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L-CARNITINE: IMPROVES COGNITIVE FUNCTION IN CENTENARIANS


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 27 May 2019

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L-Carnitine proven to reduce physical and mental fatigue while improving cognition in those over 100 years of age.

The American Journal of Clinical Nutrition has recently released data from clinical research conducted by Italian scientists regarding L-Carnitine as a medical treatment. The study was financed in order to explore the potential benefits of L-Carnitine in elderly patients. The results of the study indicate that L-Carnitine has the ability to significantly improve cognitive ability and reduce fatigue in patients of one hundred or more years of age.

How Does the Body Get L-Carnitine?

L-Carnitine is naturally produced in the human body, but like many other vital hormones and proteins, endogenous production of this vital protein declines naturally as a result of the aging process. In a healthy individual, the human body contains somewhere between twenty and twenty five grams of this molecule. L-Carnitine is most abundant in cells and organs across the body that have very high metabolic requirements. These organs include the brain, the heart, muscles, immune cells, sperm, and nerves.

Without a sufficient supply of L-Carnitine, the human body cannot sustain itself. Although a large portion of L-Carnitine that human beings utilize comes from the diet, the human body has the ability to synthesize this protein when the body has an adequate amount of the amino acids methionine and lysine. In addition to the presence of these amino acids, the body also needs the nutrients iron, Vitamin B3, Vitamin B6, and Vitamin C in order to create this hormone internally. Without proper nutrition, the human body is unable to produce its own store of L-Carnitine and health will deteriorate as a result.

L-Carnitine is Necessary for Healthy Metabolism

L-Carnitine is vitally important in maintaining a healthy level of cellular metabolism, and if the body is deficient in this vital hormone then the body's protective physiological processes slow down as well. Like Human Growth Hormone Deficiency, L-Carnitine Deficiency plays a major role in an increased rate of aging and decreased rehabilitative ability. L-Carnitine Deficiency is widely believed to be one of the primary factors which induce severe fatigue in older patients, and there is great hope that L-Carnitine can be used in order to amplify low-energy levels in geriatric patients.

L-Carnitine Study Parameters

This particular study featured 46 women and 24 men ranging in age from 100 to 106. All of these patients were chosen based on their report of experiencing significant exhaustion after even the most minor levels of physical activity. This was a tightly controlled study in which half of the patients were randomly selected to ingest two grams of L-Carnitine daily while the control group unknowingly took a placebo. The 70 patients were monitored over the course of 6 months while taking daily doses of either L-Carnitine or placebo.

Every patient underwent a routine physical both before and after the 6 month period of treatment in which their muscle mass, total body fat, and BMI were recorded. Once each month, the researchers drew blood samples in order to monitor L-Carnitine and Cholesterol levels as well as a number of other factors. In lieu of a more analytical method, patients were asked to self report levels of physical and mental fatigue and exhaustion.

The Similarity of Fatigue and Pain

Fatigue is similar to pain in that the experience of these two negative phenomena are completely relative to the perception of the patient and not to any testable analytic. Before and after the monitoring period, each patient was evaluated for overall cognitive function. Although fatigue is impossible to accurately measure, cognitive testing can scientifically prove that self-assessed fatigue limits overall cognitive ability. The physical effects of fatigue were monitored via a 6 minute session of light cardiovascular activity.

L-Carnitine Study Results

Out of the seventy patients who participated in this study, eight of the patients died before the six month testing period was complete. Three patients in the experimental group did not survive the testing period, while five patients in the placebo group died. This left 62 patients who provided a full set of usable data. Over the course of six months of therapy, the experimental group did indeed experience boosted levels of L-Carnitine in the blood stream. As a result of this increase in L-Carnitine Levels, the patients experienced a number of positive benefits, including:

  • Measurable decrease in mental and physical fatigue

  • Reduction in severity of mental and physical fatigue

  • Increases in muscle mass

  • Reduced levels of fat

  • Decreased cholesterol levels

  • Improved performance on cognitive tests

  • Increased ability to withstand light physical activity

How does L-Carnitine Benefit the Body?

It is well known in the medical community that L-Carnitine is vital for the oxidation of long-chain fatty acids by cellular mitochondria. It is believed that increased L-Carnitine levels improve the ability of the mitochondria to metabolize fatty-acids, thus causing a number of physiological benefits in the experimental participants, manifested both physically and cognitively.

This evidence also suggests that increased levels of L-Carnitine help the body utilize glucose more efficiently, allowing the body to sustain activity for a longer period of time. In addition to this, L-Carnitine preserves muscular glycogen, which is the immediate energy source for the muscles. All of this combines to preserve the rate at which ATP is efficiently expended in order to support physical activity. In patients with L-Carnitine Deficiency, ATP stores are burned up more quickly, causing these individuals to experience fatigue and exhaustion more quickly, inhibiting their ability to engage in cardiovascular activity dependent upon the severity of the deficiency.

