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OmniTrope HGH: Human Growth Hormone Product


Written by Dr. Welsh, Published on 19 November 2012

health normal testosterone levels by age

OmniTrope®: bio identical hormone therapy

OmniTrope somatropin [derived from recombinant DNA] is a specific hormone made up of polypeptide bonds. It consists of 191 residue amino acids, and it has a molecular weight of 22,125 daltons. The sequence of amino acids in this product is a bio identical hormone to that of Human Growth Hormone that originates in the pituitary (somatropin). Omnitrope is through a modification of a strain of E. coli to include the gene which is responsible for Human Growth Hormone. OmniTrope comes in the form of a white, sterile powder, lyophilized (freeze-dried) and intended for injection subcutaneously.

OmniTrope 5.8 mg is in a vial which contains 5.8 mg of the Growth Hormone somatropin (about 17.5 IU), Sodium phosphate monobasic dihydrate (0.56 mg), Sodium phosphate dibasic (2.09 mg), and glycine (27.6 mg). This product comes with a vial which contains 1.14 dilutant (Bacteriostatic Water for Use in Injection which contains 1.5% preservative benzyl alcohol). After the lyophilized powder has been reconstituted,, the total solution has a 5 mg/mL concentration (About 15 IU/mL).

OmniTrope 1.5 mg is in a vial which contains 1.5 mg of somatropin (about 4.5 IU), Sodium phosphate monobasic dihydrate (0.21 mg), sodium phosphate dibasic (0.88 mg), and glycine (27.6 mg). This product comes with a vial which contains 1.13 dilutant (water sterilized for injection). After the lyophilized powder has been reconstituted, the total solution has a 1.33 mg/mL concentration (About 4 IU/mL).

The osmolality of the solution of reconstituted somatropin is about 300 mOsm/kg. It has a pH of around 7.0. Concentration of OmniTrope is dependent upon presentation and strength (For more information, see How Supplied).

Clinical Pharmacology

Clinical, preclinical, and in vitro tests show that OmniTrope is equivalent to Human Growth Hormone that originates naturally in the pituitary in terms of therapeutic results. The body reacts in a similar fashion to Omnitrope as it does to the HGH created internally in the average adult. OmniTrope therapy in child patients who suffer from a growth hormone deficiency (GHD) succeeds in stimulating normal growth and balances concentrations of Insulin-like Growth Factor (IGF-1).

Omnitrope bioidentical hormone replacement therapy treatment in adults who are with Growth Hormone Deficiency often results in a lower level of body fat, an increased amount of lean muscle mass, and changes in metabolism which include positive changes in the metabolism of lipids and the balance of concentrations of Insulin-like Growth Factor-1.

Also, many other results have been shown through the administration of somatropin and/or Omnitrope, including the following effects of hormone replacement therapy:

1. Tissue Growth

A. Skeletal System Growth: OmniTrope bio identical hormone has to stimulate the growth of the skeletal system in young patients who suffer from Growth Hormone Disorder. There is a significant increase in the length of the body through the use of OmniTrope which results from its effect upon the epiphyseal plates which develop inside the long bones. Serum levels of Insulin-like Growth Factor-1, which likely play a part in the growth of the skeletal system, are to be usually quite low in young patients suffering from Growth Hormone Disorder. These levels increase when the patient undergoes Growth Hormone Replacement Therapy with Omnitrope. Higher serum concentrations levels of alkaline phosphatase also are caused treatment. This chemical aids in the breakdown and excretion of chemicals in the body.

B. Cell Growth: Research has shown that young, short-statured children have a lesser number of skeletal muscle cells because they have an insufficient level of natural hormone in comparison to the normal child population. Treatment with Omnitrope therapy for hormone imbalance leads to a boost in both the size and number of these muscle cells.

2. Protein Metabolism

Linear, normal growth in childhood is in part facilitated through an increase in the synthesis of cellular proteins. Retention of nitrogen, which is through a decrease in the excretion of nitrogen through urination, as well as through blood test measurements of nitrogen in the urea, is one of the many physiological changes that occur through OmniTrope therapy.

3. Carbohydrate Metabolism

Children who suffer from hypopituitarism often also experience low blood sugar when fasting and this issue are also alleviated through OmniTrope treatment, though excessive doses of Human Growth Hormone can lead to glucose intolerance.

4. Lipid Metabolism

In those who are deficient in Growth Hormone, OmniTrope therapy has to result in the mobilization of cholesterols, allowing for a reduction in storage of body fats and a higher level of fatty acid in the plasma, which provides more healthy energy for the body.

