HUMAN GROWTH HORMONE RESEARCH & NEWS

Hormone Replacement Therapy with HGH and Testosterone

Testosterone and Human Growth Hormone Therapy are increasingly being recognized for their ability to improve health and wellness for aging patients. They are central to maintaining optimal physiological function for both sexes, though Testosterone is far more abundant in the male body. As we grow older, these hormones remain just as important to our health, but the body's ability to sufficiently produce them begins to drop off, beginning in the late 20s and early thirties.

The Impact of Hormone Imbalance on Wellness

When HGH and Testosterone Levels fall too low, this leads to a wide variety of health symptoms that have long been associated with the inevitability of the aging process, but are increasingly correlated with Hormone Imbalance, such as trouble concentrating, fatigue, low libido, erectile dysfunction, and weight gain.

Hormone Replacement Therapy continues to show its capability to improve lives through restoring a more youthful hormone balance. There is no panacea for aging, but many of the issues related to aging can be mitigated through the use of Low-T Therapy and HGH Injections, by treating the contributing cause of Hormone Decline.

HGH Therapy Highly Beneficial for Many Patients

These two Hormones are considered to be among the most important for patients interested in Hormone Restoration, because Testosterone and HGH are the Hormones most likely to cause issues among aging patients when they inevitably fall into a state of decline. Human Growth Hormone should not be considered an Anti-Aging Remedy, but it should be recognized for its protective effects upon the human body when used by patients suffering from Hypopituitarism and Age-Related Growth Hormone Deficiency.

Testosterone Therapy is Safe and Effective

Testosterone Therapy for Men, when used according to a Hormone Doctor's specific recommendations, is incredibly safe and can provide profound health benefits to men with Low-T, not only with regard to improving sexual function, but also psychological and physical wellness.

What is HGH?

Human Growth Hormone is often referred to as the master hormone, for the major impact that it has on both physiological development and maintainance throughout the lifespan. HGH is released soon after conception, and continues to stimulate human development until around the age of twenty-five, when it reaches a state of equilibrium designed not to grow, but maintain, the human body. Growth Hormone is responsible for encouraging the process of cellular metabolism. This means that it is responsible for the rate at which our bodies grow and our organs and systems develop.

HGH Levels in the body are high from conception to puberty, and then skyrocket, which leads to the growth spurt associated with puberty. Testosterone also plays an anabolic role in puberty, which is why boys grow taller and stronger than girls.

Human Growth Hormone in Adulthood

After puberty, Human Growth Hormone Levels drop to a state which encourages physiological homeostasis. HGH helps bones stay strong and maintains the ligaments. It also helps hair, skin, and nails stay healthy and strong. The hormone is also responsible for bolstering both the immune system and the healing processes of the body. People suffering from Growth Hormone Deficiency are both more likely to get sick and stay sick longer. They also take longer to heal from injuries. HGH Therapy is being studied and used internationally as a method to speed up and enhance injury recovery.

The Dangers of Growth Hormone Deficiency

Without sufficient Human Growth Hormone, our bodies start to fall into a state of physiological decline. Bones weaken, muscles shrink, the body starts to hang onto stubborn fat, and we just get sicker and frailer. For patients suffering from issues related to Age-Related HGH Deficiency (also known as somatopause), HGH Injection Therapy can protect the body from the ravages of hormone imbalance and improve health and longevity.

Testosterone Therapy: The Answer to Low-T

Testosterone is currently the most common form of HRT Therapy for men over the age of thirty five in the United States today. There are decades of clinical research that show that Testosterone Therapy has numerous beneficial effects for men suffering from Age-Related Low-T, also known as Andropause. Many of these symptoms, including low bone mineral density, erectile dysfunction, mood swings, fatigue, and low libido, long were considered inevitable aspects of aging, but clinical treatments such as Low-T Therapy with Injections, Transdermal Patches, and Topical Gels, have shown that Hormone Imbalance is a major contributor to these maladies, if not the primary contributor: moreso than aging itself.

What is Andropause?

As we learn more about Testosterone Deficiency, we recognize that there are many similarities between Menopause and male Testosterone Decline. Low-T is the result of a gradual decline in Hormone Levels, but both tend to become symptomatic around the same period, and both lead to serious and life-changing effects on physical and psychological health and well-being. Testosterone Deficiency can also effect women as well. Testosterone Therapy can be administered in various different ways. Testosterone Gels and Creams are administered to the skin daily to give a rejuvenative boost of the hormone.