Elderly Patients Desperately Need L-Carnitine

By the age of 100, Endogenous L-Carnitine levels are incredibly low, allowing researchers to vividly see the potential benefits of L-Carnitine supplementation for patients with lesser deficiency. The researchers who conducted this study came to the ultimate conclusion that L-Carnitine supplementation has the ability to reduce body fat, increase muscle mass, and improve capacity for physical and cognitive activity by reducing the effects and severity of exhaustion and fatigue.

L-Carnitine Supplementation a Smart Decision

L-Carnitine is a vital part of a healthy diet and helps maximize physical and mental health. Although our body can naturally produce a certain level of L-Carnitine, it is necessary to eat foods or take supplements which contain L-Carnitine in order to maximize the benefits of the hormone. L-Carnitine is a legal supplement which can be purchased at nearly all nutrition stores. A normal and healthy dose of L-Carnitine is generally between 2 and 4 grams of L-Carnitine per day, which is around the dose provided to the patients in the study discussed above.

L-Carnitine Important for Individuals of All Ages

Although the above study is related to the use of L-Carnitine in geriatric patients, it displays the importance of maintaining a healthy level of L-Carnitine throughout one's life. Healthy levels of L-Carnitine are necessary in order to maximize the benefits of cardiovascular training because it helps the body maintain the necessary level of energy in order to engage in strenuous exercise.

The hypothesis of the researchers in the above study, that L-Carnitine is necessary to sustain ATP levels optimally over time, shows that fatigue and exhaustion are physical disorders related to the energy available to the body at any moment in time. It is not just a matter of the brain or the muscles' ability to withstand pressure, but fatigue is directly related to the rate at which the body uses up internal energy sources such as ATP.

L-Carnitine increases the Benefits of HGH

Both L-Carnitine and Human Growth Hormone are intricately related to the metabolic processes which enhance exercise ability and increase our ability to withstand physical exertion. L-Carnitine helps the body use every ounce of energy with maximum efficiency, whereas Human Growth Hormone releases internal stores of energy which provide the muscles of the body with additional energy to further enhance exercise capacity. L-Carnitine and Human Growth Hormone play unique yet inextricably linked roles in physical performance, and both HGH Deficiency and L-Carnitine Deficiency prevent individuals from achieving optimal energy levels and sapping men and women all over the world of their vitality.

Human Growth Hormone and L-Carnitine are fantastic when taken together. L-Carnitine is a vital protein that the body absolutely has to have to survive, but it is in no way a substitute for Human Growth Hormone. HGH is a vital hormone which promotes metabolism throughout the body, whereas L-Carnitine simply maximizes the effectiveness of available energy. In terms of physical performance and energy, think of HGH as an energy excavator and think of L-Carnitine as an agent of efficiency.

L-Carnitine Supplementation

What Forms of L-Carnitine Supplements are Effective?

L-Carnitine is available in a number of forms and, for the most part, the protein remains intact through the process of digestion. L-Carnitine can be commonly found as a liquid, hard tablet, or powder capsule. There are a number of options available and you are free to choose which works best for you. For patients who are significantly deficient in L-Carnitine, it is possible to receive an L-Carnitine injection from a physician via prescription.

Do Not Take Too Much L-Carnitine

We do not suggest taking a dose of L-Carnitine greater than 4 milligrams per day without the approval of a qualified physician, because there are certain risks involved with L-Carnitine overdose. L-Carnitine overdose can cause stomach problems such as cramping, nausea, vomiting, and diarrhea. Overdose of L-Carnitine can also lead to elevated levels urea in the blood which can actually hinder exercise performance and cause muscular weakness.

Natural Sources of L-Carnitine

In addition to taking L-Carnitine in supplemental form, there are also many great sources for the vital protein that you can find in your every day diet. Red meats are a significant source of L-Carnitine, although they should be eaten sparingly if at all in any diet. For individuals who are not lactose-intolerant, Milk products are a great source of L-Carnitine. L-Carnitine deficiency is a fairly common occurrence among vegans and vegetarians for this reason.

For individuals who desire to limit red meat consumption and are lactose intolerant, there are a number of fruits and vegetables which provide L-Carnitine, including bananas, apricots, kale, parsley, okra, mustard greens, garlic, collard greens, Brussels sprouts, broccoli, and asparagus. Seeds and nuts also contain a healthy dose of L-Carnitine as well. Whole wheat, rice bran, oatmeal, corn, and rye contain L-Carnitine, but remember to avoid processed rice and grains when possible.

