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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 05 July 2013

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Cardiovascular Benefits of Resveratrol

Although Resveratrol offers a lot of exciting potential benefits in systems throughout the body, nowhere do these benefits offer keener prospects for long term health and longevity than within the cardiovascular system. This article will discuss the body of scientific research in regard to Resveratrol's effect upon the heart and the rest of the cardiovascular system.

Resveratrol Prevents Arterial Plaque from Forming

One of the most dangerous diseases related to inflammation is atherosclerosis. This disorder is also referred to as the Hardening of the Arteries. In patients that suffer from this disease, the arteries become clogged up with cholesterol, fat, white blood cells, and other substances, which stick to cell walls and prevent the heart from pumping blood effectively.

At a certain point, severe blockage can lead to heart attack, stroke, or death. One reason that atherosclerosis occurs is because tiny apparatus known as cell adhesion molecules encourage white blood cells to become stuck to the walls of the arteries. After these white blood cells become stuck, they promote inflammation within the sensitive tissue of the arteries.

There is evidence that Resveratrol can slow down the rate at which atherosclerosis occurs by limiting the ability of adhesion molecules to become activated. Atherosclerosis also changes the way that Smooth Muscle Cells within the blood vessels function. As these muscle cells grow in response to damage, they increase the severity of the blockage. Preliminary research seems to suggest that Resveratrol can limit this process in a laboratory setting.

Resveratrol Stimulates the Production of Nitric Oxide by the Cardiovascular System

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Resveratrol has been shown to reduce blood pressure and increase freedom of blood flow by activating an enzyme known as Endothelial Nitric Oxide Synthase, abbreviated eNOS. Nitric Oxide is one of the most important chemical messengers in the body. This gas is one of the primary agents which control blood flow, stimulating the arteries to open in a process known as vasodilation.

Most cardiovascular ailments in aging men and women are related to high blood pressure and medical issues which occur in relation to high blood pressure. If the arteries are not producing a sufficient amount of Nitric Oxide, this prevents the arteries from functioning in a healthy manner. If the arteries are not properly stimulated by Nitric Oxide, then the arteries will not open up properly to allow for optimal blood flow.

The enzyme eNOS is directly responsible for Nitric Oxide production, because the enzyme interacts with Vascular Endothelial Cells, stimulating them to release Nitric Oxide, thereby controlling blood flow effectively through the body. Resveratrol has been shown to increase the receptivity of endothelial cells to eNOS stimulation.

Resveratrol Slows Down Platelet Clotting

Blood clotting is incredibly important for health and healing, but in many patients, the blood begins to clot too readily, and this can cause major problems. A process known as Platelet Aggregation is among the initial steps of the clotting process, and in aging patients with cardiovascular complications, internal blood clotting can cause blockages in the arteries leading to both the brain and the heart. If blood clots block off or restrict normal blood access to the brain or the heart, this leads to the conditions known as stroke and heart attack.

There is laboratory evidence that Resveratrol reduces the activity of platelet aggregation, reducing the size and danger resulting from persistent clots. It should be remembered, however, that in the laboratory setting in which this research was performed, human cardiovascular cells were exposed to concentrations of Resveratrol which were higher than the levels that would most likely be able to achieved by taking Resveratrol by mouth.

This does not mean that benefits of consuming Resveratrol offer no benefit, but the results displayed in vitro are likely more potent than those of oral ingestion in a human patient.

Red Wine, Resveratrol, and Your Health

Researchers have long been aware that modest ingestion of alcohol has been correlated with a healthier cardiovascular system. In nowhere in the world is this more apparent than in the nation of France.

France consumes more wine than perhaps any other country in the world. Amazingly, it also has one of the lowest incidences of heart disease as well. Although this may already be surprising at face value, it is made even more fascinating by the fact that a very high percentage of the French engage in smoking. They also engage in dietary practices which are high in saturated fat.

Normally, smoking and saturated fat are correlated with increased levels of heart disease, but in France, some outside variable protects the body from these negative health choices which normally wreak havoc upon the body. In the scientific community, this is known as the French Paradox.

