone is just a marketing position, and wants to discover the reality for the players, the league, and society at large.

He admits that it benefits him as an NBA owner if Recombinant HGH can increase recovery times, but in this case, what benefits him, personally has the potential to benefit everyone, which has encouraged his desire to see the truth about HGH for Healing.




Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

What Are Mesenchymal Stem Cells?

Mesenchymal Stem Cells are a unique type of connective tissue that is only partially developed and still has the ability to further specialize into specific forms of connective tissue. The scientific term for cells that have the ability to further evolve into different cell types is Multipotent. You will often find this particular form of Multipotent cell referred to as an MSC. MSCs are also referred to as Marrow Stromal Cells when scientifically appropriate.

These cells have the ability to develop into a number of different types of cells, including fat cells, cartilage cells, and bone cells. As you can imagine, there is a growing amount of interest in cultivating Mesenchymal Stem Cells for use in a number of different medical treatments, especially those related to bone and joint injuries. The ability for MSCs to develop into more complex tissues has been scientifically proven both in a laboratory environment and in animal subjects.

Why Are They Called Mesenchymal Stem Cells?

As researchers learn more about these cells, coming up with an optimally appropriate name became increasingly important:

  • Mesenchyme is a preliminary form of connective tissue which evolves in the embryo stage of development, but this name does not fully meet the needs of MSCs. This tissue forms in the central layer of the embryo, known as the mesoderm.

Further in development, Mesenchyme evolves into both connective and hematopoietic tissue, whereas Mesenchymal Stem Cells can only develop into connective tissue, which proves that Mesenchyme and MSCs are related cells, but different..

  • Stromal Cell refers to a different aspect of MSC function. These cells are a form of connective tissue that provides structural support to a larger cell. Stromal Cell is accurate enough of a term to describe one way that the body uses MSCs, but does not encapsulate the full form and function of the cell.

This is because it has only recently been determined that MSCs have the ability to facilitate the healing of damaged tissue, which necessitates a broader set of naming conventions for the cellular type.

This is why cells that were once almost universally described as Marrow Stromal Cells are now commonly referred to as MSCs by researchers. Now it is clear that these MSCs exist throughout the body in a variety of different forms of tissue including corneal stroma, adult muscle, adipose tissue, and umbilical cord blood.

They even exist in the core of the baby teeth. In spite of their multipotent configuration, they do not have the ability to recreate a whole organ, which is why the new naming convention Multipotent Stromal Cell is becoming more common.

When do Mesenchymal Stem Cells Develop?

The earliest form of MSCs that are manifest during prenatal development can be found in the tissue of the umbilical cord, specifically in the blood of the cord and in Wharton's Jelly. Although MSCs are present in the blood of the umbilical cord, they are present in greater concentrations in Wharton's Jelly, which is also a significant source of stem cells which develop into blood cells of various types, known as Hematopoietic Stem Cells.

MSCs Found in the Umbilical Cord

Today, umbilical cords are simply discarded after a successful pregnancy, but there is growing evidence that these umbilical cords may be a fantastic and safe method of obtaining these primitive MSCs for medical research and treatment.

Mesenchymal Stem Cells Found in the Molars

Another area that is dense in MSCs is the third childhood molar of the lower jawbone. These cells are considered multipotent as of today, but initial research provides evidence that these cells may actually be pluripotent. Mesenchymal Stem Cells develop into a variety of different tissues, including nervous tissues, dental pulp, blood vessels, dentin, and enamel. All told, there are at lease twenty-nine different organs produced from MSCs.

Also, because these teeth can generally be harvested before ten years of age, naturally, with negligible mortality risk, there is a high probability that this source of MSCs will become a significant source of MSCs for treatment, research, and that patients may even be recommended to save them for future potential therapeutic use. MSCs also have the capability to develop into liver cells.