5. Mineral Metabolism

Growth Hormones can also can lead to retention of phosphorus, potassium, and sodium. Concentrations of inorganic phosphate in the blood stream are increased in those patients maligned with Growth Hormone Disorder who go through Omnitrope Hormone Therapy. This is healthy because it allows these phosphates to either be used appropriately by the body or be excreted. Levels of calcium in serum are not in a significant manner through the use of OmniTrope, and Human Growth Hormone can lead to Calciuria.

6. Body Composition

Adult patients who suffer from Growth Hormone Disorder that are with OmniTrope at the suggested adult dosage (view Dosage and Administration for more information) show a decreased level of body fat and an increased level of lean muscle mass. These changes occur at the same time that the body begins to retain fluid more effectively. The result of all of this is that OmniTrope can modify the composition of the body positively, and these positive changes can be sustained through continuing treatments.

Adult Growth Hormone Deficiency

Placebo-controlled, randomized clinical trials using somatropin have been performed in adult patients suffering from Growth Hormone Deficiency.

In these clinical trials, positive changes in the fat and muscle composition of the body were noted after a six month somatropin treatment schedule. These changes were observed in comparison to the placebo group. Total body water, lean/fat ratio, and lean body mass increased as waist circumference and total fat mass decreased. These positive effects that somatropin had on the body were retained when treatment was continued past the original six month period. There was a decline in bone mineral density (BMD) after six months, but BMD returned to baseline levels after a year of treatment.

Indications and Usage

OmniTropin is for long-term therapy of pediatric patients that suffer from growth failure as a result of the inadequate production of naturally secreted Human Growth Hormone. It is not for other causes of short stature.

OmniTropin is for long-term Growth Hormone Replacement Therapy for adults that suffer from a Growth Hormone Deficiency that is of either adult or childhood-onset in its development. Growth Hormone Disorder should be diagnosed through an appropriate GH stimulation test.

Hormone Replacement Therapy Contraindictions: The dangers of hormone replacement therapy for some groups

OmniTrope should not be used if an individual shows any signs of abnormal tissue development. Intracranial spade occupying lesions must be inert and antitumor treatment must be complete before OmniTrope therapy begins. If the tumor begins to grow again, OmniTrope treatment should be discontinued immediately. Also, GH should not be administered as a means to promote growth in children who have fused growth plates in the long bones.

Human Growth hormone treatments should not be administered to provide therapy for individuals who have an acutely critical illness stemming from abdominal or open heart surgery, multiple physical accidental trauma, or to those who have suffered acute respiratory failure.

A pair of clinical trials in which the adult patients were afflicted with these conditions but did not suffer from Growth Hormone Deficiency found that there was a significantly higher incidence of mortality affecting those who were treated with somatropin in comparison to those that merely received placebo (read Warnings for more information).

Prader-Willi patients suffer from a genetic disorder that leads to obesity and low lean muscle mass. Their bodies produce extremely low or nonexistant levels of hormones. If these patients have severe respiratory problems or are acutely obese they may have issues with Growth Hormone Therapy.

OmniTrope treatment is not for any patient who is hypersensitive to the hormone somatropin or any of the other ingredients of OmniTrope.

Warnings

OmniTrope 5.8 mg preparation contains the preservative benzyl alcohol. It should not be administered to newborns.

Read the Contraindictions section for more information about increased mortality risk in those who suffer from critical illnesses in ICU because of complications due to abdominal or open heart surgery, multiple trauma due to an accident, or those who are suffering from acute respiratory failure. The proper research has not been established regarding the safety of continuing to undergo Growth Hormone Replacement Therapy for those who would be eligible for treatment but also concurrently begin to suffer from the above ailments. For this reason, the possible benefits of Growth Hormone Replacement Therapy in those patients who are suffering from critical, acute injuries must be weighed against the possible risks of undergoing such treatment.

Precautions: Is Hormone Replacement Therapy safe for you?

General

Therapy with OmniTrope, as well as any other Growth Hormone Therapy, should be guided by a hormone replacement doctor who has experience in the management and diagnosis of patients with Growth Hormone Disorder, as should be the case with the usage of any Growth Hormone preparation.

Caregivers and patients that will inject OmniTrope in situations which are medically unsupervised are to attain proper instruction and training about how to properly use OmniTrope. This training should be given by one of the many bioidentical hormone doctors in your area or any other properly trained health professional.

