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DR SANDRA CABOT ANTI-AGING BIO-IDENTICAL HORMONE THERAPY


Written by Dr. Welsh, Published on 14 January 2016

SERMORELIN GROWTH HORMONE RELEASING HORMONE ANALOG


Written by Dr. Welsh, Published on 06 April 2012

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Geref Sermorelin Acetate Therapy

Geref is one of the many forms of Sermorelin Acetate injection that have been released in the American market.

Sermorelin at a Glance

Sermorelin is a synthetic form of Growth Hormone-Releasing Hormone. GH-RH is composed of a chain of forty four amino acids, whereas Sermorelin only contains twenty nine amino acids. Despite this fact, Sermorelin functions identically to GH-RH in the human body, and is one of the most popular forms of GH-RH therapy.

One of the most common means by which Sermorelin is configured for human injection is by forming an acetate salt to which Sermorelin is attached.

Sermorelin Acetate Breakdown

Noted in molecular terms, Sermorelin Acetate is: C149 H246 N44 O42 S1. Sermorelin acetate has a weight of 3,358 daltons.

Geref is a sterilized and has been proven not to produce an inflammatory response when injected into the human body. In unconstituted form, Geref is freeze-dried through sublimation, allowing it to be transported more effectively and stored for a longer period of time than its liquid form. Before Geref is injected, it must be reconstituted, combining the lyophilized Sermorelin Acetate with a Sodium Chloride Solution. After reconstitution, the mixture has a pH of between 5 and 5.5.

How is Geref Distributed?

Geref is delivered to the patient via vials. The contents of the vial are as follows:

Each half milligram vial holds 0.5 milligrams of sermorelin acetate along with 5 milligrams of mannitol. The pH is fixated using a buffer of monobasic sodium phosphate and dibasic sodium phosphate.

Each one milligram vial holds 1.0 milligram of sermorelin acetate along with 5 milligrams of mannitol. These contents have pH levels which are also fixated using monobasic sodium phosphate and dibasic sodium phosphate.

How does Geref Work?

Geref is an injectable form of Sermorelin Acetate which has the ability to boost plasma levels of Insulin-Like Growth Factor One and Human Growth Hormone by stimulating the endogenous production of HGH by the pituitary gland. Geref functions in the body identically to endogenous GH-RH, stimulating HGH production in an identical manner in human beings.

How does Geref interact with the Human Body?

Distribution

After 0.25 to 1 milligram intravenous injection of Human Growth Hormone was delivered to twelve normal patients, the mean volume distribution had a range of 23.7 to 25.8 liters.

Absorption

After two milligrams of Sermorelin was subcutaneously injected to twelve normal patients, peak sermorelin saturation occurred between five and twenty minutes after injection. After this administration, the absolute mean bioavailability of sermorelin was around six percent.

Metabolism

There has been no human research regarding Geref.

Evacuation

Sermorelin leaves the body quite quickly after it has entered the bloodstream. In adults, Sermorelin is cleared from the body at a rate of around 2.6 liters per minute. Geref also has a short half-life of around eleven to twelve minutes after its initial subcutaneous or intravenous injection.

Among Individual Populations

Age/Gender: In healthy adults, Geref is evacuated from the body at a similar rate in both men and women. There is no clearance data as it relates to the age of the patient. There is also data which compares male and female pediatric clearance rates.

Hepatic/Renal Insufficiency: There is no available research data regarding how liver and kidney problems may effect clearance rates.