Mesenchymal Stem Cells Found in the Amniotic Fluid

Another concentrated source of MSCs is in the amniotic fluid of the placenta. Evidence suggests that at least one percent of the cells in the amniotic fluid are pluripotent MSCs

Mesenchymal Stem Cells Found in Adipose Fat

After childhood, one of the most concentrated sources of Mesenchymal Stem Cells is in Adipose Fat Tissue. Medical research has shown that in a single gram of adipose fat has more than five hundred times the MSCs as an equivalent amount of aspirated bone marrow. For this reason, there is a lot of research going on right now with regard to using MSCs found in fat cells for the treatment of various medical conditions.

Mesenchymal Stem Cells May be Found Within Peripheral Blood Cells

There is some evidence that Mesenchymal Stem Cells may be found in sufficient concentrations in Peripheral Blood Cells, but this evidence is far from conclusive. A few studies have been able to extract MSCs from these blood cells and been able to foster them in culture, however.

The History of Mesenchymal Blood Cells

A medical researcher named Alexander Maximow was able to single out a particular form of precursor tissue located in the Mesenchyme which had the ability to evolve into a variety of hematopoietic tissue.

Later in the 1960s, two researchers, James Till and Ernest McCulloch, discovered that marrow cells had the ability to essentially clone themselves. In the 1970s, a research team led by A.J. Friedenstein was able to isolate and definitively prove the ability of Stromal Marrow Cells to develop multipotently.

Further study of these cells uncovered that marrow cells had a high level of plasticity and that particular environmental triggers could alter their development into a variety of forms of tissue. For example, if these cells were allowed to develop in the same dish as dexamethasone, inorganic phospate, and Vitamin C, the marrow cells would develop into osteoblasts. On the other hand, exposure to TGF-b would induce the cells to develop into chondrocytes.

Morpology of Mesenchymal Stem Cells

MSCs can be physically described as a central body with a few thin and long processes extending out. The body of the call holds a nucleus which is round, large, and has a conspicuous nucleolus. The nucleus is covered in fine particles known as chromatin, which make it easy to see.

The rest of the cell body is occupied by polyribosomes, mitochondria, rough endoplasmic reticulum, and limited Golgi apparatus. Each of the cells is skinny and long, are dispersed widely, and the cells are connected by a small number of reticular fibrils.

How Are Mesenchymal Stem Cells Detected

The International Society for Cellular Therapy provides the most established definition for what qualifies as an MSC. They consider MSCs any cell which displays malleable properties under standard conditions and is structured like a fibroblast. There are some medical researchers that even believe that fibroblasts and MSCs are operatively identical.

Also, MSCs have the ability to undergo chondrogenic, adipogenic, and osteogenic differentiation in culture. Finally, cultured Mesenchymal Cells also have a certain set of active and inactive enzymes on their surface.

What is the Capacity for MSCs to Differentiate?

Mesenchymal Stem Cells have a tremendous ability to reproduce themselves while not losing their ability to evolve, but there is no easy way to quantify that capacity. The general method to prove multipotency is for a cell to be able to evolve into neurons, myocytes, chondrocytes, adipocytes, and osteoblasts with sufficient environmental cues. Mesenchymal Stem Cells have the capacity to develop into all of these different types of cells, but it is unclear whether it is possible to create a functioning neuron from an MSC.

The ability for an MSC to develop into a particular form depends upon the individual cell as well as the manner in which the change is produced, whether via mechanical or chemical means, for example. It is also unclear whether differentiation occurs because of an overall capacity to differentiate or the proclivity of certain cells to differentiate in their own capacity.

There is also evidence that the older a donor is when MSCs are contributed, the slower that the cells differentiate and proliferate. There is no definitive evidence regarding whether this is because there are issues in donated MSCs or a lower concentration of MSCs in a culture.

Effects of Mesenchymal Stem Cells on the Immune System

Research has shown that in human beings, MSCs block the function of T-Cells and dendritic cells. They also release cytokynes, which suppress immune response in their immediate environment. These cells alter immune function more vigorously in an area where inflammation is prominent.

In other situations, however, studies have shown that these effects are not universal and can be altered by other extenuating circumstances. Because each isolated culture of MSCs have their own unique configuration, the cell cultures often react in different ways to the same stimulus.

