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HUMAN GROWTH HORMONE RESEARCH & NEWS



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Does Growth Hormone Have Anti-Aging Properties?

It is quite true that we are all going to get old. As a matter of fact, the generation of baby boomers is quickly approaching their mid-fifties, and the number of elderly people in America will continue to increase for another generation. Why then, do we have to resign to growing old in the same way that previous generations were forced to in the ages before us? Must we be weak, frail, fatigued, depressed? Living in fear to take a walk in the park for fear that we may fall?

It is a truism that youth is wasted on those who are young. If such a saying is true, why should the opposite statement also be true? Why must wealth and experience be wasted upon those that are old? Should not older men and women be able to retain their enthusiasm and energy in a grand effort to enjoy their autumn years?

We do not have to take age lying down! We here at the Conscious Evolution Medical Institute have learned that old age is largely a state of mind that has been induced by hormonal deficiencies. It is a state in which the hormones we so enjoyed in our youth have become less bountiful. It makes logical sense that with hrt hormone replacement therapy many of these symptoms can be alleviated or reversed.

One of the most impressive hormones that can be regained through Bio identical Hormone Replacement therapy is Human Growth Hormone. It can allow an older woman or gentleman to live a healthier, longer, and more active life. The greatest point to be made about Human Growth Hormone is that it truly is not all that fantastic of a concept. Growth Hormone is naturally produced by the body, and it is produced in large quantities when we are in our youth. The longer we can retain Growth Hormone, the more we can slow down many of the devastating effects of aging.

It makes perfect sense. Growth Hormone is vital to growth processes within the body. GH supplement is provided to young children who are maligned with slow skeletal growth, and it allows them to grow taller than they would without treatment. The problem is that Human Growth Hormone levels drop at a steady rate in all men and women after they enter adulthood. After decades of research, we now know that Human Growth Hormone provides significant benefits throughout the lifespan. For this reason, we must conclude that Growth Hormone is vital for the maintenance and rejuvenation of the body in adulthood. Research regarding the effect of Growth HRT upon elderly patients provides evidence that the main role of the hormone in adulthood is to allow one to live a longer, healthier life of higher quality.

Where does Human Growth Hormone Originate?

Human Growth Hormone is produced in the anterior area of the pituitary gland which is buried deep within the brain. Human Growth Homrone is a microscopic protein molecule. It has chemical similarities with insulin, though HGH is secreted in brief, sharp pulses after a person exercises or in the initial hours of rest. Human Growth Hormone only stays in the blood stream for a few minutes. For this reason, it in incredibly difficult to measure Human Growth Hormone in serum. Though it does not remain in the blood stream for long, HGH binds to the liver which turns some of the hormone into Somatomedin-C, which is also known well by the name Insulin-Like Growth Factor I (IGF-1) Since IGF-I stays in the blood for up to one and a half days, a blood sample that contains IGF-I proves that HGH is being produced. Normal IGF-I levels in the blood tend to appear in volumes of 200 to 450 ng/ml. However, one third of men and women that are over the age of fifty display levels of HGH that are lower than 200 ng/ml. During puberty, Human Growth Hormone levels are at their peak and IGF-I reaches levels of 600-800 ng/ml or even higher. In normal women and men under the age of forty, less than five percent have levels of HGH that are below 250 ng/ml! After the age of 40 many women and men have a level of Human Growth Hormone that is similar to that of an octogenarian! Human Growth Hormone may be the means by which we can age gracefully.

When IGF-I levels drop under the baseline adult range, energy levels and bone and muscle strength tend to decrease as well. Cell regrowth, tissue repair, vital organ repair, general rejuvenative ability, enzyme production, and hair, skin, and nail revitalization will begin to occur less effectively

Though decreased levels of Human Growth Hormone and increased age are certainly directly correlated, those who lose full function of the pituitary gland, whether through accident, infection, or surgery, will immediately begin to be maligned with acute ill effects.

It is vital to understand that natural HGH will inevitably decline with age!

