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How to age rapidly or not

Written by Dr. Welsh, Published on 03 April 2012

effects of low testosterone health levels

Prevent yourself from the rapid onset of aging!

In this article, we will look at a huge contributing factor to the aging process. What can it inform us about the aging process and can it give us any hints on how to slow the ravage that time has on our health? The factor that we will learn more about today is cortisol, which is a hormone in control of a large number of the vital ongoing functions of our body. When levels of cortisol are too low or too high, the process of aging begins to accelerate.

The Adrenal Gland

The adrenal glands are responsible for cortisol secretion, and the adrenal glands are located above the kidneys. These glands are known for receiving the highest rates of blood flow among all of the other tissues of the body. Also, the adrenal glands contain the highest levels of Vitamin C: more than any other bodily tissues!

Both adrenals are made up of two different functional parts. The outside part, which is known as the cortex, releases hormone types of adenal steroids such as aldosterone, DHEA (precursor to sex hormones), and cortisol. The inner part, known as the medulla, releases adrenalin and norepinephrine. These last two hormones, also referred to as catecholamines, are well known as the €œflight/fight€ hormones.

The Significance of the Adrenal Circadian Rhythm

The adrenal glands do not release their steroidal hormones at a balanced rate throughout the day. Steroidal hormones are secreted in a cyclical manner. The highest rate of secretion is early in the day and the lowest level of secretion occurs at night. This daily cycle is referred to as the circadian rhythm. An abnormal circadian rhythm that causes adrenal hormones to be released in a suboptimal fashion can lead to negative effects upon numerous vital functions of the body, among which are immune system health and the production of sufficient levels of energy.

Production of Energy

Adrenal function which is abnormal can negatively affect the ability of your cells to make energy to perform the normal tasks of life. People who have trouble getting out of bed in the morning, have slumps of energy as they go through their day, or are simply just always exhausted often have undiagnosed abnormal rhythms of adrenal hormone.

Joint/Muscle Function

Insufficient levels of adrenal hormone and abnormal rhythms have a negative effect upon the normal healing of tissue. This impairment of the ability to repair muscle contributes to a higher incidence of tissue breakdown which eventually leads to joint and muscle injury or to chronic pain. It has been realized for a long time that taking too many steroids can lead to weakened hip muscles and shoulder girdle muscles. What is not quite so obvious is that the opposite idea is also true: bad posture (like sitting too much), also lead to weak shoulder and hip muscles. This promotes an excessive secretion of cortisol and catecholamines. But why? The Neanderthal-like position, where the hips and shoulders of flexed, is similar to the Fight/Flight response that a person assumes when fighting or running. This flexion position causes the body to secrete cortisol and catecholamines. Notice that there is a key focus in martial arts of keeping the spine straight, warding off the artificial energy boost that the catecholamines create.

Another aside in this discussion about rapid aging: the jutted chin position also leads to quicker aging, of the cognitive faculties in particular. When one's chin is positioned forward, or when the head is positioned in a downward tilt, spinal cord signals start to terminate midbrain; this form of short-circuiting that does not reach the cortex creates a mental state more conducive to reflexive responses that aid the fight/flight mechanism.

However, when the head is upright, impulses travel along the spinal cord and send messages to the brain to formulate proteins in the gray matter cells. If the signal is blocked from the cortex, then this stimulative effect does not occur and proteins in the brain start to dissipate. As they do, the negative charges held by the protein dissipate as well. As these negative charges fade, the brain cells become less negative, and as they reach action potential they may begin to fire off randomly. These uncontrolled neuron firings can cause seizures, pain, spasms, and tics.

...also, the jutted chin position tends to bring about quicker aging, of the cognitive faculties in particular.

As the cells of the brain slowly lose proteins, they begin to atrophy and shrink. This atrophy happens every day that the cells do not receive spinal cord stimulus. Essentially, this means that if you do not use your brain, you start to lose your brain. Martial arts regimens which involve total body contortion and movement also are beneficial to the brain for this reason. If one fails to move a particular muscle or joint, the corresponding cellular protein will begin to atrophy and become less functional. This also lends evidence to the efficacy of the chiropractic and osteopathic art of vertebrae mobilization, which will allow the vertebrae to move with more freedom.

Bone Health

Adrenal rhythm also determines an individual's ability to build up their bones. If nighttime cortisol levels remain high and morning levels do not come back to normal, bones do not heal very well, and the process of osteoporosis can occur even when one takes calcium supplements. In fact, higher levels of cortisol lead to the leaching of calcium from the bone which eventually causes bone demineralization. Consuming supplements of calcium during abnormal cortisol rhythms often produces no results and can sometimes even have harmful effects if leached bone calcium is deposited in an improper location.

Immune health and Cortisol Levels

High levels of cortisol inhibit the immune system. It also suppresses the immune reactions of the mucous membranes located across the body. High levels of cortisol lead to fewer surface antibodies on the mucous membranes, which are known as secretory IgAa. These SigAa assist the immune system by filtering viruses, bacteria, toxins, and plasmids. Then high levels of cortisol lead to a weakening of the defense mechanisms of the serosal and mucosal membranes, people are more likely to suffer from issues like earaches, pink eye, bronchitis, chronic coughing, sore throat, coughing, ulcers of the stomach, inflammation of the gallbladder, duodenal ulcers, vaginal infections, acid reflux, and bladder and kidney infections.

