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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 11 April 2017

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One Third of Type-Two Diabetics Suffer from Testosterone Deficiency

A new study shows that young male patients with Type-Two Diabetes have a significantly high risk of developing Testosterone Deficiency at an early age. This study shows that around one in three patients between the ages of 18 and 35 suffer from Clinically Low Levels of Testosterone.

Diabetes-Testosterone Study Information

The primary investigator in this study was Dr. Paresh Dandona. He and his associates performed their research at the New York State University of Buffalo. This study compared 62 diabetic patients. 24 of the men had been previously diagnosed with Type-Two Diabetes and 28 of the participants were males with Type One Diabetes.

Blood testing revealed that patients with Type-Two Diabetes had much lower endogenous Testosterone Levels than the male patients with Type One Diabetes. 33% of the subjects with Type-Two Diabetes were found to have clinically low levels of Testosterone, and 58% of this group had Testosterone levels which were abnormally low in comparison to healthy patients. Type-One Diabetes patients did not suffer from this clinical medical issue, however. Only 8% of Type-One Diabetics were found to have Testosterone levels which were at all abnormal.

Testosterone Deficiency Linked to FSH Deficiency and Luteinizing Hormone Deficiency

Patients in this study that were found to have low levels of Testosterone were also shown to have medically low levels of Follicle-Stimulating Hormone and Luteinizing Hormone. As a result of this, these patients clinically suffered from a disorder known as Hypogonadotrophic Hypogonadism. This disorder greatly enhances the risk of a number of medical disorders if left untreated, including cardiovascular disease and osteoporosis. Other symptoms of Hypogonadotrophic Hypogonadism include infertility, impotence, and lack of libido.

Type-Two Diabetics are High Risk Patients for Low Testosterone

In the end, the researchers came to the conclusion that young patients suffering from Type-Two Diabetes are an incredibly at-risk subset of the population for suffering from Low-T, even in their twenties. Both Free Testosterone levels and Total Testosterone levels are significantly affected. As a result of this deficiency in combination with deficiencies of Luteinizing Hormone and Follicle-Stimulating Hormone, these patients are at a high risk of a number of cardiovascular and sexual medical conditions and need to be treated with Testosterone Hormone Replacement Therapy in order to minimize health risks and help them live a healthier and more fertile life.

Facts About Testosterone Deficiency

Testosterone Deficiency is a very common symptom of both diabetes and obesity. Around one third of males with Type-Two Diabetes will also suffer from the symptoms of Testosterone Deficiency as a result. The clinical term for Low-T is known as Hypogonadism.

Symptoms of Low-T

There are a number of symptoms related to Low Testosterone. Among these symptoms are:

Decreased sex drive Low Testosterone reduces sexual desire in males, leading to bedroom dissatisfaction and contributing to rocky relationships

Depression Testosterone plays a significant role in male mood stabilization. Males who suffer from Hypogonadism are more likely to experience feelings of sadness and depression that they are unable to shake.

Fatigue and exhaustion Testosterone is a vital component of male metabolism. Although Human Growth Hormone directly causes enhanced metabolism, Low Testosterone causes problems with muscle strength and cardiovascular stamina.

Bone health deterioration Patients who suffer with Low-T are at an increased risk of bone disorders such as osteoporosis. Loss of Bone Mineral Density can even make you grow shorter over time!

Reduced strength Testosterone is directly responsible for the differences in muscle strength and muscle mass that separate males and females. Testosterone has the ability to amplify the effects of weight training and muscle building. Men who suffer from Low-Testosterone lose their ability to generate and sustain additional muscle.

Decreased erectile sensitivity Healthy Testosterone Levels are necessary for men to experience optimal pleasure in sexuality. Patients with Low-T often complain the sex just doesn't feel like it used to, which puts a damper on sex drive and libido.

Fertility Testosterone is an important factor in the production of healthy sperm. Individuals with low levels of Testosterone have lower sperm counts than those who have healthy Testosterone levels. In addition to this, normal Testosterone levels are vital for healthy and fully functional sperm.