In those who are utterly lacking a functional pituitary, body composition changes and a shift occurs where the amount of fat increases by 7-25%. Lean mass of the body decreases at a similar rate. Mass and strength of the muscles diminish as well. Studies in regard to bone density show that in those patients with no pituitary input, it seems as though an individual ages by around 15 years by analysis of the density of both the long bones and the spinal bones. As Human Growth Hormone flags, weight increases of as much as fifty pounds occur. Beyond this, there are issues regarding cholesterol as well. Levels of triglycerides go up, and good HDL cholesterol suffers. Cardiovascular complications occur more often, which could be related to the thickening of the vascular walls of the heart. Decreased output by the heart leads to further problems.

Hormonal insufficiencies such as these often lead to people such as these to report a serious decline in their capacity to exercise, and they often suffer from cardiovascular disease, which leads to early mortality. Also, they report issues with loneliness, depression, focus, and fatigue. In general, they just suffer from a general lack of well-being.

Hope on the Horizon: Food and Drug Administration approves Human Growth Hormone for Use by Adults

Recombinant HGH has recently gained approval by the FDA for women and men of adulthood for the therapy of Growth Hormone Deficiency and hypopituitarism. If a person suffers from hypopituitarism, Human Growth Hormone therapy is compatible under the majority of insurance policies. After being approved for therapy, patients are administered Human Growth Hormone treatment and testing under professional supervision. Our experience and the revelations of research provide ample evidence that Human Growth Hormone Replacement Therapy offers benefits to those that have insufficient levels of Growth Hormone. This deficiency is often referred to as Somatotropin Deficiency Syndrome. The Conscious Evolution Medical Institute also provides Human Growth Hormone treatment for patients who suffer from Somatomedin-C (Insulin-Like Growth Factor-1) levels under 200 ng/ml that are approved in our Internal Review Board registry, but these patients are required to pay for their treatment.

Please realize that by undergoing a global hormone replacement regimen, administering progesterone, estrogen, testosterone, thyroid, pregnenolone, or DHEA (other vital hormones which a patient may be co-deficient) when necessary in addition to Human Growth Hormone, one can minimize the costs, side-effects, and dosage of treatment.

Growth Hormone Replacement Therapy Changes

Administration of Human Growth Hormone often leads to substantial changes in the composition of the body: lean muscle mass increases as fat mass percentage is reduced. Using Human Growth Hormone at the modest dosage of 0.003 mg/kg over the course of six months was shown to improve lean muscle mass in 24 patients that had a Human Growth Hormone deficiency (1). Improvements in lean muscle mass have been associated with higher levels of protein synthesis, along with muscle function and mass. The percentage of body fat also drops after six months of Human Growth Hormone administration. The most fat is eliminated from the areas of the trunk and the stomach, rather than the legs, neck, and arms. This fact is evidence that Human Growth Hormone replacement treatment can reverse excess stomach fat associated with Human Growth Hormone deficiency, along with reducing risks of heart problems.

Heart Health and Metabolism of Cholesterols

Human Growth Hormone Therapy for adults also shows is believed to have a positive effect upon cholesterol. In new research, it has been shown that brief regimens of Human Growth Hormone Therapy led to reduced LDL (or bad) cholesterol (7) while also boosting heart function and capacity for exercise. Participants showed higher levels of oxygen intake as well as strength during cycling exercise. Human Growth Hormone has been associated with higher levels of muscle mass and stronger and longer action upon the treadmill (8). Recent research by Fazio has shown that those who have experienced heart failure have shown improvement after being given high dosage of Human Growth Hormone Therapy.

Bone Density

Among the most stunning effects of Human Growth Hormone is its effect upon the skeletal system, muscles, and tissues. It provides a significant level of rejuvenation to these systems. Skin health improves, damaged bones heal more effectively, and significant levels of improved muscular strength have been reported during Human Growth Hormone Therapy. Others have reported that signs of aging are fading from their skin. Sometimes hair regrowth occurs in male hormone replacement therapy patients as well as female patients. These changes provide evidence that testosterone, DHEA, and Human Growth Hormone are anabolic (synthesizing) hormones that significantly rehabilitate tissue of the body. Unfortunately, as we age, catabolic processes lead to faster levels of tissue breakdown. Human Growth Hormone combats the catabolic processes of aging.