Side Effects of Hormone Replacement Therapy

Patients who suffer from Growth Hormone Disorder in addition to an intracranial lesion need to visit their doctor with regularity to monitor the development or recurrence of the underlying process of their disease. A survey of pediatric reports regarding the use of somatotropin replacement therapy shows no correlation between somatropin replacement therapy and tumors of the central nervous system. Later in life, there has been insufficient research to discover is there is any sort of causal relationship between the occurrence of central nervous system tumors and somatropin treatment.

It is also vitally essential that patients be carefully monitored for the formation of malignant lesions on the skin.

Caution is if Human Growth Hormone Therapy is to those that are already suffering from diabetes, because the level of insulin intake may need to be changed as a result of the hormone therapy. Those undergoing Omnitrope therapy should be monitored for the development of glucose intolerance, because Growth Hormone can sometimes give rise to a state where one is more resistant to insulin. Those patients that have already had glucose intolerance or diabetes must be particularly closely monitored while taking OmniTrope. Patients that have factors that place them at a higher risk for intolerance to glucose, like obesity and/or a genetic predisposition to Type II diabetes should also be monitored carefully.

With those that have been diagnosed with hypopituitarism (a disease that is the result of multiple deficiencies of the hormonal system), the normal regimen of Hormone Replacement Therapy should be closely monitored when OmniTrope treatment commences. Hypothyroidism (lack of proper secretion of thyroid hormone) can develop as one is with OmniTrope, and as a result, inadequate medical response to hypothyroidism can cause OmniTrope to become less effective or ineffective. For this reason, it is pertinent that patients get tested for proper thyroid function periodically, and if the thyroid becomes less active, thyroid hormone should also be administered in tandem with OmniTrope. Also, testosterone levels should be checked as well, and testosterone injections may be recommended by your Growth Hormone Therapy doctor.

Pediatric patients who have a disorder of the endocrine system such as Growth Hormone Disorder have been shown to have a greater risk of developing a slipped capital femoral epiphyses. Any young patient that develops a limp or begins to complain of knee or hip pain as they undergo OmniTrope therapy should undergo evaluation.

Other side-effects

Patients who experience rapid growth as a result of OmniTrope may find that they uncover an underlying case of scoliosis. Since Growth Hormone boosts the growth rate, those patients that have battled scoliosis in the past that are with Omnitrope should be examined periodically for new progression of scoliosis. Fortunately, there is no evidence that Growth Hormone causes scoliosis.

Intracranial hypertension (IH) is an increase in pressure in the skull which is associated with with nausea, vomiting, headache, visual disruption, and/or papilledema has to be a side effect in a small minority of patients that take Growth Hormone therapies. These issues occur usually within the first two months after one begins GHT. In each reported case, symptoms and signs of Intracranial Hypertension are after hormone therapy is or the dosage is to a more minute amount.

Funduscopic examination should be performed as a patient begins therapy, and it is that they are for Intracranial Hypertension periodically as he or she continues Therapy. This test checks for abnormalities of eye pressure and the veins of the eye. Before undergoing adult treatment for Growth Hormone Deficiency, a patient who has undergone puberty and received GHRT in their childhood needs to be reevaluated in a manner that is in the section Indications and Usage. If it is advisable to continue treatment, Omnitrope therapy should continue at a lower level of dosage that is more appropriate for adults who have Growth Hormone Disorder.

Concomitant Drug Usage

Undergoing treatment with glucocorticoids concomitantly with Growth Hormone can cancel out the growth promotional effect of Hormone Therapy. Pediatric Growth Hormone deficiency patients that have a coexisting deficiency of ACTH (a precursor hormon to adrenal among other hormones) need to have their dose adjusted carefully so that the glucocorticoid does not inhibit the effect of the Growth Hormone Replacement Therapy. For more information, see Precautions. Though there is limited published research on the subject, it has that in humans, GHT increases antipyrine evacuation mediated by CP450 (cytochrome P450). The available data seems to suggest that GH administration can alter the evacuation of the compounds that become metabolized through the liver enzyme CP450. These compounds include sexual steroids, cyclosporine, anticonvulsants, and corticosteroids. It is that a patient undergo careful monitoring when OmniTropin is used in addition to other drugs that are by the liver enzyme CP450.