L-Carnitine as a Medical Treatment

There are a number of medical conditions for which L-Carnitine supplements and injections are recommended and/or prescribed. Some individuals have a genetic disorder which limits their ability to process their own L-Carnitine. Certain medical treatments such as hemodialysis can lead to L-Carnitine Deficiency as well. L-Carnitine supplements are an important thing to consider when starting a diet, because making a significant dietary transition can often lead to insufficient ingestion of certain nutrients such as L-Carnitine.

L-Carnitine is also a common supplement used during treatment of cardiovascular complications. L-Carnitine has been shown to alleviate cholesterol levels and decrease risk of heart attack, heart failure, and stroke. The protein has also been shown to relieve certain issues arising from poor circulation in the extremities.

L-Carnitine Reverses Muscle Atrophy

L-Carnitine supplementation is often recommended for AIDS patients in order to alleviate the symptoms of muscle wasting associated with the immune virus. L-Carnitine helps prevent the human body from feeding on its own musculature, which helps AIDS patients and has also been used to preserve health in patients in recovery from anorexia as well. For men who are having fertility trouble, L-Carnitine is often an early suggestion for encouraging procreative ability.

For patients too young to suffer from HGH Hormone Deficiency, L-Carnitine is a useful method of safely and legally optimizing endurance and physical performance. If you do suffer from HGH Hormone Deficiency or Testosterone Deficiency, L-Carnitine is one of the many nutrients that you will need to maximize the benefits of your treatment.


L-Carnitine and Bone Mass

As we age, L-Carnitine levels in the cells start to decline. This negatively impacts the metabolism of fatty tissues throughout the body. The bones are significantly affected by this metabolic decline. The bones are slowly but constantly undergoing a process known as remodeling and organs known as osteoblasts require adequate metabolic activity to perform their function of restructuring bone. Without sufficient osteoblast activity, the bones are slowly leeched of their calcium and an overall reduction in bone capacity will eventually result in osteoporosis.

L-Carnitine Provides Antioxidant Benefits

L-Carnitine is one of a large group of nutrients and supplements known as antioxidants. Antioxidants protect the body at a cellular level from elements known as free radicals. Free radicals are rogue atoms and molecules that lack an electric charge and can damage human cellular bodies. The purpose of antioxidants are to cancel out the potential damage caused by free radicals. When individuals lack sufficient antioxidants, these rogue elements and molecules take control and break down organs at a cellular level. L-Carnitine Deficiency is common in geriatric patients and, as a result, these patients are more at risk of cellular damage as a result.

Pharmaceutical Uses for L-Carnitine

L-Carnitine and the Heart

Clinical research has proven that L-Carnitine can be beneficial for patients that have suffered from angina. L-Carnitine supplementation reduces the need for certain medications and also increases energy and reduces fatigue while helping prevent further occurrences of chest pain. Some clinical studies even present evidence that L-Carnitine can help those that have suffered a heart attack from experiencing another. L-Carnitine can also prevent angina after a heart attack and can preserve normal heart rhythm, which may prevent the need for a pacemaker. There is not definitive evidence regarding these final claims as of yet, however.

L-Carnitine and Kidney Disease

The kidneys are one of the primary organs which create endogenous L-Carnitine. Patients who suffer from kidney disease almost universally suffer with issues with L-Carnitine production. Patients who undergo dialysis as a result of kidney disease are often prescribed L-Carnitine in order to maintain energy levels and reduce symptoms of fatigue related to kidney disease and its treatment.

L-Carnitine and Male Fertility

L-Carnitine Deficiency can lead to fertility issues in males. Sperm cells are one of the kinds of cells which most rely on L-Carnitine in order to function optimally. With insufficient L-Carnitine, sperm quality declines and the sperm are often not active enough to ensure insemination. L-Carnitine has also been proven beneficial in treating a disorder known as varicocele, which is a vascular disorder which disrupts the functional ability of the testicles. Evidence even suggests that L-Carnitine supplementation even outperforms surgery in the treatment of this disorder.

L-Carnitine and Weight Loss

Those who are interested in weight loss would be smart to use L-Carnitine as a dietary supplement. L-Carnitine is often labeled as a weight-loss treatment, but this is not quite an accurate assessment of what L-Carnitine can achieve. There is evidence that L-Carnitine can improve BMI by decreasing adipose fat while boosting muscle mass, but this may not result in overall weight loss. L-Carnitine in this respect can be understood more as a mechanism for body sculpting than for the encouragement of weight loss.

