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Sermorelin Acetate Therapy with GHRP-6

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Sermorelin Acetate Therapy with GHRP-6

With Sermorelin Acetate Therapy, it is possible to restore youthful vitality and alleviate the effects of the aging process that result from Human Growth Hormone Deficiency. Sermorelin is a safe and effective hormone substitute which has the capability to naturally stimulate the Human Pituitary Gland in order to encourage the secretion of our own internal stores of Human Growth Hormone.

HGH is created by endocrine organs known as Somatotrophs located in the Anterior Pituitary. Although as we grow older, the body drastically slows down production of HGH over time, the Somatotrophs never lose their ability to produce healthy levels of HGH. This is why Sermorelin Injections are an effective treatment for Growth Hormone Deficiency.

What is Sermorelin?

Sermorelin is the bio-synthetic form of a hormone naturally produced by the hypothalamus, known as Growth Hormone-Releasing Hormone. GH-RH is the means by which the brain sends a request to the pituitary to release HGH. GH-RH is delivered from the Hypothalamus to the Pituitary Gland via a pathway of blood vessels known as the Hypophyseal Portal System.

How is Sermorelin different from Bio-Identical HGH?

Unlike Bio-Identical Human Growth Hormone Replacement Therapy, Sermorelin Acetate is not structurally identical to GH-RH, but Sermorelin Acetate is functionally capable of producing the same biological effect on the body that is achieved naturally through GH-RH. Sermorelin Acetate is a truncated form of GH-RH, which means that the bio-synthetic hormone is structurally identical to the active portions of the GH-RH molecule, while omitting portions of the molecule that are inert and do not encourage the release of HGH. Although the Sermorelin molecule is not naturally produced by the body, there are no adverse effects related to the exogenous nature of the hormone. The treatment is perfectly safe.

HGH Decline Begins around Thirty

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Adult Human Growth Hormone production reaches its peak by the time we reach the age of around twenty. Over the course of our twenties, we maintain high levels of HGH production which help us sustain ourselves physically, cognitively, and psychologically. By the time we reach the age of thirty, however, Growth Hormone Production starts to decline at a slow, yet insipid rate of one to two percent each year. Although this may not sound like a significant amount at first, this amounts to an average reduction in endogenous HGH production of around 14% every ten years! By the time a decade of decline has occurred, the human body only produces 40% of the Human Growth Hormone emitted during the period of peak production in our early twenties.

Symptoms of HGH Deficiency

This decline in HGH secretion does not come without significant health consequences. HGH Deficiency is correlated with a number of symptoms and and syndromes that we take for granted as simply a part of the aging process, such as:

  • Immune Suppression

  • Decreased Cognitive Sharpness

  • Wrinkles and Deep Lines

  • Increased Adipose Fat, Especially around the Midsection

  • Reduced Libido

  • Fatigue

  • Reduced Willpower and Motivation

  • Many Other Symptoms throughout the Body

Benefit of Sermorelin Vs. Other Treatments

Although HGH Hormone Replacement Therapy is a safe and effective means of restoring healthy Human Growth Hormone Levels, Sermorelin Acetate Injections completely eliminate the risk of overdose while encouraging the Pituitary Gland to be responsible for the dispensation of HGH rather than self-administration techniques. Sermorelin Acetate presents no risk of HGH Overdose because HGH production by the pituitary is down-regulated by effective biological negative feedback mechanisms.

Sermorelin and Somatostatins

When the brain feels that the human body has a sufficient amount of Human Growth Hormone necessary to maintain optimal health and hormone balance, the hypothalamus releases the inhibitory hormone Somatostatin, which blocks the uptake of Sermorelin and GH-RH by the Hypothalamus, preventing the brain from overloading the body with excess HGH. Because of the effectiveness of Somatostatin at effectively regulating the pituitary, the risk of Growth Hormone Overdose Via Sermorelin Injection is nearly impossible

Clinical Body Fat Reduction Using Sermorelin

Clinical trials show that after a single year of Sermorelin Acetate Therapy, it is possible to achieve a 20% reduction in adipose fat tissue. The majority of this fat tissue is eradicated from the midsection. Fat from the waist, hips, and stomach decline by around 30% while weight loss occurs via marginal areas of body fat such as the legs, arms, neck, and chest at a mass percentage of around 13%.

Sermorelin is Delivered Via Injection

Sermorelin Acetate is a low risk treatment which is delivered via small injections just below the top layers of the skin, known as subcutaneous injection. These shots are simple to administer and patients generally perform their own injections in the privacy of their own homes or offices.