Study:

A girl we will name "Cynthia" went to see six doctors in the last month. She had received prescription for antibacterial eye drops from an ophthalmologist, cream to resolve her vaginal itching and burning from her gynecologist, cough medicine from her general practitioner, and H-2 blocker to medicate stomach acid build-up from a gastroenterologist. She had also been prescribed an antibiotic to alleviate her sinus infection from an ear, nose, and throat doctor, and finally she had gone to a rapid care clinic to acquire another antibiotic to sooth her experience of burning urination and alleviate the pressure upon her bladder. When she came to us, we told her that every one of her symtoms could be categorized as an irritation of the mucous membrane. After four weeks of corrective measures to resolve her incorrect cortisol levels and rhythm using herbs and diet, Cynthia had no more issues with any of her mucous membranes. She used herbs and diet successfully as natural alternatives to hormone replacement therapy.

Low Cortisol and Its Effect Upon the Immune System

Low cortisol has the opposite effect upon the immune system. Low levels of cortisol lead to over-response of the immune system. The immune system becomes way too aggressive and begins to attack not only antagonistic orgasms, but it also begins to develop reactions to benign agents of the environment. It can also begin to attack endogenous systems as well, hindering our body's ability to function properly. Autoimmune disorders like Rheumatoid arthritis, Sjorgrens syndrome (mucosal and physiological lack of fluids), and lupus can appear when one has low levels of cortisol.

Quality of Sleep

Quality cycles of REM sleep require low levels of cortisol during the nigh. High levels create a disruption of REM sleep which causes sleep to be less refreshing and restorative. It leaves a person feeling fatigued and groggy as they awaken in the morning. Fatigue upon waking is often misinterpreted by both doctor and patient as biological depression. It this depression does not react to medications that are directed toward norepinephrine and serotonin metabolism, it may be time to consider evaluating levels of nighttime

cortisol.

Study 2:

A dramatic case of how a disrupted circadian rhythm can affect an individual is vividly illustrated by the case of Melissa. She was a child who confused parents and teachers because of the unpredictable extremes of her behavior and the vast variations in her grades which ranged from passing to failing even in the same subject. They thought perhaps she was merely unmotivated, but psych testing showed that she was an extraordinarily motivated girl. Everyone attempted to make sense of her pattern of passing and failing grades, attempting to attribute it to the personality or style of the teacher, the gener of the teacher, or even a potential rebellious streak. Things only became worse when she entered high school. Her parents told us that it was incredibly difficult to rouse Melissa from bed in the morning. When she did finally get up, she appeared lethargic and incredibly irritable. The report card for her first semester of math class showed that she was often late for class, always forgot supplies, did not talk in class, and rarely turned in her homework. Strangely though, a couple of weeks after the next semester began, the instructor told her parents Melissa was among the smartest mathematics students that the instructor had ever had the opportunity to teach. Also, she seemed to love helping others that had trouble with math. Did Melissa change classes? She did not. She was working from the same textbook and taking instruction from the same teacher. The difference was that her first semester class was the first class of the day. She went to math class after lunch. In the second semester, Melissa now took gym first thing in the morning. The same issues began to appear. She was not participating; she kept forgetting her uniform. A cortisol test revealed that her morning levels of cortisol were only ½ of the amount the she required to be functional at that time of the morning. A lot of adults that have those low levels of cortisol are able to apply for disability because of their inability to be functional when working. In Melissa's case, being woken up and asked to get dressed was like awakening a normal person at two in the morning and expecting them to be completely functional. At noon, Melissa's level of cortisol was in a normal range. Correction of her cortisol rhythm so that it peaked in the morning and was at its lowest around midnight caused incredible changes to develop in her performance, energy, and personality. By the beginning of her sophomore year, she was going to meetings of the student council before school officially even began.

For exactly how long did Melissa suffer from a reversed cortisol rhythm? Her mom and dad told us that she was an amazing baby. She would not become irritable at night and did not want to go to bed at 8 like other babies. She also would never be terribly unhappy in the morning either, unlike her younger sister. It should be noted that Melissa's mom worked third shift at a very high-stress job when she was pregnant with her daughter. It is incredibly possible that Melissa was born with her circadian cortisol rhythm out of sync.

Regeneration of the Skin

The skin undergoes regeneration mostly at night. High levels of cortisol lead to skin the does not regenerate as effectively. A standard cortisol rhythm is a requirement to maintain healthy skin. It is especially important in preventing such conditions as acne in adulthood.

People that have skin conditions often have high levels of copper and low levels of zinc. Excess levels of copper cause norepinephrine and adrenalin to be synthesized from dopamine. Dopamine is the reward chemical of the brain and is linked to good feelings and is active during positive stimulus and is deprived through negative stimulus. This elevated level of adrenaline normally leads to an increased level of cortisol. Lower levels of dopamine increase risk of early Alzheimer's and Parkinson's as well.

Skin conditions like eczema are often correlated with intolerance to gliaden, which is a compound found in gluten grains. This issue is also made worse by the presence of high levels of copper.

Cortisol and Thyroid Function

Cellular levels of cortisol control the activation of the thyroid hormone. Adrenal hormonal imbalance often leads to symptoms associated with hypothyroidism like problems losing weight, decreased body temperature, and fatigue. If Thyroid hormonal treatment only results in temporary yet significant relief of hypothyroidism symptoms, check your cortisol rhythm and levels.

