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Human Growth Hormone 101


Written by Dr. Welsh, Published on 10 November 2018

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What is a hormone? A hormone is one of the many chemical messengers of the body. Hormones are comprised of proteins that form peptide chains and direct the functions of our body. One of the most vital of these chemical messengers is Human Growth Hormone.

We here at Bio-Identical Hormone Replacement Therapy MD, the Conscious Evolution Medical Institute, want to do everything we can to help you make an informed decision about Hormone Replacement Therapy. Therefore, we have compiled this information about the history, benefits, pros, and cons of growth hormone imbalance treatment.

GH (Growth Hormone), also known as STH (somatotropin) is a hormonal protein that stirs growth and also the reproduction of cells in people and many animals. It's a lone chain of one hundred ninety one amino type acids that makes up a hormone of the polypeptide variety. It is manufactured, secreted, and stored by somatotrophic cells inside the lateral wings of the anterior of the pituitary gland.

The following information about the physiology of Growth Hormone also reviews briefly diseases caused by a deficiency of Human Growth Hormone as well as excessive Growth Hormone (gigantism and pituitary acromegaly). It also discusses treatment that features Human Growth Hormone. To learn more about a commonly used growth hormone that is often given to cattle, look up bovine somatotropin.

Terms

Recombinant HGH Human Growth Hormone is called somatotropin as well (In Britain: Somatotrophin)

HGH is an acronym for Human Growth Hormone. This hormone, HGH, is released from or extracted in a measured fashion from the pituitary gland of human beings.

In the 1980s, Human Growth Hormone of biosynthetic form replaced Human Growth Hormone that was derived from the pituitary in bio hormone replacement therapy used in the United States and other locations. Previously, Human Growth Hormone was gathered from processed pituitary glands. Biosynthetic HGH, also referred to as Recombinant Human Growth Hormone, is known as Somatropin and the abbreviation rhGH is used.

From the middle of the 1980s, the HGH abbreviation started to carry connotations that were paradoxical. It now quite rarely is used in reference to Human Growth Hormone for the purposes that are indicated.

Gene and Structure of an HGH molecule

The HGH genes are located at region q22-24 of the 17thchromosome (GH1). They happen to be related closely to hCS (human chorionic somatomammotropin, known also as lactogen of the placenta) genes. Human Growth Hormone, PRL (prolactin) and hCS (chorionix somatomammotropin) make of a group of similar hormones that promote growth and activity that is lactogenic.

The predominant isoform that comprises Human Growth Hormone is a one hundred ninety one amino acid protein chain that has a molecular weight that is twenty two thousand daltons. The configuration has four helixes that are needed for interaction that is functional with the Growth Hormone Receptor. Growth Hormone is believed to be evolutionarily and is structurally similar to chorionic somatomammotropin and prolactin. Even though there are real similarities within the structure that correlate Human Growth Hormone with that of other species, only the HGH from primates and humans has a significant effect on people.

Secretion of Growth Hormone

Many molecular configurations of growth hormone move through the body. A large portion of the HGH circulating through the body is attached to a particular protein called growth hormone binding protein, or GHBP. The protein is manufactured by the Growth Hormone receptor.

Hormone Regulation

The hypothalamus releases peptides from the neurosecretory nuclei and those peptides enter the veins around the pituitary gland. These peptides are significant in that they stimulate the secretion of Growth Hormone by the body's somatotropes. But, even though a balance of the inhibiting and stimulating peptides controls the release of growth hormone, the balance is also affected by numerous physiological inhibitors and stimulators of Growth Hormone Secretion.

Stimulators of Growth Hormone Secretion include:

GHRH (Growth Hormone Releasing Hormone) that originates from the arcuate nucleus.

