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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 13 May 2021
Our bodies depend on the immune system for survival. The immune system is critical to protect against diseases and other foreign invaders. Unfortunately, the human immune system is also prone to over-activity. Millions in America deal with auto-immune disorders, which range from frustrating to life-threatening. While women are more likely to experience auto-immune issues, individuals of both sexes frequently experience these health problems.

Gender Differences in Chronic Inflammation

Jonathan Busada of West Virginia University is interested in exploring the mechanisms which lead to inflammation and how sexual differences cause men and women to experience inflammation differently. Women, in particular, are more prone to stomach inflammation than men. In his research, he found that androgens likely help to protect against problematic gut inflammation. This research was revealed in the medical journal Gastroenterology. Busada is specifically concerned with how inflammation influences the onset of stomach cancer. In most cases, stomach cancer results from chronic inflammation of the gut. Busada explains that there is a difference between healthy immunity and an overactive immune system. The immune system is designed to protect the body, but it can do more harm than good when it goes into overdrive. This sort of research helps scientists understand the difference between a healthy immune response and destructive inflammation and what factors lead the body down the path of harm. Busada's work shows that Testosterone is a powerful force to reign in inflammation and help the immune system perform its duties more efficiently and effectively.

Animal Research Tests the Effects of Testosterone on Inflammation

Busada explored the effects of both Testosterone and Glucocorticoids on stomach inflammation, with a focus on Testosterone. This study focused on animal research with mice. Glucocorticoids are adrenal hormones secreted by mammals. Cortisol is an example of a human glucocorticoid and is the most influential. Mice do not produce Cortisol but produce biologically similar hormones which serve the same purpose. Glucocorticoids are made in the same way by both men and women but can be influenced by sex hormone activity. Professor Busada first worked with mice that produced neither Testosterone nor Glucocorticoids. Researchers found that without the influence of these hormones, inflammation rates remained equal between male and female mice. When treated with Testosterone, on the other hand, inflammation disappeared. This research showed that female mice only have natural inflammation protection via glucocorticoids. In contrast, the male rats were protected further from inflammation due to the benefits of Testosterone, in addition to glucocorticoids.

Women at Increased Risk of Autoimmune Disorders

This research helps to explain why women are more at risk for auto-immune conditions than men. It's estimated that women experience 80% of Auto-Immune Disorders. Women have triple the chances of experiencing rheumatoid arthritis and have more than twice the risk of celiac disease, as examples. Stomach cancer is of particular concern because it's one of the most deadly forms of cancer in the world today—third behind colorectal cancer (2nd) and lung cancer (1st). Treating stomach inflammation can help patients across the globe mitigate their risk of stomach cancer, and Testosterone Therapy may be a tool at doctors' disposal.

Testosterone as Anti-Inflammatory

There's a chance that specialized Testosterone or Androgen treatments could help women improve their resistance to inflammation. This also shows the importance of being tested for Low-T, as waning Testosterone Levels in men can have an adverse impact on the functional performance of the immune system. While women are more prone to stomach inflammation, men are at greater risk of stomach cancer which is largely encouraged by inflammation. This research lays the groundwork for our understanding of how stomach inflammation is impacted by androgen activity. Further study will give medical professionals the knowledge and tools that they need to create effective therapies. For now, the results offer more evidence regarding the importance of Endocrine Balance for a healthy immune system.


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 11 May 2021

Hormone balance can be a fickle thing to maintain, especially as you age, or as a woman, during and/or after menopause. Women are very sensitive to hormonal changes, mostly because so many hormones are involved in reproduction and the menstrual cycle. Menopause, aging and lifestyle tends to wreak havoc on the delicate balance of hormones in a woman’s body, however. Here are the signs and symptoms to look out for if you suspect hormone imbalance.

What are Hormones Again?

Hormones are chemicals that are produced by several different glands and tissues throughout the body, being part of the endocrine system. Hence why the study of hormones is called endocrinology. Hormones are chemical messengers that travel through the body to organs and cells to tell them what to do and when. Aren’t our bodies amazing?

Hormones regulate sexual function, appetite, body temperature, metabolism, sleep, mood and stress levels, heart rate and more. They are incredibly important and if even just one hormone becomes significantly lowered or raised out of its normal range, problems will most likely arise.

Signs of Hormone Imbalance in Women

Excess Weight Gain: Excessive weight gain is often triggered by hormone imbalance. It seems like the weight came on quick and is incredibly difficult to lose. As said before, hormones play a big role in metabolism, as well as the nervous and reproductive systems. All three of these are involved in maintaining a healthy weight.

The hormones mainly to blame are increased oestrogen, cortisol and insulin, as well as low levels of thyroxin. Throughout a woman’s menstrual cycle, oestrogen levels naturally increase and this can cause women to crave and eat more fatty or sugary junk food.

Increased levels of the stress hormone, cortisol, slows down metabolism. Consider incorporating meditation or a calming exercise, daily, to reduce cortisol levels. Lowering sugar intake also helps with this as well as regular exercise.

Hormonal acne: Many women experience skin breakouts right before and/or during their menstrual period. In fact, about 50% of women in their twenties experience hormonal acne, as well as 25% of women in their forties who are about to experience menopause.

It’s normal for these breakouts to go away once menstruation is over and hormone levels fluctuate back down, but women who have excess androgens may experience chronic hormonal acne. This includes whiteheads, cysts, blackheads or just general redness and inflammation.