After decades of study, it seems that the consumption of alcohol, red wine in particular, has allowed the French to live healthier lives in spite of their vices. In recent years, it is becoming more and more widely hypothesized that the Resveratrol in Red Wine is the primary actor which safeguards the health of the French heart.

Red Wine Flavonoids

In addition to Resveratrol, Red Wine also contains a very high concentration of molecules known as flavonoids. Flavonoids share many health benefits with Resveratrol. They are proven to reduce the effects of inflammation, while also safeguarding the body as potent antioxidants. There is also evidence that they support the health of the arteries in other ways that we have yet to fully understand.

In a number of studies, it has been noted that patients that consume alcohol moderately, yet regularly, have a risk of heart disease that is twenty to thirty percent lower than individuals that do not consume alcohol at all. It is apparent that responsible alcohol consumption does have some beneficial effect upon health. It also seems clear that flavonoids, as well as Resveratrol, offer numerous benefits in regard to cardiovascular health.

In animal research, rodents experienced cardiovascular improvement when exposed to red wine, even if the wine was non-alcoholic. In human patients, a recent study showed that consumption of concentrated polyphenols from red grapes (including Resveratrol) had the immediate impact of improving Nitric Oxide release, stimulating healthier levels of vasodilation.

Consider Adding Sources of Resveratrol to Your Diet Today!

Although much of the research regarding Resveratrol and the heart is preliminary, researchers are quickly realizing more about this wonderful compound on a yearly basis. One should not consider Resveratrol a wonder drug than can resolve all of these serious medical issues, but it is important to realize that increasing the level of Resveratrol in your diet can improve your health and your heart in a number of different ways.

Even if some of the exciting potential benefits of Resveratrol end up being slightly exaggerated, Resveratrol represents one of the best examples of Low Risk-High Reward experimental dietary supplementation available in the world of 21st Century Nutrition.

In the next article, we will discuss the most effective ways to add Resveratrol to your diet!


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 05 July 2013

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Best Sources of Resveratrol

In previous articles we discussed various potential benefits of Resveratrol in the diet. In this article, we will discuss some ways that you can increase the level of Resveratrol that you consume in your daily routine while also encouraging you to reap the other benefits inherent in these various and healthy foods.

Resveratrol is Abundant in Red Wine

Red Wine is the most well known, as well as the most potent, form of Resveratrol available without resorting to supplemental forms of the compound. There is a reason why the French have some of the most resilient cardiovascular systems in the world, and it's not because of their smoking habits. If you choose to enjoy alcohol responsibly, then Red Wine is a fantastic way to get a physiological boost.

Red Wine is full of multiple flavonoids, as well as polyphenols such as Resveratrol, which reward the body for their consumption in multiple ways. If you choose not to consume alcohol, non-alcoholic Red Wine appears to offer many of the same benefits of its alcoholic counterpart.

Red Grape Resveratrol

Although Red Wine is the most well known source of Resveratrol, Red Grapes themselves are an efficient vehicle for Resveratrol as well. Grape seeds contain the highest concentration of Resveratrol in the plant. The skin of the grape offers the second highest level of Resveratrol. Something to keep in mind in regard to grapes: The darker the grape, the higher the concentration of Resveratrol. Choose grapes that have a sharp color as near to black as possible in order to maximize the amount of Resveratrol you receive from your snack.

Why is Red Wine a Better Source of Resveratrol?

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The reason that Red Wine is a better source of Resveratrol than Grapes themselves is a result of the wine-making process. The process of fermentation increases the amount of Resveratrol that is available in the liquid that you actually consume.

Resveratrol is largely trapped in the seeds and the skin of grapes. This means that when you eat raw grapes, much of the resveratrol that passes through your system in never unlocked and released into your body

The process of fermentation leaches the vast majority of Resveratrol from these parts of the grape which are normally poorly digested, vastly increasing the amount of Resveratrol available in your glass of wine.

Why is Red Wine a Better Source of Resveratrol than White Wine or White Zinfandel?