The most significant way that Human Growth Hormone effects the skeletal system is through its role in enhancing the body's ability to build and repair the bones. Human Growth Hormone stimulates the proliferation of fibroblast (ligament) and osteoblast (bone) cells in the skeletal system. In recent clinical research using the powerful techniques of single photon absorptiometry and quantitative tomography, marked increases of 4% and 5% were shown in cortical and spinal bone density over the course of twelve months of therapy in adults deficient in Human Growth Hormone (4). In conclusion, it seems that the administration of Human Growth Hormone may lead to an enhancement of multiple organ systems of the body through the positive effect it has upon the skeletal system.

More examples of Human Growth Hormone's anabolic effects include muscle gain and increased appetite, increased capacity for exercise, increased capacity of the lungs, and increased would rehabilitation. Many also report that liver spots, also known as senile keratoses, begin to fade after eight weeks of Human Growth Hormone Therapy.

Side-Effects of Low Dosage Human Growth Identical Hormone Replacement Therapy.

Human Growth Hormone dosage is a vital consideration in those who suffer from Human Growth Hormone Deficiency. Overdosage of Human Growth hormone is associated wit many signs of excess Human Growth Hormone. Among these symptoms are hypertension, carpal tunnel, and excess fluid retention. However, by using more modest doses of Human Growth Hormone, it was demonstrated by Bengtsson that only mild side-effects such as slight joint pain and mold fluid retention occur. Only a single case of carpal tunnel was discovered. In each of these cases, further restriction of the Human Growth Hormone dose lead to full elimination of the side-effects. Another clinical study only used a small dose of 0.01 mg/kg, which was injected three times each week. In this study, there were zero side-effects reported (8). Many studies provide evidence that says that low dosage Human Growth Identical Hormone replacement therapy generally only causes modest side-effects, if any.

Benefits of Hormone Replacement Therapy with HGH.

Improve Body Composition: Boost muscle mass and reduce fat for a shift in body composition of as much as 20 pounds. This change can lead to higher sex drive, as well as enhanced physical well-being and self perception.

Improve Energy: Human Growth Hormone patients report higher levels of energy without the need for afternoon snacks, stimulants, caffeine, or cigarettes. This energy boost helps them become more confident in their self control and enhances their capacity for exercise.

Improve Focus: An intriguing yet untested potential benefit of Human Growth Hormone is a return of mental focus and enhancement of memory. Since Human Growth Hormone provides improvement to the intracellular and vascular systems which support the cells, it is not at all surprising that these benefits have been reported in individuals.

The Future

Many fundamental questions remain regarding the exact medical definition and preferred treatment for partial versus total Human Growth Hormone Deficiency. Also, it is not clear whether all of the realized positive effect of full Human Growth Hormone Replacement Therapy will occur in those that undergo low dosage or combination treatments. Even so, is has already been made clear that even small doses that do not result in potential side-effects sufficient level may be sufficient for some to reach their metabolic goals. We here at the Conscious Evolution Medical Institute hope that our continued clinical evaluations will help lead to more efficient usage of Human Growth Hormone, as well as help reveal more of this wondrous therapy's benefits while eliminating incidence of increased cardiovascular and general morbidity.

Works Cited

Cuneo, Salomon, and Hesp, et al. Treatment effects of Recombinant HGH upon Metabolism and Body Composition among Adults with Growth Hormone Deficiency. New England Journal of Medicine 1989; Issue 321: Pages 1797-03.

Bengtsson. Consequences of Growth Hormone Deficiency in Adults. Acta Endocrinoligica 1993; Volume 128: Pages 2-5.

