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SEROSTIM®:

Serono offers Serostim® [somatropin (rDNA origin) for injection], the only growth hormone approved by the U.S. Food and Drug Administration for the treatment of HIV-associated wasting or cachexia. Through SeroCare®, Serono offers comprehensive support to healthcare providers and patients including education and appropriate access to care and treatment.

Serostim® (recombinant human growth hormone) works by interacting with specific cells to restore and build lean body mass (LBM). LBM includes muscle, organ tissue (excluding fat), and body fluids.

It is the only growth hormone approved by the U.S. Food and Drug Administration for the treatment of AIDS wasting or cachexia. Serostim® is mammalian cell-derived and produced using recombinant technology.

Clinical trials show that Serostim® has been effective in the treatment of AIDS wasting or cachexia. FDA approval is based on clinical studies up to 12 weeks in duration that analyzed body weight and lean body mass as an intermediate measure of Serostim®'s efficacy for AIDS wasting. A further study is underway to evaluate the full impact of Serostim® on patients' physical endurance and quality of life.

Serostim® must be used in conjunction with antiretroviral therapy. 76% of patients evaluated at week 2 of treatment had weight gain. Patients who continue to lose weight at week 2 should be reevaluated for concurrent opportunistic infections or other clinical events. The recommended duration of treatment is 12 weeks. No significant additional treatment benefit was observed in patients receiving therapy beyond 12 weeks. There are no data available from studies for patients who start, stop and restart treatment.

Sermorelin Growth Hormone Releasing Hormone Analog


Written by Dr. Welsh, Published on 06 April 2012

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Geref Sermorelin Acetate Therapy

Geref is one of the many forms of Sermorelin Acetate injection that have been released in the American market.

Sermorelin at a Glance

Sermorelin is a synthetic form of Growth Hormone-Releasing Hormone. GH-RH is composed of a chain of forty four amino acids, whereas Sermorelin only contains twenty nine amino acids. Despite this fact, Sermorelin functions identically to GH-RH in the human body, and is one of the most popular forms of GH-RH therapy.

One of the most common means by which Sermorelin is configured for human injection is by forming an acetate salt to which Sermorelin is attached.

Sermorelin Acetate Breakdown

Noted in molecular terms, Sermorelin Acetate is: C149 H246 N44 O42 S1. Sermorelin acetate has a weight of 3,358 daltons.

Geref is a sterilized and has been proven not to produce an inflammatory response when injected into the human body. In unconstituted form, Geref is freeze-dried through sublimation, allowing it to be transported more effectively and stored for a longer period of time than its liquid form. Before Geref is injected, it must be reconstituted, combining the lyophilized Sermorelin Acetate with a Sodium Chloride Solution. After reconstitution, the mixture has a pH of between 5 and 5.5.

How is Geref Distributed?

Geref is delivered to the patient via vials. The contents of the vial are as follows:

Each half milligram vial holds 0.5 milligrams of sermorelin acetate along with 5 milligrams of mannitol. The pH is fixated using a buffer of monobasic sodium phosphate and dibasic sodium phosphate.

Each one milligram vial holds 1.0 milligram of sermorelin acetate along with 5 milligrams of mannitol. These contents have pH levels which are also fixated using monobasic sodium phosphate and dibasic sodium phosphate.

How does Geref Work?

Geref is an injectable form of Sermorelin Acetate which has the ability to boost plasma levels of Insulin-Like Growth Factor One and Human Growth Hormone by stimulating the endogenous production of HGH by the pituitary gland. Geref functions in the body identically to endogenous GH-RH, stimulating HGH production in an identical manner in human beings.

How does Geref interact with the Human Body?

Distribution

After 0.25 to 1 milligram intravenous injection of Human Growth Hormone was delivered to twelve normal patients, the mean volume distribution had a range of 23.7 to 25.8 liters.

Absorption

After two milligrams of Sermorelin was subcutaneously injected to twelve normal patients, peak sermorelin saturation occurred between five and twenty minutes after injection. After this administration, the absolute mean bioavailability of sermorelin was around six percent.