Stress and Gluten Intolerance.

In many patients, the digestive develops inflammation within a half hour of eating grains that contain gluten, such as rye, spelt, barley, and oats. This intestinal response has been compared to have a sore throat that was thirty feet long. We call this condition colic when it occurs in infants. It is assumed that children eventually stop being allergic to gluten. In reality, the body just learns to react to this inflammation with a secretion of cortisol. In a lot of patients, a biological substance that is similar to morphine is also emitted in an effort to alleviate the inflammation and hide the pain.

This substance is then absorbed into the blood where it is transported up to the brain. Here, it stimulates receptors for morphine and a person can develop a physiological addiction to dairy and grain products that produce the inflammatory response. If one watches the patterns of behavior and symptoms of people who eat dairy and grain products, he or she can take note of the wildly apparent up and down phases of drug use and drug withdrawal. These similarities become even more apparent when the individual attempts to stop eating gluten or dairy.

High Levels of Cortisol and Low Levels of Libido

When we use up a lot of cortisol, we hinder our ability to produce other hormones. To produce extra cortisol in the body to respond to inflammation and pain, your body converts energy normally reserved for the manufacture of sex hormones into the development of more cortisol. Progesterone in particular is singled out for cannibalization so that more cortisol can be manufactured.

This lower level of progesterone causes us to have less progesterone than the male hormone testosterone or the feminine hormone estrogen, and this leads to issues of testosterone dominance and estrogen dominance. Both of these issues are connected with a higher level of aggression, violence, and irritability. Dominance of feminine hormones can also lead to uterine fibroids(benign uterine tumors), PMS, and higher risks for breast and uterine cancers, in addition to clots and heavy flow. Deficiency of progesterone causes one to be at greater risk for miscarriage.

The hormone progesterone is also vitally essential to maintain testosterone so that it does not transform into DHT (which is an essential male hormone which can cause major issues when it is present in the body in excess). Low levels of progesterone will eventually lead to low levels of testosterone, balding, high levels DHT, prostate enlargement and decreased libido.

Decreased levels of testosterone and cortisol also can make migraines occur more frequently.

What Causes Imbalance of Cortisol?

Among the factors and activities that increase levels of cortisol are:

1. Not eating breakfast.

2. Missing meals

3. Consuming a greater value of carbs than proteins over the course of five hours.

4. Being positioned in a flexed or slouched posture in which the chin is pushed forward.

5. Going to sleep after 10 pm

6. Undergoing emotional stress

7. Experiencing pain

Increased levels of cortisol and an enhanced flight/fight response are useful adaptations when one experiences infrequent stress or brief bouts of stress. The problem arises when one begins to experience chronic stress and cortisol levels rise often and stay at elevated levels for too long. When this occurs, precursor hormones begin to be used up. After a long period of elevated cortisol, the body may lose its ability to generate cortisol effectively. The experience of a low level of cortisol is how our body makes us slow down. Beneficially, low levels of cortisol can also have an effect on the aging process, slowing down aging processes associated with high cortisol levels. The problem is that low cortisol levels present a separate list of processes which enhance the aging process, such as making one more susceptible to diseases of the autoimmune system.

Means by Which to Slow Down the Process of Aging:

Have protein for breakfast by 8am and again every 5 waking hours.

Levels of cortisol begin to climb after a person does not eat after five hours. As we fast in our sleep, levels of cortisol rise until we are stirred to rise from bed with energy. If an individual eats a meal after 8pm, then the level of peak cortisol may occur later than would be desirable, and easy rousing may become more difficult. They will be more likely to feel tired when they wake up and may find that they lack a proper functional level of energy before much later in the day.

On the other hand, if a person does not eat by 8am or so, the morning level of cortisol continues to elevate and may leave the normal range. When this occurs at any point in the day it becomes difficult to bring cortisol back into a low range suitable for rapid eye movement sleep. For this reason, fatigue tends to be self-perpetuation.

Some people who have a tendency to miss breakfast do it thoughtlessly as a means to induce a brief bout of starvation so that cortisol is secreted. Doing this elevates low levels of cortisol to normal. The problem with this method is that starvation has the effect of adrenalin stimulation, which also contributes to physical deterioration.

Remember that there will be interruptions to sleep is we do not have an adequate store of glycogen to fuel the brain the whole night. Stores of glycogen are restored after every incidence in which we consume protein or eat a meal with a low glycemic index. Eating protein in five hour intervals is crucial. Each time that we neglect to eat a meal, stores of glycogen within the liver become more depleted. This also occurs when we miss a meal or over-consume carbohydrates during any period of five hours Habitual meal skipping and the consumption of excess sugar and starch can lead to sleep disruption. Among people who have totally eradicated their glycogen supply in this manner, it may be necessary to consume a small snack around time for bed for a number of days, or perhaps weeks, until stores of glycogen in the liver are restored so that the brain has enough nutrition to make it through the night.