Sleep

Ghrelin (hunger-stimulating hormone)

Exercise

Dietary protein estradiol

Low levels of blood sugar (hypoglycemia)

Arginine[2] (decreases blood pressure and enhances injury recovery)

Growth Hormone secretion inhibitors include:

Somatostatin that originates in the periventricular nucleus

Glucocorticoids (carbohydrates of a dietary variety)

Levels of Insulin-Like Growth Factor-1 and Growth Hormone circulation concentration (the body reacts negatively to this feedback)

Secretion of Growth Hormones is stimulated in non-endogenous therapies as well. There are a significant number of exogenic compounds known as xenobiotics that have been proven to stimulate and inhibit the function and secretion of Growth Hormones. This highlights the theory that the axis of Insulin-Like Growth Factor-1 and Growth Hormone is proving to be a vital target for particular chemicals that disrupt the endocrine system (referred to as endocrine disruptors).

Patterns of Secretion

The majority of physiologically vital secretion happens during a number of large peaks or pulses of growth hormone release every day. The concentration of growth hormone in blood plasma during one of these peaks can range from five to thirty five ng/mL or even more. These peaks usually last a duration of ten to thirty minutes before they return to normal levels. The most predictable and largest of the growth hormone peaks happens around an hour after one goes to sleep. Besides this particular time, there is a wide variety of Growth Hormone release patterns from person to person and even from day to day within a particular person. Between peaks, base levels of growth hormone remain low, most often less than three ng/mL for most of the night and day.

Also, the pattern and amount of growth hormone that is secreted changes over the course of one's life. Base levels of Growth Hormone are at their highest at the beginning of childhood. The frequency and amplitude of peaks is at its greatest during the growth spurt of puberty. Healthy adolescents and children average around eight peaks every 24 hours. Adults usually have around five peaks. The amplitude and frequency of peaks as well as base levels of Growth Hormone drop as one becomes older.

Growth Hormone Functions

The effect that Growth Hormone has on human tissue can most accurately be termed anabolic (meaning having a stimulative effect). Similarly to the majority of other hormonal proteins, growth hormone functions through interaction with a particular receptor that is located on the outer surface of the cell.

Increases Height

The stimulation of growth in height during childhood is the most well known effect of growth hormone action. It appears to be spurred by a minimum of 2 mechanisms.

Growth hormone stimulates the multiplication and division of the chondrocytes located in the cartilage. Chondrocytes are the main cells in the epiphyses (growing ends) of the long bones of a child's body (digits, arms, legs).

Growth hormone also encourages manufacture of IGF-1 (insulin-like growth factor 1, known previously as somatomedin C). IGF-1 is a hormone that is similar to proinsulin. Creation of IGF-1 occurs primarily in the liver, and stimulation through Growth Hormone is necessary for this vital process to occur correctly.

IGF-1 also has stimulative growth effects on various types of tissue. IGF-1 is manufactured to a lesser extent inside the tissues that are targeted, which makes Insulin-Like Growth Factor-1 seemingly an endocrine hormone as well as a paracrine/autocrine hormone. Also, IGF-1 has stimulative effects upon chondrocyte and osteoblast activity, leading to a promotion of the healthy growth of one's bones.

Other Functions of Growth Hormone

Though Growth Hormone's most well known effect is the stimulation of height growth, it also stimulates a variety of other metabolic processes.

Below is a list of some of these processes:

  • Increase in the retention of calcium, which increases bone mineralization and strengthens the bones as well
  • Increase in muscle mass due to the genesis of new muscle cells (also known as hyperplasia, which differs significantly from hypertrophy)
  • Promotion of lypolysis. This results in a loss of body fat, medically known as adipose tissue.
  • Increase in the synthesis of proteins which stimulates growth and maintenance of every organ of the body, in exclusion of the brain
  • Role in homeostasis of fuel production. Growth Hormone reduces the liver's intake of glucose, which opposes the hormone of insulin.
  • Promotion of gluconeogenesis in the liver
  • Contribution to the proper function and maintenance of the islets of the pancreas
  • Stimulant of the immune system

Diseases that are a result of an excess of growth hormone

(acromegaly and pituitary gigantism)

The disease which is most common that results in an excess of growth hormone is a pituitary gland tumor comprised of somatotroph cells that normally reside in the anterior of the pituitary gland. These somatotrophic adenomas are not cancer causing and they grow very slowly, producing a greater and greater amount of growth hormone as they develop. For many years, the main medical issue that arises from a somatotrophic adenoma is an excess of growth hormone. After many years, the adenoma can become so large that it begins to cause headaches and impair vision due to the pressure it creates upon the optical nerve. It can also create a deficiency of other hormones by displacing them on the pituitary gland.

