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MANAGING CARDIOVASCULAR RISKS ASSOCIATED WITH PROSTATE AND BREAST CANCER


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 30 April 2021
Hormone Therapy is a highly effective means to treat various forms of cancer, especially Prostate Cancer and Breast Cancer. In spite of their effectiveness, however, these treatments come with their own long-term risks. The American Heart Association recently provided a statement regarding these risks in Circulation: Genomic and Precision Medicine. For example, HRT Regimens designed to treat Prostate/Breast Cancer also increase the chance of dangerous cardiovascular dangers such as stroke and heart attack. According to the American Heart Association, these risks can be greatly mitigated with sufficient awareness and preliminary evaluation. This report offers updated information regarding the complications associated with various forms of Hormone Therapy. The report is designed to help medical specialists treat cancer effectively while managing the downstream risks associated with Hormone Replacement Therapy.

Breast and Prostate Cancer Treatments Improving

Breast Cancer is the most common kind of cancer in the United States, accounting for 30.3% of cancers in women. Among males, prostate cancer is the most common, at 21.5% of all male cancer diagnoses. Aside from skin cancer, most common cancers are associated in some way with hormones. As cancer therapies become more advanced, fewer patients succumb to the cancer itself. In fact, among those patients under HRT Treatment for hormone-dependent cancer, cardiovascular disease is the leading mortality risk.

Common Treatments for Breast and Prostate Cancer

Three of the most common Endocrine Treatments for cancer are Selective Estrogen Receptor Modulators, Aromatase Inhibitors, and Androgen Deprivation Therapy: SERMs are designed to eliminate tumor development by preventing cancer cells from feeding off of Estrogen. These treatments allow Estrogen to act normally in other parts of the body like liver/bone tissue without acting on breast tissue. Two common SERMs are ralloxifene and tamoxifen. Aromatase Inhibitors suppress the production of Estrogen and are commonly prescribed to women after menopause, especially high-risk patients. Letrozole, anastrozole, and exemestane are prominent examples of Aromatase Inhibitors. Androgen Deprivation Therapy refers to treatments designed to treat prostate cancer by cutting off access to the fuel source of Testosterone. This category is more broad. Some prescriptions block Testosterone from Prostate Cancer Cells (and prostate cells themselves). Another option includes medications that suppress the hypothalamic/pituitary activity which triggers Testosterone production.

Cardiovascular Complications Associated with Cancer Treatment

Unfortunately, all of the treatments above can have negative consequences for the cardiovascular system. For example, Aromatase Inhibitors are known to increase heart attack and stroke risk, and Tamoxifen can lead to blood clots. Because cancers can become resistant to certain treatments, sometimes patients have to change therapies for best results against the cancer. Unfortunately, while this improves cancer outcomes, it also further increases the odds of cardiovascular problems, including blood clots, arrhythmia, and high blood pressure. In men, Androgen Deprivation Therapy causes them to experience the full gamut of issues associated with Low-T, including impaired glucose metabolism, increased body fat, and heightened triglyceride/cholesterol levels. For all of the above treatments, the longer a patient is on the regimen, the greater the risks associated with the therapy. Researchers are investigating exactly how duration impacts risks. HRT Therapy for Cancer was riskiest for patients diagnosed with heart disease and those with multiple risk factors (including history of stroke/heart disease, smoking, high cholesterol, obesity, and high blood pressure). The American Heart Association published this report to help doctors and patients understand the risks associated with Prostate/Breast Cancer Treatment and the cardiovascular precautions that should be taken to maximize outcomes for patients. In the near future, there will hopefully be official guidelines to help doctors navigate the heart risks associated with HRT-Based Cancer treatment. Any patient that could benefit from Hormone Therapy for Cancer should first be directed to a cardiologist for testing and consultation.

SCIENTIFICALLY PROVEN BENEFITS OF TURMERIC THE INDIAN SPICE


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 27 April 2021

Turmeric is a yellow spice commonly found in Indian and other Asian cuisines but Americans and Europeans have been using this spice more and more after hearing about its amazing benefits for health. No wonder turmeric has been used for thousands of years as a spice and medicinal herb! The most famous Indian dish, curry, is where turmeric stands out. Turmeric is what gives curry its yellow color.

 Turmeric really does contain compounds that have medicinal properties, as scientists have recently discovered. These compounds are bioactive and are called curcuminoids with the most important one being curcumin. It is the main active ingredient in turmeric and has very powerful anti-inflammatory effects and is also a potent antioxidant.

 Turmeric contains only about 3% curcumin, by weight. The studies that have found curcumin to be so anti-inflammatory used turmeric extracts that concentrates the curcumin to over 1 gram a day. This is very hard to reach just using turmeric as a spice in your food. Therefore, to see the anti-inflammatory and antioxidant effects of curcumin, you’ll need to take a supplement. In addition, it’s best to eat black pepper with your supplement to better absorb the curcumin (by 2,000%!).

Curcumin: Natural Anti-Inflammatory Compound

 Scientists believe that chronic, low-level inflammation plays a huge role in most of the chronic, Western diseases we see today. These include cancer, metabolic syndrome, heart disease, Alzheimer’s and other degenerative conditions. All of these are pretty scary diseases and it’s wonderful that we’ve found a compound that combats chronic, low-level inflammation effectively.

