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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

The Case Against Intermittent Fasting

The concept of Intermittent Fasting is incredibly popular these days. Some would even call it a trend. But there are many exercise, nutrition, and medical professionals that aren't all that impressed by the lifestyle technique. They argue that there are downsides to Intermittent Fasting which limit its potential benefits, and that it may fall out of favor in the near future.

These professionals do recognize that rearranging one's eating patterns in such a manner can encourage weight loss, but argue that for many people that it may be unsustainable, there are non-negligible health risks, and the practice holds no special benefit for those looking to maintain or enhance their athleticism.

Little Agreement on the Correct Way to Engage in Intermittent Fasting

One of the things about Intermittent Fasting is that it seems that everyone that recommends Intermittent Fasting, whether they be professionals or simply advocates, has their own particular take on the regimen. Some call for fasting during daylight, others recommend to eat only during a four or eight hour period of the day, and still others recommend taking entire day off from eating. There are some proponents that consider intermittent fasting to mean only eating when you truly are hungry.

Just as Intermittent is interpreted in a variety of ways, so is Fasting. Some people recommend going completely without food during the fast. Others believe that you should only drink protein shakes or stick to berries and veggies during the fasting portion of your day. As you can see, there is no clear consensus regarding what Intermittent Fasting really means.

In global society, there are many religions and cultures that engage in fasting as a spiritual act, but among animals, there is little evidence that other mammals fast for any reason except for illness. In many cases, animals that are sick will even eat particular plants like grass to purge their systems.

Intermittent Fasting is Not a Natural Animal Behavior

The core basis for Intermittent Fasting as a practice originally comes from animal research. There is evidence that Intermittent Fasting can be good for male animals in some ways, because it enhances reproductive characteristics, but for female animals, the same process can limit fertility.

The process of Intermittent Fasting in animals studies induced the females to sleep less, become unnecessarily alert, and limited their ability to menstruate. Researchers hypothesize that the reason why these changes take place is that their bodies are emphasizing traits that will aid them in seeking food.

Health Issues Related to Intermittent Fasting

Although there are many that firmly stand behind Intermittent Fasting, there are other people that have experienced temporary physical and psychological symptoms from their use of the technique. The following are some issues that people that undergo Intermittent Fasting experience:

  • Sleeping issues, predominantly in women. These issues are caused primarily by the stimulation of hypocretin neurons which encourage the body and mind to stay awake.

  • Others admit to highly increased coffee consumption to deal with their fasting. This overwhelming use of coffee can lead to circadian rhythm issues, Hormone Imbalance, and significant adrenal fatigue.

  • Many dieters experienced an increased fixation on the foods that they deny themselves. This also leads to a component increase in anxiety.

  • Women often experience a variety of Hormone Issues from extended Intermittent Fasting, including menstrual irregularities, fixation on self-image, changes in metabolic activity, and acne.

It should be noted these symptoms are highly associated with the severity of the Intermittent Fasting, and that other, more limited forms of Intermittent Fasting will produce fewer of these negative symptoms. Also, these issues are more related to long term Intermittent Fasting, and certain diet plans may be able to usefully utilize Intermittent Fasting as a means to lose weight.

Those that argue against Intermittent Fasting believe that there are other methods that can more effectively extend longevity in the long term, and can help enhance muscle mass and energy at the same time. The following are five reasons why Intermittent Fasting may not be the lifestyle that you're looking for:

One: Peak Cognitive and Physical Performance Rely on Regular Meals

The Human body relies on normalized feeding patterns in order to sustain energy and physiological capacity. Intermittent Fasting can lead to Hormone Imbalance issues which lead to fatigue, deteriorated focus, and changes in base hormone patterns. Also, the body relies on amino acids to sustain and build muscle, and if you drain your body of these amino acids, your body may start to break down muscle to meet the needs of the rest of the body.

Intermittent Fasting in the short term appears to have a balancing impact on these same factors, however, and may be beneficial as a means to lose weight and reset the body. In the initial period of Intermittent Fasting, men tend to experience increased cognitive function, boosted alertness, and there is even evidence that the experience even promotes healthier insulin production. As we mentioned previously, these benefits are less pronounced among women, and come with some potentially negative side-effects.