Clinical Evaluation of Geref

In one particular non-blind clinical research study performed across multiple medical centers, prepubescent adolescents suffering from idiopathic HGH Deficiency were given Geref injections of 30 micrograms per kilograms on a daily basic via SC injection. After one year of treatment, 56 participants were available for an evaluation of efficacy after twelve months. Another 54 participants were not qualified for evaluation. Twenty four violated criteria eligibility, ten discontinued the required protocol for treatment, and twenty others did not meet the criteria for evaluation after the initial six months of the study. 56 of the total of 110 participants, including 47 of the 56 patients who were among the subset of participants who were qualified for evaluation and continued Sermorelin Acetate therapy over the course of an entire year, were shown to grow in height at a rate of two centimeters per year faster than their baseline rate of growth. Among those 56 participants who qualified for evaluation, their height velocity changed at a rate of 4.1 centimeter per year after six months and increased at a rate of 7.2 centimeters per year after one year. The average patient grew taller at a rate of 3.1 centimeters centimeters per year. The bone age of these patients after one year of Geref therapy were in proportion to their height gains.

When should Geref be used?

Geref injections are intended for pediatric patients who suffer from HGH Deficiency with no discernible cause, which results in a failure to grow properly. The majority of these pediatric patients who suffer from HGH Deficiency still have active pituitary glands which respond readily to GH-RH. Pediatric patients who use Geref should be prepubescent. Geref Therapy should be instituted at a bone age of eight in males and seven and a half in females.

Geref Contraindications

Geref should not be utilized by individuals which have been proven to have an allergy or sensitivity to Sermorelin. It should also be avoided by any patients that have an sensitivity or allergy to any of the other ingredients included in the product.

Geref Warning

It is vitally important to use Geref immediately after it is reconstituted with the accompanied diluent. The reconstituted solution will begin to degrade a short time after reconstitution. If there is any solution that is left over after the injection is complete, it should be thrown away, and under no circumstances should you consider using it at a later time.


Geref Precautions

Geref should only be used with the express consent of a physician who specializes in either Growth Disorders or Anti-Aging Therapy, and when prescribed, hormone levels should be carefully monitored over time to ensure that proper hormone levels are restored.

Young patients who undergo Geref Hormone Replacement Therapy also need to be evaluated to ensure that Geref produces height gains. Some patients will not respond to Geref or other GH-RH analogues even if they are not growing at a proper rate. Those pediatric patients who do not respond to Geref therapy will more than likely be fully served through the usage of Human Growth Hormone HRT. It has been thoroughly proven that Geref produces positive changes in height following a single year of treatment; however, there has been no research as to the extent of the effect of Geref upon a patient's final height as an adult.

Geref and Hypothyroidism

In clinical research, 6.5% of participants were diagnosed with hypothyroidism as a result of Geref therapy. In the most significant Geref clinical trial, 8 participants among 110 who were enrolled were taking thyroid HRT before being administered Geref. 5 more participants began Thyroid Replacement HRT after treatment began.

If a patient suffers from undetected hypothyroidism it can negate or diminish the effects of Geref Hormone Replacement Therapy. For this reason, the administering physician should test for proper thyroid function before as well as periodically during Geref treatment. If at any point before or during therapy, the patient begins to show signs of hypothyroidism, Thyroid Hormone HRT should be instituted as soon as possible to maximize the effect of therapy and the health of the patient.

In addition to Thyroid Hormone testing, patients who are undergoing Geref Hormone Replacement Therapy should also be tested periodically for bone age. This is particularly important among patients who are currently undergoing puberty, or are concurrently receiving Thyroid Hormone HRT. In these particular patients, the epiphyseal plates can sometimes grow at a very fast rate. It is important to suspend Geref Sermorelin Acetate Therapy ones the ephyseal plates close, because at this point, the bones will no longer grow in length and Geref Therapy will no longer be needed.

Geref Hormone Replacement Therapy is not recommended for patients who suffer from an HGH Deficiency which resulted from an intracranial lesion. There has been no testing as to the safety of Sermorelin Acetate Therapy in this subset of patients.

Reactions to Geref

As is the case with the administration of any Hormone Replacement Therapy, systemic or local allergic responses can sometimes result. It is vital that patient (and parent if applicable) be aware that such responses can potentially occur. If the patient suffers an allergic reaction as a result of Geref Therapy it is vital that they receive medical attention promptly.