Metabolism

There has been no human research regarding Geref.

Evacuation

Sermorelin leaves the body quite quickly after it has entered the bloodstream. In adults, Sermorelin is cleared from the body at a rate of around 2.6 liters per minute. Geref also has a short half-life of around eleven to twelve minutes after its initial subcutaneous or intravenous injection.

Among Individual Populations

Age/Gender: In healthy adults, Geref is evacuated from the body at a similar rate in both men and women. There is no clearance data as it relates to the age of the patient. There is also data which compares male and female pediatric clearance rates.

Hepatic/Renal Insufficiency: There is no available research data regarding how liver and kidney problems may effect clearance rates.

Clinical Evaluation of Geref

In one particular non-blind clinical research study performed across multiple medical centers, prepubescent adolescents suffering from idiopathic HGH Deficiency were given Geref injections of 30 micrograms per kilograms on a daily basic via SC injection. After one year of treatment, 56 participants were available for an evaluation of efficacy after twelve months. Another 54 participants were not qualified for evaluation. Twenty four violated criteria eligibility, ten discontinued the required protocol for treatment, and twenty others did not meet the criteria for evaluation after the initial six months of the study. 56 of the total of 110 participants, including 47 of the 56 patients who were among the subset of participants who were qualified for evaluation and continued Sermorelin Acetate therapy over the course of an entire year, were shown to grow in height at a rate of two centimeters per year faster than their baseline rate of growth. Among those 56 participants who qualified for evaluation, their height velocity changed at a rate of 4.1 centimeter per year after six months and increased at a rate of 7.2 centimeters per year after one year. The average patient grew taller at a rate of 3.1 centimeters centimeters per year. The bone age of these patients after one year of Geref therapy were in proportion to their height gains.

When should Geref be used?

Geref injections are intended for pediatric patients who suffer from HGH Deficiency with no discernible cause, which results in a failure to grow properly. The majority of these pediatric patients who suffer from HGH Deficiency still have active pituitary glands which respond readily to GH-RH. Pediatric patients who use Geref should be prepubescent. Geref Therapy should be instituted at a bone age of eight in males and seven and a half in females.

Geref Contraindications

Geref should not be utilized by individuals which have been proven to have an allergy or sensitivity to Sermorelin. It should also be avoided by any patients that have an sensitivity or allergy to any of the other ingredients included in the product.

Geref Warning

It is vitally important to use Geref immediately after it is reconstituted with the accompanied diluent. The reconstituted solution will begin to degrade a short time after reconstitution. If there is any solution that is left over after the injection is complete, it should be thrown away, and under no circumstances should you consider using it at a later time.


Geref Precautions

Geref should only be used with the express consent of a physician who specializes in either Growth Disorders or Anti-Aging Therapy, and when prescribed, hormone levels should be carefully monitored over time to ensure that proper hormone levels are restored.

Young patients who undergo Geref Hormone Replacement Therapy also need to be evaluated to ensure that Geref produces height gains. Some patients will not respond to Geref or other GH-RH analogues even if they are not growing at a proper rate. Those pediatric patients who do not respond to Geref therapy will more than likely be fully served through the usage of Human Growth Hormone HRT. It has been thoroughly proven that Geref produces positive changes in height following a single year of treatment; however, there has been no research as to the extent of the effect of Geref upon a patient's final height as an adult.

Geref and Hypothyroidism

In clinical research, 6.5% of participants were diagnosed with hypothyroidism as a result of Geref therapy. In the most significant Geref clinical trial, 8 participants among 110 who were enrolled were taking thyroid HRT before being administered Geref. 5 more participants began Thyroid Replacement HRT after treatment began.

If a patient suffers from undetected hypothyroidism it can negate or diminish the effects of Geref Hormone Replacement Therapy. For this reason, the administering physician should test for proper thyroid function before as well as periodically during Geref treatment. If at any point before or during therapy, the patient begins to show signs of hypothyroidism, Thyroid Hormone HRT should be instituted as soon as possible to maximize the effect of therapy and the health of the patient.

