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SAIZEN HGH: Human Growth Hormone Product


Written by Dr. Welsh, Published on 07 May 2013

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Saizen Human Growth Hormone Replacement Therapy

Saizen is one of a small, but growing number of legal HGH Hormone Replacement Therapy medications in the United States. Saizen is produced by the pharmaceutical manufacturer Merck Serono. Merck Serono is one of the largest drug manufacturers in the world, and is based in Geneva, Switzerland. This company is not to be confused with the domestic pharmaceutical company Merck & Company, and in North America, Merck Serono is known as EMD Serono. Saizen is an injectable form of Synthetic Human Growth Hormone.

The History of HGH

Originally, HGH Hormone Treatments were made from real Growth Hormone harvested from human tissue, but in the year 1981, medical researchers were able to figure out a way to synthetically produce Bio-Identical HGH in a laboratory. Before it was possible to manufacture Bio-Identical Human Growth Hormone, HGH treatments were far more costly than they are today, and as a result of this breakthrough, and others since, Human Growth Hormone Injectable Therapy has continued to become cheaper and more affordable to the average consumer.

Saizen Human Growth Hormone is Simple and Easy to Use

Saizen HGH follows in that legacy of making Growth Hormone cheaper and easier to use. The following are a number of products released by Serono in order to perform HGH Hormone Replacement Therapy:

Saizen HGH Therapy Administration Devices

Saizen Cool.Click HGH Treatment

The Saizen cool.click is a revolutionary means of delivering Human Growth Hormone. Although the HGH is still delivered subcutaneously via injection, the Saizen cool.click does not need a needle! The cool.click works by creating a small hole through which Saizen Human Growth Hormone is delivered. This tiny hole is produced using a spring mechanism. In the past, many people have been nervous about HGH Hormone Replacement because before this point, the only way to deliver HGH was directly through a potentially imposing needle. Many people just can't commit to any medical therapy which requires them to stick themselves with a needle every day.

Although the Saizen cool.click was the first needle-free means of delivering HGH Hormone Replacement Therapy, EMD Sorono has updated the design to increase ease of use, comfort, and accuracy, with an updated version known as the Saizen cool.click2.

EMD Serono lists the following features of the Saizen cool.click2:

  • Needle-less delivery This form of HGH Delivery vastly reduces needle anxiety.

  • Easy-to-read LCD monitor The monitor displays dosing information and can ensure that a patient delivers exactly enough Saizen HGH in order to properly treat his or her HGH Deficiency.

  • Thoughtful shape and design the Saizen cool.click2 is ergonomically configured in order to maximize ease of use.

  • Reduced noise the cool.click2 is much quieter than its previous design, allowing you to deliver HGH without bringing attention to yourself.

  • Reverse dosage dialing this mechanism allows the patient to adjust and readjust dosage at any point before administering HGH Hormone Replacement Therapy.

  • Alterable injection pressure This HGH Injection Tool lets you adjust the rate at which the spring mechanism pierces the skin, allowing you to minimize potential discomfort at the injection site.

  • Safer than needles Because of the way that the cool.click2 is designed, there is virtually no risk of accidentally pricking yourself. The spring mechanism only exposes itself at your command, and you don't have to cautiously prepare a needle for every injection.

  • Delivers doses in both milligrams and milliliters the cool.click2 can adapt to different measurement scales, allowing you to dose accurately in regard to both mass and volume.

HGH Therapy with Saizen Easypod

Like the Saizen cool.click, the Saizen easypod is another product produced by EMD Serono which is designed with comfort and ease of use particularly in mind. The easypod is a simple-to-use injection device which quickly and accurately delivers injections of Bio-Identical HGH.

The easypod is what is known as an easy injector. This means that the easypod is a means to deliver injections of HGH without the vigorous protocol of a standard needle injection. The Saizen easypod has the capability of quickly and automatically titrating the appropriate dose of HGH. Upon pressing the trigger button, the machine automatically provides an injection of Human Growth Hormone, minimizing the amount of potential contact the you will make with the needle.

The Saizen easypod exclusively uses cartridges known as Saizen click.easy in order to deliver the intended dosage. The click.easy device serves two primary purposes. First, the click.easy is a reconstitution device. The Saizen Human Growth Hormone is combined with a fully sanitized solution in order both to rehydrate anhydrous HGH and to convert the Human Growth Hormone into a deliverable form. Second, the click.easy is a delivery device.

The click.easy is designed and shaped in a way which allows the patient to use it in combination with the Saizen easypod in order to maximize safety and ease of delivery. The Saizen easypod can be used repeatedly in order to deliver HGH injections as long as it is properly maintained, and new needles are use for every injection. The easypod has a large monitor which allows patients of all ages to easily see and understand the instructions and options provided by the device.