The Culturing of Mesenchymal Stem Cells

There are a number of methods to develop MSC cultures, but the most prominent is taking ficoll-purified bone marrow or unadulterated bone marrow and placing the mononuclear cells straight into flasks or culture plates. After one to two days, MSCs will stick to the specialized plastic, but hematopoietic cells and red blood cells will not. There is some evidence that this technique is not a perfect method, and at least some MSCs do not adhere in the given time frame, if at all.

How Are Mesenchymal Stem Cells Related to Cancer?

MSC proliferation is involved in many forms of cancer, especially those which impact the bone marrow. Hematological Cancers most commonly impact the function of MSCs.

What Are the Medical Uses for Mesenchymal Stem Cells

There are methods currently by which MSCs can be mobilized and activated if necessary. Unfortunately, using today's medical methods, there is a limited efficiency. For example, muscles recover quite slowly from injury because of this limited mobilization. There is promising research which suggests that there may be scientific methods to speed up this healing process.

In recent history, there have been a number of medical success stories involving the transplantation of MSCs directly into the blood stream in medical conditions such as sepsis, but in many of these cases, alternative forms of treatment have been found to be more effective, especially in the case of conditions related to peripheral tissues.

The most effective form of MSC administration appears to be to distribute the cells directly to the area which requires rehabilitation. When delivered directly to the blood stream, the lungs absorb many of the MSCs, limiting the capacity of the treatment. MSCs have been used frequently in an orthopedic environment, but these treatments need more rigorous and widespread use before their effectiveness can be fully determined.

One physician, Dr. Wakitani, has released a set of five case studies in which he treated five defective knees by implanting MSCs and quantified the effectiveness of the treatment.

Effectiveness of Cryogenically Preserved MSCs

Researchers have shown that MSCs are highly receptive to cryogenic freezing, but slowly regain their efficacy after they've been thawed, meaning that they should be allowed to thaw and propagate before implantation for maximum effectiveness. Many clinical studies have failed explicitly because MSCs were implanted directly after they were thawed. By allowing the cells to propagate after thawing, the cells will fully recover from being frozen, with the cells being just as useful as if they were never frozen.


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

What is Norditropin?

Norditropin is a brand of Bio-Identical Human Growth Hormone which is released by Novo Nordisk. Norditropin is created using Recombinant-DNA Technology, and is molecularly the same as the Endogenous HGH that the body creates on its own.

How Can I Get Norditropin?

Norditropin is one of the many forms of Recombinant Human Growth Hormone available from the Conscious Evolution Institute. The treatment is available in lyophilized form, as well as mechanical pens which efficiently and effectively deliver the medication to the patient.

Norditropin Prescribing Information

For children, Norditropin is prescribed as a treatment for Childhood HGH Deficiency and Idiopathic Short Stature. For adults, the medication is prescribed for Adult Human Growth Hormone Deficiency and HIV-Related Muscle Atrophy.

One of the most common reasons for Human Growth Hormone Deficiency later in life is Somatopause, or Age-Related HGH Deficiency. As men and women grow older, they lose the ability to produce natural Human Growth Hormone effectively. Many patients become symptomatic over time, leading to a number of symptoms of HGH Deficiency, including:

  • Unexplained Weight Gain

  • Depression

  • Declining Lean Muscle Mass

  • Weakened Immune System

  • Exacerbated Menopause Symptoms

  • Reduced Ability to Heal from Injury

  • Trouble Sleeping Through the Night

  • Premature Aging of the Skin

  • Cognitive Decline

  • Memory Loss

Norditropin Therapy can mitigate the effects of HGH Decline in patients suffering from Human Growth Hormone Deficiency, helping them live happier, healthier, and more productive lives.

If you are interested in Norditropin HGH, simply call the Conscious Evolution Institute today, and we can make an appointment with one of our representatives so that you can get the preliminary diagnostic testing you need to discover if you need Norditropin!

Is Norditropin Safe?

When Norditropin is used by patients that display a real, clinical need, Norditropin is incredibly safe and has a low risk of side-effects. Side-effects, when experienced, can be treated quickly and effectively.