Nutropin HGH Detailed Description


Written by Dr. Welsh, Published on 15 January 2016

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Description

Nutropin is a Growth Hormone derived from recombinant DNA. Nutropin is of 191 residue amino acids and has a molecular weight 22,125 daltons. The sequence of Nutropin's amino acids is perfectly identical to the sequence of HGH derived naturally from the pituitary. Nutropin is from a specific lab strain of the E. coli bacteria as a precursor chemical. It consists of the recombinant Human Growth Hormone molecule that is by a signal for secretion that originates with a protein from the E. coli bacteria. This precursor chemical travels through the protective membranes of the cells. After the E. coli secretion signal is initiated, the native protein enters into the periplasm, and the protein begins to be folded correctly into Human Growth Hormone.

Nutropin is an intensely purified preparation. The biological potency of Nutropin is configured through a bioassay designed to proliferate Growth Hormone cells.

Nutropin is a white, sterile freeze-dried powder that is by subcutaneous injection after it has with Bacteriostatic Water for Injection, USP, and the preservative benzyl alcohol. After the product has been reconstituted, it is nearly isotonic at a 5 mg/mL concentration of Human Growth Hormone. It also has a pH of about 7.4.

Every 5 mg vial of Nutropin holds 5 mg (about 15 IU) somatropin which has 1.7 mg glycine 45 mg of mannitol, and 1.7 mg sodium phosphates (1.3 mg sodium phosphate dibasic, 0.4 mg sodium phosphate monobasic).

Every 10 mg vial of Nutropin holds 10 mg (about 30 IU) somatropin which has 3.4 mg glycine 90 mg of mannitol, and 3.4 mg sodium phosphates (2.6 mg sodium phosphate dibasic, 0.8 mg sodium phosphate monobasic).

Bacteriostatic Water for Injection, USP, is sterilized water that contains 0.9% benzyl alcohol per milliliter. This sterilized water is in a vial that can be used multiple times. The benzyl alcohol acts as a preservative which protects the fluid from microbial contamination. The pH of the dilutant is 4.5-7.

Clinical Pharmacology

General

In vivo and in vitro clinical and preclinical testing have provided ample evidence that Nutropin is equivalent therapeutically to Human Growth Hormone naturally derived from the pituitary. Children who do not secrete adequate levels of Growth Hormone endogenously, patients who suffer from chronic renal insufficiency (CRI), and patients who suffer from Turner syndrome all report benefits when taking Nutropin. Patients who took Nutropin were found to experience an increase in their rate of growth and also an increase in their Insulin-like Growth Factor-1 (IGF-I) levels in a manner than is compatible with Human Growth Hormone naturally produced by the pituitary.

Benefits that have been shown through studies regarding Nutropin, somatrem, somatropin, and/or Human Growth Hormone derived naturally from the pituitary include:

A. Tissue Growth --

1) Skeletal Growth: Growth Hormone stimulates skeletal growth in

young patients that experience growth failure as a result of inadequate secretion of natural Growth Hormone, or as a secondary effect of chronic kidney insufficiency or also with patients that suffer from Turner syndrome. Turner syndrome is a genetic disorder which seriously hinders hormone production and has devasting effects on the physiology of a woman from birth. It is caused when the second chromosome does not form properly, or does not develop at all, leaving only one functional X chromosome. Growth of the long bones of the skeleton is a result of the expansion of the epiphyseal plates that are on the ends of the growing bone. The metabolism and growth of the cells of the epiphyseal plates are stimulated directly by Growth Hormone and Insulin-like Growth Factor-1, an important stimulator of Growth Hormone. Levels of Insulin-like Growth Factor-1 in the blood serum are low in adolescents and children who are deficient in GH, but their levels increase when treated with Growth Hormone. In these young patients, new bone begins to develop in the growth plates after Growth Hormone and Insulin-like Growth Factor-1 have been introduced to the body. As one reaches the end of puberty, the growth plates fuse, and adult height is in.

2) Cell Growth: Human Growth Hormone leads to an increase in both the size and number of skeletal muscle cells. This leads to enhanced strength as there are more muscle fibers. Each individual muscle fiber can handle a larger load as well.

3) Organ Growth: Growth Hormone has a direct effect on the size of the internal organs, including the kidneys. It also increases the mass of red cells. Growth Hormone Treatment of genetic dwarf or hypophysectomized rats (rats that had their pituitary glands removed) leads to organ development that is in proportion to the growth of the rest of the body. In healthy rats that were induced with uremia (high levels of nitrogen) through nephrectomy, Growth Hormone promoted body and skeletal growth.