There is a lot of confusion over which foods boost stores of glycogen. This confusion originated in the 70s when coaches commonly encouraged athletes to load up on carbohydrates before they participated in athletic events. In fact, one of the most common diet fads during this era was to only consumer fruit before lunchtime. The practice of consuming inadequate amounts of protein actually had the opposite effect, leading to depletion of glycogen and contributing to negative alterations of the cortisol rhythm. Hypotheses during this era that foods that were highly glycemic would lead to increased stores of glycogen were incorrect, and a whole generation of dieters and athletes were plagued with exhaustion and fatigue in consequence. There is still a belief in carbo-loading with effects athletes and patients today.

Quickly Control Pain

The occurrence of pain is the single most significant thing that can happen that spikes levels of cortisol in the body. One migraine can lead secreted levels of cortisol to become elevated to multiple times the normal baseline. It should be obvious that those who suffer from chronic pain will quickly start to show symptoms and signs that represent an excess of cortisol. Mental and physical fatigue occur, patients gain weight around their middles, and reports of muscle weakness abound (more weakness than is to be expected from merely a lack of physical activity, alone). Quick bruising, digestive complications, restless sleep, bloating, and a higher instance of infections of the mucous membranes (bronchitis, sinusitis, bladder infection, etc.) also occur. Chronic pain sufferers can not find alleviation from these symptoms until their pain is taken care of.

Fall Asleep by Ten at Night

Ben Franklin truly understood the importance of following the natural rhythm of the body when he suggested that those who go to sleep early and wake up early find themselves more wise, healthy, and wealthy. An individual is more likely to feel refreshed after five hours rest between ten pm and three a.m. than with five hours or more of sleep that does not begin until three am.

Also, remember that some beneficial functions of the immune system do not begin until a person has rested for seven or more hours without disruption. The immune system suffers when sleep deprivation takes its toll.

Fix Your Circadian Rhythm

After it has been established that one's circadian rhythm has been disrupted, there are multiple approaches to therapy that a patient may choose. The goal of therapy regimens is to correct inopportune elevations and depressions of cortisol during different periods of the day. Herbal supplements can be of assistance, but they must be used precisely and carefully. Deglycerinized licorice has the effect of lowering cortisol, but whole root of licorice boosts cortisol. The compound phosphorylated serine has the effect of elevating depressed levels of IgA (which controls mucosal immunity) back to baseline. It does this presumably through the lowering of cortisol which leads to the suppression of SigA.

Taking phosphorylated serine at 6 pm in an effort to lower elevated nighttime cortisol can be the secret recipe to a perfect night of sleep.

Elevated Cortisol Today Leads to a Lack of Cortisol Later

There is an unfortunate pattern that eventually leads to an imbalance of cortisol later in life. Lifestyle patterns and choices today can lead to prolonged or periodic high levels of cortisol. After a period of time, the overspending of cortisol leads to a theft of pregnenolone. This hormone is the progenitor hormone from which cortisol and other sex hormones are created. When too much cortisol is summoned, the body subverts pregnenolone from its standard function creating testosterone, estrogen, and DHEA to manufacture additional cortisol.

In every single moment in our lives, we make decisions based on our posture, bedtime, control of pain, and response to stress whether our bodies will manufacture unhealthy stress hormones or vital sexual hormones. If we choose stress, we choose to age more rapidly. If we choose sexual hormones, we will feel younger and healthier.

When too much cortisol is emitted, the speed of catabolism increases. Catabolism is a function of the body which proceeds to break down tissues in every area of the body. This effect dramatically increases the speed of aging. Processes of catabolism weaken bone, blood vessels, muscles, and ligaments. One of the cyclical effects of catabolism is that it encourages bleeding, bone diseases, and poor posture, which further stimulates cortisol production. Excess levels of cortisol also contribute to glaucoma and cataracts and can lead to dangerously high blood sugar, intraocular pressure, and blood pressure. Secreting an excess level of cortisol also weakens the skin which leads to thin skin, easily bruised skin, and skin prone to stretch marks. High levels of cortisol at night disrupt normal REM sleep and cause us to remain fatigued and groggy long after we awaken.

Low levels of cortisol has a negative effect too. Low levels of cortisol when we awaken make it difficult to pop out of bed as we were meant to do. Any time that cortisol lowers below baseline in any period of the day it leads to a slump of energy.

It is not uncommon for people to often unconsciously and sometimes consciously seek an energy boost to produce an increase in the level of active cortisol. Among activities that raise levels of cortisol are consuming a starch or sugar carbohydrate snack, skipping a meal, or undergoing an activity which elevates levels of cortisol, included behaviors which are quite risky. We feel that inappropriate behavior is often an adaptive measure which serves to elevate levels of cortisol and adrenalin to a baseline or greater state in order to make up for having cortisol levels that are too low.

The problem is that many of these tactics which lead to an elevated level of cortisol cause us to produce too much cortisol and propagate an imbalance.

Efforts to correct abnormal cortisol levels and rhythms are quite effective.

People should be happy to find that belly fat, lethargy, and stretch marks can all be alleviated when cortisol rhythms are corrected. Irritation and/or infection of the mucous membranes can often be resolved just by going by through these lifestyle changes:

1. Fall asleep by ten pm.

2. Eat protein by 7 am

3. Eat less starch and sugar

4. Consume meals that feature low glycemic index once every five hours. For example, eat meals in which quick-digesting starches and sugars do not exceed the mass of meats that are digested slowly such as eggs, poultry, and fish. For better effects, entirely skip starches and sugars (especially gluten grains) and choose vegetables that are uncooked or lightly cooked.