Why is Sermorelin Combined with GHRP-6?

Many treatment protocols combine Sermorelin Acetate Therapy with GHRP-6. GHRP-6 is a synthetic hormone which functions similarly to Sermorelin by encouraging the healthy stimulation of the Pituitary Gland. Although the two hormones achieve the same end, they do so via different chemical pathways and enzyme reactions. GHRP-6 is useful because it helps emulate the normal biological cycle of HGH Release, providing more noticeable gains in HGH Levels than Sermorelin Acetate injections alone while still producing biologically safe levels of Human Growth Hormone.

GHRP-6 and Ghrelin

GHRP-6 shares no significant structural similarity to any hormone produced naturally by the human body, but synthetic GHRP-6 has been proven to encourage the production of Growth Hormone by simulating the biological effect of the hormone Ghrelin on pituitary stimulation. Ghrelin is primarily produced by the stomach and plays a significant role in gastrointestinal function, but the hormone also influences HGH production as well, which is not surprising considering that Human Growth Hormone stimulates cellular metabolism. Ghrelin is an acronym for Growth Hormone-Releasing Peptide.

The Effect of Age On GH-RH Production

GH-RH is released at its highest rates during our youth, which corresponds directly with the rate at which our pituitary releases HGH at its most abundant. As we grow older, GH-RH levels start to decline, leading directly to a deficiency of Human Growth Hormone which speeds up the aging process and reduces overall health and well being as a result. HGH Deficiency is also referred to as Hypopituitarism, relating to the suppression of pituitary function that causes the organ to release insufficient levels of vital Growth Hormone.

Phases of HGH Decline

At first, the effects of Hypopituitarism are qualitative in nature and relatively hard to measure, yet vivid to experience. Low HGH first affects energy levels, which can affect overall motivation and suppress innate desires. After energy levels start to decline, the body starts to experience greater levels of fatigue on a physical level. Aside from being sapped of mental energy, the human body loses its ability to sustain itself in the face of high levels of activity. Endurance starts to decrease significantly, and during this period, the body becomes less prepared for high levels of physical exertion and gains from exercise start to decline.

Also, the body's capacity for restorative sleep starts to drop, exacerbating further decline. During the third phase of HGH Deficiency, overall health starts to deteriorate as well. Early in this phase, aesthetic skin health starts to decline rapidly as wrinkles and deep creases start to develop. Cholesterol and Triglyceride levels increase, hypertension often develops as a result of cardiovascular strain and arterial plaques. The body begins to seep calcium from deep within the bones, which inevitably leads to symptoms of osteoporosis over time. During this phase, the body not only responds less readily to exercise, but it will be difficult to make significant gains at all, and in the worst cases, exercise will only serve to prevent muscle atrophy from occurring.

Goal of Sermorelin Therapy

Sermorelin Therapy with GHRP-6 has the potential to alleviate or even reverse many of the symptoms of HGH Deficiency and aging listed above. The Conscious Evolution Institute is one of the premier Anti-Aging Clinics in the country, and we specialize in the legal and legitimate use of Hormone Replacement Therapy as a means to encourage a longer life with enhanced health outcomes. Our fully-trained and board-certified staff of clinical specialists and physicians are dedicated to helping our patients live a longer and healthier life that is full of vigor, energy, and characterized by an overwhelming sense of well-being.

Meet the New You with Sermorelin and GHRP-6

Sermorelin Acetate Therapy with GHRP-6 is a verified safe, effective, and biologically self-containing means to stimulate the pituitary to produce healthy and normal levels of Human Growth Hormone by emulating the effects of GH-RH and Ghrelin on Somatotroph activity. Sermorelin GHRP-6 is available at numerous pharmacies across the United States and is generally compounded on site by a licensed pharmacist. Sermorelin Therapy is not subject to the same restrictions as Bio-Identical Human Growth Hormone, and is available with a physician's prescription.

Unlike HGH Hormone Replacement Therapy, there are no legal restrictions placed on the prescribing physician in regard to his or her medical expertise and opinion, and as a result, Sermorelin Injections can be prescribed off-label in order to treat many symptoms of HGH Deficiency that have been clinically shown to be beneficial, yet have not yet been approved by the FDA.