Clinical Tests have shown that increased blood-serum levels of Insulin-Like Growth Factor One (IGF-1), Human Growth Hormone, alkaline phosphatase, and inorganic mineral phosphorus can occur as a result of Geref Sermorelin Acetate Therapy.

Drug Interactions

Taking glucocorticoid steroids in combination with Sermorelin Acetate Therapy maybe reduce the effectiveness of Geref. In clinical studies of Geref Sermorelin Acetate Therapy, no pediatric patient who concomitantly took medications to treat normal youthful illnesses/problems had any problems as a result of combining their normal medications with Geref Hormone Replacement Therapy. Though no evidence has been discovered, it is still important to note that their have been no clinical studies regarding formal medical interations.

Fertility Impairment, Mutagenesis, Cancer risk

There has been no longitudinal animal research regarding fertility impairment or carcinogenicity risk regarding Geref Hormone Replacement Therapy. There has been absolutely no clinical research linking Geref Sermorelin Acetate Therapy to genetic abnormalities.

Pregnancy

There has been some animal research conducted regarding Geref Therapy. At a dosage somewhere between three and six times the normal daily dosage that a human patient receives adjusted for physical surface area, minor fetal changes occurred in rabbits and rats. There have been no adequately controlled studies regarding the usage of Geref by women who are pregnant. Geref Sermorelin Acetate Therapy should only be administered to women that are pregnant if the likely benefits of the therapy outweigh the possible risk to the unborn child.


Nursing Women

It is unknown if Geref is produced in human milk. There are many medications that are released by the mother in the nursing process, and for this reason mothers and physicians should exercise caution when using Geref Hormone Repalcement Therapy while nursing.

Patient Information

All patients who are prescribed Geref (along with their parents, if applicable) should be adequately informed of the possible risks and benefits that are related to the therapy. If the prescribing physician has determined that Geref should be administered by either patient or parent at home, the physician must provide appropriate guidance regarding its use. This includes verbally discussing the content of the Patient Information Booklet with the patient (and parent, if applicable). The Insert which accompanies the prescription is meant to assist the patient in effective and safe usage of Geref, and does not provide a complete and total disclosure of all potential effects whether intended or adverse.

Disposal Information

If the physician approves home usage, the patient should be provided with or directed to a location which provides SHARPS containers meant for the proper disposal of used needles and syringes accumulated as a result of Geref Therapy. These containers are puncture resistant and are a necessary safety measure to protect both patient and anyone who may come in contact with the used needles and syringes. It is vital that patient (and parent, if applicable) be directed thoroughly as to the vital important of proper needle disposal. Also, they should be informed of the dangers of reusing syringes and needles as well.

Side Effects

A significant portion of Geref Sermorelin Acetate HRT patients antibodies against Growth Hormone Factor during at least one point of therapy. There is no clear assessment of the significance of the presence of these antibodies, and the levels of these antibodies can change quickly from test to test. A positive result at one juncture regularly turns into a negative result after the next test. The production of these antibodies does not seem to have any adverse effect on the patient. Also, these antibodies do not seem to produce any change in the effectiveness of Geref therapy. There have been no reported general allergic responses to Geref Sermorelin Acetate Therapy.

The most common reaction to Geref Hormone Replacement Therapy which is related to treatment is local irritation around the injection site, which occurs in around one of every six patients. This irritation is characterized by redness, pain, or swelling. Though this side effect is relatively common, only a small minority of patients find the irritation bothersome enough to suspend therapy. Out of a sample of 350 patients who underwent Geref Therapy in clinical trial, only three suspended therapy as a result of injection-site irritation. There are other side effects which occurred in less than one percent of patients. These side effects include: severe drowsiness, hives, vomiting, headache, nausea, difficulty swallowing, hyperactivity, chest tightness and pallor, distortion in perception of taste, and flushing of the skin.