The level of Resveratrol available in a glass of wine is directly related to the amount of time that the fermented liquid has been in contact with the pressed skin and seeds of the wine. The color of the wine is directly related to the amount of time that the wine is allowed to soak in the presence of the grape skin. Darker Wine = More Resveratrol

Dark Chocolate: A Significant Source of Resveratrol

Dark chocolate is one of the densest forms of natural Resveratrol available from any food product. Red Wine contains the highest level of Resveratrol out of any other food or drink, but dark chocolate is the third best source of this amazing polyphenol compound, behind red wine and boiled peanuts. A serving of dark chocolate contains around three quarters as much resveratrol as a glass of wine.

All forms of chocolate contain at least some Resveratrol, but the amount of Resveratrol is directly related to the purity of the chocolate. Cocoa powder has the highest concentration of Resveratrol among chocolate products. After the powder itself, baking chocolate has the second highest amount of the compound, followed by dark chocolate. The least potent form of chocolate is milk chocolate.

Peanuts: An Efficient Alternative to Red Wine

Peanuts are an incredibly versatile food, but did you know that they are also a fine source of Resveratrol? The amount of Resveratrol in a serving of boiled peanuts is nearly identical to that contained within a glass of wine. Boiled peanuts are the best source of Resveratrol from peanuts. Peanut butter comes in second place, and Roasted Peanuts come in third place.

The reason why boiled peanuts provide higher levels of Resveratrol than peanut butter or roasted peanuts is similar to why Red Wine provides more of the compound than grapes. The highest level of Resveratrol is available in the shell, and the thin casing of the peanut itself. The boiling process works the Resveratrol out of the portions of the peanut that the human body is less effective at digesting, providing a higher active dose. The process of making peanut butter also coaxes these same polyphenols free, but to a lesser extent.

Various Berries Contain Resveratrol

A number of types of berries contain Resveratrol. Like grapes, the concentration of Resveratrol is related to the color of the berry itself. Dark berries like cranberries and blueberries contain the highest levels of Resveratrol.

Resveratrol is also available in the same primary locations in berries: The seeds and the skin. Like Red Grapes, the fermentation products can also draw out increased levels of Bio-Available Resveratrol.

Resveratrol Supplements

You may be interested in turning to supplemental forms of Resveratrol. As we mentioned in earlier articles, the levels of Resveratrol used in scientific study of the compound are often higher than the levels of Resveratrol that can normally be acquired from diet alone.

Supplemental sources of Resveratrol provide a higher dose of this particular polyphenol than can be acquired from normal dietary sources. You should be conscientious when choosing your Resveratrol Supplement, because supplements are not regulated by the FDA and, as a result, don't carry the same guarantees of quality and conformity.

Just do your research, and choose a Resveratrol Supplement that actually offers what it claims to provide. Most Resveratrol Pills contain between ten and fifty milligrams of Resveratrol, although there is evidence that the body can benefit from much higher doses. Although there are many brands of Resveratrol, one of the most trusted brands of Supplemental Resveratrol is Biotivia Transmax Trans-Resveratrol.

Although there is not a strict Recommended daily allowance, it appears that the ideal level of Resveratrol for optimized physiological health is between five hundred and two thousand milligrams per day. This is not to say that the lesser amount you can acquire from a normal diet will not provide benefits, but that the maximum potential benefits of Resveratrol continue to accumulate as the dosage grows!

Add Resveratrol to your Daily Routine!

As you can see, there are many ways to add Resveratrol to your diet. We encourage you to at least try out Supplemental Resveratrol, to see if it works for you. Even if you find the results unsatisfactory, there is absolutely no risk in adding this potentially highly beneficial nutrient to your diet!


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 July 2013

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Increased Awareness of Testosterone Deficiency Beneficial to Aging Men

Many males suffer from the symptoms of Low Testosterone. It is clear that Testosterone Deficiency is a legitimate medical condition which needs to be appropriately treated. The problem is that even though Low-T is a real issue that can be treated and needs to be dealt with, there is still no clear line at which Testosterone Hormone Replacement Therapy is unequivocally recommended. There are a few reasons for this.

What Are the Roadblocks to a Concrete Diagnosis of Testosterone Deficiency?