Sermorelin Acetate Injections from the Conscious Evolution Institute

The Conscious Evolution Institute specializes in comprehensive and remote Hormone Replacement Treatments. Although we diagnose and treat our patients remotely, we still play an intimate and responsible role in your medical treatment, providing advice as well as diagnostic services in order to ensure the safety and effectiveness of your Hormone Therapy. In addition to providing services that relate directly to your medication, we also provide nutritional, dietary, and exercise advice in order to help you maximize the effects of your Sermorelin treatment. Sermorelin is highly effective even without making the choice to alter your lifestyle, but committing to a life of more responsible and healthy life choices will allow you to potentially see incredible results over a relatively short period of treatment.

Conscious Evolution Institute Medical Services

A full list of services we provide (either directly or via local affiliate) are:

  • Pre-treatment Medical Questionnaire and Self-Evaluation

  • Initial Physical Examination

  • Diagnostic Testing (via LabCorp)

  • Prescription Hormone Therapy

  • Administrative Services

  • Monthly Doctor's Assessment (per necessity or request)

  • Workout Regimen

  • Nutrition Plan

HGH and IGF-1

After Human Growth Hormone is released into the human body, HGH circulates through the body for a brief period before being mostly converted into a hormone known as IGF-1 in the liver. IGF-1 is the primary vehicle by which Human Growth Hormone affects its incredible, age-defying characteristics. Increased levels of IGF-1 circulate through the blood and boost the rate by which metabolism occurs, providing increased energy levels to all aspects of physiological function. In addition to this, IGF-1 stimulates the healthy development of new cells within the bones and the various organs throughout the body. This pattern of cellular replacement is normal, but slows down significantly as endogenous levels of HGH decline. Increased levels of Growth Hormone and IGF-1 revamp this muted processes, allowing the body to rebuild itself at a pace which protects human youth and vitality more effectively.

Sermorelin and GHRP-6 Frequently Asked Questions:

What are the benefits of Increased HGH Production via Sermorelin and GHRP-6?

  • Increased structural integrity on the bones with improved calcium retention

  • Improved quality of sleep predicated by increased REM Sleep

  • Boosted immune health

  • Higher levels of stamina

  • Improved muscular strength

  • Thicker, fuller hair

  • Enhanced emotional health with increased vitality and energy

  • Improved cardiac function

  • Speedier physical rehabilitation from surgery and injury

  • Increased metabolism which burns adipose fat

  • Smoother, tighter skin

  • Increased muscle mass

  • Enhanced libido and restored sexual ability

  • Improved cognition

  • Enhanced renal function

How do I use Sermorelin?

Sermorelin Acetate is only available via injection. These injections are generally provided once daily before bed, but dependent upon your particular health goals and the advice of your doctor, you may decide to administer your injection either in the morning or before you engage in exercise. Nighttime injections are generally recommended because HGH production primarily occurs during sleep. Dosage will depend upon your individual hormone profile, along with your age and gender.

Should I use Sermorelin or HGH?

Both of these are viable treatment options for patients over the age of thirty. There are fewer restrictions on the usage of Sermorelin Acetate therapy, though both treatment options provide similar potential gains. Some patients claim that HGH produces results at a slightly faster rate than Sermorelin alone. When combined with GHRP-6, however, physiological changes take place more quickly as a result of the biological pathway of GHRP-6. Sermorelin Acetate Therapy is much cheaper than Human Growth Hormone, but some are more pleased with the results they receive from the direct injection of HGH.

What are the side effects of Sermorelin?

Sermorelin Acetate Therapy with GHRP-6 has a small risk of side-effects. The most common of these are swelling and pain around the injection site. Some other patients experience itching because of injection, or difficulty swallowing. Although these two side-effects are not dangerous, it is important to let your doctor know so that corrective measures can be taken. In very rare cases, other side-effects occur, such as vomiting, hyperactivity, headache, and dizziness. These symptoms should be reported to a physician immediately if they occur.

How Can I get Sermorelin with GHRP-6?

If you are interested in Sermorelin Therapy, the Conscious Evolution Institute is your quickest and best source for Hormone Replacement Therapy. In any case, you should only choose a physician or clinic which specializes in hormone balance or is highly experienced in the field of treatment. The Conscious Evolution Institute Specializes in Hormone Replacement Therapy for Adult-Onset Hormonal Deficiency. We maintain regular contact with our patients and provide regular diagnostic testing in order to ensure that the therapy is both safe and successful. We provide reasonable payment plans to help you afford and pay for the treatments we provide at a rate which conforms to your budget and needs.