Prolonged excess of growth hormone can lead to a thickening of the bones of the toes, fingers, and jaw. The jaw heaviness and digit thickness that occurs as a result is known as acromegaly. Problems that accompany acromegaly often include pressure upon the nerves (carpal tunnel among other conditions), weakness of the muscles, a reduction of sexual ability, and even possibly resistance to insulin, which can result in a rare kind of type-2 diabetes.

Tumors that secrete growth hormone are most often discovered during a patient's 50s. It is very uncommon for this type of tumor to develop during childhood or adolescence, but if it does develop, it can lead to an excess of growth hormone that can lead to excessive growth commonly called pituitary gigantism. Growth hormone-producing tumors are usually treated by means of surgical removal. In unique cases, focused blasts of radiation may be used. In other cases, a Growth Hormone antagonist like octreotide or bromocriptine may be administered to block the function of growth hormone or cause the tumor to shrink.

Deficiency of Growth Hormone (GHD)

A deficiency of growth hormone can produce very different issues dependent upon the age at which the deficiency occurs. In young children, an inhibition of growth leading to short stature and size is the most common manifestation of Growth Hormone Deficiency. For adults, however, effects that are caused by Growth Hormone deficiency are much more subtle. These effects can include weakness, lack of energy, reduction in bone mass in addition to a higher risk of cardiovascular complications.

There are numerous causes of Growth Hormone deficiency. These include genetic mutations, genetic defects of the pituitary and/or the hypothalamus, and also damage that occurs to the pituitary gland from disease, surgery, or injury.

A proper diagnosis of Growth Hormone Deficiency is a multi-step diagnostic procedure which usually culminates in growth hormone stimulation tests. In these tests, various stimuli are administered in an effort to spur the pituitary gland into releasing a pulse of Growth Hormone.

A deficiency in Growth Hormone is treated through bio identical hormones therapy. All of the Growth Hormone that is currently used is of a biosynthetic variety created through technology derived from recombinant DNA.

Because Growth Hormone is a very large protein, it has to be administered by injection into subcutaneous tissue to reach the blood stream. Injections used to be administered into muscle mass until 1985, when manufacture of synthetic Growth Hormone began. If an individual has been long-suffering from the effects of Growth Hormone deficiency, treatment benefits are quite often gratifying and dramatic. Side effects are rare, as well. When Growth Hormone is used properly in children who have a deficiency, the end result is a more normal and average height in adulthood.

Growth Hormone Replacement Therapy is used as a treatment for adults that struggle with a Growth Hormone deficiency of adult-onset (which is usually caused by the development of a tumor on the pituitary gland) or childhood-onset (upon completion of the growth phase). In these individuals, the benefits often include a reduction in body fat, an increase in lean muscle, stronger bones, improved cholesterol levels, fewer risk factors for cardiovascular complications, and an overall improvement in mental well being.

Advantages of Hormone Replacement Therapy

Other uses for Growth Hormone and other indications of treatment

A number of other ailments other than Growth Hormone deficiency can lead to lackluster growth; however, the benefits of growth and height gain are very often poorer when not treated for Growth Hormone Deficiency as well.

Other examples of reduced stature that feature treatment regimens involving Growth Hormone include:

Chronic Renal Failure

Turner syndrome

Prader-Willi syndrome

In-utero growth complications

Severely small stature with no discernible cause

In conditions such as these, larger, pharmacological doses of Growth Hormone are needed to induce growth. The amount of Growth Hormone administered to the body by an HRT doctor in these instances is much higher than normal physiological levels. Luckily, treatment with these pharmacological doses rarely result in unwanted hormone side effects. Also, the Growth HRT side effects show little variation relative to the condition treated.