One: Unity Within the Medical Community: Different Doctors, Different Opinions

First is an issue of scientific agreement. It is true that Testosterone Replacement Therapy has been available to patients for decades, but our knowledge of Testosterone Deficiency is still not complete. Original studies compared healthy patients to those with severe or total deficiency. We definitely know the issues involved with having a clear lack of healthy Testosterone.

The problem is, our knowledge of the titrated effects of Testosterone Deficiency lag far behind our knowledge of the black and white of severe deficiency and absolute health. Some patients may benefit greatly from a small infusion of Testosterone, while others may need full treatment in order to restore their physiological hormone balance.

Two: Physiological Individuality: Testosterone Deficiency is Different for Everyone

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The second issue is a matter of physiology. As we learn more about health and the human body, it is clear that every person's body is fine-tuned in a somewhat unique way. Some patients can have a relatively low level of Testosterone (without fully being declared deficient) and still have to deal with symptoms of Low-T.

Other patients have Clinically Low Testosterone Levels but don't seem to suffer from symptoms of that deficiency in the same way. As our knowledge of Testosterone and its Function continues to grow and become more elaborate, these lines will eventually be drawn accurately, and we will more fully take into account individual physiology in regard to Testosterone Deficiency Diagnosis.

Three: Disorders Symptomatically Similar to Testosterone Deficiency

Another issue related to Testosterone Use and Replacement is that there are a number of other conditions that can mimic the symptoms of Testosterone Deficiency, such as Anemia, in addition to other medical disorders and nutritional deficiencies. Reduced Sex Drive, Diminished Erectile Ability, Fatigue, and Reduced Muscle Mass can be the result of a number of different medical problems, and it is important to make an accurate diagnosis for the sake of every patient's health.

Current Trends in Testosterone Deficiency Diagnosis

In recent years, Hormone Physicians came together in order to form a more concrete set of guidelines to streamline an approach to Testosterone Deficiency that is more careful and considerate. They believe that Testosterone Deficiency Diagnosis should be the result of a consistent set of guidelines which take into account chronic symptoms in males that suffer from decidedly low levels of Testosterone.

In spite of these recommendations for care by Endocrine Doctors, drug manufacturers continue to work hard to increase public awareness of Testosterone Deficiency, showcasing the numerous benefits of treatment in order to spur conversations about Hormone Replacement Therapy between patients and their physicians.

Testosterone Awareness at It's Highest Levels

Research has shown that in recent years, national awareness of both the symptoms of Testosterone Deficiency and the Benefits of Testosterone Replacement Therapy have become an engrained aspect of the communal American Psyche, as Testosterone Prescriptions have risen at a rapid pace. When discussing the increase in popularity of Testosterone Hormone Treatments, it is important to not only look at the issue from a medical perspective, but from the perspective of advertising as well.

Testosterone Commentaries

In a recent study regarding the nature of Advertising and Testosterone, the authors presented two commentaries regarding the marketing and marketability of Testosterone Sprays, Creams, and Gels.

Testosterone Advertising Perspective One

One perspective comes from a writer that has been intricately involved in the process of advertising Testosterone and other health treatments. This writer, named Stephen Braun, intimately understands the process, because he has written pamphlets and other advertisements for Testosterone, both to medical audiences and to the audience of the potential patient.

He has often written under his own name, and admits to ghostwriting for a number of clients as well. He claims that the rapid increase in Testosterone Prescriptions is largely the result of an ingenious marketing campaign in order to globally define Low-T as a set of individual symptoms related to the aging process, which can be treated effectively through the use of Testosterone Treatment, rather than simply a hormonal disorder.

Testosterone Advertising Perspective Two

Another point of view comes from two physicians that work in Veterans Affairs for Dartmouth. Their names are Dr. Steven Woloshin and Doctor Lisa Schwartz. A major aspect of their research is to figure out ways to encourage older patients to go visit their doctor, especially older patients that are experiencing negative medical symptoms.

They say that there is an immense value in regard to the overall campaign to increase awareness for Testosterone Deficiency and Low-T, because these campaigns provide working examples regarding how to get older men engaged and interested in preserving their health and talking to their physician about other medical issues which may be adversely affecting their health.