For patients with Human Growth Hormone Deficiency, Bio-Identical HGH injections vastly outperform L-Carnitine in the treatment over obesity, although L-Carnitine does produce many positive benefits regarding cardiovascular and metabolic health. It is important to think of L-Carnitine as a supplement which can increase the effectiveness of various forms of Hormone Replacement Therapy rather than a fully-fledged treatment option in and of itself.

L-Carnitine and Muscle Developmental

Clinical research has proven that L-Carnitine significantly improves muscle development and function. One study shows that L-Carnitine supplementation can even help healthy individuals increase muscle mass and reduce fatigue associated with exercise. Of course, until research suggests otherwise, it is important to limit L-Carnitine consumption to no more than 4 grams per day. As the body loses the ability to produce its own L-Carnitine with age, the benefits of L-Carnitine supplementation continue to become more and more pronounced.

L-Carnitine Can Benefit Patients with Mild to Moderate Asthmatics

Studies are beginning to show that some forms of asthma may be the result of L-Carnitine Deficiency in youth. In comparison to healthy children, kids with mild to moderate chronic asthma were shown to have comparatively lower levels of L-Carnitine. L-Carnitine has been shown to be a useful and successful treatment option for a significant portion of children with this form of asthma. L-Carnitine is thought to improve metabolism in cells within the lungs which helps the organ to absorb oxygen more efficiently, often reducing and eliminating the need for an inhaler.

L-Carnitine and Hyperthyroidism

Hyperthyroidism is the result of an overactive thyroid gland. Symptoms of hyperthyroidism include fatigue, insomnia, muscle atrophy, weight loss, and anxiety. There is clinical proof that hyperthyroidism pulls L-Carnitine from the body and impoverishes cells throughout the body from healthy L-Carnitine levels. There is significant evidence that L-Carnitine supplementation can alleviate and reverse many symptoms of Hyperthyroidism. L-Carnitine is secondary to hyperthyroidism and does not prevent hyperthyroidism, but can alleviate symptoms when they occur.

L-Carnitine is an Important Part of any Health Regimen

L-Carnitine is a potent metabolism-enhancing protein which can provide significant benefits throughout the body. Many Anti-Aging Hormone Panels include testing for L-Carnitine Deficiency. This test will help your physician optimize your Hormone Replacement Therapy Regimen, providing you the greatest possible benefits.

Healthy levels of L-Carnitine help Human Growth Hormone HRT patients by optimizing physiological and cellular metabolism. L-Carnitine also helps patients undergoing Testosterone Hormone Replacement Therapy by providing additional energy for muscle development and helping to preserve or even restore fertility in Testosterone Deficient patients.

Even if you do not choose to utilize Hormone Replacement Therapy, we encourage you to take supplemental L-Carnitine in order to help improve your physiological profile.


STEM CELL THERAPY NANOG FOR IMMORTALITY


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 11 June 2015

Stem Cells and the Future of Health Care

Although the medical field of Stem Cell Research is in its infancy, its potential for improving health care around the world is unprecedented. In the next generation of medicine, there is no doubt that new procedures and methodologies utilizing stem cells will change the way that people all across America and the globe live.

What is a Stem Cell?

Stem cells are literally the building blocks of a human being. Stem cells are cells which contain the genetic code to build something larger than themselves. When a human being is conceived, it begins as a microscopic ball of these stem cells. Over time, these cells differentiate and develop into the various cells, tissues, and organs that an organism must have to survive.

By investing our time and energy in researching stem cells, we are able to observe how a human is formed one tiny step at a time. Research involving Stem Cells and how to utilize them effectively in a medical environment will eventually change the way that physicians and surgeons practice medicine and conduct patient care.

Although human beings have an amazing capacity for regeneration, there are limitations to the ways in which an adult stem cell can repair injured tissue or organs. For example, neurons have an extremely limited capacity to heal and regenerate. There is evidence that stem cells have the ability to regenerate tissue in ways that are simply impossible for adult cells, because of their immature state.

Because of the unique nature of stem cells, in the future, the potential for stem cells to be utilized in order to repair or replace damaged organs and tissues has the ability to significantly alter the way that we treat everything from cancer to arthritis.

How Can Stem Cell Research Improve our Lives?

There are numerous ways in which Stem Cells may improve the way that we practice medicine. A number of medical afflictions have the terrible capacity to destroy tissue to an extent that regrowth and rehabilitation is not possible. By manipulating Stem Cells, it will likely be possible to stimulate the regrowth of tissues and organs like the liver or kidneys that the body no longer has the ability to repair on its own. There is even potential that sometime in the future, stem cells may be used to completely regrow new organs for transplantation, vastly reducing the risk of rejection and reducing the need to wait on donor organs.