Often, Growth Hormone is utilized to attain benefits other than an increase in height. Growth Hormone Replacement Therapy leads to an increase in muscle strength and a modest reduction in body fat for those who suffer from Prader-Willi syndrome. In those children who suffer from this condition, these two benefits are significantly more vital than simply growing in height. Growth Hormone has also proven to be useful to ward off the muscle atrophy and wasting caused by AIDS. Growth Hormone also can be administered to individuals suffering from short bowel syndrome so that their bodies are not dependent upon being fed totally intravenously.

Less Commonly Known benefits of Hormone Replacement Therapy include:

  • Attempting to induce remission in those who suffer from Multiple Sclerosis
  • Weight loss treatment for those with obesity
  • Anti-aging treatment to reverse effects of the aging process (read more below)
  • Combating fibromyalgia
  • Relieving ulcerative colitis and Crohn's disease symptoms
  • General treatment for being of small stature
  • Administration to assist in physical enhancement for athletics or bodybuilding

Growth Hormone as an anti-aging therapy

The first claims of Growth Hormone as a valid treatment to combat the aging process dates back to the year 1990. The New England Journal of Medicine released a study in which Growth Hormone was implemented to treat twelve males over the age of sixty. At the end of this study, every male was shown to have increases in lean body mass and bone density that were of statistical significance. The control set of males showed no such improvements. The scientists who conducted the research noted that reduction in bone density and an increase in lean body mass are among the changes that occur normally over a ten to twenty year period of aging. Even though the authors did not claim that Growth Hormone reversed the process of aging, the results that they released were interpreted incorrectly, leading many to believe that Growth Hormone was effective as an agent to prevent and reverse aging.

A survey of clinical research conducted by the Stanford University School of Medicine released in 2007 revealed that Growth Hormone Replacement Therapy administered to older, yet healthy patients, led to an increase in muscle mass of around two kilograms. It also led to a reduction in body fat by two kilograms as well. These effects, however, were the only positive effects that the survey revealed. Cholesterol levels, bone density, maximal aerobic capacity, and lipid profiles showed no change, nor did any other significant factor that would indicate an increase in general fitness. The survey did not discover gains in muscle strength. They concluded that Growth Hormone merely allows the body to store greater amounts of water in muscle tissues, which would not lead to an increase in the actual growth of the muscles. This also explains the improved lean body mass as well. Standardized administration of Growth Hormone did induce several negative issues like pain and swelling of the joints, carpal tunnel syndrome, and a higher risk of developing diabetes.

Complications and risks of Growth Hormone therapy: bio identical hormone replacement therapy side effects

With Growth Hormone Replacement Therapy, some adults may experience the side effects of nerve compression, pain and swelling of the joints, and water retention. Also, there is a concern that, theoretically, growth hormone treatment might raise the risk of developing cancer or diabetes, even more so in individuals who have other risk factors and take higher doses of Growth Hormone. It should be noted, though, that diabetes generally develops due to the accumulative effects of bad eating habits over the course of thirty or forty years. The most probable cause for diabetes in those patients who undergo Growth Hormone Replacement Therapy is the lack of proper nutrition that the individual experienced throughout his or her life. One particular survey of patients who were administered Growth Hormone that was collected from cadavers as children were shown to have a modestly higher risk of colon cancer as adults; however, cadaver Growth Hormone ceased to be used anywhere worldwide around 1985. Also, a link between the treatment and the incidence of colon cancer was not adequately established in the survey.

History

Choh Hao Li is associated with the discovery, refinement, and eventual synthesis of Growth Hormone. The history of the use of growth hormone from the initial extraction of the hormone from the human pituitary, to the minor catastrophe that resulted in a small group of patients acquiring Creutzfeldt-Jakob disease, to the eventual expansion of use and large expenses of synthetic Growth Hormone is explained in further detail in more detail elsewhere on Growth Hormone Treatment.