The easypod also provides multiple means of decreasing discomfort associated with injection. The individual patient can adjust injection administration via four distinct settings: Needle Speed, Injection Speed, Injection Depth, Injection Time.

HGH Easypod Settings

Needle Speed This setting adjusts the speed at which the needle is injected through the skin. Using this method is much more precise than performing a manual injection.

Injection Speed This refers to the rate by which the Saizen Human Growth Hormone is delivered into the body. This setting is a substitute for manually adjusting the speed using the plunger of a needle.

Injection Depth With this setting, you can alter the depth at which the needle descends. Dependent upon the location of the injection, different depths may be required. In addition to this, some may find that deeper injections cause increased discomfort. Injection depth also depends upon which needle the patient uses.

Injection Time This prompt controls the amount of time that the needle remains in the skin after injection. Some patients find it more comfortable to increase the time between injection and needle removal.

The Saizen easypod also maintains a diary of past injections, allowing both you and your physician to have a record of your injection schedule. The goal of the Saizen easypod is to reduce the effort it takes to undergo safe and effective Human Growth Hormone Injections while also minimizing pain or discomfort which can result from the use of needles. The easypod even allows you to input expiration dates to ensure that you dispose of your reconstituted synthetic Human Growth Hormone as soon as it becomes expired and ineffective.

Saizen one.click HGH Injector

The Saizen one.click is another means of injecting Saizen Human Growth Hormone. Like the easypod, the one.click is another injection device which focuses on being easy to use. The one.click is a much simpler device than the easypod. This product is mechanical only and features no monitor or electrical equipment of any kind.

The one.click has an adjustable dial which controls how much Human Growth Hormone you inject in a single dose. In addition to this, you can also adjust the depth of the needle injection manually. One of the primary advantages of the Saizen one.click is that it is simple to store and easy to carry and conceal. Also, because the one.click is a completely mechanical device, it is cheaper than the easypod while also being easier to use than a standard injection.

The Saizen one.click automatically delivers the HGH injection with a single click, minimizing the time it takes to deliver the injection. The device itself also minimizes potential inappropriate contact with the needle as well. As with all forms of Recombinant Human Growth Hormone, the reconstituted solution should be stored at temperatures between 36 and 46 degrees Fahrenheit in order for the hormone to remain effective and useful.

Saizen click.easy

The Saizen click.easy is the simplest injection device that Merck-Serono provides. This product still has the capability of injecting HGH Hormone Replacement Therapy quicker and more simply than a standard injection, but lacks all of the bells and whistles associated with the other Saizen Delivery Devices. This product still minimizes needle exposure and also delivers a subcutaneous injection with a single click, however. This device is for patients who want a quick and easy way to inject HGH Therapy without the need or desire to make more precise adjustments with other more high-tech injection devices.

How is Saizen HGH Supplied?

Saizen is generally provided to the patient via two means:

HGH Direct Injection

For patients who are not interested in using the Saizen Delivery devices listed above, there is the option of simply delivering the Human Growth Hormone via needle and syringe. For patients who are interested in administering HGH in this way, Saizen is available in vials. Saizen vials are available in two different sizes. Both 5 milligram vials and 8.8 milligram vials are available. These vials contain lyophilized Bio-Synthetic Human Growth Hormone. HGH is highly sensitive in its normal form, and must be freeze-dried and hermetically sealed in order to survive periods of extended storage and transport. When the Saizen is ready to be used, the powdered HGH must be reconstituted with a diluent. The diluent is a sterilized, clear solution that does not interact with the HGH molecule and can deliver the medication into subcutaneous tissue.

HGH Cartridge Delivery

For patients who wish to use delivery devices such as those listed above, Merck-Serono provides Saizen HGH Cartridges which are designed especially to be used with Saizen Human Growth Hormone Administration Devices. Saizen cartridges contain both lyophilized Human Growth Hormone and the sterilized diluent, separated by a small barrier. When you are ready to use the Saizen HGH Cartridge in one of the devices listed above, you will insert the cartridge into the device and follow the instructions provided with the device in order to combine and reconstitute the solution. After the cartridge of Human Growth Hormone has been activated and given time to fully hydrate, the solution is ready for injection. There are a few different options for the Saizen Cartridge, and these options are dependent upon both the size and strength of your individual dose.

Saizen Questions

At what Temperature Should Saizen be Stored?

Like all forms of Bio-Identical Human Growth Hormone, Saizen must be properly stored in order to remain potent. Lyophilized Saizen which has not been combined with diluent can be safely stored at room temperature (between 59 and 86 degrees Fahrenheit). After reconstitution, Saizen should always be refrigerated, except when it is immediately going to be used for injection. Reconstituted Saizen HGH should be stored between temperatures of 36 and 46 degrees Fahrenheit.

Does Saizen Contain Preservatives?