Low-T Patches release a steady flow of Testosterone administered daily, but acting continuously over the course of a 24 hour period. Testosterone Pellets are surgically implanted under the skin for months of constant Low-T Treatment. Testosterone Injections (most commonly Testosterone Cypionate and Testosterone Enanthate) deliver a dose of Testosterone which is designed to deliver treatment over the course of 2-4 weeks with a single dose.

Is Hormone Replacement Therapy Right for Me?

The only way to establish a clinical need for Hormone Replacement Therapy is to establish contact with a reputable Hormone Clinic and undergo medical assessment to determine your need for HRT Treatment. If your blood tests and physical determine that you are a candidate for Testosterone or HGH Restoration, both hormones can lead to potentially miraculous changes in your health and wellness.

Don't be timid when it comes to your well-being. If you think you may benefit from Hormone Restoration and Optimization, there are licensed and board-certified professionals across the country that can help!

Sermorelin Frequently Asked Questions

The goal of this article is to help you become better informed about a new form of Hormone Treatment known as Sermorelin Acetate Therapy. This article serves as a reference point to help you become more knowledgeable about this highly beneficial therapy.

Question: What is Sermorelin Acetate?

Answer: Sermorelin Acetate is a hormone derivative that spurs the natural secretion of endogenous Human Growth Hormone by the pituitary gland. Sermorelin Acetate serves as the functional equivalent of a hormone produced by the hypothalamus known as Growth-Hormone Releasing Hormone. GH-RH is also often referred to as Growth Hormone Releasing Factor.

Although Sermorelin and GH-RH are not biologically identical, they are functionally identical, meaning that the two molecules produce the exact same effects in the human body, despite being arranged in different configurations. Sermorelin and GH-RH share the same initial sequence of amino acids, but Sermorelin Acetate is truncated, meaning that the hormone sequence is cut short. Scientific researchers found that by producing a bio-synthetic hormone which only contains the first twenty nine amino acids of Growth Hormone-Releasing Hormone, they could create a potent medication that is cheaper to produce while maintaining the exact same medical effect upon the human body.

Sermorelin Acetate was isolated and invented by Nobel Prize Winners Andrew Schally and Roger Guillemin. The chemical configuration of GH-RH is referred to as GRH 1-29 NH 2. GRH 1-29 is the active sequence of Growth Hormone-Releasing Hormone. The NH-2 refers to a closing sequence which is inert and serves to tie off the end of the molecule.

Question: What is the difference between Sermorelin Acetate and HGH?

Answer: Many people get this somewhat confused, thinking that because Sermorelin Acetate increases internal levels of Human Growth Hormone, that Sermorelin is actually a form of HGH. This is untrue. Sermorelin is a hormone which scientists label a secretagogue. Secretagogues are hormones produced by the brain which stimulate other hormones to be produced. They serve as intermediary messengers which move the message along to target organs and tissues in the rest of the body.

GH-RH is released by the pituitary gland and flows through a series of blood vessels in the brain known as the epiphyseal portal system. Upon reaching the Anterior Pituitary Gland, Growth Hormone Releasing Factors then stimulate organs known as somatotrophs within the pituitary to manufacture and secrete Human Growth Hormone to circulate to the liver and other organs. Sermorelin Acetate imitates the function of GH-RH, producing a biologically identical response when is reaches the somatotrophs.

Sermorelin is a much smaller hormone than both GH-RH and Human Growth Hormone. Sermorelin contains 29 amino acids, whereas GH-RH contains 45. HGH dwarfs both of these hormones in size, as it is comprised of 191 amino acids!

Question: Health Stores and Online Websites often advertise supplements known as Human Growth Hormone Releasers. These supplements are available over the counter and do not need a prescription. Are these supplements similar to Sermorelin?

Answer:Absolutely not. Supplemental HGH Releasers are most often component amino acids which comprise Human Growth Hormone, including L-Dopa, Glycine, L-Ornithine, L-Glutamine, and L-Arginine. Other chemincals are also marketed as HGH Releasers, including Tribulus Terrestris, Macuna Pruriens, and Ornithine Alpha-Ketoglutarate.

It is true that these amino acids do have a stimulative effect upon HGH production, but they are not healthy for the body and do not produce a strong enough benefit to in any way warrant the risk. HGH Releasers work (if they truly work) by creating an increased level of overall activity throughout the brain. This increased level of activity does have a slightly stimulative effect upon Human Growth Hormone Levels, but it also stimulates other activities, but positive and negative, throughout the brain.