In addition to Thyroid Hormone testing, patients who are undergoing Geref Hormone Replacement Therapy should also be tested periodically for bone age. This is particularly important among patients who are currently undergoing puberty, or are concurrently receiving Thyroid Hormone HRT. In these particular patients, the epiphyseal plates can sometimes grow at a very fast rate. It is important to suspend Geref Sermorelin Acetate Therapy ones the ephyseal plates close, because at this point, the bones will no longer grow in length and Geref Therapy will no longer be needed.

Geref Hormone Replacement Therapy is not recommended for patients who suffer from an HGH Deficiency which resulted from an intracranial lesion. There has been no testing as to the safety of Sermorelin Acetate Therapy in this subset of patients.

Reactions to Geref

As is the case with the administration of any Hormone Replacement Therapy, systemic or local allergic responses can sometimes result. It is vital that patient (and parent if applicable) be aware that such responses can potentially occur. If the patient suffers an allergic reaction as a result of Geref Therapy it is vital that they receive medical attention promptly.

Clinical Tests have shown that increased blood-serum levels of Insulin-Like Growth Factor One (IGF-1), Human Growth Hormone, alkaline phosphatase, and inorganic mineral phosphorus can occur as a result of Geref Sermorelin Acetate Therapy.

Drug Interactions

Taking glucocorticoid steroids in combination with Sermorelin Acetate Therapy maybe reduce the effectiveness of Geref. In clinical studies of Geref Sermorelin Acetate Therapy, no pediatric patient who concomitantly took medications to treat normal youthful illnesses/problems had any problems as a result of combining their normal medications with Geref Hormone Replacement Therapy. Though no evidence has been discovered, it is still important to note that their have been no clinical studies regarding formal medical interations.

Fertility Impairment, Mutagenesis, Cancer risk

There has been no longitudinal animal research regarding fertility impairment or carcinogenicity risk regarding Geref Hormone Replacement Therapy. There has been absolutely no clinical research linking Geref Sermorelin Acetate Therapy to genetic abnormalities.

Pregnancy

There has been some animal research conducted regarding Geref Therapy. At a dosage somewhere between three and six times the normal daily dosage that a human patient receives adjusted for physical surface area, minor fetal changes occurred in rabbits and rats. There have been no adequately controlled studies regarding the usage of Geref by women who are pregnant. Geref Sermorelin Acetate Therapy should only be administered to women that are pregnant if the likely benefits of the therapy outweigh the possible risk to the unborn child.


Nursing Women

It is unknown if Geref is produced in human milk. There are many medications that are released by the mother in the nursing process, and for this reason mothers and physicians should exercise caution when using Geref Hormone Repalcement Therapy while nursing.

Patient Information

All patients who are prescribed Geref (along with their parents, if applicable) should be adequately informed of the possible risks and benefits that are related to the therapy. If the prescribing physician has determined that Geref should be administered by either patient or parent at home, the physician must provide appropriate guidance regarding its use. This includes verbally discussing the content of the Patient Information Booklet with the patient (and parent, if applicable). The Insert which accompanies the prescription is meant to assist the patient in effective and safe usage of Geref, and does not provide a complete and total disclosure of all potential effects whether intended or adverse.

Disposal Information

If the physician approves home usage, the patient should be provided with or directed to a location which provides SHARPS containers meant for the proper disposal of used needles and syringes accumulated as a result of Geref Therapy. These containers are puncture resistant and are a necessary safety measure to protect both patient and anyone who may come in contact with the used needles and syringes. It is vital that patient (and parent, if applicable) be directed thoroughly as to the vital important of proper needle disposal. Also, they should be informed of the dangers of reusing syringes and needles as well.