Geref Dependency and Abuse:

There is no evidence to suggest that the use of Geref for any period of time will result in any sort of dependency or proclivity toward abuse. The general pharmacology of Geref does not produce any addictive effect, and clinical trials have produced no evidence of such an effect.


Never Take More than Prescribed

It is not recommended to exceed the recommended dosage of Geref prescribed by your physician. Overdose will not provide better results. It will only increase the occurrence of side effects.

Administration and Dosage

The recommended dosage for Geref Sermorelin Acetate Therapy for pediatric patients is 0.03 milligrams per kilogram of body weight. This dosage should be administered every day before bed (unless otherwise advised by your physician) via subcutaneous injection. It is also that sites of injection be rotated periodically in order to reduce the risk of irritation.

In pediatric patients who are prescribed Geref Sermorelin Acetate Therapy, therapy should be discontinued after the epiphyseal plantes have fused. Patients who do not respond to Geref Treatment should undergo further evaluation in order to discover the root cause of their unresponsiveness to therapy. Patients who do not experienced increased levels of Human Growth Hormone as a result of therapy likely suffer from some other ailment or deficiency which prevents them from producing sufficient HGH levels.

Regular Height Assessment is Important

Pediatric patients should undergo a height assessment at least twice a year as they continue Geref Therapy. It is important that children who take Geref experience growth rates that are consistent with both their stage of development and their age. If Geref Sermorelin Acetate Treatments is discovered to be inadequate, other forms of therapy should be considered. HGH Hormone Replacement Therapy is the most common consideration for patients who have a waning or poor response to Geref Treatments.

Avoid Contamination of Geref Sermorelin Acetate Therapy

To avert contamination risk, clean the rubber stopper containing the reconstituted solution before piercing it with the needle. It is also strongly recommended that Geref be injected using disposable and sterile needles and syringes. The syringe should be small enough to where the proper dose of Geref can be drawn with reasonably high accuracy.

After the correct dose has been determined, the vial of Geref should be reconstituted using 0.5-1.0 milliliters of NaCl solution.

In order to reconstitute Geref Sermorelin Acetate, insert the diluent into the Geref vial via injection. Tilt the vial in a manner so that the liquid rolls down the wall of the vial onto the active ingredient below. Gently swirl the container in a circular motion until the solution has become completely dissolved.

IMPORTANT: Geref should not be administered if there are visible particles in the solution after reconstution, nor should it be used if the resultant reconstitution is cloudy.

Before Geref Therapy is Reconstituted for use, it must be refrigerated at a temperature between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius). Expiration dates are also clearly shown on the label. If the Vial becomes unrefrigerated or becomes expired, the treatment should be discarded.


HGH SECRETAGOGUE-P2


Written by Dr. Welsh, Published on 08 June 2013

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Sermorelin Frequently Asked Questions

The goal of this article is to help you become better informed about a new form of Hormone Treatment known as Sermorelin Acetate Therapy. This article serves as a reference point to help you become more knowledgeable about this highly beneficial therapy.

Question: What is Sermorelin Acetate?

Answer: Sermorelin Acetate is a hormone derivative that spurs the natural secretion of endogenous Human Growth Hormone by the pituitary gland. Sermorelin Acetate serves as the functional equivalent of a hormone produced by the hypothalamus known as Growth-Hormone Releasing Hormone. GH-RH is also often referred to as Growth Hormone Releasing Factor.

Although Sermorelin and GH-RH are not biologically identical, they are functionally identical, meaning that the two molecules produce the exact same effects in the human body, despite being arranged in different configurations. Sermorelin and GH-RH share the same initial sequence of amino acids, but Sermorelin Acetate is truncated, meaning that the hormone sequence is cut short. Scientific researchers found that by producing a bio-synthetic hormone which only contains the first twenty nine amino acids of Growth Hormone-Releasing Hormone, they could create a potent medication that is cheaper to produce while maintaining the exact same medical effect upon the human body.

