Frequently Asked Questions
of this article is to help you become better informed about a new
form of Hormone Treatment known as Sermorelin Acetate Therapy. This
article serves as a reference point to help you become more
knowledgeable about this highly beneficial therapy.
What is Sermorelin Acetate?
Sermorelin Acetate is a hormone derivative that spurs the natural
secretion of endogenous Human Growth Hormone by the pituitary gland.
Sermorelin Acetate serves as the functional equivalent of a hormone
produced by the hypothalamus known as Growth-Hormone Releasing
Hormone. GH-RH is also often referred to as Growth Hormone Releasing
Sermorelin and GH-RH are not biologically identical, they are
functionally identical, meaning that the two molecules produce the
exact same effects in the human body, despite being arranged in
different configurations. Sermorelin and GH-RH share the same initial
sequence of amino acids, but Sermorelin Acetate is truncated, meaning
that the hormone sequence is cut short. Scientific researchers found
that by producing a bio-synthetic hormone which only contains the
first twenty nine amino acids of Growth Hormone-Releasing Hormone,
they could create a potent medication that is cheaper to produce
while maintaining the exact same medical effect upon the human body.
Acetate was isolated and invented by Nobel Prize Winners Andrew
Schally and Roger Guillemin. The chemical configuration of GH-RH is
referred to as GRH 1-29 NH 2. GRH 1-29 is the active sequence of
Growth Hormone-Releasing Hormone. The NH-2 refers to a closing
sequence which is inert and serves to tie off the end of the
What is the difference between Sermorelin Acetate and HGH?
Many people get this somewhat confused, thinking that because
Sermorelin Acetate increases internal levels of Human Growth Hormone,
that Sermorelin is actually a form of HGH. This is untrue. Sermorelin
is a hormone which scientists label a secretagogue. Secretagogues are
hormones produced by the brain which stimulate other hormones to be
produced. They serve as intermediary messengers which move the
message along to target organs and tissues in the rest of the body.
released by the pituitary gland and flows through a series of blood
vessels in the brain known as the epiphyseal portal system. Upon
reaching the Anterior Pituitary Gland, Growth Hormone Releasing
Factors then stimulate organs known as somatotrophs within the
pituitary to manufacture and secrete Human Growth Hormone to
circulate to the liver and other organs. Sermorelin Acetate imitates
the function of GH-RH, producing a biologically identical response
when is reaches the somatotrophs.
is a much smaller hormone than both GH-RH and Human Growth Hormone.
Sermorelin contains 29 amino acids, whereas GH-RH contains 45. HGH
dwarfs both of these hormones in size, as it is comprised of 191
Health Stores and Online Websites often advertise supplements known
as Human Growth Hormone Releasers. These supplements are available
over the counter and do not need a prescription. Are these
supplements similar to Sermorelin?
not. Supplemental HGH Releasers are most often component amino acids
which comprise Human Growth Hormone, including L-Dopa, Glycine,
L-Ornithine, L-Glutamine, and L-Arginine. Other chemincals are also
marketed as HGH Releasers, including Tribulus Terrestris, Macuna
Pruriens, and Ornithine Alpha-Ketoglutarate.
It is true
that these amino acids do have a stimulative effect upon HGH
production, but they are not healthy for the body and do not produce
a strong enough benefit to in any way warrant the risk. HGH Releasers
work (if they truly work) by creating an increased level of overall
activity throughout the brain. This increased level of activity does
have a slightly stimulative effect upon Human Growth Hormone Levels,
but it also stimulates other activities, but positive and negative,
throughout the brain.
Releasers Do Not Work As Advertised
medications labeled as HGH Releasers are completely ineffective,
veritable snake-oil products. Supplements are not certified for
effectiveness in the same way as medications such as Sermorelin
Acetate and Bio-Identical Human Growth Hormone, so there is not
necessarily a proven or guaranteed medical benefit to using the
supplements. At best, HGH Releasers stimulate a Growth Hormone
release that is just about equivalent to exercise, and at worst,
you'll damage your liver and experience no benefits at all.
Growth Hormone Releasers produce incredibly unreliable effects,
because different areas of the body and brain may experience
different levels of response every time you take the pill. High Doses
of Growth Hormone Releasers can lead to liver and kidney issues, as
the human body does not have the capacity to process extremely high
levels of unprocessed amino acids without accumulating damage in the
filtering and processing organs of the human body.