Side Effects

A significant portion of Geref Sermorelin Acetate HRT patients antibodies against Growth Hormone Factor during at least one point of therapy. There is no clear assessment of the significance of the presence of these antibodies, and the levels of these antibodies can change quickly from test to test. A positive result at one juncture regularly turns into a negative result after the next test. The production of these antibodies does not seem to have any adverse effect on the patient. Also, these antibodies do not seem to produce any change in the effectiveness of Geref therapy. There have been no reported general allergic responses to Geref Sermorelin Acetate Therapy.

The most common reaction to Geref Hormone Replacement Therapy which is related to treatment is local irritation around the injection site, which occurs in around one of every six patients. This irritation is characterized by redness, pain, or swelling. Though this side effect is relatively common, only a small minority of patients find the irritation bothersome enough to suspend therapy. Out of a sample of 350 patients who underwent Geref Therapy in clinical trial, only three suspended therapy as a result of injection-site irritation. There are other side effects which occurred in less than one percent of patients. These side effects include: severe drowsiness, hives, vomiting, headache, nausea, difficulty swallowing, hyperactivity, chest tightness and pallor, distortion in perception of taste, and flushing of the skin.

Geref Dependency and Abuse:

There is no evidence to suggest that the use of Geref for any period of time will result in any sort of dependency or proclivity toward abuse. The general pharmacology of Geref does not produce any addictive effect, and clinical trials have produced no evidence of such an effect.


Never Take More than Prescribed

It is not recommended to exceed the recommended dosage of Geref prescribed by your physician. Overdose will not provide better results. It will only increase the occurrence of side effects.

Administration and Dosage

The recommended dosage for Geref Sermorelin Acetate Therapy for pediatric patients is 0.03 milligrams per kilogram of body weight. This dosage should be administered every day before bed (unless otherwise advised by your physician) via subcutaneous injection. It is also that sites of injection be rotated periodically in order to reduce the risk of irritation.

In pediatric patients who are prescribed Geref Sermorelin Acetate Therapy, therapy should be discontinued after the epiphyseal plantes have fused. Patients who do not respond to Geref Treatment should undergo further evaluation in order to discover the root cause of their unresponsiveness to therapy. Patients who do not experienced increased levels of Human Growth Hormone as a result of therapy likely suffer from some other ailment or deficiency which prevents them from producing sufficient HGH levels.

Regular Height Assessment is Important

Pediatric patients should undergo a height assessment at least twice a year as they continue Geref Therapy. It is important that children who take Geref experience growth rates that are consistent with both their stage of development and their age. If Geref Sermorelin Acetate Treatments is discovered to be inadequate, other forms of therapy should be considered. HGH Hormone Replacement Therapy is the most common consideration for patients who have a waning or poor response to Geref Treatments.

Avoid Contamination of Geref Sermorelin Acetate Therapy

To avert contamination risk, clean the rubber stopper containing the reconstituted solution before piercing it with the needle. It is also strongly recommended that Geref be injected using disposable and sterile needles and syringes. The syringe should be small enough to where the proper dose of Geref can be drawn with reasonably high accuracy.

After the correct dose has been determined, the vial of Geref should be reconstituted using 0.5-1.0 milliliters of NaCl solution.

In order to reconstitute Geref Sermorelin Acetate, insert the diluent into the Geref vial via injection. Tilt the vial in a manner so that the liquid rolls down the wall of the vial onto the active ingredient below. Gently swirl the container in a circular motion until the solution has become completely dissolved.

IMPORTANT: Geref should not be administered if there are visible particles in the solution after reconstution, nor should it be used if the resultant reconstitution is cloudy.

Before Geref Therapy is Reconstituted for use, it must be refrigerated at a temperature between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius). Expiration dates are also clearly shown on the label. If the Vial becomes unrefrigerated or becomes expired, the treatment should be discarded.


Nutropin HGH: Human Growth Hormone Product


Written by Dr. Welsh, Published on 01 October 2017

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Nutropin Hormone Replacement Therapy

If you are over the age of thirty, you may not fully recognize how Human Growth Hormone Deficiency can impact the body. In our early development, all the way through our teenage years, the primary function of HGH is to help us grow taller and help us develop into healthy adults. But did you know that Growth Hormone Levels naturally impact health at all stages of the life span?