By the year 2005, Growth Hormone of the synthetic variety was attainable in the U.S. by means of a number of manufacturers. Among these manufacturers are Genentech (Nutropin), Lilly (Humatrope), Pfizer (Genotropin), Novo (Norditropin), and Merck Serono (Saizen). All of these products are almost identical in their composition, cost, and efficacy. They vary mainly through means of delivery and ultimate formulation. Also in the year 2005, Teva, a company from Israel, began to offer Tev-Tropin in the United States for a cheaper price. In the year 2006, the United States FDA gave the go ahead to a follow-up type of rhGH known as Omnitrope, released by Sandoz. Alkermes and Genentech developed a form of Growth Hormone that releases over time known as Nutropin Depot. This treatment was FDA-approved in 1999 and it minimized the need for daily injections, requiring one injection every two to four weeks; however, this product became discontinued in the year 2004.

See also:

Human Growth hormone; Human Growth hormone treatment; Bodybuilding and Human Growth; Hormone Treatment; Human Growth Hormone controversies; Recombinant protein List; Insulin-Like Growth Factor-1

References

Alba-Roth, M'ller, Schopohl, von Werder (Published 1988). Arginine can enhance Human Growth Hormone secretion through the suppression of internal secretion of somatostatin. Journal of Clinical Endocrinology and Metabolism Volume 67 Issue 6: Pages 1186-9. PubMedID 2903866.

Scarth. Controlling the Human Growth Hormone and-Insulin-Like Growth Factor axis by nutraceutical, environmental, and pharmaceutical xenobiotics: a new role for enzymes that metabolize xenobiotics and the factors which regulate their expression. A review". Xenobiotica Volume 36 (Issue 2-3): Pages 119-218. PubMedID 16702112.

Takahashi, Kipnis, Daughaday (Published 1968). Human Growth Hormone secretion during sleep". Journal of Clinical Investigation Volume 47 Issue 9: Pages 2079-90. PubMedID 5675428.

Actions of Ant. Pit. Growth Hormones. Med. Coll of Ga, 2007

King. Growth Hormone. Indiana SU 2006

Study finds no proof that Human Growth Hormone Therapy leads to longer life.

British Broadcasting Company News. July 26, 2002. Human Growth Hormone therapy linked to cancer.


Bio-Identical HGH Hormone Replacement Therapy


Written by Dr. Welsh, Published on 11 July 2013

health pituitary growth hormone side effects

Bio-Identical Hormone Replacement Therapy and HGH Deficiency

It is becoming more and more commonly known that HGH levels begin to drop as a natural result of the aging process. In certain individuals, Growth Hormone Levels can drop to rates which have a significant impact on health and wellness. Although every person on the planet follows the same gradual and downward track in regard to their HGH Levels, some experience this decline faster than others. Do you feel that you may be a victim of Adult-Onset Human Growth Hormone Deficiency?

Human Growth Hormone and Testosterone Combination Therapy

In men, a number of the complications of HGH Deficiency are related to the symptoms of Testosterone Deficiency. At the Conscious Evolution Institute, we've realized that a significant number of men simultaneously suffer from the effects of both Low Human Growth Hormone Levels and Low-T. When a patient is experiencing a severe deficiency of both of these vital hormones, the negative effects appear to stack exponentially, creating even greater and more significant complications as a result of hormone imbalance.

Many patients will only need one form of therapy or the other. The numerous diagnostic tests that we perform will highlight exactly where your medical issues likely arise, and will help us prepare a treatment regimen that appeals directly to your needs and desires. Many patients will see the greatest level of benefit from a combination-approach that utilizes both HGH Hormone Replacement Therapy and Testosterone Replacement Therapy in order to restore a more harmonious balance of hormones, which has the capacity to benefit the patient in numerous and vital ways.

Hormone Treatments for those that don't Qualify for Bio-Identical HGH

In addition to Bio-Identical Hormone Replacement Therapy, we also utilize other therapies and techniques in the case of patients that may not qualify directly for HGH Injections. Among these treatments are L-Ornithine and L-Arginine Amino Acid Treatments, which can achieve modest boosts in evening HGH Secretion if administered just as you head to bed.