Researchers hypothesize that numerous diseases which are considered incurable today will likely find their cure via Stem Cell Research. The benefits of Stem Cell Replacement can potentially lead to amazing changes in the way that we treat cancer, arthritis, stroke, heart disease, spinal cord damage, diabetes, burns, and even neurological disorders such as Parkinson's Disease and Alzheimer's.

In addition to the potential benefits provided by Stem Cell Treatments themselves, Stem Cells are currently being used in order to foster an enhanced understanding of how our genetics contribute to the initial stages of cellular development. By studying this initial stage of development at a cellular level, we will be able to more fully realize exactly how certain cells and cellular constructs develop improperly, contributing to both birth defects and cancer.

Through a more complete understanding of Stem Cell Replication and Differentiation, medical researchers will gain vital insights as to how to eliminate the spread of many of these diseases of early development.

What are the Goals of Modern Stem Cell Research?

At this stage in Stem Cell Research, physicians and researchers are looking to enhance the effectiveness of current medical treatments and find ways to treat patients while diminishing the invasive nature of many forms of current treatment.

Although ideally, medical professionals would like to use the stem cells of the patient, current Stem Cell Treatments are generally administered using cells received from a donor. Although these cells still have the potential to provide significant benefits, the ideal stem cells would come from the patient being treated. Even with modern techniques to prevent rejection, there is still the potential that the immune system of the patient will reject the donor stem cells.

As we learn more about Adult Stem Cells, we will eventually be able to treat a patient with his or her own stem cells. By using a patient's own stem cells, the risk of rejection drops significantly, and may even be removed completely. There are a number of hypotheses regarding how this goal may be achieved:

  • Harvesting adult stem cells from an individual and alter them in a laboratory environment so that they develop into a certain type of tissue. After the tissue forms and develops, it could be transplanted to a target area of the body in need of treatment, where it could restore function lost through tissue damage.

  • A technique known as Therapeutic Cloning could be used in order to create embryos full of immature stem cells which would be identical to those of the individual.

  • A third technique to use Stem Cells for therapeutic advantage would be to encourage stem cells contained within the body naturally to perform healing functions. One scientific hypothesis is that it may be possible to design medications which would encourage a certain form of stem cell to multiply therapeutically within the patient. This form of treatment would reduce the need to go under the knife in order to gain the therapeutic benefit of stem cell therapy.

    At face value, the potential benefits of Stem Cell Treatment seem endless. Would it not be possible to utilize stem cells to heal or replace damaged or destroyed tissue within the patient? In order to reveal the true healing capacity of Stem Cell Treatment, there are a number of questions which must be answered first:

    How Effective will Stem Cell Treatments be Long-Term?

    One of the primary reasons that we grow older is because our cells themselves age for a variety of reasons. An important question that must be answered is if Adult Stem Cell Treatments will malfunction or lose efficiency faster than cells naturally formed by the human body. There is limited evidence regarding the long-term potential of Stem Cell Therapy.

    What can we do to make sure that Stem Cell Treatments don't develop into uncontrolled tumors?

    Stem Cells harvested from embryos are genetically designed to divide repeatedly and not develop differentiation. In order for Stem Cell Treatment to be effective,, scientists have to be able to manipulate the stem cells into a desired form of differentiation.

    If the goal of differentiation is not reached, this has the potential to lead to tumor formation, because the embryo will continue to divide and flood its immediate area with more undifferentiated cells. In order for Embryonic Stem Cells to be an effective treatment, they must be effectively and tightly controlled.

    In both adult and embryonic stem cells, if the genes within the cells are not guided and regulated properly, it may lead to tumor development. There are questions regarding how stem cells will act when they have been active in a laboratory environment before transplantation. There is a possibility that these cells may differentiate in a different way than stem cells that are harvested directly from a patient.

    What would cause this?

    The majority of cells in the human physiology are not designed for infinite revision, and they definitely aren't designed to develop in a sterile laboratory environment. Numerous types of tissue, such as skin cells and blood cells, have particular biological processes which control differentiation, division, and apoptosis after a certain length of time. These cues are the result of biological signals received from the entire environment of an organ or organism.

    In order for cells to divide indefinitely in a laboratory environment, the process of normal development must be stalled. The way that scientists achieve this form of artificial growth is to house the cells in an solution which contains the nutrients vital for their survival as well as proteins which encourage their reproduction. In the majority of these environments, many of the developmental signals that exist in a living environment do not exist in the lab.

    Evidence shows that some kinds of cells don't react as well to this type of environment as others. A certain percentage of the cells will not survive, and the cells which are more effectively designed to withstand non-finite growth will propagate.

    After a certain number of divisions in vitro, the cells which remain could hypothetically evolve so much that they no longer react effectively to the normal signals provided by its natural physiological ecosystem. There are even theories that keeping stem cells in vitro for an extended period of time could even alter the genetic structure of the cells. These changes could encourage the development of tumorous growths.