B. Protein Metabolism: Proper growth is in part by protein synthesis which is caused by Growth Hormone. This is through retention of nitrogen that reveals itself through a lower level of nitrogen excreted through the urine, as well as clinical testing for nitrogen in the blood urea which occurs during Growth Hormone Therapy.

C. Carbohydrate Metabolism: Growth Hormone is a significant controlling mechanism in charge of carbohydrate. In patients that do not adequately secrete Growth Hormone, hypoglycemia is during periods of fast. This issue is largely resolved with Human Growth Hormone Therapy. It is a possibility that Growth Hormone therapy can lead to a decrease in the body's sensitivity to insulin. Patients who are not for chronic kidney insufficiency and/or Turner syndrome have a higher risk to develop intolerance to glucose. Human Growth Hormone treatment provided to children or adults has resulted in an increase in post-meal insulin levels and serum fasting. These two results happen most commonly with those that are overweight or obese. Also, post-meal glucose, mean fasting, and A1c hemoglobin (a measure of blood glucose) stays at a healthy level.

D. Lipid Metabolism: In patients who are Growth Hormone Deficient, Growth Hormone Therapy led to the mobilization of lipids, a reduction in stores of body fat, increased fatty acids entering the plasma, and lower levels of cholesterol in the plasma.

E. Mineral Metabolism: Use of Growth Hormone leads to the retention of potassium in the body. This retention apparently is due to the enhanced cell growth that begins to occur. Inorganic phosphorus levels in the blood serum can sometimes increase modestly among patients who undergo Growth Hormone Therapy because they do not produce enough Growth Hormone on their own, have a chronic kidney deficiency, or suffer from Turner syndrome. This is because Growth Hormone enhances the metabolic processes associated with growth of bone, in addition to improving tubular reuptake of phosphate by the kidneys. Serum calcium levels do not change significantly among these patients. Retention of sodium also occurs. Adults that developed a Growth Hormone Deficiency as children display low levels of bone mineral density (Acronym: BMD). (See also Precautions: Laboratory Tests.)

F. Metabolism of the Connective Tissues:Growth Hormone chondroitin sulfate synthesis and collagen synthesis in addition to encouraging the urinary expulsion of hydroxyproline.

Pharmacokinetics

Absorption after Subcutaneous InjectionThe total bioavailability of recombinant HGH after being injected subcutaneously into a healthy adult male is to be 81 plus or minus 20%. The terminal mean t after subcutaneous injection is much longer than the terminal mean after intravenous injection (2.1 plus or minus 0.43 hr vs. 19.5 plus or minus 3.1 min). This indicates that subcutaneous injection of Growth Hormone causes the compound to be released slowly and at a more modest rate.

DistributionRecombinant Human Growth Hormone Animal Research has shown that Growth Hormone is vital to organ function, especially to the kidneys and liver. The distribution volume at steady state for Recombinant Human Growth Hormone in a healthy adult male is around 50 mL/kg of body weight, essentially the serum volume.

MetabolismBoth the kidney and liver have been proven to be essential organs for the proper metabolism of Growth Hormone. Animal research provides evidence that the kidneys are the primary organs of clearance. Growth Hormone filtration occurs at the glomerulus and Growth Hormone is by the proximal tubules. After that it is inside the kidney cells into its component amino acids, after which the acids return to normal circulation.

Elimination--The terminal mean t after intravenous injection of recombinant Human Growth Hormone adult males in good health is to be 19.5 plus or minus 3.1 minutes. Elimination of recombinant Human Growth Hormone after intravenous injection among healthy children and adults is to range from 116-174 mL/hr/kg.

Formulation bioequivalenceNutropin [somatropin injection derived from recombinant DNA] has to be the bioequivalent of Nutropin [somatropininjection derived from recombinant DNA]. This is upon statistical evaluation of Area Under the Curve (AUC) and mean C.

Special Populations

PediatricCurrent research data suggests that there is no difference in Human Growth Hormone clearance between children and adults.

GenderThere is no data available for exogenously injected recombinant Human Growth Hormone. The data that have been collected regarding methionyl Human Growth Hormone, naturally produced and extracted pituitary Growth Hormone, and endogenous Growth Hormone produce no evidence that suggests that men and women clear GH at different rates.

GeriatricsThe limited amount of published research shows that Growth Hormone plasma clearance and normal steady-state GH plasma concentration do not appear to be different among young and elderly populations.