If you are thinking about choosing Nutropin for the treatment of HGH Deficiency, the goal of this article is to help you understand Nutropin HGH Therapy and how it can benefit and improve your life. Although it is incredibly important to discuss these issues and medical treatments with a qualified physician, it is beneficial to both you and your doctor that you are as fully informed as possible.

Below is a list of Frequently Asked Questions regarding Nutropin Injection Treatments.



Nutropin FAQ



What is Adult Growth Hormone Deficiency?

Adult Growth Hormone Deficiency (abbreviated AGHD) is a medical condition that arises when the Human Pituitary Gland (located near the base of the brain) does not naturally release enough Human Growth Hormone. This medical issue is also sometimes referred to as Somatotropin Deficiency.

What Causes AGHD?


In adulthood, there a number of reasons why GH Levels can become lower than normal. Some of these reasons are the result of medical illnesses. For example:


  • Tumors of the Pituitary Gland can alter the normal physiological release of hormones, including Biological HGH.

  • Surgery in or around the Pituitary can damage the gland, reducing or eliminating its capacity to produce Growth Hormone.

  • Cancer Radiation Treatments can render Somatotrophs inside the Pituitary Gland nonfunctional.

  • Head injuries such as severe concussions can damage the pituitary as well, due to both blunt force trauma and swelling.


In addition to these medical causes of Low HGH, the body slowly begins to lose its ability to produce Endogenous Human Growth Hormone as a natural result of aging. Although not pathological, this can still severely limit human health and potential, and many patients choose Nutropin or other forms of HGH Replacement in order to alleviate the effects of this natural deficiency.


What Are the Types of HGH Deficiency?


Adults with Low Human Growth Hormone Levels can generally be split into two primary groups:


  • Most Adults develop Growth Hormone Deficiency during adulthood, as a result of Natural Physiological HGH Decline, or as a result of medical issues during adulthood. These patients are considered to have Adult-onset HGH Deficiency.

  • Some patients have experienced Issues with HGH Secretion their entire lives. These patients have what is called Childhood-onset Human Growth Hormone Deficiency.


The difference between the two forms of deficiency share some similarity between Type-One and Type-Two Diabetes. Some patients are just born with the issue, and others develop it during adulthood for a variety of reasons.


How can Nutropin HGH Treatments Benefit Me as an Adult?


Even though HGH is the most important requirement for growth and development, most potently during puberty, the human body needs Human Growth Hormone throughout the lifespan. Just because our bodies have stopped growing in height doesn't mean that the growth stimulating effects of the hormone are no longer beneficial in adulthood.


Medical researchers and clinical scientists have found that Somatotropin Deficiency can lead to numerous physiological issues, many of which are related to the aging process, including:


  • Increased Body-fat

  • Decreased Muscle Mass

  • Fuzzy Memory

  • Hindered Mental Cognition

  • Poor Cholesterol

  • Low Energy

  • Weakened Immune System

  • Increased Injury Rehabilitation Time

  • Sleeping Disorder


I'm Taking Other Medications for Hormone Optimization. Why Should I also Consider Nutropin Injections?


Dependent upon the root cause of Adult-Onset Growth Hormone Deficiency, patients may be taking other Hormone Replacement Therapies in addition to HGH. Although the Pituitary Gland is most widely recognized for the release of Endogenous HGH, the Pituitary is also responsible for the release of a number of different hormones as well. Sometimes issues with the Hypothalamus also contribute to symptoms related to Growth Hormone Deficiency.


All hormones released by the pituitary are delivered through the body via the circulatory system. After the Pituitary Gland releases hormones into the blood, each hormone circulates to different target organs or tissues in order to accomplish particular important goals. Human Growth Hormone is released by the pituitary and is responsible for a number of different vital functions, including:


  • Childhood Growth

  • Muscle Development

  • Weight Control

  • Healthy Sleep

  • Mental and Cognitive Optimization

  • Energy Maintenance and Fatigue Reduction

  • Improved Cholesterol Profile


Although Human Growth Hormone produces a number of benefits and performs many vital functions, other hormones released by the pituitary also impact physical health in ways that alter the release and benefits provided by HGH.