Cuneo, Salomon, Wiles et al. Effects of Human Growth Hormone Treatment Among Adults Whom are Deficient. Applied Physiology Journal 1991; Volume 70: Pages 695-700.

Halloran, Tsatsoulis, Whitehouse et al. Increased Bone Density after Human Growth Hormone Therapy Upon Deficient Adults. Journal of Clinical Endocrine Metabolism 1993;Volume 76: Pages1344-48.

McGauley, Cuneo, Salomon et al. Psych. Self-perception changes due to Growth Hormone Treatment in Adults with Human Growth Hormone Deficiency. Hormone Research 1990; Volume 33(Supplement 4): Pages 52-54.

Bengtsson, Eden, Lonn et al. Therapy of Adults with Human Growth Hormone Deficiency with Recombinant Growth Hormone therapy. Journal of Clinical Endocrine Metabolism 1993;Volume 76:Pages 309-17.

Johnston, Bengtsson. Effects of Growth Hormone and its Deficiency upon Heart and Lipids. Acta Endocrinologica 1993;Volume 128(Supplement 2):Pages 69-70.

Amato, Carella, Fazio et al. Heart Structure, Metabolism of Bone, and Body Composition Heart Structure in Growth Hormone-Deficient Adults Effects of Human Growth Hormone Replacement Therapy at Mild Dosage. Journal of Clinical Endocrinology and Metabolism. 1993;Volume 77:Pages1671-76.

Fazio, Sabatini, Capaldo, et.al. Test study of GH in the treatment of cardiomyopathy. New England Journal of Medicine. 1996;Volume 334:Pages 809-14.

The above information does not provide sufficient evidence to self-diagnose a particular procedure or treatment. It should not lead one to believe that this is the only treatment option available.


Dr Sandra Cabot Anti-Aging Bio-Identical Hormone Therapy


Written by Dr. Welsh, Published on 14 January 2016

Sermorelin Growth Hormone Releasing Hormone Analog


Written by Dr. Welsh, Published on 06 April 2012

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Geref Sermorelin Acetate Therapy

Geref is one of the many forms of Sermorelin Acetate injection that have been released in the American market.

Sermorelin at a Glance

Sermorelin is a synthetic form of Growth Hormone-Releasing Hormone. GH-RH is composed of a chain of forty four amino acids, whereas Sermorelin only contains twenty nine amino acids. Despite this fact, Sermorelin functions identically to GH-RH in the human body, and is one of the most popular forms of GH-RH therapy.

One of the most common means by which Sermorelin is configured for human injection is by forming an acetate salt to which Sermorelin is attached.

Sermorelin Acetate Breakdown

Noted in molecular terms, Sermorelin Acetate is: C149 H246 N44 O42 S1. Sermorelin acetate has a weight of 3,358 daltons.

Geref is a sterilized and has been proven not to produce an inflammatory response when injected into the human body. In unconstituted form, Geref is freeze-dried through sublimation, allowing it to be transported more effectively and stored for a longer period of time than its liquid form. Before Geref is injected, it must be reconstituted, combining the lyophilized Sermorelin Acetate with a Sodium Chloride Solution. After reconstitution, the mixture has a pH of between 5 and 5.5.

How is Geref Distributed?

Geref is delivered to the patient via vials. The contents of the vial are as follows:

Each half milligram vial holds 0.5 milligrams of sermorelin acetate along with 5 milligrams of mannitol. The pH is fixated using a buffer of monobasic sodium phosphate and dibasic sodium phosphate.

Each one milligram vial holds 1.0 milligram of sermorelin acetate along with 5 milligrams of mannitol. These contents have pH levels which are also fixated using monobasic sodium phosphate and dibasic sodium phosphate.

How does Geref Work?

Geref is an injectable form of Sermorelin Acetate which has the ability to boost plasma levels of Insulin-Like Growth Factor One and Human Growth Hormone by stimulating the endogenous production of HGH by the pituitary gland. Geref functions in the body identically to endogenous GH-RH, stimulating HGH production in an identical manner in human beings.

How does Geref interact with the Human Body?