Acetate produces real and beneficial effects with minimal risk of
side-effects. Sermorelin Acetate Therapy has an incredibly safe track
record and has been proven to be effective at treating Adult-Onset
I've read a bit about Human Growth Hormone Replacement Therapy, and
it seems to be perfectly capable of resolving issues surrounding HGH
Deficiency and Hypopituitarism. What would make me choose Sermorelin
Therapy over Bio-Identical HGH?
There are a number of reasons why a patient would choose Sermorelin
Acetate over Recombinant Growth Hormone, although both certainly have
their place as treatment options. Both HGH and Sermorelin are capable
of producing the same exceptional benefits to the human body, but
they share a couple of profound differences as well.
Imitates Normal Physiological Processes
Sermorelin Acetate functions in a manner which is more streamlined
with the actual function and overall needs of the human body. You
see, when you use Growth Hormone HRT, there are no safeguards which
protect the body against accidental overdose. Any Human Growth
Hormone injected into the body directly cycles through the liver and
the body and stimulates the body. Sermorelin, on the other hand, as
an Growth Hormone Secretagogue, can be affected by processes known as
Negative Feedback Mechanisms. Negative Feedback Mechanisms kick in
when the body sends signals to the brain that Human Growth Hormone
Secretion has satisfied the needs of the body.
receiving these signals, hormones known as somatostatins block GH-RH
and Sermorelin from reaching the Pituitary, preventing excess
secretion of Growth Hormone. Because Sermorelin works according to
the normal physiological rules of the human body, it is almost
impossible to overdose on Human Growth Hormone via Sermorelin
Injection. Other patients may choose Sermorelin Acetate in order to
avoid the temptation to overdose on or abuse HGH.
Releases Episodic HGH
benefit that Sermorelin Acetate Injections have over Human Growth
Hormone Injections is that they are processed by the body in
different patterns. Although HGH and Sermorelin ostensibly accomplish
the same goals, Human Growth Hormone Injections supply a relatively
constant level of HGH Release over time, which is not actually how
the body produces Human Growth Hormone. HGH Release is categorized by
a function known as Square Wave release. Square Wave means that HGH
concentrations rise to a peak during the course of the day, plateau,
and drop back down to baseline. This can cause a problem over time,
inducing a medical response known as Tachyphylaxis.
can be understood most simply as a decrease in sensitivity due to
outside pressures. The body can sometimes slowly recognize that HGH
is being provided by an outside source and the body builds resistance
as a response. Sermorelin releases Human Growth Hormone via an
episodic pattern which more closely resembles the natural pattern of
release by the human body. The pituitary only releases Human Growth
Hormone when the body is ready for it, thus significantly reducing
the threat of internal resistance to increased levels of HGH.
Preserves the Normal Hormonal Equilibrium
Benefit to Sermorelin Acetate, related to the second, is that
Sermorelin Acetate more appropriately preserves the Neuroendocrine
Axis. The Neuroendocrine Axis is the cascade of hormone release
throughout the body. Simply put, all hormones released by the human
body have a certain impact on the release of other hormones.
Injecting HGH directly into the body on a daily basis can actually
suppress the body's natural ability to produce it's own Human Growth
Hormone, which can effect the release of other hormones as a result.
Acetate makes less of a physiological imprint onto the endocrine
system, meaning that it more naturally resolves hormonal deficiency
while causing minimal impact on the normal function of other hormones
and systems of the body.
Available for Off-Label Use
and final benefit of Sermorelin Acetate is less physiological and
more technical. Sermorelin Acetate Hormone Replacement Therapy is not
as tightly regulated as Human Growth Hormone Replacement Therapy. The
FDA prohibits the use of Human Growth Hormone for off-label uses,
whereas Sermorelin Acetate can be used off-label at the discretion of
the prescribing physician.
I understand that Human Growth Hormone can only be delivered via
Injection. Is this also true for Sermorelin Therapy?