Sermorelin Acetate was isolated and invented by Nobel Prize Winners Andrew Schally and Roger Guillemin. The chemical configuration of GH-RH is referred to as GRH 1-29 NH 2. GRH 1-29 is the active sequence of Growth Hormone-Releasing Hormone. The NH-2 refers to a closing sequence which is inert and serves to tie off the end of the molecule.

Question: What is the difference between Sermorelin Acetate and HGH?

Answer: Many people get this somewhat confused, thinking that because Sermorelin Acetate increases internal levels of Human Growth Hormone, that Sermorelin is actually a form of HGH. This is untrue. Sermorelin is a hormone which scientists label a secretagogue. Secretagogues are hormones produced by the brain which stimulate other hormones to be produced. They serve as intermediary messengers which move the message along to target organs and tissues in the rest of the body.

GH-RH is released by the pituitary gland and flows through a series of blood vessels in the brain known as the epiphyseal portal system. Upon reaching the Anterior Pituitary Gland, Growth Hormone Releasing Factors then stimulate organs known as somatotrophs within the pituitary to manufacture and secrete Human Growth Hormone to circulate to the liver and other organs. Sermorelin Acetate imitates the function of GH-RH, producing a biologically identical response when is reaches the somatotrophs.

Sermorelin is a much smaller hormone than both GH-RH and Human Growth Hormone. Sermorelin contains 29 amino acids, whereas GH-RH contains 45. HGH dwarfs both of these hormones in size, as it is comprised of 191 amino acids!

Question: Health Stores and Online Websites often advertise supplements known as Human Growth Hormone Releasers. These supplements are available over the counter and do not need a prescription. Are these supplements similar to Sermorelin?

Answer:Absolutely not. Supplemental HGH Releasers are most often component amino acids which comprise Human Growth Hormone, including L-Dopa, Glycine, L-Ornithine, L-Glutamine, and L-Arginine. Other chemincals are also marketed as HGH Releasers, including Tribulus Terrestris, Macuna Pruriens, and Ornithine Alpha-Ketoglutarate.

It is true that these amino acids do have a stimulative effect upon HGH production, but they are not healthy for the body and do not produce a strong enough benefit to in any way warrant the risk. HGH Releasers work (if they truly work) by creating an increased level of overall activity throughout the brain. This increased level of activity does have a slightly stimulative effect upon Human Growth Hormone Levels, but it also stimulates other activities, but positive and negative, throughout the brain.

HGH Releasers Do Not Work As Advertised

Many medications labeled as HGH Releasers are completely ineffective, veritable snake-oil products. Supplements are not certified for effectiveness in the same way as medications such as Sermorelin Acetate and Bio-Identical Human Growth Hormone, so there is not necessarily a proven or guaranteed medical benefit to using the supplements. At best, HGH Releasers stimulate a Growth Hormone release that is just about equivalent to exercise, and at worst, you'll damage your liver and experience no benefits at all.

Also, Growth Hormone Releasers produce incredibly unreliable effects, because different areas of the body and brain may experience different levels of response every time you take the pill. High Doses of Growth Hormone Releasers can lead to liver and kidney issues, as the human body does not have the capacity to process extremely high levels of unprocessed amino acids without accumulating damage in the filtering and processing organs of the human body.

Sermorelin Acetate produces real and beneficial effects with minimal risk of side-effects. Sermorelin Acetate Therapy has an incredibly safe track record and has been proven to be effective at treating Adult-Onset HGH Deficiency.

Question: I've read a bit about Human Growth Hormone Replacement Therapy, and it seems to be perfectly capable of resolving issues surrounding HGH Deficiency and Hypopituitarism. What would make me choose Sermorelin Therapy over Bio-Identical HGH?

Answer: There are a number of reasons why a patient would choose Sermorelin Acetate over Recombinant Growth Hormone, although both certainly have their place as treatment options. Both HGH and Sermorelin are capable of producing the same exceptional benefits to the human body, but they share a couple of profound differences as well.