    Recreating the body's natural ecosystem within a lab is one of the most difficult aspects of stem cell research. It is actually one of the primary goals of global stem cell research across the globe. In order for stem cell treatments to be maximally effective, we will have to learn how to store and develop stem cells in an environment which closely mimics that of its location within our body.

    Importance of the Nanog Protein

    There are important studies and advances in recent years which give hope that we can extend the usefulness of stem cells, even those that have remained in vitro for an extended period of time. Recently, Stem Cell Researchers have discovered exactly how stem cells can persist in their undifferentiated state for an infinite period of time.

    The study was endowed by a charity known as the Wellcome Trust, which specializes in providing independent funding to novel research regarding the enhancement of human and animal life and longevity. Researchers have discovered a unique protein which has the ability to preserve non-differentiated stem cells. Another name for these cells are Pluripotent Stemcells. This means that the stem cells have the ability to evolve into a multitude of different types of tissue.

    Although scientists for years have suspected that Nanog played a special role in the control of differentiation, researchers from Cambridge have discovered that Nanog is actually the mechanism which controls the development and differentiation of stem cells.

    By enhancing scientific knowledge regarding Nanog, researchers are able to more fully understand the mechanisms by which stem cells function, and the more that we understand stem cells, the more safely that we will be able to use them for more and greater medical treatments.

    The Isolation of the Nanog Protein

    Nanog had been previously hypothesized, but was not isolated until a decade ago, when it was discovered to play a significant role in the maintenance of pluripotency. Although researchers recognized its importance, they could not yet pinpoint exactly how Nanog prevented differentiation in stem cells.

    In this Cambridge Study, scientists were able to demonstrate that Nanog is the lynchpin of a complex balance of protein and gene maintenance which maintains the stem cells in the pluripotent stage.

    Without the presence of Nanog, Stem Cells cannot remain indefinitely undifferentiated. Also, without the influence of Nanog, it is impossible to recalibrate fully developed cells to return to a state of pluripotence. the specific period in which Nanog must be present is during the last stage of reprogramming. Without the presence of Nanog, the stem cell gets locked in a state of partial development.

    One medical representative from the Wellcome Trust Center, Doctor Silva, explains that the medical research demonstrates that Nanog has the specific power to maintain the property on non-differentiation indefinitely.

    In order to more fully recognize the influence of Nanog, researchers must study more deeply into the function of Nanog in order to determine exactly how the protein influences early human development during the embryonic phase.

    The Importance of Understanding Pluripotency

    In order to expand the usefulness of Stem Cell Therapies to a greater variety of potential treatments, it is vital to understand exactly how stem cells thrive in a pluripotent state as well as how they differentiate. Nanog research is an important gateway into the future of Stem Cell Utilization.

    By understanding the pluripotent nature of stem cells, researchers hope to one day be able to convert adult cells back into their early forms so that they can be used in order to treat a variety of medical conditions more effectively and more cheaply than we ever thought possible. Rather than be stuck with limited sources of stem cells, such as those acquired from donors, or those acquired from embryonic stem cells, scientists could revert adult cells into embryonic stem cells, then convert them into other vitally needed types of tissue, such as nerve cells or kidney cells.

    If scientists are able to make these hypotheses realities, then numerous chronic diseases like Alzheimer's and Parkinson's could be treated more effectively, or even one day completely cured.

    With the success of this research, we may one day be able to live far longer than we ever thought imaginable.


  • RESTRICT YOUR CALORIES 30% AND LIVE 30% LONGER?


    Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
    Published on 08 October 2018

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    The Theories of Caloric Restriction and Aggressive Supplementation

    Do shortcuts exist to a longer life?

    There are many people that believe that there are. One older couple feel that they have realized the key to longevity, and they are dedicating their lives to testing the hypothesis. Paul McGlothin, age 60, and Meredith Averill, age 61, have been following a strict regimen of caloric restriction over the last fourteen years in an attempt to prove that the technique produces enhanced life expectancy.

    What is Caloric Restriction?

    Caloric Restriction is a form of diet in which an individual consumes a lower than average number of calories in an attempt to increase overall health and life expectancy. It is based on the assumption that as long as we meet basic physiological needs through human diet, the fewer calories we eat per day, the longer that we will live as a direct result.

    There is a significant amount of evidence which correlates caloric restriction and life extension in animals, but studies are just beginning to take place examining this phenomenon and how it may relate to human beings. McGlothin and Averill are the inspiration for one of these human studies, and are active participants in one of those studies as well. Washington University Researchers are monitoring the couple in order to investigate the potential benefits of caloric restriction in human beings. This study is one of the first three of its kind ever conducted.