Sermorelin Treatments Potent and Beneficial

Sermorelin Acetate Therapy with GHRP-6 is a fantastic therapy for those suffering from Adult-Onset Hypopituitarism. If you feel that you are suffering from the effects of the aging process and that HGH Deficiency may be speeding up your decline, Sermorelin Injections can help you restore physical health and alleviate many of the most significant effects of aging. Sermorelin Acetate, especially when combined with a conscientious lifestyle, can help you add years to year life while shaving years off of your old age.

We encourage you to call or contact the Conscious Evolution Institute today!

13 April 2013

Synthetic Resveratrol Shows Promise as a Highly Potent Anti-Aging Therapy

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A new and landmark medical study suggests that a compound known as Resveratrol may be able to greatly aid us in the war against aging. There is even evidence that medicines derived from Resveratrol may one day allow us to live until we are 150. It is believed that inside the next 5 years, medical forms of Synthetic Resveratrol will likely reach the market, and help us extend longer and healthier lives.

Resveratrol is a naturally occurring compound, one of the key ingredients of red wine. There is significant evidence that Resveratrol and Synthetic Resveratrol derivatives have the ability to increase enzymatic activity of a vital protein known as SIRT1. Medical researchers have now come up with a strategy for synthesizing man-made Resveratrol for medical use, and the Pharmaceutical company GlaxoSmithKline has commenced clinical medical trials of Resveratrol in order to attempt to treat patients who are afflicted with age-related diseases such as diabetes, cancer, and cardiovascular disease.

SIRT1 May be Ultimate Key to Longevity

Research regarding Resveratrol suggests that SIRT1 may be one of the primary keys to unlocking a longer and healthier life, and if the effects of this protein can be amplified, there is a great level of potential that manipulating this single human protein may have profound effects on human health and longevity, lengthening life and alleviating age-related disorders which impact quality of life as well.

What is SIRT1?

The scientific name for SIRT1 is NAD-Dependent Deacetylase Sirtuin-1. Informally, the protein is known as Sirtuin 1. This protein performs a number of restorative functions in the body and protects the cells and organs against negative stimuli. SIRT1 breaks down proteins that have the ability to hinder longevity and cause our bodies to respond negatively to stress. SIRT1 is one of the central biological players in stress reduction at the cellular level.

SIRT1 and other similar proteins help protect the cells from physiological breakdown when under duress. SIRT1 activation increases the rate at which DNA strands are repaired, which slows down the rate at which the cells break down. For this reason, studies regarding this protein display an immense amount of promise in preventing the natural atrophy of the cells that occur as a result of the aging process.

It has been proven that SIRT1 has the ability to help cells live longer while remaining fully functional, and current studies in human patients seek to examine the ultimate promise of Resveratrol and Resveratrol Derivatives in enhancing and lengthening life by stimulating these vital protective proteins.

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What is Resveratrol?

Resveratrol is a naturally occurring compound which is present in red wine and in the skin of grapes. Although Resveratrol is most recognized for its connection to red wine, the compound is also present in other berries such as cranberries, blueberries, and pomegranate. Peanuts have also been shown to contain a high level of Resveratrol Research shows that the compound has immense potential as a medical treatment, and that the protein acts as both an anti-inflammatory agent and as an antioxidant.

Although there is much evidence that supports the use of Resveratrol as a medical supplement, the amount of Resveratrol present in a glass of red wine is relatively low. Pharmaceutical companies such as GlaxoSmithKlein are devoting large amounts of time, money, and research in order to create synthetic forms of Resveratrol that are concentrated and can provide medical benefits that are much more pronounced and potentially life-changing.

Although studies have been limited in regard to Resveratrol so far, there is evidence that the protein may have a number of highly beneficial uses, including increasing exercise tolerance and boosting cognition. There is even evidence that Resveratrol and Resveratrol Derivatives may be able to safeguard the body against some of the devastating effects of Herpes and HIV.

117 Forms of Synthetic Resveratrol in Testing

There are 117 medications which are currently being tested in order to amplify the effects of SIRT1 through the manipulation of Resveratrol. Each of these drugs has the ability to effect SIRT1 activity in its own way, which means that there is an entire new class of longevity medications in the process of being designed and perfected which very well may have the capability to greatly reduce the risk of a number of vicious diseases including Type-2 Diabetes, Alzheimer's Disease, and Cancer.

Dr. David Sinclair is a professor of genetics at Harvard University and has spent a significant amount of his career studying SIRT1. He believes that this new group of drugs which amplify the activity of SIRT1 enzymes will have the ability to increase health and prevent disease in a number of significant ways. Each of these drugs will have a primary focus regarding the treatment of a particular disease, but in treating one particular disease, the medicines will also have the ability to prevent a number of other diseases at the same time that one primary disease is prevented. In doing so, these drugs will essentially have the unique ability to slow down the aging process.