Saizen does contain preservatives in order to maximize the length of time that HGH is stable and usable. The vial form of Saizen contains benzyl alcohol, and the cartridge form of Saizen contains metacresol.

How Often Should I Take Saizen Injections?

The frequency with which you administer HGH Hormone Injections is completely dependent upon your physician's advice. Generally, injections are delivered once daily, just before bed, but there are a number of other options available which will not have a negative effect on your therapy. Nightly injections are thought to have the most beneficial effect on sleep and the cortisol cycle. Some prefer to take their doses early in the morning, or before engaging in exercise. Injecting before exercise is believed by some to increase the effectiveness of exercise, reducing fatigue and feeling of exhaustion. Some physicians even recommend that certain patients take two small doses each day rather than one larger dose once per day. It all depends on your age, goals, and needs as a patient.

What Are Saizen's Side-Effects?

The majority of patients will suffer from no side effects, or only the most minor symptoms. The most common symptoms are injection site irritation and possible headaches. Adult patients may rarely experience increased blood sugar, joint pain, and swelling as a result of Saizen. If any of these symptoms occur, please talk to your doctor.


All The Different Brands of Human Growth Hormone


Written by Dr. Welsh, Published on 26 February 2012

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Real HGH (Somatropin) brands
The method of manufacturing HGH that is most often used now is through either Protein Secretion technology or Mouse-cell technology . Both of these means of manufacturing create HGH that is identical to the GH produced naturally in a human body.
       
Nutropin - Genentech
Nutropin was developed by Genentech and is available for sale worldwide. Nutropin is manufactured by Protein Secretion technology.
       
Hypertropin - Neogenica BioScience Ltd.
Hypertropin is manufactured by NeoGenica Bioscience Ltd. It is one of the most potent brands of HGH on the market. Hypertropin is produced by secretion technology and is 191 amino acid sequence human growth hormone - identical to human body's own. It is a rather new product available for sale in China.
       
Genotropin - Genentech
Genotropin was developed by Genentech. It is available for sale in the U.S. through Pharmacia, in Europe through Pierrel, and in Japan through Sumitomo. Genotropin is manufactured by Protein Secretion technology.
       
Humatrope - Eli Lilly
Humatrope was both developed by and is available for sale in the U.S. and Europe through Eli Lilly. Humatrope is manufactured by Protein Secretion technology.
       
Saizen - Serono
Saizen was developed by Switzerland's Serono. It is available for sale in both the U.S. and Europe. Saizen is manufactured by Mouse-cell technology.
       
Serostim - Serono
Serostim was also developed by Serono. It is available for sale in the U.S. Serostim is manufactured by Mouse-cell technology.
       
Zorbtive - Serono
Zorbtive was developed by Serono. It is available for sale in the U.S. Zorbtive is manufactured by Mouse-cell technology.
       
Norditropin Novo Nordisk
Norditropin was developed by Danish pharmaceutical company Novo Nordisk. It is available for sale in the U.S. and Europe through Novo Nordisk and in Japan through Yamanouchi. Norditropin is manufactured by Protein Secretion technology.
       
Jintropin - GeneScience Pharmaceuticals
Jintropin is manufactured and distributed by GeneScience Pharmaceutical Co., Ltd. It was the first 191 amino acid sequence HGH in China. GenSci is a China-based pharmaceutical company which has been active since 1997.
       
Zomacton - Ferring Pharmaceuticals
Zomacton was developed by Ferring Pharmaceuticals. It is available for sale worldwide. Zomacton is manufactured by Protein Secretion technology.
       
192 amino acid sequence HGH (Somatrem)
Inclusion Body technology was the first biosynthetic form of HGH developed (known as Met-GH , Somatorm or 192 amino acid sequence HGH ). When researchers first developed HGH using Inclusion Body Technology, they were comparing it to cadaver-GH. However, Met-GH was not pure GH, so met-GH produced side effects in many users. Met-GH has an additional methionyl amino acid that caused a person's body to build up antibodies against it. Some users experienced allergic reactions to met-GH, some even built up so much resistance that it neutralized the effect of the drug.
Ansomone - AnkeBio
Ansomone is manufactured and distributed by Anhui Anke Biotechnology. Tests performed by independent researchers have shown that Ansomone is a good quality HGH drug. However, HGH that is created by Inclusion Body technology is not identical to human GH.
       
Tev-Tropin - TEVA Pharmaceuticals
Tev-Tropin was developed by TEVA Pharmaceuticals. It is sold in the U.S. Tev-Tropin is manufactured by Inclusion Body technology.
      
Fitropin Kexing
Fitropin is manufactured and distributed by Kexing. Kexing is a China-based pharmaceutical company. Because GeneScience Pharmaceutical Co., Ltd. has the patent for manufacturing HGH by secretion technology in China, Kexing cannot manufacture their product through such a pure and effective means. Rather, Fitropin is manufactured by Inclusion Body technology.         
 