These ad campaigns may exaggerate slightly, but in the end, it benefits the consumer even if they do not choose Testosterone Hormone Replacement Therapy. These advertisements increase the awareness of Testosterone Treatment to patients while also reducing any underlying stigma and increasing the odds that the patient will go see a medical professional for treatment.

The Doctors' perspective continues as follows: There are a lot of aging men in the United States that don't regularly visit their doctor, but are concerned with many of the symptoms of the aging process that are often a direct result of Testosterone Deficiency, including irritation, fatigue, and low-libido. This audience is also one of the primary audiences which make up a large number of aging veterans in the United States that share the same concerns.

Increased Medical Awareness Good for Everyone!

The mythos behind Testosterone Replacement has the capability of both treating patients with the legitimate issue of Testosterone Deficiency while also increasing the odds that patients will just go visit a doctor! Medical professionals around the United States can learn a lot from Testosterone Advertisements, because this market has really figured out how to target their audience perfectly.

Testosterone HRT Promising

As we learn more about the complex interactions of different hormones within the endocrine system, we will undoubtedly uncover a number of new, potent, and amazing methods to preserve ourselves and our bodies throughout the lifespan. Testosterone Hormone Replacement Therapy shows a large amount of promise in spite of the hype, and as we learn more about other treatments such as HGH Hormone Injections and Estrogen Replacement Therapy, we will no doubt uncover more and more secrets to enhancing our lives well into old age.

Testosterone and Aging

Aging is a natural and inevitable process, but it is becoming more and more clear that there are countless things that we can do to improve our ability to live a long and healthy life. It is also becoming evident that, although some aspects of aging may be unpreventable in the long term, a large number of the symptoms of aging are related to Hormone Balance, and only tangentially related to aging. Although our knowledge of the field as a whole is relatively young, the study and practice of Hormone Optimization will have a vastly net-positive effect on national and global health in the coming decades.

Testosterone Replacement is another piece of the puzzle in regard to health maintenance, and, even though it may not be needed in every instance, even increased interest in the therapy will help patients turn to physicians and health professionals that can help them take control of their health and make knowledgeable and empowered life choices.

Androgel Low-T Campaign

One of the most vivid campaigns regarding Testosterone Deficiency is that of Androgel by the pharmaceutical company AbbVie. These advertisements are heavily broadcast both on the radio and on television, while also being printed in newspapers and magazines across the United States. Their advertisements popularized the use of the term Low-T as the layman's term for Testosterone Deficiency. These Low-T Ads aggressively target middle-aged men in order to increase the odds that they will visit a doctor in order to assess their hormone status.

A representative of AbbVie and Androgel explains that such targeted efforts are not discouraged, but actively encouraged by the Food and Drug Administration because of the way that they rapidly increase disease awareness in a target population. These type of advertisements are allowed by the FDA because they lean on patients to become more proactive about their own lives, even if Testosterone Deficiency doesn't turn out to be their biggest problem.

In addition to this, it gets middle-aged males to go visit a physician, which is important, because this subset of the population is rewarded heavily for preventative care while simultaneously being the group of patients among the least likely to take advantage of preventative care. The FDA sees Testosterone Replacement as only one tool in the arsenal of Public Health, and advertisements for Low-Testosterone are beneficial because they encourage the patient to learn about various forms of therapy which they may not have been previously aware of.

All advertisements for Androgel are written in total compliance with Food and Drug Administration Regulations, and were designed to increase knowledge among the general population of aging men regarding the potential benefits of Testosterone Replacement and the Drawbacks of Testosterone Deficiency, so that they can be more appropriately armed to talk to a qualified medical professional regarding their personal campaign to safeguard their health. In the end, it is the doctor that chooses which therapy is right for the patient.

Self-Awareness is the Key to Good Health!

This is why it is important to learn as much as you can about your own body and your personal health risks as you grow older. Testosterone Replacement Therapy is just one of many tools that can help you live a longer, happier, life. If you feel that you may be experiencing the symptoms of Testosterone Deficiency, don't be afraid to talk to a doctor!

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