 In fact, curcumin is so powerful, it matches the effectiveness of some anti-inflammatory drugs, but without the side effects! Great news!

Specifically, curcumin blocks NF-kB, a molecule that travels to our cells, to our nuclei and turns on genes that are associated with inflammation. Take some curcumin and stop that sucker in its tracks!

Turmeric Improves Antioxidant Capacity

 Free radicals, the highly reactive molecules that wreak havoc on our bodies, are presumed to be behind aging/premature aging and multiple diseases. These molecules damage our cells and DNA, reacting with organic substances such as fatty acids.

 We need antioxidants to protect us from these free radicals. Thankfully, we have plant foods – veggies and fruits – that are chock full of antioxidants. In addition, we also have curcumin which is VERY potent, neutralizing free radicals on its own while also boosting the activity of your body’s own antioxidant enzymes. Win-win!

Curcumin Boosts Brain Function

 We now know that brain cells (neurons) are capable of forming new connections well past childhood, even multiplying and increasing in number. A neurotrophic factor called BDNF is a type of growth hormone of the brain. Diseases such as Alzheimer’s and depression have been linked to low levels of the BDNF hormone.

 The good news is that curcumin is capable of increasing the levels of BDNF in the brain, possibly delaying or even reversing brain ailments and cognitive decline. Curcumin could also improve your memory and make you smarter.

Curcumin certainly sounds amazing, doesn’t it? If you have history in your family of any of the diseases or ailments discussed in this article, consider seriously getting a good curcumin supplement and adding turmeric to your diet. The science certainly backs up many of these claims discussed here, especially with curcumin supplements. Nobody wants to experience Alzheimer’s, cancer or heart disease so be proactive and consider all possibilities of prevention!

Reference

Healthline


HYPERTENSION-ASSOCIATED CARDIOVASCULAR RISKS INCREASE DUE TO BOTH LOW-T AND HIGH TESTOSTERONE


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 22 April 2021
A recent Chinese study provides evidence that Hypertension is associated with suppressed Total Testosterone, Free Testosterone, and SHBG Levels in older men. The results were released in a recent edition of the Journal of the American Heart Association. Clinical evidence shows that both Elevated Testosterone and Low Testosterone are potentially threatening risk factors for dangerous cardiovascular events.

Testosterone, Aging, Diabetes, and Cardiovascular Disease

Testosterone Levels naturally drop as an element of the male aging process. While this decline is natural, the body still requires a certain level of Testosterone to promote optimized health. On the other hand, there is also significant evidence that cardiovascular disease and diabetes both result in significantly reduced Testosterone Levels resulting from the conditions themselves. Many health conditions suppress Testosterone, which creates a negative feedback loop where Low-T exacerbates the existing disorder, further dropping Testosterone Production. For that reason, researchers continue to take steps to identify ideal Testosterone Levels as a factor of age. Millions of men can undoubtedly benefit from Testosterone Therapy, but it's essential to identify the high and low Testosterone Thresholds which provide the maximum benefit for the least risk.

Chinese Study Evaluates Correlation between Testosterone and Hypertension

In order to broaden our knowledge of how Testosterone interacts with Cardiovascular outcomes, Chinese researchers conducted a broad study that included 6296 participants, selected between the years of 2013 and 2016. Patients were evaluated clinically, provided basic patient information, and filled out health questionnaires. During clinical evaluation, doctors obtained a number of data points, including levels of Free Testosterone, Total Testosterone, Luteinizing Hormone, and SHBG, along with blood pressure. In the end, the scientists used data collected from 5786 of the original 6296. The collection of patients were an average of 55 years old, and 37.2% suffered from clinical Hypertension. When looking at all of this data together, researchers were able to make some critical observations. Hypertensive patients were more likely to have lower SHBG, Free Testosterone, and Total Testosterone. SHBG is responsible for the transport of Testosterone for use by the body. Total Testosterone refers to all bound and unbound Testosterone in the bloodstream. Free Testosterone is biologically active Testosterone readily available for use by cells.

Healthy Testosterone Levels Associated with Strong Hearts

Using advanced statistical analysis, researchers were able to determine that Total Testosterone was most strongly correlated with cardiovascular risk. Testosterone is critical to male cardiovascular health because it plays a vital role in vascular constriction and relaxation. Impaired Testosterone Levels had the worst effects on patients under 65 with a BMI less than 24. Patients that smoked and/or had a family history of high blood pressure were most likely to have suppressed Testosterone and high blood pressure. On the other hand, elevated Luteinizing Hormone Levels were associated with an increased risk of Hypertension. High Luteinizing Hormone Levels combined with Testosterone Deficiency is the physiological marker for Primary Hypogonadism and is considered to be a big risk factor for Cardiovascular Disorder. Hormone Balance is one of the keys to good health. Both Low-T and abnormally high Testosterone lead to increased cardiovascular risk. This is why getting appropriate treatment for Low-T is so important.

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Testosterone Therapy Benefits

Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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