    In order to maximize the effectiveness of their diet, they only consume certain foods which are loaded with nutrition, while also being low in caloric content. These diets consist largely of fruits, vegetables, and greensand proteins are consumed relatively sparingly. They and other participants in this study keep total track of the food that they consume. The couple have shown that they consume around nine percent of their calories from protein, thirty two percent from fat, and fifty nine percent from carbohydrates.

    During every possible meal, the participants in this study weigh the food that they consume and maintain detailed digital records of the calories and nutrition that they eat and drink. Participants log into a computer program known as the Cron-O-Meter in order to post their daily results. McGlothin consumes around 1,900 calories per day, and Averill eats around 1,500 calories. These amounts are around 1/3 less than what the average American male and female consume, respectively. Although the couple are noticeably thinner than average, they maintain BMIs of 18, which are considered normal for men and women their age.

    McGlothin and Averill are convinced that the benefits of their monitored diet plan are astounding. The couple have authored a book titled The Caloric-Reduction Way as a means to express to the public their lifestyle tips and their dietary choices in order to spread their life-changing knowledge to a wider audience.

    Averill has been told by doctors that her heart and cardiovascular system are structured like a woman many decades younger than herself. Her husband says that caloric restriction, as it is engaged in by he and his wife, produces incredibly positive effects on all manners of physical function. McGlothin is sixty years old and says that he has perfect vision. In addition to this, he has performed exceedingly well on cognitive tests, and his scores have actually improved as he enters his sixties, when among most people, the opposite occurs and the mental faculties slowly begin to deteriorate. He laments that his old chess buddies just dont have the ability to keep up any longer.

    Caloric Restriction in the Animal Kingdom

    Gerontologist Robert Butler was a psychologist profoundly concerned with gerontology and reducing the suffering and pain caused by the aging process. He coined the term Ageism in order to highlight the unfair treatment of the elderly by the generations that proceed them. The concept of ageism, Butler believed, was the reason why scientific understanding of the latter part of the aging process was so understudied and thus misunderstood.

    Butler is also well-known for spearheading the belief that senility is not an inevitability of the aging process, thus opening the door for Anti-Aging and Longevity science. Butler was the founder of the International Center for Longevity, and was an important force in the group until his death in 2010 of leukemia at the age of 83.

    Doctor Butler says that caloric restriction has produced the ultimate effect of life expectancy extension in nearly every animal ever studied. It has been shown that a thirty percent reduction in caloric intake has been connected to a thirty percent longer life. Butler understands that there are normally certain limits when attempting to relate animal research studies to humans, because animal and human physiology can be quite different. This particular case produces stronger evidence, however, because the same results are being produced all throughout the animal kingdom. Although we are likely to differ from a single animal, we are much less likely to differ significantly from all animals as a group, Butler strongly believes.

    A recent study conducted with monkeys provides the strongest evidence yet that Humans can benefit from caloric restriction. Caloric restriction has produced evidence that monkeys who are put on this diet live healthier lives. Butler does admit that there are a couple of drawbacks, however. Caloric Restriction has the potential to lead to both decreased libido and overall energy. Also, there is the issue of compliance. Many people simply dont have the willpower or patience for a restricted-calorie diet. For these individuals, however, there is a chemical being researched known as resveratrol which may have the capability to reduce the desire to over-consume food and thus make living by a more restrictive diet a simpler proposition.

    Supplements and Nutrition

    Of course, there are other strategies used to enhance longevity as well. Doctor Grossman is the executive director of Denvers Grossman Wellness Center. He believes that the key to a longer life is to engage in a long-term regimen that includes a healthy and nutritious diet, anaerobic strength training, cardiovascular exercise, and meditation or other forms of stress reduction. Dr. Grossman emphasizes prevention, and he begins his patients initial treatments with a two day battery of complete medical testing.

    Dr. Grossmans team runs a comprehensive testing program in order to unearth underlying hereditary diseases and predispositions that have the potential to effect longevity. In addition to this, the doctor works with his patients in order to diagnose underlying health disorders and build a profile of the hereditary history of family disease. Dr. Grossman uses all of the information provided to him through testing and uses the results in order to provide medications and supplements that work to optimize the health of his patients.

    Grossman has teamed up with a man named Ray Kurzweil in order to co-author a book about the future of longevity and Anti-Aging titled The Fantastic Voyage. Kurzweil is sixty years old, and is a highly regarded inventor and scientist. Among the list of prestigious recognitions he has received is the National Medal of Technology. Kurzweil is currently serving in a top level technological position with Google, attempting to create programs that enhance the learning capability and speech recognition of computers.