Androgens are male hormones such as testosterone and these can make the skin produce extra oil which clogs pores, causing acne. In addition, high androgens may be caused by excess insulin (another hormone). To combat this, you may need hormonal contraceptive pills or anti-androgen pills. To soothe inflammation, corticosteroids can help temporarily. Weight loss can prevent insulin resistance.

Mood Swings: One of the most common (and make fun of) symptoms of PMS is moodiness. Menopausal and pregnant women are also known to experience moodiness. Mood changes include anger, sadness, depression, irritability and anxiety and are mostly caused by fluctuations in oestrogen levels. Oestrogen affects neurotransmitters such as dopamine, norepinephrine and serotonin.

Some doctors prescribe hormonal birth control pills to control moodiness in extreme cases. Relieve mood swings naturally by engaging in regular exercise, avoiding stimulants (caffeine, sugar), taking calcium supplements, getting enough sleep and eating smart.

Digestive Issues: Oestrogen imbalances commonly lead to frequent stomach upsets. The gastrointestinal tract actually has receptors for both oestrogen and progesterone. If either of these are out of balance, symptoms such as abdominal pain, constipation, bloating, nausea and diarrhea may result. This could be the reason why women experience IBS more than men as they are twice as likely to have it. It’s interesting to note that male hormones such as testosterone have been seen to have protective effects against IBS.

Hormonal birth control pills do not seem to relieve digestive issues resulting from hormone imbalance. Try taking magnesium supplements or eating magnesium-rich foods to relieve constipation and get your digestive tract running smoothly. The foods to eat are whole grains, sweet potatoes, leafy greens, bananas and fish. Try incorporating fermented foods in your diet as well as ingesting enough fiber.

Low Sex Drive: Low testosterone levels are to blame here. Testosterone actually plays a major role in the sex drives of women, not just men. One study showed that postmenopausal women who reported low libido had increased sexual desire after being given testosterone. They also reported more satisfying sexual experiences. It’s critical that testosterone is taken under the supervision of a doctor or endocrinologist because women do not need high doses of the hormone – unwanted side effects such as unwanted hair growth and other masculine traits may result.

Besides testosterone replacement therapy, other ways to increase your libido include maintaining a healthy diet and engaging in regular exercise.



The Standard


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2021

Belly fat is stubborn and frustrating. Resculpting the body to get rid of body fat is not a simple and easy task, though it is certainly not impossible. One of the reasons why it is so hard to burn belly fat is that your body primarily uses the midsection as its storage unit for fat. Hormone Balance helps us avoid the buildup of belly fat. It's also true that, as we get older, we become more prone to hormone imbalance as levels of HGH and Testosterone fall into decline. In women, the changes associated with Menopause also contribute heavily to increased body fat. What it comes down to is that the older that you get, the harder that it becomes to stay lean. Body fat can become especially stubborn when folks reach their forties and fifties. This is the period when the decline of important hormones often becomes noticeable and problematic.

Sources of Hormone Imbalance Associated with Belly Fat

Hormone Imbalance is often multifaceted, and the accumulation of body fat is often the result of multiple sources of imbalance. The following are several hormones and how they are associated with belly fat: Testosterone – Testosterone is intimately associated with masculinity and male optimal function. Testosterone helps maintain muscle mass. The more lean muscle that you have, the higher your basal metabolism, which protects against body fat. Testosterone Levels decline when men get older, which reduces metabolism and muscle mass and makes it easier for belly fat to stick around.

Estrogen – Estrogen is most important for women but also plays a critical role in men's health (in small doses). Men produce Estrogen from body fat. The more fat accumulates, the more Estrogen that they will make. Unfortunately, Estrogen is also a limiting factor on Testosterone Production. This is one of several feedback loops associated with obesity. Belly Fat increases Estrogen, which Suppresses Testosterone. Lower Testosterone makes it easier to gain weight which further increases the influence of Estrogen.

Insulin – Insulin is the tool that the body uses to capture free glucose from the bloodstream and transport it to fat cells for storage. Insulin resistance leads to weight gain because the increased concentrations of Insulin in the bloodstream make it harder to free energy stored as body fat.

DHEA – DHEA is a precursor hormone produced by the Adrenal Glands, which is integral to the production of Estrogen and Testosterone. Healthy DHEA activity helps ward off belly fat by promoting healthy Sex Hormone Production and improving the body's responsiveness to Insulin.

Cortisol - Cortisol is the body's key stress hormone, associated with both physical and psychological stress. Cortisol initiates fight-or-flight response and stimulates activity. Cortisol is critical to health but also very prone to imbalance. Chronic Stress causes Cortisol Levels to skyrocket, depleting the building blocks that would normally be available to produce Testosterone and other hormones that are important to stave off body fat. Cortisol both increases appetite and increases Insulin, meaning that you eat more calories, and your body is more prone to storing them as fat.

Ghrelin – Ghrelin is the hormone most directly associated with the sensation of hunger. Ghrelin is responsible for increasing appetite, and high levels of Ghrelin also encourage you to both eat more and store more calories as fat. Crash diets significantly increase Ghrelin production, which contributes to the long-term failure of extreme diets. Ghrelin increases the production of HGH, which helps break energy free from body fat. Intermittent Fasting and other diets which allow for moderate Ghrelin activity are good for weight loss, but extreme diets are counterproductive.

Adiponectin – Adinopectin stimulates weight loss and the breakdown of body fat. Obesity reduces Adinopectin activity. Adiponectin Levels are adversely affected by high levels of Insulin, blood sugar, and body fat. The body's fat-burning power is directly correlated with healthy glucose/Insulin dynamics.

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