HGH Releasers Do Not Work As Advertised

Many medications labeled as HGH Releasers are completely ineffective, veritable snake-oil products. Supplements are not certified for effectiveness in the same way as medications such as Sermorelin Acetate and Bio-Identical Human Growth Hormone, so there is not necessarily a proven or guaranteed medical benefit to using the supplements. At best, HGH Releasers stimulate a Growth Hormone release that is just about equivalent to exercise, and at worst, you'll damage your liver and experience no benefits at all.

Also, Growth Hormone Releasers produce incredibly unreliable effects, because different areas of the body and brain may experience different levels of response every time you take the pill. High Doses of Growth Hormone Releasers can lead to liver and kidney issues, as the human body does not have the capacity to process extremely high levels of unprocessed amino acids without accumulating damage in the filtering and processing organs of the human body.

Sermorelin Acetate produces real and beneficial effects with minimal risk of side-effects. Sermorelin Acetate Therapy has an incredibly safe track record and has been proven to be effective at treating Adult-Onset HGH Deficiency.

Question: I've read a bit about Human Growth Hormone Replacement Therapy, and it seems to be perfectly capable of resolving issues surrounding HGH Deficiency and Hypopituitarism. What would make me choose Sermorelin Therapy over Bio-Identical HGH?

Answer: There are a number of reasons why a patient would choose Sermorelin Acetate over Recombinant Growth Hormone, although both certainly have their place as treatment options. Both HGH and Sermorelin are capable of producing the same exceptional benefits to the human body, but they share a couple of profound differences as well.

Sermorelin Imitates Normal Physiological Processes

First, Sermorelin Acetate functions in a manner which is more streamlined with the actual function and overall needs of the human body. You see, when you use Growth Hormone HRT, there are no safeguards which protect the body against accidental overdose. Any Human Growth Hormone injected into the body directly cycles through the liver and the body and stimulates the body. Sermorelin, on the other hand, as an Growth Hormone Secretagogue, can be affected by processes known as Negative Feedback Mechanisms. Negative Feedback Mechanisms kick in when the body sends signals to the brain that Human Growth Hormone Secretion has satisfied the needs of the body.

Upon receiving these signals, hormones known as somatostatins block GH-RH and Sermorelin from reaching the Pituitary, preventing excess secretion of Growth Hormone. Because Sermorelin works according to the normal physiological rules of the human body, it is almost impossible to overdose on Human Growth Hormone via Sermorelin Injection. Other patients may choose Sermorelin Acetate in order to avoid the temptation to overdose on or abuse HGH.

Sermorelin Releases Episodic HGH

Another benefit that Sermorelin Acetate Injections have over Human Growth Hormone Injections is that they are processed by the body in different patterns. Although HGH and Sermorelin ostensibly accomplish the same goals, Human Growth Hormone Injections supply a relatively constant level of HGH Release over time, which is not actually how the body produces Human Growth Hormone. HGH Release is categorized by a function known as Square Wave release. Square Wave means that HGH concentrations rise to a peak during the course of the day, plateau, and drop back down to baseline. This can cause a problem over time, inducing a medical response known as Tachyphylaxis.

Tachyphylaxis can be understood most simply as a decrease in sensitivity due to outside pressures. The body can sometimes slowly recognize that HGH is being provided by an outside source and the body builds resistance as a response. Sermorelin releases Human Growth Hormone via an episodic pattern which more closely resembles the natural pattern of release by the human body. The pituitary only releases Human Growth Hormone when the body is ready for it, thus significantly reducing the threat of internal resistance to increased levels of HGH.

Sermorelin Preserves the Normal Hormonal Equilibrium

A third Benefit to Sermorelin Acetate, related to the second, is that Sermorelin Acetate more appropriately preserves the Neuroendocrine Axis. The Neuroendocrine Axis is the cascade of hormone release throughout the body. Simply put, all hormones released by the human body have a certain impact on the release of other hormones. Injecting HGH directly into the body on a daily basis can actually suppress the body's natural ability to produce it's own Human Growth Hormone, which can effect the release of other hormones as a result.

Sermorelin Acetate makes less of a physiological imprint onto the endocrine system, meaning that it more naturally resolves hormonal deficiency while causing minimal impact on the normal function of other hormones and systems of the body.

Sermorelin Available for Off-Label Use

A fourth and final benefit of Sermorelin Acetate is less physiological and more technical. Sermorelin Acetate Hormone Replacement Therapy is not as tightly regulated as Human Growth Hormone Replacement Therapy. The FDA prohibits the use of Human Growth Hormone for off-label uses, whereas Sermorelin Acetate can be used off-label at the discretion of the prescribing physician.