For men that are overweight, Intermittent Fasting can be a highly effective means to re-balance the body, especially in the short term, but for men that are already thin and looking to promote enhanced athletic ability, the benefits of Intermittent Fasting are limited.

This is primarily because asymmetrical eating pattern can lead to blood sugar issues and insulin spikes. Over time, this can cause the circadian rhythm, neurotransmitter activity, and hormone production to get out of sorts.

Many nutritionists and fitness experts recommend using a Paleolithic diet to accentuate many of the positive aspects of Intermittent Fasting while avoiding the negative aspects. A Paleolithic diet encourages healthy Insulin Balance, and provides a dependable stream of amino acids which aid metabolism, cognition, and muscle building.

A diet which revolves around healthy fats and high protein while limiting carbohydrates, with small meals consumed five to six times per day is one of the best ways to keep your body working and your metabolism pumping. This helps energy levels, muscle health, and cognitive ability, while also keeping blood sugar in check and promoting enhanced longevity.

Two: Regular Protein Consumption Necessary For Muscle Building Protein Synthesis

It is important to recognize that there is a significant difference building muscle and sustaining muscle. If you don't get your body the protein that it needs, you stand to lose muscle mass. It is very easy to design an Intermittent Fasting diet that prevents loss of muscle mass, but the issue is that Intermittent Fasting is not an ideal method for growing and enhancing muscles.

Again, if you are interested in losing weight, Intermittent Fasting may be a valid option, but if you are looking to enhance lean muscle and longevity from a healthy weight, other options are likely more beneficial. There is a body of research out there that explains exactly why Intermittent Fasting is not ideal for muscle development.

There are a lot of chemical processes that happen when your body builds muscles, and there are a number of important ingredients to make it happen. To build muscle optimally, the body needs a steady stream of hormones which promote anabolic activity, proteins and amino acids which supply the body's anabolic needs, and strength training which stimulates the use of these ingredients. If every ingredient is not available, it makes it very difficult to build muscle.

A study released in 2010 exemplifies this clearly. In this study, male participants were placed on a caloric-restriction diet, but still obtained high levels of protein each day1.5 grams per kilogram by weight. In spite of getting the necessary protein to build muscle, they still experienced a decline in muscle-building power because they weren't consuming enough calories.

Overall, this led to a loss of one kilogram of lean muscle mass in ten days. If the body isn't getting all of the nutrients that it needs, it will convert consumed protein into other products to meet the body's needs, to the deficit of the muscles.

Other studies show the benefits of multiple modest meals per day. In one particular study, athletic men performed anaerobic lower body exercise routines and consumed proteins in three experimental patterns dependent upon their group. One group took two doses of forty grams every six hours, a second group took twenty gram doses four times daily every three hours, and the third group took a ten gram dose every hour and a half eight times daily. The group that experienced the most enhanced protein utilization was the group which took twenty gram doses.

A final study examined how taking protein before bed affected protein synthesis. Researchers found that young males that consumed forty grams of protein before falling asleep experienced a 25% boost in protein utilization. In this study, participants worked out in the evening, consumed protein, and went to bed. The benefits continued to take place even overnight.

The opposite result is seen in studies mimicking the effects of Intermittent Fasting. In one study, conducted over the course of three days, young males ate twice per day with a twelve hour space between meals. Instead of building muscle, these patients burned the protein they consumed for energy, whereas men that consumed five meals per day utilized protein for protein synthesis.

It's important to note that this was only a three day study, and does not necessarily characterize how the body eventually adapts to regular Intermittent Fasting. Nutrition experts caution older men and women from engaging in Intermittent Fasting, because of issues related to sarcopenia and loss of muscle mass.

The line between protein burning and protein synthesis is finer than one would assume. Building muscle depends on supplying your body with a healthy diet, and giving your body the nutrients that it needs in the periods after physical activity. If you do not provide your body the necessary building materials, you slow down your body's recovery and slow down the rate at which your body synthesizes muscle.

Three: Adrenal Stress and Intermittent Fasting

The body eventually adapts to a pattern of Intermittent Fasting, but in the short term, the abrupt change in dietary patterns can have a significant impact on the way that your body functions, and can interrupt your circadian rhythm. The body will eventually get over adrenal fatigue over the course of an extended period of Intermittent Fasting, but there are other methods that can impact body composition in a more effective manner.