Who is Dr. David Sinclair?

Dr. Sinclair is Co-Director of Paul F. Glenn Laboratory at Harvard Medical School. This laboratory is dedicated toward studying the effects of the aging process and methods by which humans can extend their lives. Dr. Sinclair is one of the preeminent minds regarding Anti-Aging in the world. Dr. Sinclair has studied Resveratrol and was the first scientist to discover that the compound has the ability to activate and increase the activity of SIRT1.

SIRT1 is a unique enzyme which is turned on by both exercise and responsible caloric restriction. Although these two mechanisms are the primary means by which the human body produces more of the enzyme, there are certain compounds such as Resveratrol which have the capability to medically enhance the activity of the protein.

Resveratrol Increases SIRT1 Enzyme Activity

Although there are a number of different compounds which amplify SIRT1 activity, Resveratrol appears to be the most common and profligate form of SIRT1 enhancer. This compound naturally develops during the crafting of red wine, but the strength of the amplification is limited. Scientists working with Resveratrol have the ultimate goal of tweaking the compound and making synthetic versions of it which are much more medically potent. Scientists are achieving this goal with aplomb.

Synthetic Resveratrol Shows Great Promise

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Scientists, universities, and pharmaceutical companies have been studying Resveratrol for more than a decade, and until very recently, there has been debate as to the basic biological mechanisms which lead to the hypothetical medical benefits of the drug. Although we are just learning how Resveratrol and its derivatives act within the human body, there have been a number of clinical trials regarding the compound which suggest that Resveratrol provides a number of medical benefits in regard to age-related disorders such as Parkinson's Disease, Alzheimer's Disease, Type-2 Diabetes, Heart Failure, Cardiovascular Disease, Cancer, Sleep Disorders, Muscle Atrophy, Osteoporosis, Cataracts, Liver Disease, as well as inflammatory issues such as colitis, arthritis, and psoriasis.

Researcher Confident that Resveratrol will Quickly Becomes a Widely Used Therapy

Dr. Sinclair is confident that Resveratrol will be converted into a new, unique, and powerful form of medical treatment in a matter of years. He says that in the entire history of medical science, Resveratrol Derivatives are the first class of drugs ever discovered that have the ability to increase the rate at which an enzyme functions. GlaxoSmithKlein bought the rights to Resveratrol and its related compounds in 2008 in order to unlock further uses for the drug. The pharmaceutical company is confident that this class of drugs displays an incredible amount of medical promise for those with serious age-related ailments.

Since Resveratrol was first successfully synthesized, there have been more than 4000 derivatives designed which are far more potent than Resveratrol alone one hundred times stronger than the Resveratrol contained within a single glass of wine.

Resveratrol Will Likely First Be Used to Treat Diabetes

Dr. Sinclair believes that the first medical use of synthetic Resveratrol will be as a treatment for diabetes. Sinclair wrote an article in the publication Science, suggesting that Resveratrol has the ability to copy the benefits of exercise and diet without actually changing the weight of the patient.

Small trials of SERT1 activators have been performed in regard to Inflammatory Psoriasis and Type-2 Diabetes which have shown great promise. In the psoriasis study, researchers found that Synthetic Resveratrol has the ability to alleviate the redness and peeling associated with psoriasis. In the Diabetes trial, the drug had the ability to increase and optimize metabolism, providing useful health benefits.

Topical Resveratrol and Oral Resveratrol

These Synthetic Resveratrol Drugs are quite versatile and can be administered both topically and orally. Thus far, there have been no drugs of this class that have been designed to alleviate the effects of aging upon the skin, but there is currently one topical skin cream that features Resveratrol

Resveratrol as Preventative Medicine

Dr. Sinclair says that although each form of Resveratrol-based medication would only be prescribed for specific purposes in the near future, he believes that one day not too far away, medical forms of Resveratrol will begin to be prescribed as preventative medicine, not to treat any particular disease, but simply as a means of disease prevention and longevity.

Medically, Dr. Sinclair thinks that Resveratrol Derivatives will eventually be utilized in the same manner as Statin drugs. Statins are not used only to treat cardiovascular disease, but to prevent the disease as well. There is strong evidence that Resveratrol can be used to treat numerous disorders, but the maximum level of benefit very well may be in the medical issues that drugs like Resveratrol can prevent, making lives happier, longer, and less medically afflicted.