What Are the Side Effects of Norditropin?

There are some side-effects that you may experience while using Norditropin. These include:

  • Irritation around the administration site

  • Fluid Retention, leading to swelling of the hands and feet

  • Hyperglycemia

  • Joint Stiffness

  • Muscle Pain

  • Headaches

In most cases, these symptoms simply mean that you need to have your dosage adjusted, and are receiving too high of a Norditropin Dose. Adjusting the Norditropin Dosage reduces the impact of these symptoms in most cases.

There are some serious, but rare, side-effects associated with Norditropin Injections. These include:

  • Vomiting

  • Nausea

  • Vision Issues

  • Headaches

These symptoms are generally caused by High Intracranial Pressure, and can be relieved by reducing the dose, or suspending treatment.

Norditropin Safety Information

Of course, no medication is perfect for everyone, and some people should not use Norditropin. The following adult patients should not use Norditropin:

  • Adult patients allergic to the ingredients of Norditropin

  • Adult patients with active tumors or cancer

  • Adult patients currently experiencing a serious illness involving stomach or heart surgery

  • Adult patients with severe respiratory issues

  • Pregnant or Nursing Women

Patients that have diabetes or have a history of cancer may be eligible for Norditropin HGH Injections, but should discuss their medical history honestly with their doctors. Human Growth Hormone can impact insulin levels, so it's important to monitor Insulin Levels closely if you are a patient with Diabetes, and you may need to adjust your Insulin Dosage to compensate.

How Much Does Norditropin Cost?

The cost of Norditropin will vary dependent upon the needs of the patient. The price of Norditropin will depend upon the dosage prescribed. The physicians at the Conscious Evolution Institute will only allow patients to buy Norditropin that display a clear medical need.

The Conscious Evolution Institute offers competitive prices for Norditropin, and also offers affordable payment plans to help patients get the treatment they deserve.

How to Use Norditropin

Norditropin is delivered using a method known as Subcutaneous Injection. In this method of treatment, a small, thin needle delivers the medication into the deepest layers of the skin, where it is slowly absorbed into the blood stream through the course of the day. Norditropin can be purchased in vials and delivered via syringe, but Norditropin also offers devices which make the Norditropin Injection Process simpler and easier.

Norditropin Pens

Novo Nordisk provides two Norditropin Pens which are used to deliver the medication: The Norditropin Flexpro and the Norditropin Nordiflex.

Norditropin Flexpro

The Flexpro Pen is the most popular form of Norditropin Pen. These pens come preloaded and prefilled, so there is no muss and fuss when getting ready to perform an injection. Flexpro Pens come in three variations, depending on the dose prescribed, with max doses of two, four, and eight milligrams, respectively. There is a dial on the side of the device which allows the patient to easily adjust the medication to the perfect dose.

Norditropin Nordiflex

The Nordiflex Pen is similar to the Flexpro Pen, using a similar design philosophy. The Nordiflex Pen delivers a maximum dose of three milligrams.

Norditropin Needles

Nordtropin Pens use a particular needle, known as NovoFine Needles. Although these needles are smaller than other, similar needles, they are still able to effectively deliver the medication. NovoFine needles are 30 gauge, which means that they are just over 1/3rd of a millimeter in thickness. These needles are 8 millimeters in length. Vaccination needles, on the other hand, are 15-31 millimeters in length and are more than a half a millimeter thick.

Because of the small size of the needles, and the short length, most patients have absolutely no issue with the injections. In fact, nine out of ten patients say that NovoFine Needles are essentially pain-free.

Norditropin Storage

Norditropin Pens should be stored in the refrigerator before they are used for the first time, but after their first use, they can be kept at room temperature and do not need refrigeration. Norditropin is good for three weeks after the first use. Always adhere strictly to expiration dates and never use Norditropin three weeks after its first use.

Is Norditropin Right for You?

The Conscious Evolution Institute is your source for quality Hormone Replacement Therapy all across the United States. If you are interested in Norditropin or any other form of Bio-Identical HGH, we can find out if you qualify for treatment!

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