In order to monitor your treatment and assess the benefits of therapy, we occasionally draw blood samples in order to determine the success of your treatment, as well as monitor for any potential minor complications which may lead us to adjust your treatment.

Physical Symptoms of Growth Hormone Deficiency

Human Growth Hormone Deficiency affects systems throughout the body, but some of the most obvious physical changes that take place as a result of HGH Deficiency are increased fat around the midsection, the development of sharp lines and wrinkles, thinning hair, and significant changes in sleep quality.

Human Growth Hormone for Those That Need It

We should note that, although we specialize in Human Growth Hormone Replacement Therapy, only patients that display a clinical and diagnosable need for HGH Replacement, as outlined by the Endocrine Society's Criteria for Deficiency, qualify for Human Growth Hormone HRT. There are a number of other treatment options available with which we can assist you (such as Sermorelin Acetate Therapy or Amino Acid Treatment), but as a result of the legal status of HGH, we may be unable to provide Human Growth Hormone Injections for your particular case.

Hormone Balance Key to a Long and Healthy Life

At the Conscious Evolution Institute, we are keenly aware of the importance of Hormone Balance in preserving health and wellness throughout the lifespan. We have years of clinical experience in assisting patients to achieve a greater state of Hormone Optimization, and if you feel that the aging process is wearing you down prematurely, we are confident that we can help you take steps to achieving a renewed state of vitality.

Symptoms of Human Growth Hormone Deficiency

Changes in Body-Fat Metabolism which increase the rate at which you accumulate unhealthy adipose body fat, especially around the midsection. These changes occur in spite of the fact that you do not change your activity level or your diet.

A Decrease in Lean Muscle Mass that is not the result of changes in physical activity. Human Growth Hormone and Testosterone both play significant roles in muscle development, and as these hormones begin to decline, it becomes harder to build and maintain muscle mass.

Decline in Sex Drive is associated with both Human Growth Hormone Deficiency and Testosterone Deficiency. If you don't feel as interested in sex as you were in the past, and that change is not the result of emotional or relationship-related issues between you and your partner, you may experience significant benefit from Hormone Replacement Therapy.

Both sexes may also experience Changes in Sexual Arousal which make sexual activity difficult or embarrassing. In men, this means that you may have trouble getting it up or keeping it up. In women, this means that you might not be physically ready for sex, which can make the experience uncomfortable or even painful.

Both Human Growth Hormone Deficiency and Low-T can contribute to changes in bone structure which can Decrease Bone Mineral Density and increase the risk of medical disorders such as Osteoporosis.

Human Growth Hormone is one of the body's most important metabolites. If you suffer from Low Levels of HGH, you will likely experience Significant Reductions in Stamina, Endurance, and Vitality, which affect you in both your day to day life and your ability to engage and enjoy physical activity.

Changes in skin tone also occur when HGH Levels Decline. Human Growth Hormone plays a role in both the strength of the muscles underneath the skin and the fullness and beauty associated with proper water balance. When HGH Production gets too low, this can increase the incidence of Fine Lines and Wrinkles associated with age.

The metabolic changes that occur as a result of Human Growth Hormone Deficiency also change the way that your body balances cholesterol. This can lead to an imbalance which encourages Increased Levels of Unhealthy LDL Cholesterol while Decreasing Levels of Healthy HDL Cholesterol.

HGH Deficiency not only affects the skin, but the hair as well. Human Growth Hormone Deficiency can contribute to both Premature Graying and Severe Changes in the Health of the Hair, making the strands more brittle and less smooth and luxurious.

Human Growth Hormone is intricately related to proper physiological rehabilitation and healthy immune function. People that suffer from HGH Deficiency are much More Likely to Get Sick. Also, they Take Longer to Heal and Recover from Injury than their counterparts with a healthier hormone balance.

Reduced Renal Function can also occur as a direct result of changes in hormone balance. The kidneys depend upon Human Growth Hormone in order to maintain optimal function.