It is important to discuss any and all medications that you are taking with a medical specialist in order to ensure that Nutropin Growth Hormone Injections are right for you. In some cases, your medications may not permit you to use this therapy. In other cases, medications that you are taking may simply lead your Hormone Specialist to alter your dosage in order to optimize your HGH Benefits.


It is also important to inform your Prescribing Growth Hormone Physician about any supplements you take or vitamin regimens you engage in. Human Growth Hormone HRT is usually combined with Dietary and Nutritional Guidelines in order to increase the effectiveness of treatment, and your current health choices can help your doctor tailor your HGH Plan in ways that can help you get the most out of therapy.


What are the Forms of Adult-Onset GH Deficiency?


There are two forms of Adult Onset HGH Deficiency, and there are different ways to diagnose each form of deficiency:


One form of Growth Hormone Deficiency is the result of a direct malfunction of the Pituitary Gland. This is the rarer cause of Low HGH Levels, and this form of deficiency is normally caused by health conditions which have hindered the body's ability to produce natural levels of Human Growth Hormone. Nutropin Hormone Replacement Therapy naturally restores Normal Hormone Levels by directly replacing HGH that the pituitary is unable to secrete properly on its own.


A second type of Growth Hormone Deficiency is the result of the reduced function of the Hypothalamus. Low Levels of HGH are rarely caused directly by medical complications arising from the Hypothalamus, but Age-Related HGH Decline is a direct result of changes in Hypothalamic function that occur in adults over the age of thirty.


As we enter our thirties, the Hypothalamus begins releasing less and less Growth Hormone-Releasing Hormone (also known as GH-RH). This intermediary hormone is the direct precursor of Human Growth Hormone, and, for reasons not fully understood by Endocrine Scientists, declined release of GH-RH is a direct cause of Adult GH Deficiency.


How is Adult Human Growth Hormone Deficiency Diagnosed?


Growth Hormone Deficiency directly caused by Pituitary malfunction can be diagnosed using a method known as the GH Stimulation. With this test, your physician will use GH-RH or another chemical such as Arginine in order to directly stimulate the pituitary gland to release HGH.


HGH Deficiency involving a healthy pituitary gland can be diagnosed by testing the blood stream for a hormone known as Insulin-like Growth Factor One (IGF-1). Although Human Growth Hormone quickly dissipates from the blood stream, making natural production hard to track, IGF-1 stays in the blood stream for a longer period of time, making it a more useful barometer for your innate HGH Production.


How Can I Be Diagnosed with Low Growth Hormone?


In order to be diagnosed with Chronically Low HGH Levels, you must both have a demonstrably reduced ability to secrete Human Growth Hormone, and you must also be symptomatic.


If you experienced Youth-Onset Growth Hormone Deficiency as a child, you will need to show your physician documentation to prove your ongoing deficiency.


What Pituitary Issues can Lead to Adult HGH Deficiency?


In adults, Low Levels of Growth Hormone can be the direct result of damage to the pituitary, or diseases which hinder the function of the gland. In addition to this, pituitary tumors can lead to Growth Hormone Deficiency, the most common of which is a pituitary adenoma. Direct damage to the brain as a result of surgery, trauma, and internal bleeding can also reduce the function of the pituitary. Radiation can also limit the effectiveness of the pituitary gland.


Why did my Medical Specialist Request a DEXA Scan Before Prescribing Nutropin Shots?


DEXA Scans have the ability to monitor body composition. One of the most significant symptoms of HGH Deficiency is a reduction in bone density, and the Dual-Energy X-Ray Absorptiometry Scan can be used to quickly and vividly show the health of a patients bones.