Animal Studies Show Promise of Resveratrol

In animal research studies, obese mice provided synthesized Resveratrol were found to be able to run twice as far as trim mice and also lived fifteen percent longer than their otherwise healthy counterparts.

Although Resveratrol shows great amounts of promise in regard to treating at-risk patients, Dr. Sinclair says that the next step in Resveratrol research is to see how the drug can benefit patients that are completely healthy. If Resveratrol is able to stave off diseases associated with the aging process, then Resveratrol Derivatives will likely quickly become a central player in any anti-aging health regimen.

Resveratrol Provides Evidence that Aging is a Disease

We've always had this idea that aging is something completely unavoidable, but as we learn more about human biology and physiology, we learn that the aging process is largely a series of symptoms which slowly cause our bodies to degrade and atrophy. If we can treat the symptoms of the aging process, we can surely extend our lives significantly, and also very soon. One day, research on drugs like Resveratrol and Human Growth Hormone may allow us to breach the age of 150, but to accomplish that long-term goal, we must continue funding anti-aging and regenerative research so we can lengthen and enhance the lives of everyone.

GlaxoSmithKlein Resveratrol Study May Change Our Perception of Aging

This GlaxoSmithKlein studies is one of the first of its kind to show how Concentrated Synthetic Resveratrol may be able to help us live longer than we ever thought possible. Although a lot of research still needs to be done, preliminary results in both animals and humans have been very promising.

We believe that in the near future, Synthetic Resveratrol will become another vital medical tool in the war against aging. Human Growth Hormone Replacement Therapy and Resveratrol Anti-Aging Therapy will be used in combination in order to maximize the health benefits of both treatments. HGH Injections have the ability to increase cellular rejuvenation, while Synthetic Resveratrol has the ability to protect the cells as a hyper-effective clinical strength antioxidant.

The Conscious Evolution Institute

The Conscious Evolution Institute is one of the best sources in America for high quality Anti-Aging Therapy. We specialize in treatments such as Human Growth Hormone HRT, Testosterone Replacement Therapy, Estrogen Replacement Therapy, and HCG Therapy. We also utilize supplements such as refined Resveratrol in order to maximize the benefits of the treatments we provide. Although Clinical-Strength Synthetic Resveratrol is still in clinical stages, natural Resveratrol is a safe and legal nutritional supplement.

If you are curious about Resveratrol or any form of Hormone Replacement Therapy, we encourage you to continue exploring HGH.tv for more information. Our website is intended as an informational resource in order to disseminate information about life-changing Anti-Aging Therapies. If you feel that you may be a potential candidate for any of the treatments that we provide, we encourage you to call or email us today.

12 October 2013

Estrogen Hormone Replacement Therapy May Diminish Alzheimers Disease Risk

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Estrogen Hormone Replacement Therapy May Diminish Alzheimer's Disease Risk

What is Alzheimer's?

Alzheimer's disease is the most diagnosed form of dementia in the world. As of yet there is no cure for the disease, but researchers worldwide are spending their entire careers attempting to discover ways to alleviate or even cure the syndrome. Our knowledge of the disease grows more quickly by the year and there is significant hope that within the coming generation our world's greatest minds will discover a means to defeat this dreaded degenerative condition. Alzheimer's develops in a different pattern and at a different speed for every patient, but the common symptoms are:

  • Increased aggression and irritability

  • High levels of confusion and disorientation

  • Rapid changes in mood

  • Atrophy of language ability

  • Long term, and eventually short term memory loss

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  • In later stages, a loss of physiological control, in which over time, the patient is eventually completely dependent upon a caregiver

There are three primary hypotheses regarding the cause of Alzheimer's:

Cholinergenic Hypothesis:

This was the original hypothesis regarding Alzheimer's disease, and treatment approaches using this theory as a starting point produce only minimal beneficial effects. This hypothesis predicts that Alzheimer's disease is largely the result of a reduced ability for the brain to synthesize acetylcholine.

Tau Hypothesis:

This hypothesis centers around the idea that abnormalities in a certain type of protein known as Tau Protein can cause the effects of Alzheimer's disease. It is hypothesized that hyperphosphorylated tau interacts with other forms of tau protein, creating clumps of protein known as neurofibrillary tangles inside of nerve cells. These tangles disrupt the function of nerve cells, clogging up the active transport system and preventing neuronal messages from reaching target destinations. At first, this leads to misdirected neuron firing but can eventually lead to the death of the neurons themselves.