    Kurzweil and Grossman believe that living a healthy lifestyle can only do so much to enhance the lifespan, and that the aggressive use of supplements is an important step in slowing down the process of aging, in addition to living a healthy lifestyle.

    Kurzweil aggressively utilizes nutritional supplementation. At one time in his life he claims that he utilized over 250 supplements in order to attempt to optimize his own health. Today, he has whittled that number down to 150. He is confident that without this aggressive use of medical supplementation, he would not be as healthy as he is today. Mr. Kurzweil undergoes a regular hormone profile every three months in order to monitor his nutrient levels.

    Using this testing as a guideline, he engages in this extreme form of supplementation in order to maximize his nutritional intake. In addition to this supplementation, he drinks ten cups of green tea and ten glasses of alkaline water each day. He claims that the hormone and nutrient levels in his body are the equivalent of a man twenty years younger than himself. He urges that this sort of supplementation should only be done with regular monitoring, so that an individual can adjust to changing physiological conditions within the body.

    The majority of the supplements and nutrients that Kurzweil uses will be quite familiar to you, because they are an essential part of every diet, such as the common minerals and vitamins. Many others, however, are much more obscure, such as phosphatidylcholine, which the inventor claims has the ability to maintain cell membranes and prevent them from aging. Phosphatidylcholine is a phospholipid which is contained within every cell membrane of the human body. Studies have shown that this phospholipid is likely beneficial to the liver, but there is little evidence for Kurzweils use of the substance.

    A Counterargument

    Although Kurzweil is incredibly confident in his endeavour, there are certainly detractors, such as University of Chicago School of Public Health Professor Jay Olshanksy. Professor Olshanksy feels that the overuse of supplements is a waste of both money and time. He feels that for most individuals who utilize this sort of aggressive supplementation, there is minimal benefit outside of placebo, and the majority of the supposed nutrients consumed are simply eliminated during urination and never make their way effectively to the blood stream.

    Three things that everyone agrees on is that everyone should eat healthy, engage in exercise, and take measures to alleviate stress. Although there is a lot of evidence which suggests that methods such as supplementation and caloric restriction can have a positive effect on life expectancy, it will be a long while before enough evidence accrues that we know for sure.

    How does all this relate to the Conscious Evolution Institute?

    The paths of both Paul McGlothin and his wife, and Ray Kurzweil converge in many ways in our Hormone Replacement Therapy Treatment Plan. We do believe in the use of caloric restriction. The caloric intake of Mr. McGlothin and his wife are right around what we believe is ideal for both sexes. Although Paul and his wife may be in good health for their age, to look at them, one can still see that time is taking its toll upon them. We feel that if they combined their unique diet with Hormone Supplementation, they would benefit much more.

    We also believe that supplements and proper nutrition are vital to a healthy body and healthy hormones, as does Mr. Kurzweil. We believe that Mr. Kurzweil almost certainly over-utilizes many supplements, however. Just think of the expense of taking 150 separate supplements simultaneously. He has also been accused of using many supplements that have been proven ineffective by the scientific community. We at the Conscious Evolution Institute are forward thinking and attempt to stay ahead of the curve while also remaining grounded in legitimate medical science.

    Even though we may view Mr. Kurzweil with a tinge of scepticism, we recognize that in doing so much, he is likely making many of the correct decisions as well. We do not share the pessimism of Aging researchers such as Olshansky who are unable to foresee the amazing changes in Longevity medicine just over the horizon. By constantly researching new therapies, yet remaining grounded in a base of traditional medical theory, we are able to pick and choose the most effective breakthrough anti-aging theories before they become common techniques.

    The Best of Both Worlds

    Our form of Longevity Therapy centers on hormone restoration and optimization rather than full nutrient overload. There is a very high likelihood that Mr. Kurzweils therapy is quite successful, but we also believe that he is likely spending a lot of money on supplements that do not work well, and more money on others that dont work at all. Ray Kurzweil is a wealthy and wildly successful inventor, so he has the discretionary income to take significant chances in order to maximizing his health.

    The process at the Conscious Evolution institute is streamlined, and the majority of the cost comes from the purchase of Bioidentical Hormone Replacement Therapy, not raiding the local General Nutrition Center. Human Growth Hormone and Testosterone HRT have decades of research showing the multitude of benefits of hormone replacement.

    We urge you to take the theories presented in this article to heart, but take them with a grain of salt as well. We are certain that if you research the impressive benefits of Hormone Replacement Therapy, you will be convinced that it provides the best opportunity to maintain health and vitality, especially HGH and Testosterone Treatments are combined with proper nutrition and smart lifestyle choices.

    http://abcnews.go.com/Health/Longevity


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