DEXA Scans are also able to provide other information such as your personal Body-Fat Ratio, highlighting the percentage of Lean Muscle to Body Fat in your body. By monitoring fat, muscle, and bone density, DEXA Scans allow your physician to monitor the benefits of your treatment by comparing before and after pictures which will track the effectiveness of your individualized Nutropin Hormone Therapy.


How Important Is It to Rotate Sites of Nutropin Injection?


It is very important to Inject Nutropin in a different location every time you administer the hormone treatment. Subcutaneous injection can sometimes lead to irritation and skin atrophy if you repeatedly inject treatment into the same location. By rotating the location at which you administer Nutropin, you greatly reduce the risk of issues related to inflammation and tissue breakdown.


Does Nutropin Lead to Fluid Retention?


Nutropin and other forms of HGH Therapy can sometimes lead to edema. Although edema is possible, the medical issue can easily be resolved by adjusting the Nutropin Dosage or taking a medication or supplement which reduces fluid retention. In most cases,0 water retention subsides naturally.


What Other Side-Effects Can Occur as a Result of Nutropin Injections?


The most common side-effect of Nutropin HRT is irritation at the injection site. This can manifest itself as redness, soreness, or general discomfort. These issues are not dangerous, but it is still important to inform your physician.


Most other side-effects related to Nutropin Injection in adult patients are the result of Nutropin Overdose or Nutropin Abuse. If you experience any of the following symptoms, inform your doctor immediately:


  • Knee pain, hip discomfort, or the development of a slight limp

  • Swelling

  • Water Retention

  • Carpal Tunnel Syndrome

  • General allergic reaction

  • Stomach pain: pancreatic inflammation very rarely occurs as a result of Nutropin Treatment

  • Nausea, migraine, vision changes: Nutropin can very rarely increase fluid pressure in the brain. This symptom is generally not dangerous if caught relatively early.


Before using Nutropin for the first time, talk to your doctor about appropriate Nutropin Injection Protocol in order to ensure that you utilize the drug in a safe and effective manner.


Who is Nutropin HGH For?


Nutropin Hormone Replacement Therapy is a form of HGH Hormone Treatment that is only attainable via prescription and is delivered via a device known as the NuSpin Pen.


Nutropin can be used both by young patients with Childhood-Onset HGH Deficiency and patients past the age of puberty that suffer from Adult-Onset Growth Hormone Deficiency.


Children that suffer from the following medical issues can use Nutropin Hormone Treatments:

  • Children that are unable to produce adequate HGH

  • Young patients suffering from Idiopathic Short Stature. These individuals suffer from a medical condition which prevents them from growing in height at the same rate as their peers.

  • Adolescents with Turner Syndrome qualify for Nutropin Injection Therapy. Turner Syndrome is a genetic disorder which hinders the body's ability to produce Human Growth Hormone adequately.

  • Young boys and girls that suffer from Chronic Kidney Disease: Kidney malfunction prevents the body from producing HGH normally, and Nutropin can encourage normal growth and development as the patient waits for kidney transplant.

Adults can qualify for Bio-Identical Nutropin if they meet any of the following criteria:

  • For continuing treatment of Childhood HGH Deficiency.

  • For management of Adult-Onset Growth Hormone Deficiency as a result of any medical condition which renders the pituitary unable to function properly.

  • For treatment of Age-Related HGH Deficiency in order to restore health and Normal Human Growth Hormone Levels.

The Safety of Nutropin Treatment

Before choosing Nutropin, examine the following information closely. If you have any questions or concerns, be sure to discuss them with your Hormone Replacement Physician.

Nutropin Injections Should Not be used by:

  • Individuals that currently are experiencing significant medical issues resulting from abdominal surgery, open heart surgery, multiple-organ trauma or severe breathing difficulty. Nutropin has been linked with increased risk of death in these instances.

  • Young patients suffering from Prader-Willi Syndrome that are significantly obese and have experienced issues with breathing in the past: Prader Willi Patients that have issues with breathing problems such as sleep apnea, airway blockages, or obesity have increased mortality risk as a result of Nutropin and other forms of HGH Replacement.