5. If you have a gluten intolerance avoid all grains. Give children grains of sprouts to delay or avoid gluten intolerance.

6. Sustain proper posture and do not sit or enter the flexion position for prolonged periods of time.

7. Manage pain.

8. Keep your stress in check. (by following the initial seven rules it should be much easier to accomplish guideline eight.)

Maintaining a standard circadian rhythm will help you preserve precursors of adrenalin and cortisol, leading to a marked delay of the process of aging. Restoring a disrupted circadian rhythm to normal and restoring reserves of adrenal hormones can encourage a reversal of many issues that a patient may feel they will be plagued with for the rest of their lives.

Article comes from the NOHA NEWS, Volume 27, Number One

Winter issue pages three to six.

Winter 2002, pages 3-6.


HGH Secretagogue-P2

Written by Dr. Welsh, Published on 08 June 2013

foods that increase health testosterone levels


Sermorelin Frequently Asked Questions

The goal of this article is to help you become better informed about a new form of Hormone Treatment known as Sermorelin Acetate Therapy. This article serves as a reference point to help you become more knowledgeable about this highly beneficial therapy.

Question: What is Sermorelin Acetate?

Answer: Sermorelin Acetate is a hormone derivative that spurs the natural secretion of endogenous Human Growth Hormone by the pituitary gland. Sermorelin Acetate serves as the functional equivalent of a hormone produced by the hypothalamus known as Growth-Hormone Releasing Hormone. GH-RH is also often referred to as Growth Hormone Releasing Factor.

Although Sermorelin and GH-RH are not biologically identical, they are functionally identical, meaning that the two molecules produce the exact same effects in the human body, despite being arranged in different configurations. Sermorelin and GH-RH share the same initial sequence of amino acids, but Sermorelin Acetate is truncated, meaning that the hormone sequence is cut short. Scientific researchers found that by producing a bio-synthetic hormone which only contains the first twenty nine amino acids of Growth Hormone-Releasing Hormone, they could create a potent medication that is cheaper to produce while maintaining the exact same medical effect upon the human body.

Sermorelin Acetate was isolated and invented by Nobel Prize Winners Andrew Schally and Roger Guillemin. The chemical configuration of GH-RH is referred to as GRH 1-29 NH 2. GRH 1-29 is the active sequence of Growth Hormone-Releasing Hormone. The NH-2 refers to a closing sequence which is inert and serves to tie off the end of the molecule.

Question: What is the difference between Sermorelin Acetate and HGH?

Answer: Many people get this somewhat confused, thinking that because Sermorelin Acetate increases internal levels of Human Growth Hormone, that Sermorelin is actually a form of HGH. This is untrue. Sermorelin is a hormone which scientists label a secretagogue. Secretagogues are hormones produced by the brain which stimulate other hormones to be produced. They serve as intermediary messengers which move the message along to target organs and tissues in the rest of the body.

GH-RH is released by the pituitary gland and flows through a series of blood vessels in the brain known as the epiphyseal portal system. Upon reaching the Anterior Pituitary Gland, Growth Hormone Releasing Factors then stimulate organs known as somatotrophs within the pituitary to manufacture and secrete Human Growth Hormone to circulate to the liver and other organs. Sermorelin Acetate imitates the function of GH-RH, producing a biologically identical response when is reaches the somatotrophs.

Sermorelin is a much smaller hormone than both GH-RH and Human Growth Hormone. Sermorelin contains 29 amino acids, whereas GH-RH contains 45. HGH dwarfs both of these hormones in size, as it is comprised of 191 amino acids!

Question: Health Stores and Online Websites often advertise supplements known as Human Growth Hormone Releasers. These supplements are available over the counter and do not need a prescription. Are these supplements similar to Sermorelin?

Answer:Absolutely not. Supplemental HGH Releasers are most often component amino acids which comprise Human Growth Hormone, including L-Dopa, Glycine, L-Ornithine, L-Glutamine, and L-Arginine. Other chemincals are also marketed as HGH Releasers, including Tribulus Terrestris, Macuna Pruriens, and Ornithine Alpha-Ketoglutarate.

It is true that these amino acids do have a stimulative effect upon HGH production, but they are not healthy for the body and do not produce a strong enough benefit to in any way warrant the risk. HGH Releasers work (if they truly work) by creating an increased level of overall activity throughout the brain. This increased level of activity does have a slightly stimulative effect upon Human Growth Hormone Levels, but it also stimulates other activities, but positive and negative, throughout the brain.

HGH Releasers Do Not Work As Advertised

Many medications labeled as HGH Releasers are completely ineffective, veritable snake-oil products. Supplements are not certified for effectiveness in the same way as medications such as Sermorelin Acetate and Bio-Identical Human Growth Hormone, so there is not necessarily a proven or guaranteed medical benefit to using the supplements. At best, HGH Releasers stimulate a Growth Hormone release that is just about equivalent to exercise, and at worst, you'll damage your liver and experience no benefits at all.

Also, Growth Hormone Releasers produce incredibly unreliable effects, because different areas of the body and brain may experience different levels of response every time you take the pill. High Doses of Growth Hormone Releasers can lead to liver and kidney issues, as the human body does not have the capacity to process extremely high levels of unprocessed amino acids without accumulating damage in the filtering and processing organs of the human body.