GENOTROPIN HGH: Human Growth Hormone Product


Written by Dr. Welsh, Published on 25 February 2018

GENOTROPIN®:

Growth hormone affects many parts of the body, including the bones, muscles, and fat. Children need growth hormone to grow taller. Adults also need growth hormone to maintain health. When the body does not produce enough of this hormone, growth hormone deficiency (GHD) occurs

GENOTROPIN® is human growth hormone replacement therapy that can be used to help compensate for low levels of growth hormone. GENOTROPIN® is exactly like the natural growth hormone produced by the body's pituitary gland.

Growth hormone deficiency (GHD) in adults and growth failure in children. Find out more about the symptoms, diagnosis, and treatment of these conditions, along with general information about GENOTROPIN® and delivery devices for GENOTROPIN®.

Approved Uses
GENOTROPIN® Lyophilized Powder (somatropin [rDNA origin] for injection) is indicated for:
Pediatric Indications.

  • Long-term treatment of children who have growth failure due to an inadequate secretion of endogenous growth hormone (GH).
  • Long-term treatment of growth failure in children born small for gestational age (SGA) who fail to manifest catch-up growth by age 2.
  • Long-term treatment of children who have growth failure due to Prader-Willi syndrome (PWS). The diagnosis of PWS should be confirmed by appropriate genetic testing.
    Other causes of short stature in children should be excluded.
    Adult Indications
  • Long-term replacement therapy in adults with growth hormone deficiency (GHD) of either childhood- or adult-onset etiology. GHD should be confirmed by a special growth hormone test called a stimulation test.

Safety

Contraindications
Growth hormone (GH) should not be used in patients with active tumors or receiving antitumor therapy. GH should not be used to increase height in children with bones with closed growth plates.
GH should not be started to treat patients with critical illness due to complications of surgery, injury, or respiratory failure. The safety of continuing GH replacement therapy for approved uses in patients who develop these illnesses has not been established.

Growth hormone is contraindicated in patients with PWS who are severely obese or have severe respiratory impairment.

Additional Safety Information
Tell the doctor if the patient has any allergies to a preservative called cresol, because the 5.8 mg and 13.8 mg cartridge strengths of GENOTROPIN® contain this substance.

Deaths have been reported with the use of growth hormone in pediatric PWS patients with severe obesity, history of respiratory impairment or sleep apnea, and/or unidentified respiratory infection. Therefore, all patients with PWS should be evaluated and monitored for sleep apnea and respiratory infections, and have effective weight control.

Insulin dosage may need to be adjusted during therapy with GH if the patient has diabetes. Dosages of other medications also may need adjustment, so be sure to tell the doctor about any medications the patient may be taking.

GH should be used during pregnancy only if clearly needed and with caution in nursing mothers because it is not known whether GENOTROPIN® is excreted in human milk.
Children with disorders such as growth hormone deficiency have a higher rate of slipped growth plates in the hip. Therefore, it is important to tell the doctor if the patient begins to limp or complains of hip or knee pain during GH therapy.
In children experiencing rapid growth, curvature of the spine may worsen. The doctor may check the patient for spine curvature during GH therapy.

In a small number of patients treated with growth hormone products, intracranial hypertension, or IH (increased pressure in the brain) has been reported. Symptoms usually occurred within the first 8 weeks of therapy in all reported cases, signs/symptoms went away after stopping therapy or reducing the dose. Do not change GH dose without consulting your doctor. Be sure to tell the doctor if symptoms such as headache, visual changes, nausea and/or vomiting occur. Patients with PWS may be at increased risk for IH.

In studies with GENOTROPIN® in children with growth hormone deficiencies, side effects included injection-site reactions including pain or burning associated with the injection, redness/swelling, scarring, lumps, or rash; headache; blood in the urine; low thyroid activity; and mildly increased blood sugar.

In studies with GENOTROPIN® in children with PWS, side effects included swelling from water/fluid retention, aggressiveness, joint pain, intracranial hypertension, or IH (increased pressure in the brain), hair loss, headache, and muscle pain.

In clinical studies of 273 pediatric patients born SGA treated with GENOTROPIN®, the following side effects were reported: mild temporary increased blood sugar; increased pressure in the brain; early puberty; jaw prominence; aggravation of pre-existing back curvatures; injection-site reactions; and progression of pigmented moles or birthmarks.

In studies with GENOTROPIN® in adults with GHD, the majority of side effects were mild to moderate symptoms of water/fluid retention including swelling of the hands or feet, stiffness of the extremities, joint or muscle pain, and numbness and tingling in the extremities. These side effects were reported early in therapy and tended to be temporary and/or helped by a dosage reduction.
Tell your doctor about these or any other side effects that you notice.


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