  • Patients of any age currently suffering from an active cancer: HGH Deficiency can rarely be the sign of a tumor of the brain or pituitary gland. Before using Nutropin, your physician should test to make sure that your deficiency is not the result of cancer.

  • Individuals with certain diseases of the eye, influenced by diabetes.

  • Young patients that have finished the growth spurt associated with puberty.

  • Persons with an allergy to Bio-Identical Somatropin, which is the functional component of Nutropin HRT. These allergies are not generally dangerous, and most commonly manifest themselves as points of high irritation where the HGH Treatment was injected.

What should your physician know before you begin Injecting Nutropin?

Your doctor must know what medications you are currently taking and what medical conditions that you suffer from. Certain medical treatments must be adjusted when taking Nutropin HRT, including:

  • Other forms of Hormone Treatment

  • Diabetic medicines, including, but not limited to, Insulin

  • Steroids such as Testosterone HRT

  • Cyclosporine

  • Certain Seizure medications

Nutropin and Tumors

Tell your doctor if you have any benign tumors present on the brain, or if your HGH may be the result of tissue abnormalities on the brain. HGH Hormone Treatments may agitate these issues, and must be monitored closely by your physician.

Nutropin and Cancer

If you have had a history of cancer, especially cancers of the brain, prostate, or ovaries, inform your doctor. There is a minor risk that certain cancers can manifest themselves once again as a result of Nutropin Injection Treatments.

Nutropin and Diabetes

If you are currently diagnosed with diabetes, or have a high clinical risk of developing diabetes, you should only engage in Nutropin HRT with regular blood sugar monitoring. Human Growth Hormone does have an effect on blood-glucose levels and you may need to adjust your Nutropin or Insulin dosage as a result.

Nutropin and Hypopituitarism

If you suffer from general Hypopituitarism and are already taking hormones for overall Pituitary Deficiency, your physician should closely monitor both your Nutropin Treatments and your other Hormone Treatments in order to ensure the safety and effectiveness of your medical protocol.

Nutropin, Pregnancy, and Nursing

Nutropin Injections should only be used by female patients in cases where an absolute need is established. If you are planning pregnancy or currently nursing, you should discuss your treatment options with your doctor. It is currently unclear if Human Growth hormone is released by the mother in breast milk.

Nutropin and Thyroid Health

Thyroid Health should be monitored intermittently throughout Nutrogen Treatments. Some patients may also require Thyroid Hormone Replacement in addition to HGH HRT.

Geriatric Nutropin

Although Human Growth Hormone Replacement Therapy has been studied clinically in patients over the age of sixty five, Nutropin HRT has not been officially cleared. Geriatric patients may respond more actively to Nutropin, so there may be a slightly increased risk of side effect.

Nutropin and Turner Syndrome

Turner Syndrome Patients should be evaluated for heart conditions or ear infection when using Nutropin Hormone Replacement Therapy.

Nutropin and Corticosteroids

Nutropin Bio-Identical Somatotropin Treatments may interact with the human body's ability to properly utilize cortisone and cortisol, leading to a medical issue known as hypoadrenalism. In patients where this medical issue arises, Glucocorticoid Treatments may be needed to restore optimal hormone function.

Nutropin Handling and Storage

It is vital to store Nutropin under refrigeration at a temperature ranging from 36-46 Degrees Fahrenheit. Never freeze Nutropin. After reconstituting your Nutropin Cartridge for the first time, it must be disposed of within four full weeks. Always check the expiration date before using Nutropin. Discard expired medications. If your Recombinant Nutropin Solution is not clear, you should never inject the treatment.

Contact the Conscious Evolution Institute for More Information!

To learn more about Nutropin HRT or other forms of Hormone Replacement Therapy or HGH Treatment Brands, call the Conscious Evolution Today!




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Norditropin Pen System is activated with first usage and can be used for three weeks without any refrigeration, Pen will last 4 weeks with refrigeration after which potency might begin to degrade. Pens not being used must be refrigerated.



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Testosterone Therapy Benefits

Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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