Sermorelin Acetate produces real and beneficial effects with minimal risk of side-effects. Sermorelin Acetate Therapy has an incredibly safe track record and has been proven to be effective at treating Adult-Onset HGH Deficiency.

Question: I've read a bit about Human Growth Hormone Replacement Therapy, and it seems to be perfectly capable of resolving issues surrounding HGH Deficiency and Hypopituitarism. What would make me choose Sermorelin Therapy over Bio-Identical HGH?

Answer: There are a number of reasons why a patient would choose Sermorelin Acetate over Recombinant Growth Hormone, although both certainly have their place as treatment options. Both HGH and Sermorelin are capable of producing the same exceptional benefits to the human body, but they share a couple of profound differences as well.

Sermorelin Imitates Normal Physiological Processes

First, Sermorelin Acetate functions in a manner which is more streamlined with the actual function and overall needs of the human body. You see, when you use Growth Hormone HRT, there are no safeguards which protect the body against accidental overdose. Any Human Growth Hormone injected into the body directly cycles through the liver and the body and stimulates the body. Sermorelin, on the other hand, as an Growth Hormone Secretagogue, can be affected by processes known as Negative Feedback Mechanisms. Negative Feedback Mechanisms kick in when the body sends signals to the brain that Human Growth Hormone Secretion has satisfied the needs of the body.

Upon receiving these signals, hormones known as somatostatins block GH-RH and Sermorelin from reaching the Pituitary, preventing excess secretion of Growth Hormone. Because Sermorelin works according to the normal physiological rules of the human body, it is almost impossible to overdose on Human Growth Hormone via Sermorelin Injection. Other patients may choose Sermorelin Acetate in order to avoid the temptation to overdose on or abuse HGH.

Sermorelin Releases Episodic HGH

Another benefit that Sermorelin Acetate Injections have over Human Growth Hormone Injections is that they are processed by the body in different patterns. Although HGH and Sermorelin ostensibly accomplish the same goals, Human Growth Hormone Injections supply a relatively constant level of HGH Release over time, which is not actually how the body produces Human Growth Hormone. HGH Release is categorized by a function known as Square Wave release. Square Wave means that HGH concentrations rise to a peak during the course of the day, plateau, and drop back down to baseline. This can cause a problem over time, inducing a medical response known as Tachyphylaxis.

Tachyphylaxis can be understood most simply as a decrease in sensitivity due to outside pressures. The body can sometimes slowly recognize that HGH is being provided by an outside source and the body builds resistance as a response. Sermorelin releases Human Growth Hormone via an episodic pattern which more closely resembles the natural pattern of release by the human body. The pituitary only releases Human Growth Hormone when the body is ready for it, thus significantly reducing the threat of internal resistance to increased levels of HGH.

Sermorelin Preserves the Normal Hormonal Equilibrium

A third Benefit to Sermorelin Acetate, related to the second, is that Sermorelin Acetate more appropriately preserves the Neuroendocrine Axis. The Neuroendocrine Axis is the cascade of hormone release throughout the body. Simply put, all hormones released by the human body have a certain impact on the release of other hormones. Injecting HGH directly into the body on a daily basis can actually suppress the body's natural ability to produce it's own Human Growth Hormone, which can effect the release of other hormones as a result.

Sermorelin Acetate makes less of a physiological imprint onto the endocrine system, meaning that it more naturally resolves hormonal deficiency while causing minimal impact on the normal function of other hormones and systems of the body.

Sermorelin Available for Off-Label Use

A fourth and final benefit of Sermorelin Acetate is less physiological and more technical. Sermorelin Acetate Hormone Replacement Therapy is not as tightly regulated as Human Growth Hormone Replacement Therapy. The FDA prohibits the use of Human Growth Hormone for off-label uses, whereas Sermorelin Acetate can be used off-label at the discretion of the prescribing physician.

Question: I understand that Human Growth Hormone can only be delivered via Injection. Is this also true for Sermorelin Therapy?

As of 2013, Subcutaneous Injection is the only effective method to administer Sermorelin Acetate . Like, Human Growth Hormone, the Sermorelin Acetate molecule is too large to breach other barriers of the human body at this date. On the bright side, since Sermorelin is significantly smaller than Bio-Identical HGH, there is a hypothetical chance that Sermorelin may one day be administer by breaching the mucous membrane barrier using a nasal spray. This method is currently being tested and may be effective at some point in the near future.

Question: Do Sermorelin and Human Growth Hormone Injections require similar doses to be effective?

Answer: Even though HGH and Sermorelin activate in different regions of the body (Sermorelin in the anterior pituitary, Human Growth Hormone in the liver) the volume of hormone that is required in order to sufficiently increase endogenous IGF-1 production is nearly identical. Human Growth Hormone is most commonly prescribed at doses which vary between one and two international units. Sermorelin Acetate is generally administered with a dose of two hundred micrograms daily.

Question: How much does Sermorelin cost in comparison to HGH?

Answer: Per vial, Sermorelin is a good bit cheaper than Human Growth Hormone. In addition to this, a single vial of Human Growth Hormone takes twelve to fourteen days to fully administer, whereas a single vial of Sermorelin takes fifteen days to fully utilize.

Question: In many patients, the benefits of Human Growth Hormone start to fade of the course of continual use. Why does this happen, and does Sermorelin lose potency as well?