Cardiovascular Complications are a significant and potentially life threatening symptom of Human Growth Hormone Deficiency. Changes in fat metabolism encourage LDL Cholesterol Levels to soar in the blood stream, and Human Growth Hormone helps prevent dangerous plaques from forming in the arteries by breaking down Triglycerides and LDL Cholesterol in the blood stream.

Many patients with Growth Hormone Deficiency even suffer from Changes in Cognitive Function. There is evidence that HGH Deficiency is correlated with poorer cognitive function as a result of age, and may even contribute to Alzheimer's disease and other disorders of the brain.

Hormone Deficiency Significantly Damages Long-Term Health

A recent clinical survey of nearly 4,000 men showed that men with Healthy Levels of Testosterone and HGH are considerably less likely to die of any premature cause than men with lower levels of either of these hormones. There is a direct correlation between hormone balance and mortality risk.

A New Approach to Human Growth Hormone Replacement Therapy

As a result of current laws regarding the sale and distribution of HGH, there are many patients that do not qualify for Human Growth Hormone Injections that may still benefit significantly from increase HGH Levels. Although Growth Hormone Shots aren't as accessible as we believe that they should be, there are still a number of innovative ways to naturally or medically increase Human Growth Hormone Levels.

The Conscious Evolution Institute combines proven medical therapies with 21st Century Nutritional, Dietary, and Lifestyle Plans in order to encourage optimal hormone production which helps restore a more youthful physiological state.

Based upon the diagnostic data that we receive from your hormone profile and physical, as well as the symptoms that you display, we will have more than enough information to design a health care regimen that conforms to your own personal and unique needs as an individual.

Decades of scientific study regarding the importance of Human Growth Hormone has shown that HGH Deficiency leads to a number of major negative physiological changes, including reduced fat metabolism, reduced bone mineral density, and muscle atrophy. In addition to these three major symptoms, Human Growth Hormone Deficiency also has a detrimental effect upon exercise capacity, energy production, and cardiovascular health. HGH Deficiency is like a weight on your shoulders, dragging you down in almost every way imaginable.

There is hope, however. Every year, new studies come out which show how Human Growth Hormone Replacement has the potential to restore healthier, more optimal function.

In addition to Human Growth Hormone, our physicians will also test for any other hormonal issues or deficiencies that you may be dealing with. The most effective approach to Hormone Replacement is to optimize your entire endocrinological system. If you are eligible, combining therapies will produce more potent benefits than simply restoring HGH Levels alone.

The Conscious Evolution Institute: Premium Care from Accredited Professionals

At the Conscious Evolution Institute, we realize that every patient that contacts us has a unique set of needs and desires, and this is why we offer such a personalized approach to Hormone Replacement. We work with you to find the Hormone Treatment Option which best fits the needs of your body, your financial circumstances, as well as your future goals and desires, in order to provide you with the healthcare that you deserve as a patient. Although we specialize in Hormone Replacement, we understand that long term health and longevity are about more than simply hormone balance.

Benefits of HGH Hormone Replacement

  • Improved Rehabilitation Outcomes after Exercise and Physical Injury

  • Improved Cholesterol Balance

  • Lower Blood Pressure, Improved Blood Flow

  • Better Skin Health

  • Increased Fat Metabolism

  • Increased Muscle Tone and Mass

  • Improved Kidney Filtration

  • Stronger Bones

  • Stress Alleviation and Anxiety Reduction


HGH Benefits


Written by Dr. Welsh, Published on 28 August 2017

The Benefits of HGH Therapy for Patients Suffering from Adult-Onset HGH Deficiency

aging comparison

Human Growth Hormone has quite a controversial track record—for the most part entirely undeserved. Though HGH Abuse is a problem that should indeed be addressed, there are hundreds of thousands of men and women nationwide that can benefit from Bio-Identical HGH Therapy, if not more. As the body of research evolves and grows, it becomes clear that Human Growth Hormone is an immensely important hormone, not only during human development but throughout the human lifespan.