The Amyloid hypothesis

The Amyloid Hypothesis is the most widely researched and studied hypothesis, and is the hypothesis for which the research discussed in this article is related to. According to this hypothesis, Alzheimer's is primarily caused by the formation of Beta-Amyloid deposits in the brain which clog up neuronal pathways, leading to the detrimental effects of the disease. One of the primary reasons why this hypothesis carries so much weight is because individuals who display an increased proclivity for the formation of these proteins display a greatly increased risk of the disease. Individuals with Down syndrome have three copies of this genetic abnormality, and as a result, these patients display symptoms of Alzheimer's at an age as early as 40.

New Study: APoE4 Precursor for Alzheimer's and Advanced Aging

Endocrinologists have made a number of discoveries regarding the effect of Estrogen Replacement Therapy on Alzheimer's, and New clinical research provides evidence that Estrogen Hormone Treatments may be able to slow down the process of aging in middle-aged females who are at increased risk of Alzheimer's disease. In this clinical study, otherwise healthy female patients who were going through menopause while also harboring a genetic increased risk of Alzheimer's did not succumb to the disease when treated with Hormone Replacement Therapy.

The genetic abnormality APoE4 has been linked to processes which speed up the natural aging process in women. Hormone Replacement Therapy featuring Estrogen may counteract the detrimental effects of this genetic condition and help older women avoid the ravages of Alzheimer's disease.

What is APoE4?

AP0e4 is the strongest causal genetic link for developing Alzheimer's disease. This gene is responsible for the production of an enzyme known as Apolipoprotein E Type 4. Apolipoprotein E is primarily released by macrophages and the liver in order to break down triglycerides. Ap0E4 performs this function, but is also correlated with creating devastating protein abnormalities in the brain which lead to Alzheimer's. Those who carry 2 copies of the Ap0E4 gene have a ten to thirty times increased likelihood of developing Alzheimer's disease.

Ap0E4 is so strongly correlated with Alzheimer's disease that James Watson, one member of the duo of scientists who first discovered the existence of DNA, refuses to be tested for the genetic abnormality. Individuals who have an active Ap0E4 gene have a 90% chance of developing Alzheimer's by the age of eighty without treatment. Although Alzheimer's research is incredibly active, there are still more questions than answers in regard to this devastating disease.

APoE4 Slowly Degrades the Body

According to Dr. Natalie Rasgon, ApoE4 affects women at the cellular level long before these changes affect the body to a noticeable extent, increasing the physiological age of the cells long before this aging process becomes apparent and symptomatic. Dr. Rasgon is a professor of behavioral science and psychiatry at the Stanford School of Medicine in California.

This new study provides further evidence that Estrogen Replacement Therapy may be able to shield many older women from the effects of Alzheimer's diseaseespecially those who harbor this critical gene.

One of a Number of Studies Linking APoE4 to Alzheimer's

There have been a number of previously conducted studies which have shown that ApoE4 likely plays a role in Alzheimer's disease and general cognitive decline as a result of the aging process.

In another similar study, not directly related to ApoE4, 472 female patients were followed for 16 years. Some of the participants utilized Hormone Replacement Therapy while others did not utilize the treatment. Researchers found that patients who used Estrogen in addition to other forms of Hormone Replacement Therapy had an incidence of Alzheimer's which was fifty percent lower than those patients which did not use the therapy.

This gene is incredibly common among Alzheimer's patients, and is active in around forty percent of patients that are afflicted with the disease.

Dr. Rasgon's laboratory group focused primarily on telomeres, which are caps which close off the ends of chromosomes and are responsible for genetic stability. These telomeres function like genetic fuses over time. Each time that a cell reproduces, the telomeres become slightly shorter in length.

What are Telomeres?

Telomeres are areas of DNA which are at the ends of chromosome strands which consist of repeating lines of genetic data which are inert. These lines form a sort of cap on the ends of the chromosomes in order to prevent them from breaking down. During the process of cell replication, the enzymes which encourage the reproduction of chromosomes are unable to perform their function all the way to the very ends of cells, leaving a very brief portion of the chromosome un-copied.

If chromosomes did not have telomeres which featured this inert genetic data, then every time the cells divided, our chromosomes would lose vital genetic code and our bodies would deteriorate. These telomeres are partially consumed by the enzymes which encourage cell replication, but there are other cellular enzymes which are responsible for rebuilding telomeres. These cells are known as Telomerase Reverse Transcriptase. Under normal circumstances, telomeres set a soft limit on the natural life spans of animals, including humans. Telomeres play a major role in the aging process.