Distribution

After 0.25 to 1 milligram intravenous injection of Human Growth Hormone was delivered to twelve normal patients, the mean volume distribution had a range of 23.7 to 25.8 liters.

Absorption

After two milligrams of Sermorelin was subcutaneously injected to twelve normal patients, peak sermorelin saturation occurred between five and twenty minutes after injection. After this administration, the absolute mean bioavailability of sermorelin was around six percent.

Metabolism

There has been no human research regarding Geref.

Evacuation

Sermorelin leaves the body quite quickly after it has entered the bloodstream. In adults, Sermorelin is cleared from the body at a rate of around 2.6 liters per minute. Geref also has a short half-life of around eleven to twelve minutes after its initial subcutaneous or intravenous injection.

Among Individual Populations

Age/Gender: In healthy adults, Geref is evacuated from the body at a similar rate in both men and women. There is no clearance data as it relates to the age of the patient. There is also data which compares male and female pediatric clearance rates.

Hepatic/Renal Insufficiency: There is no available research data regarding how liver and kidney problems may effect clearance rates.

Clinical Evaluation of Geref

In one particular non-blind clinical research study performed across multiple medical centers, prepubescent adolescents suffering from idiopathic HGH Deficiency were given Geref injections of 30 micrograms per kilograms on a daily basic via SC injection. After one year of treatment, 56 participants were available for an evaluation of efficacy after twelve months. Another 54 participants were not qualified for evaluation. Twenty four violated criteria eligibility, ten discontinued the required protocol for treatment, and twenty others did not meet the criteria for evaluation after the initial six months of the study. 56 of the total of 110 participants, including 47 of the 56 patients who were among the subset of participants who were qualified for evaluation and continued Sermorelin Acetate therapy over the course of an entire year, were shown to grow in height at a rate of two centimeters per year faster than their baseline rate of growth. Among those 56 participants who qualified for evaluation, their height velocity changed at a rate of 4.1 centimeter per year after six months and increased at a rate of 7.2 centimeters per year after one year. The average patient grew taller at a rate of 3.1 centimeters centimeters per year. The bone age of these patients after one year of Geref therapy were in proportion to their height gains.

When should Geref be used?

Geref injections are intended for pediatric patients who suffer from HGH Deficiency with no discernible cause, which results in a failure to grow properly. The majority of these pediatric patients who suffer from HGH Deficiency still have active pituitary glands which respond readily to GH-RH. Pediatric patients who use Geref should be prepubescent. Geref Therapy should be instituted at a bone age of eight in males and seven and a half in females.

Geref Contraindications

Geref should not be utilized by individuals which have been proven to have an allergy or sensitivity to Sermorelin. It should also be avoided by any patients that have an sensitivity or allergy to any of the other ingredients included in the product.

Geref Warning

It is vitally important to use Geref immediately after it is reconstituted with the accompanied diluent. The reconstituted solution will begin to degrade a short time after reconstitution. If there is any solution that is left over after the injection is complete, it should be thrown away, and under no circumstances should you consider using it at a later time.


Geref Precautions

Geref should only be used with the express consent of a physician who specializes in either Growth Disorders or Anti-Aging Therapy, and when prescribed, hormone levels should be carefully monitored over time to ensure that proper hormone levels are restored.

Young patients who undergo Geref Hormone Replacement Therapy also need to be evaluated to ensure that Geref produces height gains. Some patients will not respond to Geref or other GH-RH analogues even if they are not growing at a proper rate. Those pediatric patients who do not respond to Geref therapy will more than likely be fully served through the usage of Human Growth Hormone HRT. It has been thoroughly proven that Geref produces positive changes in height following a single year of treatment; however, there has been no research as to the extent of the effect of Geref upon a patient's final height as an adult.

Geref and Hypothyroidism

In clinical research, 6.5% of participants were diagnosed with hypothyroidism as a result of Geref therapy. In the most significant Geref clinical trial, 8 participants among 110 who were enrolled were taking thyroid HRT before being administered Geref. 5 more participants began Thyroid Replacement HRT after treatment began.