Smaller testicles One of the most obvious visible symptoms of Testosterone Deficiency is testicular shrinkage. Without sufficient levels of Testosterone, the Testicles are not as healthy or functional, and one of the ways in which this can be seen is through testicular size and shape.

Reduced sexual ability Men with Low Testosterone even complain that their disorder prevents them from even engaging in satisfying sexual activity. Testosterone is a big part of what allows a man to get turned on, and when Testosterone levels in the body are insufficient, the physiological process which produces a firm, hard erection is hindered.

Increased inflammation Low Testosterone is correlated with increased levels of cortisol, which is the human body's central agent of inflammation, which can cause pain as well as slow the body's natural healing processes.

Low-T Exacerbates Symptoms of Diabetes

Testosterone Deficiency has been shown to make the symptoms of diabetes worse. In addition to this, suffering from Low Testosterone while also dealing with Diabetes can increase the risk of many heart complications such as stroke, cardiovascular disease, and high cholesterol.

Dr. Paresh Dandona and Dr. Sandeep Dhindsa have dedicated their careers to the study of Diabetes and have found a number of critical links between Type-Two Diabetes and Testosterone Deficiency.

Type-Two Diabetes Hastens Declining Testosterone Levels

Testosterone levels naturally decline over time beginning in the late twenties, and this decline continues throughout the lifespan. In otherwise healthy individuals, this decline occurs at a rate of between one or two percent each year, similar to the rate at which Human Growth Hormone levels decline. There are a number of medical conditions which increase the rate at which Testosterone Decline occurs, and there are other disorders which greatly reduce Testosterone Levels very quickly.

Type-Two Diabetes significantly depresses natural Testosterone levels, leading to a number of life changing and potentially dangerous side-effects as a result. Studies like the one we mentioned at the beginning of this article have led endocrine scientists to the conclusion that four out of every ten men who suffer from obesity will have clinically low levels of Testosterone in comparison to males of the same age that are not overweight. When diabetes is thrown into the mix as well, the resulting difference is even more profound. Low-Testosterone levels plague fifty percent of obese males clinically diagnosed with diabetes.

Type-Two Diabetics Suffer Primarily from Secondary Hypogonadism

One may come to the conclusion that the primary correlation here would be between weight and testosterone level, but this is not necessarily the case. Although men that are both obese and diabetic are most at risk of Low Testosterone Levels, there is ample evidence that Type-Two Diabetes significantly reduces Testosterone Levels even in patients who do not suffer from weight issues. This seems to suggest that Type-Two Diabetes seriously inhibits the human body's ability to produce Testosterone is a direct physiological way.

Type-Two Diabetes Equivalent to Twenty Pounds of Fat

Dr. Dhindsa, one of the primary investigators of the study discussed at the beginning of this article, says that Diabetes has an effect on Testosterone Levels that can be correlated with weight gain. He says that those that suffer from Type-Two Diabetes experience a decline in Testosterone levels that is the equivalent of gaining twenty pounds of body fat.

Another study produced by Dr. Dhindsa shows that endogenous Testosterone production declines at a rapid and non-linear rate dependent upon Body Mass Index. The more that an individual weighs, the more likely they are going to suffer from an acute deficiency of Testosterone.

Largest Testosterone-Diabetes Study Ever Conducted

Dr. Dandona and Dr. Dhindsa have been responsible for the largest study regarding Testosterone, Diabetes, and Obesity ever conducted. Before these two doctors began their study, most research regarding Testosterone Deficiency was only concerned with patients who suffered from obesity, or patients who suffered from Diabetes. These two doctors focused on how the two diseases interact and amplify the symptoms of Testosterone Deficiency. In their largest study, they utilized data from the 2003-2004 Hypogonadism in Males study. This clinical study involved over 1800 males from 95 medical clinics. The study was underwritten by the company Solvay Pharmaceuticals.

The scientists recommend that males with diabetes and obesity keep a close eye on their Testosterone Levels. Healthy Testosterone levels are an important part of living a healthy life, and Low-Testosterone can increase the dangers of both diabetes and obesity, while also preventing patients from being able to successfully manage their disease. Dr. Dhindsa's primary goal as a medical researcher is to improve treatment options for male patients who suffer from Hypogonadism and diabetes. Dr. Dandona is primarily interested in the effects and causes of Low Testosterone in younger men who for all intents and purposes should be participating in the most reproductive period of their lives.