Sermorelin Imitates Normal Physiological Processes

First, Sermorelin Acetate functions in a manner which is more streamlined with the actual function and overall needs of the human body. You see, when you use Growth Hormone HRT, there are no safeguards which protect the body against accidental overdose. Any Human Growth Hormone injected into the body directly cycles through the liver and the body and stimulates the body. Sermorelin, on the other hand, as an Growth Hormone Secretagogue, can be affected by processes known as Negative Feedback Mechanisms. Negative Feedback Mechanisms kick in when the body sends signals to the brain that Human Growth Hormone Secretion has satisfied the needs of the body.

Upon receiving these signals, hormones known as somatostatins block GH-RH and Sermorelin from reaching the Pituitary, preventing excess secretion of Growth Hormone. Because Sermorelin works according to the normal physiological rules of the human body, it is almost impossible to overdose on Human Growth Hormone via Sermorelin Injection. Other patients may choose Sermorelin Acetate in order to avoid the temptation to overdose on or abuse HGH.

Sermorelin Releases Episodic HGH

Another benefit that Sermorelin Acetate Injections have over Human Growth Hormone Injections is that they are processed by the body in different patterns. Although HGH and Sermorelin ostensibly accomplish the same goals, Human Growth Hormone Injections supply a relatively constant level of HGH Release over time, which is not actually how the body produces Human Growth Hormone. HGH Release is categorized by a function known as Square Wave release. Square Wave means that HGH concentrations rise to a peak during the course of the day, plateau, and drop back down to baseline. This can cause a problem over time, inducing a medical response known as Tachyphylaxis.

Tachyphylaxis can be understood most simply as a decrease in sensitivity due to outside pressures. The body can sometimes slowly recognize that HGH is being provided by an outside source and the body builds resistance as a response. Sermorelin releases Human Growth Hormone via an episodic pattern which more closely resembles the natural pattern of release by the human body. The pituitary only releases Human Growth Hormone when the body is ready for it, thus significantly reducing the threat of internal resistance to increased levels of HGH.

Sermorelin Preserves the Normal Hormonal Equilibrium

A third Benefit to Sermorelin Acetate, related to the second, is that Sermorelin Acetate more appropriately preserves the Neuroendocrine Axis. The Neuroendocrine Axis is the cascade of hormone release throughout the body. Simply put, all hormones released by the human body have a certain impact on the release of other hormones. Injecting HGH directly into the body on a daily basis can actually suppress the body's natural ability to produce it's own Human Growth Hormone, which can effect the release of other hormones as a result.

Sermorelin Acetate makes less of a physiological imprint onto the endocrine system, meaning that it more naturally resolves hormonal deficiency while causing minimal impact on the normal function of other hormones and systems of the body.

Sermorelin Available for Off-Label Use

A fourth and final benefit of Sermorelin Acetate is less physiological and more technical. Sermorelin Acetate Hormone Replacement Therapy is not as tightly regulated as Human Growth Hormone Replacement Therapy. The FDA prohibits the use of Human Growth Hormone for off-label uses, whereas Sermorelin Acetate can be used off-label at the discretion of the prescribing physician.

Question: I understand that Human Growth Hormone can only be delivered via Injection. Is this also true for Sermorelin Therapy?

As of 2013, Subcutaneous Injection is the only effective method to administer Sermorelin Acetate . Like, Human Growth Hormone, the Sermorelin Acetate molecule is too large to breach other barriers of the human body at this date. On the bright side, since Sermorelin is significantly smaller than Bio-Identical HGH, there is a hypothetical chance that Sermorelin may one day be administer by breaching the mucous membrane barrier using a nasal spray. This method is currently being tested and may be effective at some point in the near future.

Question: Do Sermorelin and Human Growth Hormone Injections require similar doses to be effective?