One study involving Islamic athletes shows the impact of short term fasting on athletic performance. In athletes that fasted during the day for Ramadan, the act of fasting led to higher levels of fatigue. It also contributed to reduced anaerobic performance and strength. Over the course of Ramadan, the athletes lost an average of 0.65 kilograms of fat and 1.8% of their total mass.

To date, there are no significant studies regarding the long term impact of Intermittent Fasting among athletes, but researchers hypothesize that it has a negative impact on physical output based on the scientific understanding of overtraining.

Going a long time without eating encourages the activation of hormones known as catecholamines. If this pattern is sustained for an extended period of time, it can lead to adrenal fatigue, and reduces the responsiveness of the adrenal glands. This modifies the metabolism, the priorities of the central nervous system, and leads to chronic fatigue.

All in all, engaging in Intermittent Fasting for brief periods of time has the impact of inhibiting physical performance. Engaging in it for an extended period can impact the body's homeostasis and can cause adrenal fatigue. It should be noted that these ideas regarding Long Term Intermittent Fasting are not fully tested, and the body may have some adaptive ability which has not been fully explored in the academic literature.

Four: Healthy Blood Sugar and Insulin Levels Depend on the Content of Your Diet More than the Timing of Your Meals

Intermittent Fasting and other similar eating patterns do have an effect on blood sugar and insulin. To date, the body of medical knowledge is still being fleshed out, and results are not fully conclusive. It appears that Intermittent Fasting has a positive influence on male Insulin Health under many circumstances, while women tend to experience more negative consequences.

If you are overweight or obese, Intermittent Fasting seems to have an overall-positive influence on Insulin Sensitivity, but many nutrition scientists do not believe that Intermittent Fasting is a long-term, sustainable diet plan because of the potential impact that it has on other issues, such as blood pressure. The same is believed with regard to caloric restriction.

This doesn't mean that Intermittent Fasting helps balance Insulin for everyone, however, and its benefits may be limited even among the overweight. In one piece of research released in PLOS One, researchers compared glucose and insulin levels over the course of three days among two groups: One group ate five meals per day at regular intervals, and the other engaged in Intermittent Fasting. Both groups consumed a diet consisting of 15% protein, 30% fat, and 55% carbs.

Researchers found that participants in the Intermittent Fasting group experienced more significant variation in their insulin levels through the course of the day, which is considered one of the factors which encourage Insulin Resistance over time. It should be noted that the body may adapt to Intermittent Fasting over time, which may balance out these issues with Insulin. Low-carb diets (Paleo Diets recommend around 40% carbs, for example), may also balance out these Insulin issues as well.

Rather than focus on when you eat, however, the best way to control your blood sugar is simply to scale back on your consumption of high glycemic carbohydrates. For example, one study consisted of three groups: One group ate six low-carb, high protein meals daily, a second group ate six high-carb meals daily, and a third group ate three high-carb meals daily.

Glucose levels were the lowest in the high-protein meal and highest in the six high-carb meal group. On the other hand, Insulin levels remained equivalent in both experimental groups that consumed high-carbs. The high-protein group experienced healthier Insulin levels.

In order to promote optimal Insulin sensitivity and utilization, it's more important to engage in a diet consisting of the conscientious use of low-glycemic carbohydrates, healthy fat, and protein, than to alter your eating patterns. Smart and consistent eating patterns are a positive influence, however.

Five: Intermittent Fasting Affects Natural Rhythms and Hormone Balance

One of the most potentially disruptive impacts of Intermittent Fasting is in regard to circadian rhythm and hormone balance. All of the important metabolic and anabolic hormones that our body produces are interrelated with one another, including Human Growth Hormone, Testosterone, Insulin, and Adrenal Hormones. This delicate interplay of hormones is known as the Hormone Cascade.

This means that when you have an issue with one particular hormone, all of your hormones can be affected in their own ways. Hormone Imbalance can lead to a wide variety of negative health conditions, including infertility, loss of muscle mass, weight gain, reduced metabolism, increased inflammation, sleep disruption, fatigue, and inhibited immune function.