Studies such as those performed by Dr. Ragson help us understand more about telomeres and how we can extend our lifespans by manipulating the rate at which telomeres break down. There is also ongoing research regarding ways that telomeres can be adequately preserved or even lengthened in order to extend the lifespan. In many ways Hormone Replacement Therapy and Telomere Maintenance appear to be related.

Alzheimer's Correlated to Quicker Aging

The current body of scientific knowledge suggests that Alzheimer's and the biological aging process are likely correlated in a large subset of female patients.

If the telomeres reach a certain abridged size, the cells can begin to die off, or in other cases, the cells may lose their ability to continue to divide.

When the cells start to function abnormally as a result of the aging process, the signs of aging begin to become physiologically apparent on a holistic level. Symptoms of aging such as loss of muscle tone and cognitive sharpness, as well as wrinkled skin start to manifest, in addition to other negative side-effects which affect every system of the human body.

The rate at which the telomeres shorten is highly variable among individuals, and this can be used in order to accurately measure biological age, which is systematically different from chronological age, affecting each individual at a unique rate not entirely dependent upon simply time.

The researchers studied telomeres sampled from white blood cells drawn from seventy completely healthy women, generally aged between forty five and sixty five. All seventy were taking Estrogen Hormone Replacement Therapy.

How Might Estrogen Prevent Alzheimer's?

When menopause begins, estrogen levels decline at a rapid pace. There are a number of symptoms that almost all women are aware of, including cold sweats, hot flashes, mood instability, and lapses in memory. What most women probably do not realize is that menopause can increase the risks of a number of other medical issues as well, including Alzheimer's disease. In the past, there have been a few small scale studies that suggested that Estrogen Replacement Therapy may be a treatment option for those who suffer from Alzheimer's disease.

Although the benefits in regard to reversing the effects of Alzheimer's with Estrogen Replacement Therapy seem to be slim, there is growing evidence that Estrogen may be able to prevent the disease or slow its progression, especially when utilized during the period of Menopause. These benefits may persist later in life as well, when Estrogen HRT is utilized in smaller doses.

New studies have also shown that Estrogen provides a number of benefits to the brain in addition to safeguarding it against the threat of Alzheimer's. There has been a significant amount of animal research performed in regard to the Effects of Estrogen on Brain Cells, and it is apparent that the hormone plays a major role in protecting and supporting the function of brain cells.

Estrogen Associated with Healthy Acetylcholine Levels

Healthy Estrogen levels are associated with optimal levels of acetylcholine in the brain, which is important to the maintenance of cognition and memory. Estrogen also apparently has the ability to shut down the formation of plaques known as Beta Amyloids, which cause the symptoms of Alzheimer's disease. Beta Amyloid plaques are the result of an enzyme abnormality which causes the enzymes to produce malfunctioning proteins which breakdown the function of the brain, eventually leading to total cognitive breakdown and death.

Although Estrogen alone may not be a proper treatment for active Alzheimer's, there is still promise that Estrogen HRT when utilized in combination with other forms of Alzheimer's medical treatment such as Aricept (donepezil) may be able to improve health outcomes for patients with Alzheimer's disease.

APoE4 Study Parameters

The seventy women on Estrogen HRT were split into two variable groups. The first group of women stayed on Hormone Replacement Treatments, while the second group stopped all hormone therapy.

After two years, the participants had their white blood cells drawn a second time, and the scientists measured the rate by which the length of the telomeres shortened.

Among the healthy patients who halted Hormone Replacement Therapy, those with the active Alzheimer's gene were found to be 6 times as likely to have telomeres which shortened at an abnormally rapid pace than participants who did not have an active Alzheimer's gene.

For these women who did have the active ApoE4 gene, the telomeres reduced in length at a rate which would normally be expected over the course of a decade, rather than simply two years. Physiologically, these women were aging at a rate which was five times as fast as those with the deactivated gene.

Estrogen Slows Down Biological Aging Associated with APoE4

Hormone Replacement Therapy featuring Estrogen was shown to alleviate this issue, however. In patients who were at enhanced risk of Alzheimer's yet remained on Estrogen HRT, telomere length shortened at a normal rate which correlated with their cohorts with the deactivated gene.

This is powerful evidence that Hormone Replacement Treatments with Estrogen may have the ability to delay or prevent Alzheimer's disease, although much more study is needed in order to prove the hypothesis.

Professor Rasgon says that this study increases our knowledge of the benefits of Estrogen Replacement Therapy and in the future will help us pinpoint exactly which patients are likely to receive the maximum benefit from the hormone treatment.

08 March 2013

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