If a patient suffers from undetected hypothyroidism it can negate or diminish the effects of Geref Hormone Replacement Therapy. For this reason, the administering physician should test for proper thyroid function before as well as periodically during Geref treatment. If at any point before or during therapy, the patient begins to show signs of hypothyroidism, Thyroid Hormone HRT should be instituted as soon as possible to maximize the effect of therapy and the health of the patient.

In addition to Thyroid Hormone testing, patients who are undergoing Geref Hormone Replacement Therapy should also be tested periodically for bone age. This is particularly important among patients who are currently undergoing puberty, or are concurrently receiving Thyroid Hormone HRT. In these particular patients, the epiphyseal plates can sometimes grow at a very fast rate. It is important to suspend Geref Sermorelin Acetate Therapy ones the ephyseal plates close, because at this point, the bones will no longer grow in length and Geref Therapy will no longer be needed.

Geref Hormone Replacement Therapy is not recommended for patients who suffer from an HGH Deficiency which resulted from an intracranial lesion. There has been no testing as to the safety of Sermorelin Acetate Therapy in this subset of patients.

Reactions to Geref

As is the case with the administration of any Hormone Replacement Therapy, systemic or local allergic responses can sometimes result. It is vital that patient (and parent if applicable) be aware that such responses can potentially occur. If the patient suffers an allergic reaction as a result of Geref Therapy it is vital that they receive medical attention promptly.

Clinical Tests have shown that increased blood-serum levels of Insulin-Like Growth Factor One (IGF-1), Human Growth Hormone, alkaline phosphatase, and inorganic mineral phosphorus can occur as a result of Geref Sermorelin Acetate Therapy.

Drug Interactions

Taking glucocorticoid steroids in combination with Sermorelin Acetate Therapy maybe reduce the effectiveness of Geref. In clinical studies of Geref Sermorelin Acetate Therapy, no pediatric patient who concomitantly took medications to treat normal youthful illnesses/problems had any problems as a result of combining their normal medications with Geref Hormone Replacement Therapy. Though no evidence has been discovered, it is still important to note that their have been no clinical studies regarding formal medical interations.

Fertility Impairment, Mutagenesis, Cancer risk

There has been no longitudinal animal research regarding fertility impairment or carcinogenicity risk regarding Geref Hormone Replacement Therapy. There has been absolutely no clinical research linking Geref Sermorelin Acetate Therapy to genetic abnormalities.

Pregnancy

There has been some animal research conducted regarding Geref Therapy. At a dosage somewhere between three and six times the normal daily dosage that a human patient receives adjusted for physical surface area, minor fetal changes occurred in rabbits and rats. There have been no adequately controlled studies regarding the usage of Geref by women who are pregnant. Geref Sermorelin Acetate Therapy should only be administered to women that are pregnant if the likely benefits of the therapy outweigh the possible risk to the unborn child.


Nursing Women

It is unknown if Geref is produced in human milk. There are many medications that are released by the mother in the nursing process, and for this reason mothers and physicians should exercise caution when using Geref Hormone Repalcement Therapy while nursing.

Patient Information

All patients who are prescribed Geref (along with their parents, if applicable) should be adequately informed of the possible risks and benefits that are related to the therapy. If the prescribing physician has determined that Geref should be administered by either patient or parent at home, the physician must provide appropriate guidance regarding its use. This includes verbally discussing the content of the Patient Information Booklet with the patient (and parent, if applicable). The Insert which accompanies the prescription is meant to assist the patient in effective and safe usage of Geref, and does not provide a complete and total disclosure of all potential effects whether intended or adverse.

Disposal Information

If the physician approves home usage, the patient should be provided with or directed to a location which provides SHARPS containers meant for the proper disposal of used needles and syringes accumulated as a result of Geref Therapy. These containers are puncture resistant and are a necessary safety measure to protect both patient and anyone who may come in contact with the used needles and syringes. It is vital that patient (and parent, if applicable) be directed thoroughly as to the vital important of proper needle disposal. Also, they should be informed of the dangers of reusing syringes and needles as well.