There is evidence that Intermittent Fasting contributes to this hormone imbalance. In one particular study, participants stuck to an assigned diet eight weeks, either eating once per day or three times per day. At the conclusion of the study, participants that ate once per day lost an average of two kilograms of fat more than the opposing group. On the other hand, they also experienced heightened blood pressure, which is an indication of changes in the circadian rhythm.

Also, cortisol levels before consuming their single meal were nearly half of their normal levels. This suggests that the subjects were experiencing abnormal day-night hormone cycles. It is true that cortisol levels are important to control for optimal health, but normally, cortisol levels increase naturally as a result of hunger and drop in response satiation. Abnormal cortisol patterns are a indication of adrenal fatigue.

Of course, based off of this evidence, there may be particular forms of Intermittent Fasting that do not impact Hormone Balance so severely, and also, a responsible diet plan may mitigate the impact of this Hormone Imbalance. In the case of this study, however, a one-meal-per-day diet plan negatively impacted the health of the patients, overall, as a result of the impact on cortisol and the Circadian Rhythm.

Muscle Building and Weight Loss Tips

So, severe Intermittent Fasting can help you lose weight, but you would likely benefit from other methods. You can potentially increase your risk of illness and fatigue, and you can inhibit your body's self-regulating ability. The following are some recommended tips for men and women to consider rather than turning to Intermittent Fasting:

  • Eat five or six meals each day. Choose whole foods, limit processed foods, and eat healthy fat, a lot of protein, and limit your carbs.

  • Respect your food, but do not rely on it as a reward.

  • Don't abuse stimulants like coffee to help you keep your mind off food.

  • Find an eating pattern that works for you and does not cause undo stress on your mind or your body.

  • Eat lots of different kinds of food to ensure you get the nutrients you need.

  • Combine your diet and your exercise regimen to maximize results

  • Drink lots of water. Water is an essential component for muscle synthesis.


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

Mark Cuban to Finance Medical Study to Prove Benefits of HGH for Rehabilitation

Medical researchers have long understood the potential benefits of HGH Hormone Replacement Therapy to patients suffering from Age-Related Human Growth Hormone Deficiency, but we are just beginning to learn about a wide variety of other potentially beneficial uses for HGH Shots.

There has been growing evidence that HGH Injection Therapy can be useful for rehabilitation, and Mark Cuban, the owner of the Dallas Mavericks, is interested in finding out the real benefits and drawbacks of HGH for Injury Rehabilitation, and is willing to contribute large sums of money to find out the truth of the matter.

Two Year Study Will Test the Effectiveness of HGH

Mark Cuban has already made a major financial contribution with the intention of funding a clinical study at a prominent university. According to his description, the medical study will be conducted over the course of two years and will evaluate the potential ability for Human Growth Hormone Injections to speed up the rate of rehabilitation after an injury. The study will monitor patients from before their operation until long into their recovery process.

Human Growth Hormone Has Long Been Used by Athletes

HGH Injection Therapy has long been used by athletes of all kinds for the purpose of performance enhancement, and there are even rumors abound that many athletes travel overseas to Europe, because medical facilities in Europe often utilize Subcutaneous HGH Therapy in their treatment processes, which many believe speed up the healing process.

HGH Injections Currently Only Legal for a Few Limited Treatments

In the United States, Recombinant HGH is a highly regulated form of medical treatment, and can only be used legally in the country for a few explicit purposes: Human Growth Hormone Deficiency, Idiopathic Short Stature in Children, and HIV/AIDS-Related Wasting. Overseas, some alternative uses for HGH are often encouraged, and off-label use of the medication is considered legal practice. Since HGH was lumped in with Anabolic Steroids in the late 1980s and early 1990s, HGH Prescriptions are highly limited.

With this medical study, Mark Cuban aims to discover the real potential benefit of Human Growth Hormone Injections. There is a large amount of anecdotal evidence regarding the use of HGH for Rehabilitation, but there has been inconclusive medical study to provide a definitive answer. Cuban looks to provide that answer once and for all.