2013, Subcutaneous Injection is the only effective method to
administer Sermorelin Acetate . Like, Human Growth Hormone, the
Sermorelin Acetate molecule is too large to breach other barriers of
the human body at this date. On the bright side, since Sermorelin is
significantly smaller than Bio-Identical HGH, there is a hypothetical
chance that Sermorelin may one day be administer by breaching the
mucous membrane barrier using a nasal spray. This method is currently
being tested and may be effective at some point in the near future.
Do Sermorelin and Human Growth Hormone Injections require similar
doses to be effective?
Even though HGH and Sermorelin activate in different regions of the
body (Sermorelin in the anterior pituitary, Human Growth Hormone in
the liver) the volume of hormone that is required in order to
sufficiently increase endogenous IGF-1 production is nearly
identical. Human Growth Hormone is most commonly prescribed at doses
which vary between one and two international units. Sermorelin
Acetate is generally administered with a dose of two hundred
How much does Sermorelin cost in comparison to HGH?
Per vial, Sermorelin is a good bit cheaper than Human Growth Hormone.
In addition to this, a single vial of Human Growth Hormone takes
twelve to fourteen days to fully administer, whereas a single vial of
Sermorelin takes fifteen days to fully utilize.
In many patients, the benefits of Human Growth Hormone start to fade
of the course of continual use. Why does this happen, and does
Sermorelin lose potency as well?
The human body can develop a resistance to HGH Hormone Replacement
Therapy over time. If this has occurred to you, the change in
effectiveness is not the result of any inadequacy of the medicine
itself. Human Growth Hormone Injections increase serum levels of
Growth Hormone to levels which are higher than normal for a number of
hours every day, although the average release across the day is
Up-Regulation and Sermorelin Down-Regulation
addition to this, Human Growth Hormone Therapy leads to a stable
release of IGF-1 throughout the body, slowly rising and falling in
the body through the course of the day. This causes the tissues of
the body to have a steady supply of IGF-1 throughout the day, rather
than receiving the hormone in the normal bursts in which it is
accustomed to. As a result, IGF-1 Receptors in the tissue have a
tendency to go through a hormonal process known as down-regulation in
order to preserve normal function. This means that the target tissues
become desensitized to IGF-1 and Human Growth Hormone exposure,
reducing the effectiveness of the hormone treatment.
body is functioning normally, Human Growth Hormone is released
naturally from the pituitary gland in a number of short, brief, and
potent bursts, which supply the body with sufficient levels of IGF-1
and Human Growth Hormone while also giving the receptors time to rest
between periods of hormone release. If outside hormone release
properly imitates the natural processes of the body, this gradual
down regulation does not occur, and the benefits of increased HGH
production do not decline in the same manner over time.
the influence of Somatostatin, described above, Sermorelin
Administration only leads to the optimal release of Human Growth
Hormone. Sermorelin actually has the ability to make the pituitary
stronger, through a process of up-regulation which strengthens its
health by increasing the level of HGH it produces on a daily basis.
Does Sermorelin Acetate provide any benefits for patients suffering
from Adult-Onset HGH Deficiency that are not directly related to its
effect upon the endocrine system?
Yes. There is a large body of evidence that shows that Growth
Hormone-Releasing Hormone and Sermorelin Injections directly have the
capacity to increase sleep quality and promote the increased
experience of the deepest stages of sleep, which are the most
rejuvenative and beneficial to health and wellness.
What is the normal administration protocol for Sermorelin Hormone
Sermorelin is delivered once each day via injection. Sermorelin is
normally administered just before bed in order to more closely mimic
the natural hormone production of the body. Sermorelin is intended to
supplement the body's own natural production of Growth
Hormone-Releasing Hormone, which occurs primarily at night.
Sermorelin Dosage that the patient is described will be dependent
upon the physiological needs of the individual. Sermorelin Shots are
provided in vials which contain multiple doses The vial will contain
enough Sermorelin in order to treat the patient for at least fifteen
Conscious Evolution Institute
If you have any other questions about Sermorelin Acetate, Human
Growth Hormone Shots, or any other hormone treatments, we would be
happy to provide you with answers to any questions you may have.
Different patients respond differently to treatment, and some
patients respond more actively to Human Growth Hormone Replacement
Therapy than Sermorelin Acetate. If you choose the Conscious
Evolution Institute, our knowledgeable and top-of-the-line staff of
physicians and longevity specialists will help you decide which
treatments are right for you!