Answer: The human body can develop a resistance to HGH Hormone Replacement Therapy over time. If this has occurred to you, the change in effectiveness is not the result of any inadequacy of the medicine itself. Human Growth Hormone Injections increase serum levels of Growth Hormone to levels which are higher than normal for a number of hours every day, although the average release across the day is medically appropriate.

HGH Up-Regulation and Sermorelin Down-Regulation

In addition to this, Human Growth Hormone Therapy leads to a stable release of IGF-1 throughout the body, slowly rising and falling in the body through the course of the day. This causes the tissues of the body to have a steady supply of IGF-1 throughout the day, rather than receiving the hormone in the normal bursts in which it is accustomed to. As a result, IGF-1 Receptors in the tissue have a tendency to go through a hormonal process known as down-regulation in order to preserve normal function. This means that the target tissues become desensitized to IGF-1 and Human Growth Hormone exposure, reducing the effectiveness of the hormone treatment.

When the body is functioning normally, Human Growth Hormone is released naturally from the pituitary gland in a number of short, brief, and potent bursts, which supply the body with sufficient levels of IGF-1 and Human Growth Hormone while also giving the receptors time to rest between periods of hormone release. If outside hormone release properly imitates the natural processes of the body, this gradual down regulation does not occur, and the benefits of increased HGH production do not decline in the same manner over time.

Because of the influence of Somatostatin, described above, Sermorelin Administration only leads to the optimal release of Human Growth Hormone. Sermorelin actually has the ability to make the pituitary stronger, through a process of up-regulation which strengthens its health by increasing the level of HGH it produces on a daily basis.

Question: Does Sermorelin Acetate provide any benefits for patients suffering from Adult-Onset HGH Deficiency that are not directly related to its effect upon the endocrine system?

Answer: Yes. There is a large body of evidence that shows that Growth Hormone-Releasing Hormone and Sermorelin Injections directly have the capacity to increase sleep quality and promote the increased experience of the deepest stages of sleep, which are the most rejuvenative and beneficial to health and wellness.

Question: What is the normal administration protocol for Sermorelin Hormone Therapy?

Answer: Sermorelin is delivered once each day via injection. Sermorelin is normally administered just before bed in order to more closely mimic the natural hormone production of the body. Sermorelin is intended to supplement the body's own natural production of Growth Hormone-Releasing Hormone, which occurs primarily at night.

The Sermorelin Dosage that the patient is described will be dependent upon the physiological needs of the individual. Sermorelin Shots are provided in vials which contain multiple doses The vial will contain enough Sermorelin in order to treat the patient for at least fifteen days.

The Conscious Evolution Institute

If you have any other questions about Sermorelin Acetate, Human Growth Hormone Shots, or any other hormone treatments, we would be happy to provide you with answers to any questions you may have.

Different patients respond differently to treatment, and some patients respond more actively to Human Growth Hormone Replacement Therapy than Sermorelin Acetate. If you choose the Conscious Evolution Institute, our knowledgeable and top-of-the-line staff of physicians and longevity specialists will help you decide which treatments are right for you!


Don't Eat Before you Sleep Increase HGH

Written by Dr. Welsh, Published on 22 November 2013

growth hormone stimulates normal health body growth


Dont Eat Before You Sleep - Increasing Human Growth Hormone Effectiveness Through Smarter Eating Habits

Although Human Growth Hormone Therapy is a highly effective form of therapy, your results will increase significantly if you make a resolution to live in a healthier way. Maintaining a nutritious diet of moderation is a key to living a balanced life and maximizing the benefits of your treatment. Also, it is important to eat the right portions at the right time in order to maintain a healthy metabolism and encourage restful sleeping patterns. If you choose the wrong foods and eat them at the incorrect times you may not achieve the results you desire with your Hormone Replacement Therapy.

Eat Smart, Eat Early

One of the keys to successfully losing weight is to eat your meals at the right times. Eat dinner two hours before you go to bed for the night so that your body has the time to digest your meal. Although it is important not to go to bed on a hungry and empty stomach, it is equally important not to fall into bed right after you eat your final meal. Going to bed with just a tinge of hunger is ideal. This hunger is your body telling you that you are doing the right things and that you are burning calories faster than you are consuming them. Your body uses hunger as a mechanism to help you sleep properly throughout the night, and to wake up at the right time as well.

When your body starts to experience significant hunger after around 8 hours of sleep, cortisol levels in your body will naturally start to rise and stir you from sleep. If you eat just before bed, then your body does not digest the food you eat as ideally as it should, and a higher portion of that food will be converted into fat. In addition to this, if you give in to your brains demands for more food, your body will not utilize reserves of body fat stored in adipose tissue around the body, which will also prevent you from losing weight.

Every time you put food in your mouth, this results in a slight increase of metabolism. The problem with consuming food just before bed is that sleep decreases the beneficial effect of this metabolism. As your body prepares for sleep, the internal metabolic processes begin to slow down in order to prepare your body and mind for sleep. The same calories that you consume during the day will lead to a higher number of calories burned off during your waking hours than during your resting hours. Once you fall asleep, your body will only burn the calories necessary to maintain your basic processes such as your heartbeat and simple digestion.