Players Should Be Able to Use All Effective Medical Tools Available to Recover from Injury

Although Mark Cuban leaves no indication that he believes that Human Growth Hormone should be used as a Performance Enhancing Drug, he sees no reason to deny players that ability to use the treatment as a legitimate medical therapy, especially one that is highly useful and beneficial for athletes prone to muscle and joint injuries.

He believes that if Human Growth Hormone Injections can limit the muscle atrophy associated with medical surgery, it should be available to players that have their rehabilitation times lengthened by such atrophy. He believes that reduced recovery times are good both for the player and for professional basketball itself. Cuban feels that if there is no downside, the players should be afforded the opportunity to use the treatment.

What We Know About This Future Study

Cuban does not go into specific details about the study. He does not name the University, and he does not mention the specific injury, but he does explain that the injury affects well over one hundred thousand patients annually. He implies that both groups will go through the exact same treatment regimen, except one group of patients will undergo routine rehabilitation with HGH Injections, and the other group will undergo routine rehabilitation with placebo injections.

Besides the use of injections, the experiment will not negatively impact the normal rehabilitative process, and will provide a clear image of the effects of HGH on Injury Rehab. If the treatment does improve recovery times, it not only benefits NBA Players, it benefits millions of potential patients all across the United States.

Study Awaits DEA and FDA-Approval

Mark Cuban refused to release any overly-specific information regarding the medical study, because it still awaits FDA and DEA-Approval, although at this time he believes there are no roadblocks to approval.

Also, even though he did not mention the university in particular that would conduct the research, he did express that it was a very well-regarded medical institution. At this stage, Cuban is unsure when the study will actually start, because of the need for federal approval.

Mark Cuban Has Long Been an Advocate for Judicious Use of HGH If Deemed Beneficial

Today, Human Growth Hormone is fully banned as a Performance Enhancing Drug by the National Basketball Association. This means that the drug cannot be used by healthy players to attempt to improve their game, but it also means that injured players are not allowed to use the Bio-Identical Hormone as a medical treatment.

Cuban is interested in providing players this opportunity if research suggests that it is beneficial, and discussed this in a recent Board of Governors meeting. He believes that if HGH Injections prove beneficial for Injury Recovery, they should be allowed for use by injured players. After talking about the subject at the meeting, a number of universities contacted him to discuss potential research opportunities.

Motivations for Supporting HGH Research

Mark Cuban says that his main goal in financing this study is to uncover the truth about Human Growth Hormone. He believes that the NBA's current position toward Human Growth Hormone is just a marketing position, and wants to discover the reality for the players, the league, and society at large.

He admits that it benefits him as an NBA owner if Recombinant HGH can increase recovery times, but in this case, what benefits him, personally has the potential to benefit everyone, which has encouraged his desire to see the truth about HGH for Healing.




Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

What Are Mesenchymal Stem Cells?

Mesenchymal Stem Cells are a unique type of connective tissue that is only partially developed and still has the ability to further specialize into specific forms of connective tissue. The scientific term for cells that have the ability to further evolve into different cell types is Multipotent. You will often find this particular form of Multipotent cell referred to as an MSC. MSCs are also referred to as Marrow Stromal Cells when scientifically appropriate.

These cells have the ability to develop into a number of different types of cells, including fat cells, cartilage cells, and bone cells. As you can imagine, there is a growing amount of interest in cultivating Mesenchymal Stem Cells for use in a number of different medical treatments, especially those related to bone and joint injuries. The ability for MSCs to develop into more complex tissues has been scientifically proven both in a laboratory environment and in animal subjects.

Why Are They Called Mesenchymal Stem Cells?

As researchers learn more about these cells, coming up with an optimally appropriate name became increasingly important:

  • Mesenchyme is a preliminary form of connective tissue which evolves in the embryo stage of development, but this name does not fully meet the needs of MSCs. This tissue forms in the central layer of the embryo, known as the mesoderm.

Further in development, Mesenchyme evolves into both connective and hematopoietic tissue, whereas Mesenchymal Stem Cells can only develop into connective tissue, which proves that Mesenchyme and MSCs are related cells, but different..

  • Stromal Cell refers to a different aspect of MSC function. These cells are a form of connective tissue that provides structural support to a larger cell. Stromal Cell is accurate enough of a term to describe one way that the body uses MSCs, but does not encapsulate the full form and function of the cell.