Answer: Even though HGH and Sermorelin activate in different regions of the body (Sermorelin in the anterior pituitary, Human Growth Hormone in the liver) the volume of hormone that is required in order to sufficiently increase endogenous IGF-1 production is nearly identical. Human Growth Hormone is most commonly prescribed at doses which vary between one and two international units. Sermorelin Acetate is generally administered with a dose of two hundred micrograms daily.

Question: How much does Sermorelin cost in comparison to HGH?

Answer: Per vial, Sermorelin is a good bit cheaper than Human Growth Hormone. In addition to this, a single vial of Human Growth Hormone takes twelve to fourteen days to fully administer, whereas a single vial of Sermorelin takes fifteen days to fully utilize.

Question: In many patients, the benefits of Human Growth Hormone start to fade of the course of continual use. Why does this happen, and does Sermorelin lose potency as well?

Answer: The human body can develop a resistance to HGH Hormone Replacement Therapy over time. If this has occurred to you, the change in effectiveness is not the result of any inadequacy of the medicine itself. Human Growth Hormone Injections increase serum levels of Growth Hormone to levels which are higher than normal for a number of hours every day, although the average release across the day is medically appropriate.

HGH Up-Regulation and Sermorelin Down-Regulation

In addition to this, Human Growth Hormone Therapy leads to a stable release of IGF-1 throughout the body, slowly rising and falling in the body through the course of the day. This causes the tissues of the body to have a steady supply of IGF-1 throughout the day, rather than receiving the hormone in the normal bursts in which it is accustomed to. As a result, IGF-1 Receptors in the tissue have a tendency to go through a hormonal process known as down-regulation in order to preserve normal function. This means that the target tissues become desensitized to IGF-1 and Human Growth Hormone exposure, reducing the effectiveness of the hormone treatment.

When the body is functioning normally, Human Growth Hormone is released naturally from the pituitary gland in a number of short, brief, and potent bursts, which supply the body with sufficient levels of IGF-1 and Human Growth Hormone while also giving the receptors time to rest between periods of hormone release. If outside hormone release properly imitates the natural processes of the body, this gradual down regulation does not occur, and the benefits of increased HGH production do not decline in the same manner over time.

Because of the influence of Somatostatin, described above, Sermorelin Administration only leads to the optimal release of Human Growth Hormone. Sermorelin actually has the ability to make the pituitary stronger, through a process of up-regulation which strengthens its health by increasing the level of HGH it produces on a daily basis.

Question: Does Sermorelin Acetate provide any benefits for patients suffering from Adult-Onset HGH Deficiency that are not directly related to its effect upon the endocrine system?

Answer: Yes. There is a large body of evidence that shows that Growth Hormone-Releasing Hormone and Sermorelin Injections directly have the capacity to increase sleep quality and promote the increased experience of the deepest stages of sleep, which are the most rejuvenative and beneficial to health and wellness.

Question: What is the normal administration protocol for Sermorelin Hormone Therapy?

Answer: Sermorelin is delivered once each day via injection. Sermorelin is normally administered just before bed in order to more closely mimic the natural hormone production of the body. Sermorelin is intended to supplement the body's own natural production of Growth Hormone-Releasing Hormone, which occurs primarily at night.

The Sermorelin Dosage that the patient is described will be dependent upon the physiological needs of the individual. Sermorelin Shots are provided in vials which contain multiple doses The vial will contain enough Sermorelin in order to treat the patient for at least fifteen days.

The Conscious Evolution Institute

If you have any other questions about Sermorelin Acetate, Human Growth Hormone Shots, or any other hormone treatments, we would be happy to provide you with answers to any questions you may have.

Different patients respond differently to treatment, and some patients respond more actively to Human Growth Hormone Replacement Therapy than Sermorelin Acetate. If you choose the Conscious Evolution Institute, our knowledgeable and top-of-the-line staff of physicians and longevity specialists will help you decide which treatments are right for you!


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Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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