Late Night Binging Ruins HGH Production and Effectiveness

You probably dont realize this, but going on a late night binge before bed can also prevent you from properly maintaining your metabolism and burning calories the next morning. Lets provide an example. One night, you get hungry after dinner and decide to eat a bowl of pasta and a pear at 10:30 at night, then you fall asleep at 11. When you wake up the next morning at 7:30, your body will still be full from the night before, and you will not be ready for breakfast.

If this occurs, then there is a significant chance that you will skip your first meal of the day since you arent hungry and, and you will wait until later to have a snackor perhaps you will wait all the way until lunch. Metabolism is intrinsically connected to the digestive process. When you skip your morning meal, it prevents your natural metabolism from boosting as a result of breakfast. Its a bit counterintuitive, but eating breakfast burns more calories than skipping the meal. You are better off eating a nutritious and healthy breakfast because it will boost both your energy and your overall metabolism, encouraging the body to burn more calories and helping you lose weight.

In addition to this, there are multiple research studies which have shown a significant correlation between skipping the first meal of the day and overeating through the course of the day. Also, there is evidence that those that skip breakfast are more likely to choose unhealthy foods during the later meals of the day and experience cravings at a higher rate throughout the rest of the day.

How to Maintain an Optimal Diet for Weight Loss and Health Maintenance in Combination with BioIdentical Hormone Replacement Therapy HRT

It is not necessary to eat a large meal for dinner in order to eat healthy. A modest meal will suffice, and a healthy and balanced breakfast and lunch are more important. Consuming too much food during this final mealor worse, after dinnercan lead to increased storage of fats. The over consumption of simple carbohydrates such as processed grains and pastas can make this issue become even more pronounced.

In addition to this, eating carbohydrates with a high-glycemic index such as sugar, white rice, potatoes, and pasta will lead to spiked insulin levels while you are asleep, which is incredibly unhealthy. Elevated insulin levels have the effect of reducing endogenous Human Growth Hormone Production. If you go to bed with a stomach full of carbohydrates, this wreaks havoc upon your natural Human Growth Hormone production because your body produces the majority of your Human Growth Hormone during deep sleep.

Nearly eighty percent of your endogenous Growth Hormone secretion occurs during these resting hours. In addition to this, Insulin also reduces the effect of injectable Human Growth Hormone as well, making it extremely detrimental to an HGH Hormone Replacement Therapy regimen. If you are not producing sufficient levels of Human Growth Hormone, this will cause you to age at a faster rate, and it will also reduce your bodys metabolism, leading to unwanted weight gain.

HGH Diet Tips

Below is a list of suggestions to help you eat the right way and minimize the meals negative effects on your HGH Hormone Replacement Therapy:

  • Plan your dinner three hours before bedtime. For example, if you normally go to sleep at ten, eat dinner at seven oclock, and avoid bedtime snacks. This way, your body will have burned off a significant portion of your dinner before you fall asleep, allowing you to wake up hungry to seize both breakfast and the day.

  • Rather than having two or three large meals at lunch and dinner, spread meals throughout the day. Aim for six small meals every day, every two to three hours. Make sure they are healthy, nutritious, and moderate in nature. Breakfast and lunch should be the most significant meals of the day, because breakfast kickstarts your metabolism, and lunch helps you make it through the entire day with the energy you need to function optimally.

  • Your nightly dinner should consist primarily of lean meats such as turkey, fish, or chicken breasts. Cottage cheese is also a smart and healthy option. Combine your protein with carbohydrates that feature a low-glycemic index such as fruits and vegetables. Carbs which have a low-glycemic index tend to be lower in calories and fill you up quicker. Your body must work harder to digest them, and in doing so you burn calories. In addition to this, low-glycemic carbohydrates dont spike your insulin levels, so they do not hinder the effects of natural Human Growth Hormone Replacement Therapy and endogenous HGH production. As was mentioned earlier, try your best to avoid processed carbohydrates and other carbs which spike insulin levels such as cereals, potatoes, and white rice, because of the negative effect which they have on your insulin levels.

  • Only eat carbohydrates with a high glycemic index before your daily workout. High-glycemic carbs can have a positive effect when burned soon afterward during exercise.

  • If you do experience late night hunger pangs which make sleep difficult, it is acceptable to break the rules and eat a small snack from time to time. Pick a low-glycemic food high in dietary fiber such as an oranges, peaches, apples, plums, or berries. Many fresh vegetables will also suffice, as will vegetable juice.

  • Flaxseed is an amazing food which enhances the effectiveness of HGH injections. It is an excellent source of dietary fiber and is an alternate source to acquire Omega-Three Essential Fatty Acids. Four Tablespoons of Flaxseed is the suggested daily requirement. In addition to providing fiber and Omega-Threes, Flaxseed also has the ability to ward off cancers of the endocrine system such as breast cancer and prostate cancer, increasing longevity and further decreasing the already low potential for HGH bio identical Hormone Replacement Therapy side-effects!

  • If you are using Human Growth Hormone for bodybuilding with hopes of increasing muscle strength and mass, choose low-fat cottage cheese made from skim milk. Cottage cheese is a fantastic option, because it is chock full of a protein known as casein, which the body expends a high level of energy to digest.

By eating smart and following the dietary guidelines set forth in this article, you will go a long way in maximizing the outcome of your Human Growth Hormone Replacement Therapy.


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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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