This is because it has only recently been determined that MSCs have the ability to facilitate the healing of damaged tissue, which necessitates a broader set of naming conventions for the cellular type.

This is why cells that were once almost universally described as Marrow Stromal Cells are now commonly referred to as MSCs by researchers. Now it is clear that these MSCs exist throughout the body in a variety of different forms of tissue including corneal stroma, adult muscle, adipose tissue, and umbilical cord blood.

They even exist in the core of the baby teeth. In spite of their multipotent configuration, they do not have the ability to recreate a whole organ, which is why the new naming convention Multipotent Stromal Cell is becoming more common.

When do Mesenchymal Stem Cells Develop?

The earliest form of MSCs that are manifest during prenatal development can be found in the tissue of the umbilical cord, specifically in the blood of the cord and in Wharton's Jelly. Although MSCs are present in the blood of the umbilical cord, they are present in greater concentrations in Wharton's Jelly, which is also a significant source of stem cells which develop into blood cells of various types, known as Hematopoietic Stem Cells.

MSCs Found in the Umbilical Cord

Today, umbilical cords are simply discarded after a successful pregnancy, but there is growing evidence that these umbilical cords may be a fantastic and safe method of obtaining these primitive MSCs for medical research and treatment.

Mesenchymal Stem Cells Found in the Molars

Another area that is dense in MSCs is the third childhood molar of the lower jawbone. These cells are considered multipotent as of today, but initial research provides evidence that these cells may actually be pluripotent. Mesenchymal Stem Cells develop into a variety of different tissues, including nervous tissues, dental pulp, blood vessels, dentin, and enamel. All told, there are at lease twenty-nine different organs produced from MSCs.

Also, because these teeth can generally be harvested before ten years of age, naturally, with negligible mortality risk, there is a high probability that this source of MSCs will become a significant source of MSCs for treatment, research, and that patients may even be recommended to save them for future potential therapeutic use. MSCs also have the capability to develop into liver cells.

Mesenchymal Stem Cells Found in the Amniotic Fluid

Another concentrated source of MSCs is in the amniotic fluid of the placenta. Evidence suggests that at least one percent of the cells in the amniotic fluid are pluripotent MSCs

Mesenchymal Stem Cells Found in Adipose Fat

After childhood, one of the most concentrated sources of Mesenchymal Stem Cells is in Adipose Fat Tissue. Medical research has shown that in a single gram of adipose fat has more than five hundred times the MSCs as an equivalent amount of aspirated bone marrow. For this reason, there is a lot of research going on right now with regard to using MSCs found in fat cells for the treatment of various medical conditions.

Mesenchymal Stem Cells May be Found Within Peripheral Blood Cells

There is some evidence that Mesenchymal Stem Cells may be found in sufficient concentrations in Peripheral Blood Cells, but this evidence is far from conclusive. A few studies have been able to extract MSCs from these blood cells and been able to foster them in culture, however.

The History of Mesenchymal Blood Cells

A medical researcher named Alexander Maximow was able to single out a particular form of precursor tissue located in the Mesenchyme which had the ability to evolve into a variety of hematopoietic tissue.

Later in the 1960s, two researchers, James Till and Ernest McCulloch, discovered that marrow cells had the ability to essentially clone themselves. In the 1970s, a research team led by A.J. Friedenstein was able to isolate and definitively prove the ability of Stromal Marrow Cells to develop multipotently.

Further study of these cells uncovered that marrow cells had a high level of plasticity and that particular environmental triggers could alter their development into a variety of forms of tissue. For example, if these cells were allowed to develop in the same dish as dexamethasone, inorganic phospate, and Vitamin C, the marrow cells would develop into osteoblasts. On the other hand, exposure to TGF-b would induce the cells to develop into chondrocytes.

Morpology of Mesenchymal Stem Cells

MSCs can be physically described as a central body with a few thin and long processes extending out. The body of the call holds a nucleus which is round, large, and has a conspicuous nucleolus. The nucleus is covered in fine particles known as chromatin, which make it easy to see.

The rest of the cell body is occupied by polyribosomes, mitochondria, rough endoplasmic reticulum, and limited Golgi apparatus. Each of the cells is skinny and long, are dispersed widely, and the cells are connected by a small number of reticular fibrils.