Questions about Testosterone Deficiency

What is Follicle-Stimulating Hormone?

Follicle-Stimulating Hormone (often abbreviated FSH) is a member of a group of hormones known as Gonadotrophins. Gonadotrophins are hormones which are responsible for the stimulation of the sexual organs which are vital for healthy sexual function. These hormones are derivatives of Testosterone and Estrogen which promote the normal function of the testes and the ovaries. FSH is both manufactured and secreted by the pituitary.

In females, FSH increases the formation of egg follicles while also stimulating the ovulation process. In males, FSH primarily stimulates a group of cells known as Sertoli cells. These cells are responsible for the healthy development of sperm cells. Low Levels of FSH in adults have no real negative consequences outside of fertility issues, but monitoring FSH levels helps doctors identify the exact source of Testosterone Deficiency. In young boys and girls experiencing puberty, however, low levels of FSH can hinder the proper development of the testes and ovaries, significantly affecting the development of secondary sexual characteristics.

What is Luteinizing Hormone?

Although Follicle-Stimulating Hormone and Luteinizing Hormone are both Gonadotrophins, a deficiency of Luteinizing Hormone is much more harmful to human physiology. Luteinizing hormone is sometimes referred to as Lutropin. This hormone is produced by the pituitary gland by formations known as Gonadotroph Cells. These cells are located in the anterior portion of the pituitary.

In women, Luteinizing Hormone is the base trigger mechanism for ovulation. In males, the hormone is responsible for stimulating the production of Testosterone by triggering the function of Leydig cells. In males, a deficiency of Luteinizing hormone can contribute to a number of negative symptoms, including Testosterone Deficiency and the symptoms inherent with that Deficiency.

A deficiency in Luteinizing Hormone during puberty can delay and limit the natural changes that occur. A Testosterone Deficiency combined with a deficiency of FSH and Luteinizing Hormone is known as Idiopathic Hypogonadotrophic Hypogonadism.

What is Hypogonadism?

Hypogonadism is the blanket term for any disorder which prevents the human body from optimally producing sex hormones such as Testosterone, Estrogen, and Progesterone. Adult-onset Testosterone Deficiency is a form of Hypogonadism which generally results from the slow and steady decreased hormone production of the testes. Hypogonadism as a result of Obesity and Type-Two Diabetes is the result of the conversion of existing Testosterone into Estrogen and Cortisol as well as reduced input from the hypothalamus and pituitary gland.

What is Hypogonadotrophic Hypogonadism?

Hypogonadotrophic Hypogonadism is a form of gonadal deficiency that is the result of an insufficiency of the pituitary gland or the hypothalamus. This range of disorders is also referred to as Secondary Hypogonadism. Primary Hypogonadism is the result of a hormonal deficiency of the sex organs. Adult-onset, age related Testosterone Deficiency is generally related to Primary Hypogonadism. Testosterone Deficiency resulting from Type-Two Diabetes is mostly the result of Secondary Hypogonadism, which is why the disorder is very powerful and not related to normal testosterone decline as a result of aging.

There are a few important steps to normal testicular function. The hypothalamus releases a hormone known as Gonadotropin-Releasing Hormone, abbreviated GnRH. GnRH then flows from the hypothalamus to the anterior pituitary gland. After stimulation, the pituitary gland secretes and releases the hormones FSH and Luteinizing Hormone. These hormones then move through the blood stream down to the male and female sex organs where they stimulate the normal production of sex hormones such as Testosterone and Estrogen as well as other important hormones which control sexual function. If there is a hormonal imbalance at any point between the hypothalamus and the sex organs, this has the potential to greatly alter normal hormone production which can be detrimental to human health.