Along with human development, HGH plays an influential role in cellular regeneration and rejuvenation, and research provides substantial evidence that healthy Human Growth Hormone Levels promote longevity and elevated quality of life. While it would be misleading to say that HGH has anti-aging properties, Human Growth Hormone Therapy does have the ability to relieve many symptoms that have long been associated with aging.

It turns out that many issues related to aging actually have a strong hormonal component, and by balancing and restoring Hormone Levels to a more youthful balance, it is possible to mitigate these symptoms, allowing patients to live a healthier life.

The Lurking Threat of Somatopause

Many people think that HGH Deficiency is incredibly rare, but that is simply not the case. Without HRT Intervention, Human Growth Hormone Levels follow a distinct track from the late twenties onward—HGH Levels start to fall from their adult peak at around thirty years of age, and Human Growth Hormone Production slowly falls for the rest of the lifespan. Simply put, given that you live a long enough life, you will experience issues with Human Growth Hormone Deficiency in your lifetime.

Generally, symptoms of HGH Imbalance manifest during middle-age, in the 40s or 50s, though some patients may experience these symptoms earlier or later than others. Age-Associated Human Growth Hormone Deficiency is referred to in therapeutic circles as Somatopause. Though far more gradual than menopause, Somatopause represents a change in how the body operates.

As HGH Levels drop, so does the body's ability to rejuvenate, recover, repair, and revitalize, which leads to symptoms which significantly impair quality of life, such as aerobic capacity, energy level, strength, depression, poor cholesterol balance, trouble sleeping, thinning hair, and more.

HGH Therapy Benefits Patients Suffering from Somatopause

chronic fatigue somatopause

Luckily, there is no reason to resign yourself to the decline associated with Hormone Imbalance, because advances in Recombinant-DNA Technology have led to a burgeoning field of Hormone Restoration techniques such as Bio-Identical HGH Therapy and Sermorelin Acetate Injections which have the ability to safely restore Hormone Levels to a concentration associated with youthful resilience and vitality. Hundreds of thousands of patients nationwide have benefited from Hormone Therapy, and HGH Injections are just one of many proven medical techniques that have revolutionized medical care in the 20th century.

Human Growth Hormone Injections are usually prescribed for an initial period of six-months before the patient must return for re-evaluation. It should be noted that HGH Shot Therapy is a treatment for Growth Hormone Deficiency, and not a cure. After six months, the patient's Growth Hormone Levels will be re-evaluated, and changes to the treatment regimen may be conducted to streamline the therapy and ensure the best and safest results.

Over the course of six months of injections, patients should experience ongoing and progressive relief from symptoms. During the initial stage of treatment, most benefits will be in the form of energy level and mood, while other benefits will need time to accrue. This is because many symptoms, such as diminished muscle mass and increased body fat, take time to adapt to modified hormone balance, which means that you won't see major improvements in these areas for a few months. Be patient, and remember that Human Growth Hormone is working, even if it's not readily apparent in the first few days!

Benefits to Expect Over Six Months of HGH Therapy

The following are standard benefits that patients experience as a result of Bio-Identical Human Growth Hormone Therapy. Remember that every patient is different, and your individual results will undoubtedly vary:

  • Increased Blood Flow and Improved Circulation

  • Enhanced Libido and Sexual Desire

  • Improved Mood and Cognitive Function

  • Deeper and More Restful Sleep

  • Increased Exercise Capacity

  • More Energy

  • Improved Body Fat Percentage—More Muscle Mass and Less Fat

  • Stronger Hair

  • Smoother Skin

Interested in HGH Therapy? Our HRT Representatives are Standing By

somatopause doctor specialists

Somatopause may be a stage in the human lifespan, but that does not mean that its end result is a positive one. If you feel that HGH Deficiency is diminishing your ability to enjoy and love your life, our Board-Certified Hormone Doctors can help! We work with physicians in your vicinity to provide affordable and efficient HRT Care. If you'd like to speak with one of our staff Hormone Specialists, we offer free consultation to interested clients at no cost to you! Just contact us at the phone number above or fill out the form on this page to get started!

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Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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