Question: I understand that Human Growth Hormone can only be delivered via Injection. Is this also true for Sermorelin Therapy?

As of 2013, Subcutaneous Injection is the only effective method to administer Sermorelin Acetate . Like, Human Growth Hormone, the Sermorelin Acetate molecule is too large to breach other barriers of the human body at this date. On the bright side, since Sermorelin is significantly smaller than Bio-Identical HGH, there is a hypothetical chance that Sermorelin may one day be administer by breaching the mucous membrane barrier using a nasal spray. This method is currently being tested and may be effective at some point in the near future.

Question: Do Sermorelin and Human Growth Hormone Injections require similar doses to be effective?

Answer: Even though HGH and Sermorelin activate in different regions of the body (Sermorelin in the anterior pituitary, Human Growth Hormone in the liver) the volume of hormone that is required in order to sufficiently increase endogenous IGF-1 production is nearly identical. Human Growth Hormone is most commonly prescribed at doses which vary between one and two international units. Sermorelin Acetate is generally administered with a dose of two hundred micrograms daily.

Question: How much does Sermorelin cost in comparison to HGH?

Answer: Per vial, Sermorelin is a good bit cheaper than Human Growth Hormone. In addition to this, a single vial of Human Growth Hormone takes twelve to fourteen days to fully administer, whereas a single vial of Sermorelin takes fifteen days to fully utilize.

Question: In many patients, the benefits of Human Growth Hormone start to fade of the course of continual use. Why does this happen, and does Sermorelin lose potency as well?

Answer: The human body can develop a resistance to HGH Hormone Replacement Therapy over time. If this has occurred to you, the change in effectiveness is not the result of any inadequacy of the medicine itself. Human Growth Hormone Injections increase serum levels of Growth Hormone to levels which are higher than normal for a number of hours every day, although the average release across the day is medically appropriate.

HGH Up-Regulation and Sermorelin Down-Regulation

In addition to this, Human Growth Hormone Therapy leads to a stable release of IGF-1 throughout the body, slowly rising and falling in the body through the course of the day. This causes the tissues of the body to have a steady supply of IGF-1 throughout the day, rather than receiving the hormone in the normal bursts in which it is accustomed to. As a result, IGF-1 Receptors in the tissue have a tendency to go through a hormonal process known as down-regulation in order to preserve normal function. This means that the target tissues become desensitized to IGF-1 and Human Growth Hormone exposure, reducing the effectiveness of the hormone treatment.

When the body is functioning normally, Human Growth Hormone is released naturally from the pituitary gland in a number of short, brief, and potent bursts, which supply the body with sufficient levels of IGF-1 and Human Growth Hormone while also giving the receptors time to rest between periods of hormone release. If outside hormone release properly imitates the natural processes of the body, this gradual down regulation does not occur, and the benefits of increased HGH production do not decline in the same manner over time.

Because of the influence of Somatostatin, described above, Sermorelin Administration only leads to the optimal release of Human Growth Hormone. Sermorelin actually has the ability to make the pituitary stronger, through a process of up-regulation which strengthens its health by increasing the level of HGH it produces on a daily basis.

Question: Does Sermorelin Acetate provide any benefits for patients suffering from Adult-Onset HGH Deficiency that are not directly related to its effect upon the endocrine system?

Answer: Yes. There is a large body of evidence that shows that Growth Hormone-Releasing Hormone and Sermorelin Injections directly have the capacity to increase sleep quality and promote the increased experience of the deepest stages of sleep, which are the most rejuvenative and beneficial to health and wellness.

Question: What is the normal administration protocol for Sermorelin Hormone Therapy?

Answer: Sermorelin is delivered once each day via injection. Sermorelin is normally administered just before bed in order to more closely mimic the natural hormone production of the body. Sermorelin is intended to supplement the body's own natural production of Growth Hormone-Releasing Hormone, which occurs primarily at night.

The Sermorelin Dosage that the patient is described will be dependent upon the physiological needs of the individual. Sermorelin Shots are provided in vials which contain multiple doses The vial will contain enough Sermorelin in order to treat the patient for at least fifteen days.

The Conscious Evolution Institute

If you have any other questions about Sermorelin Acetate, Human Growth Hormone Shots, or any other hormone treatments, we would be happy to provide you with answers to any questions you may have.

Different patients respond differently to treatment, and some patients respond more actively to Human Growth Hormone Replacement Therapy than Sermorelin Acetate. If you choose the Conscious Evolution Institute, our knowledgeable and top-of-the-line staff of physicians and longevity specialists will help you decide which treatments are right for you!