Although there are some forms of extreme or total Hypogonadotrophic Hypogonadism, Diabetes and obesity produce a moderate form of Hypogonadotrophic Hypogonadism which causes a number of detrimental symptoms which are very similar to Age-Related Testosterone Deficiency as a result of Andropause. Most individuals will not experience the negative effects of Testosterone Deficiency until their thirties and forties, but patients who suffer from Hypogonadotrophic Hypogonadism often experience hormonal issues from birth. Many others, as is the case with those suffering from Type-Two Diabetes, begin to experience the symptoms of Testosterone Deficiency in their early twenties.

What is the importance of these Testosterone Deficiency Studies?

Dr. Dandona's research study sheds a significant amount of light on how Testosterone Deficiency, Obesity, and Diabetes interact. The pathology of Testosterone Deficiency in Type-Two Diabetes does not seem to be related to an insufficiency of the testes, but to issues resulting from hormonal balance resulting from the pituitary gland and the hypothalamus. This causes symptoms of hormonal deficiency which normally do not begin to occur until patients are in their thirties and forties to appear while patients are in their twenties.

Fatigue and exhaustion prevent patients from efficiently engaging in exercise, and changes in muscular metabolism prevent them from building muscle as a result of exercise. Low Testosterone also encourages higher levels cortisol and estrogen, which are incredibly detrimental to male patients and reduce cardiovascular health significantly. Obesity complicates issues with Low Testosterone and Type-Two Diabetes by increasing the rate at which Testosterone is converted into estrogen by the fat cells. Adipose fat tissue naturally has the ability to convert Testosterone into Estrogen and Estrogen-related hormones. The more fat tissue present on the body, the less of an impact endogenous Testosterone produces on the human body.

Scientific evidence shows that Type-Two Diabetes and Obesity are intricately connected in a number of ways, although not all diabetics are obese and not all obese individuals develop diabetes. Diabetes reduces the effectiveness of insulin to process blood sugar which makes it harder to maintain a healthy body weight and deteriorates physical health in a numerous ways. Dr. Dandona's study shows that both obesity and Type-Two Diabetes impact Testosterone negatively via their own unique yet interconnected pathways.

Also, the study shows that Testosterone Hormone Replacement Therapy can be a highly beneficial treatment that alleviates some of the effects of Diabetes while also improving metabolism, boosting energy levels, and encouraging weight loss in order to help obese patients lose weight and improve their BMI.

If you suffer from Type-Two Diabetes we encourage you to monitor your Testosterone Levels closely. Although you may be in control of your insulin levels, you may be allowing Low Testosterone to decrease the quality of your life in significant ways. To learn more about Testosterone Hormone Replacement Therapy, feel free to contact the Conscious Evolution Institute with any questions you may have!


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 29 March 2012

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Boca Raton trainer sentenced for role in prescription drug scheme
Palm Beach Post Staff Writer
Wednesday, July 30, 2008
WEST PALM BEACH รข€” Moments before a judge was to sentence him today for participating in a black market prescription drug scheme, Boca Raton personal trainer Patrick Bronder tearfully pleaded for mercy.
"I'm sorry for what I've done," he said. "I'm not the same person today."
U.S. District Court Judge Donald Middlebrooks then sentenced Bronder, 48, to seven years and three months in prison, followed by three years of supervised release. That was the shortest prison term possible under federal sentencing guidelines, which called for a maximum of nine years in prison.
Bronder pleaded guilty in May to conspiracy to commit mail fraud and engaged in the wholesale distribution of prescription drugs without a valid state license, and to federal income tax evasion.
Bronder and a New Jersey chiropractor bought human growth hormone, cancer medications and other prescription drugs on the black market, then sold them for more than $7 million to a wholesaler during 14 months in 2001 and 2002.
Bronder had more than $3.3 million wired into bank accounts in the Bahamas with the help of his former brother-in-law, authorities said. He paid nearly $326,000 to the government as part of his plea deal. But Middlebrooks imposed no fines on Bronder, saying he doesn't appear to have the ability to pay them.
After sentence was pronounced, Bronder's attorney asked the Middlebrooks if his client could begin serving his prison time later. The judge denied the request. Bronder then removed his coat, blew a kiss to his family and friends and was escorted out of the courtroom.
Source: http://www.palmbeachpost.com/


Recommended by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 23 April 2020

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