Side Effects

A significant portion of Geref Sermorelin Acetate HRT patients antibodies against Growth Hormone Factor during at least one point of therapy. There is no clear assessment of the significance of the presence of these antibodies, and the levels of these antibodies can change quickly from test to test. A positive result at one juncture regularly turns into a negative result after the next test. The production of these antibodies does not seem to have any adverse effect on the patient. Also, these antibodies do not seem to produce any change in the effectiveness of Geref therapy. There have been no reported general allergic responses to Geref Sermorelin Acetate Therapy.

The most common reaction to Geref Hormone Replacement Therapy which is related to treatment is local irritation around the injection site, which occurs in around one of every six patients. This irritation is characterized by redness, pain, or swelling. Though this side effect is relatively common, only a small minority of patients find the irritation bothersome enough to suspend therapy. Out of a sample of 350 patients who underwent Geref Therapy in clinical trial, only three suspended therapy as a result of injection-site irritation. There are other side effects which occurred in less than one percent of patients. These side effects include: severe drowsiness, hives, vomiting, headache, nausea, difficulty swallowing, hyperactivity, chest tightness and pallor, distortion in perception of taste, and flushing of the skin.

Geref Dependency and Abuse:

There is no evidence to suggest that the use of Geref for any period of time will result in any sort of dependency or proclivity toward abuse. The general pharmacology of Geref does not produce any addictive effect, and clinical trials have produced no evidence of such an effect.


Never Take More than Prescribed

It is not recommended to exceed the recommended dosage of Geref prescribed by your physician. Overdose will not provide better results. It will only increase the occurrence of side effects.

Administration and Dosage

The recommended dosage for Geref Sermorelin Acetate Therapy for pediatric patients is 0.03 milligrams per kilogram of body weight. This dosage should be administered every day before bed (unless otherwise advised by your physician) via subcutaneous injection. It is also that sites of injection be rotated periodically in order to reduce the risk of irritation.

In pediatric patients who are prescribed Geref Sermorelin Acetate Therapy, therapy should be discontinued after the epiphyseal plantes have fused. Patients who do not respond to Geref Treatment should undergo further evaluation in order to discover the root cause of their unresponsiveness to therapy. Patients who do not experienced increased levels of Human Growth Hormone as a result of therapy likely suffer from some other ailment or deficiency which prevents them from producing sufficient HGH levels.

Regular Height Assessment is Important

Pediatric patients should undergo a height assessment at least twice a year as they continue Geref Therapy. It is important that children who take Geref experience growth rates that are consistent with both their stage of development and their age. If Geref Sermorelin Acetate Treatments is discovered to be inadequate, other forms of therapy should be considered. HGH Hormone Replacement Therapy is the most common consideration for patients who have a waning or poor response to Geref Treatments.

Avoid Contamination of Geref Sermorelin Acetate Therapy

To avert contamination risk, clean the rubber stopper containing the reconstituted solution before piercing it with the needle. It is also strongly recommended that Geref be injected using disposable and sterile needles and syringes. The syringe should be small enough to where the proper dose of Geref can be drawn with reasonably high accuracy.

After the correct dose has been determined, the vial of Geref should be reconstituted using 0.5-1.0 milliliters of NaCl solution.

In order to reconstitute Geref Sermorelin Acetate, insert the diluent into the Geref vial via injection. Tilt the vial in a manner so that the liquid rolls down the wall of the vial onto the active ingredient below. Gently swirl the container in a circular motion until the solution has become completely dissolved.

IMPORTANT: Geref should not be administered if there are visible particles in the solution after reconstution, nor should it be used if the resultant reconstitution is cloudy.

Before Geref Therapy is Reconstituted for use, it must be refrigerated at a temperature between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius). Expiration dates are also clearly shown on the label. If the Vial becomes unrefrigerated or becomes expired, the treatment should be discarded.


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If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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