How Are Mesenchymal Stem Cells Detected

The International Society for Cellular Therapy provides the most established definition for what qualifies as an MSC. They consider MSCs any cell which displays malleable properties under standard conditions and is structured like a fibroblast. There are some medical researchers that even believe that fibroblasts and MSCs are operatively identical.

Also, MSCs have the ability to undergo chondrogenic, adipogenic, and osteogenic differentiation in culture. Finally, cultured Mesenchymal Cells also have a certain set of active and inactive enzymes on their surface.

What is the Capacity for MSCs to Differentiate?

Mesenchymal Stem Cells have a tremendous ability to reproduce themselves while not losing their ability to evolve, but there is no easy way to quantify that capacity. The general method to prove multipotency is for a cell to be able to evolve into neurons, myocytes, chondrocytes, adipocytes, and osteoblasts with sufficient environmental cues. Mesenchymal Stem Cells have the capacity to develop into all of these different types of cells, but it is unclear whether it is possible to create a functioning neuron from an MSC.

The ability for an MSC to develop into a particular form depends upon the individual cell as well as the manner in which the change is produced, whether via mechanical or chemical means, for example. It is also unclear whether differentiation occurs because of an overall capacity to differentiate or the proclivity of certain cells to differentiate in their own capacity.

There is also evidence that the older a donor is when MSCs are contributed, the slower that the cells differentiate and proliferate. There is no definitive evidence regarding whether this is because there are issues in donated MSCs or a lower concentration of MSCs in a culture.

Effects of Mesenchymal Stem Cells on the Immune System

Research has shown that in human beings, MSCs block the function of T-Cells and dendritic cells. They also release cytokynes, which suppress immune response in their immediate environment. These cells alter immune function more vigorously in an area where inflammation is prominent.

In other situations, however, studies have shown that these effects are not universal and can be altered by other extenuating circumstances. Because each isolated culture of MSCs have their own unique configuration, the cell cultures often react in different ways to the same stimulus.

The Culturing of Mesenchymal Stem Cells

There are a number of methods to develop MSC cultures, but the most prominent is taking ficoll-purified bone marrow or unadulterated bone marrow and placing the mononuclear cells straight into flasks or culture plates. After one to two days, MSCs will stick to the specialized plastic, but hematopoietic cells and red blood cells will not. There is some evidence that this technique is not a perfect method, and at least some MSCs do not adhere in the given time frame, if at all.

How Are Mesenchymal Stem Cells Related to Cancer?

MSC proliferation is involved in many forms of cancer, especially those which impact the bone marrow. Hematological Cancers most commonly impact the function of MSCs.

What Are the Medical Uses for Mesenchymal Stem Cells

There are methods currently by which MSCs can be mobilized and activated if necessary. Unfortunately, using today's medical methods, there is a limited efficiency. For example, muscles recover quite slowly from injury because of this limited mobilization. There is promising research which suggests that there may be scientific methods to speed up this healing process.

In recent history, there have been a number of medical success stories involving the transplantation of MSCs directly into the blood stream in medical conditions such as sepsis, but in many of these cases, alternative forms of treatment have been found to be more effective, especially in the case of conditions related to peripheral tissues.

The most effective form of MSC administration appears to be to distribute the cells directly to the area which requires rehabilitation. When delivered directly to the blood stream, the lungs absorb many of the MSCs, limiting the capacity of the treatment. MSCs have been used frequently in an orthopedic environment, but these treatments need more rigorous and widespread use before their effectiveness can be fully determined.

One physician, Dr. Wakitani, has released a set of five case studies in which he treated five defective knees by implanting MSCs and quantified the effectiveness of the treatment.

Effectiveness of Cryogenically Preserved MSCs

Researchers have shown that MSCs are highly receptive to cryogenic freezing, but slowly regain their efficacy after they've been thawed, meaning that they should be allowed to thaw and propagate before implantation for maximum effectiveness. Many clinical studies have failed explicitly because MSCs were implanted directly after they were thawed. By allowing the cells to propagate after thawing, the cells will fully recover from being frozen, with the cells being just as useful as if they were never frozen.

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Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.

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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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