RaceThe half-life values for endogenous Growth Hormone in healthy black males is not to be any different than the half-life values of Growth Hormone for healthy white males. There are no available data regarding other races.

Growth Hormone Deficiency (GHD)The reported values regarding the clearance of recombinant Human Growth Hormone in children and adults suffering from GHD range from 138-245 mL/hr/kg. These values are similar to those that occur in healthy children and adults. The terminal mean t values following subcutaneous and intravenous administration in pediatric and adult Growth Hormone Deficiency patients have also proven to be similar to the values observed in the population of healthy adult males.

Kidney InsufficiencyAdults and children who suffer from end-stage renal disease (ESRD) and chronic renal failure (CRF) to to clear Human Growth Hormone at a lower rate than healthy individuals. Endogenous Growth Hormone production can sometimes increase in individuals suffering from ESRD. Even so, no accumulation of Human Growth Hormone has in children with ESRD of CRF that are normal Growth Hormone Replacement Therapy.

Turner SyndromeNo pharmacokinetic data is currently available regarding Turner syndrome and Growth Hormone Therapy. It has, however, that absorption, half life, and clearance rates for internally produced Growth Hormone for this population show little difference when compared to the rates of healthy patients and patients only suffering from Growth Hormone Deficiency.

Hepatic InsufficiencyA reduction in recombinant Growth Hormone clearance has in patients that are suffering from extreme liver dysfunction. The clinical significance of this data is still unknown.

Summary of Pharmacokinetic Nurotropin Parameters in Adult Men of Good Health

0.1 mg (about 0.3 IU a)/kg SubC max C

(g/L) max T

(hour) t 1/2

(hour) (Area Under the Curve)

ghr/L) Ev/F SubC

(mL/[hrkg])

Average b

67.2 / 6.2 / 2.1 / 643 / 158

CV

29 / 37 / 20 / 12 / 12

Key

maximum

t1/2life

Ev=systemic

F SubC =biological subcutaneously (indeterminant);

CV=variation coefficient

SubC=subcutaneous

a

b

Effectiveness Studies

Nutropin's upon as a of CRI

Two randomized, controlled, multi-center clinical trials were conducted in an effort to learn whether Nutropin treatment before patients who are suffering from chronic renal insufficiency receive renal transplants could possibly lead to an improvement in growth rate and a decrease in height deficit. One of the studies was a placebo-controlled, double-blind trial, and the second trial was randomized and open-label. In both of these controlled studies, that participants took a Nutropin dose of 0.05 mg/kg/day (0.35 mg/kg/wk). These doses were given daily by means of subcutaneous injection. Taking data from both studies of patients who underwent treatment for two full years resulted in 62 participants who received Nutropin treatment and 28 participants who were either untreated or treated by placebo. The year one mean rate of growth was 10.8 cm/yr for patients treated with Nutropin, as compared to an average rate of growth of 6.5 cm/yr for the untreated/placebo controls.


How to Use HGH


Written by Dr. Welsh, Published on 22 September 2017

hgh hrt health cost of therapy

Instructions and Protocol for Injection

Read over these instructions fully and carefully before you undergo your first injection. This information was gathered so that you can self-administer your injectable HRT therapy effectively and safely.

Prepping for self-injection administration:

1. Wash hands extremely thoroughly with warm water and soap.

2. Choose a clean, hard, and well lit surface that has a mirror, if possible (the countertop of the bathroom is an excellent location)

3. Make sure that you have gathered all of the supplies that you will need and that there is no sign of damage or tampering on and of the wrapping or packaging of your medication and your devices. Recheck the dates of expiration on each medication.

Notice: When taking Testosterone injections Intramuscularly for low testosterone, you will be using two needles. The first needle will be used to draw in the medicine. This needle will be referred to as the drawing needle. The second needle will be use to administer the solution. This needle will be referred to as the administration needle.

Taking up the solution with the syringe:

1. Use sanitizing alcohol swabs to disinfect the vial tops. Sanitize in a single direction and only use one swab per vial.

2. Take the syringe along with the needle out of packaging and fill up the syringe with the same amount of air that you will later fill with your dose of medicine. Do this by pulling back on the plunger until the mark you desire is reached (for example, If you plan on taking up 2 milliliters of the solution, you would draw the plunger back to the 2 marked on the syringe

3. Press the needle directly through the stopper of rubber so that it enters the vial. If you happen to make bodily contact with the stopper, use another new alcohol swab to disinfect it again before drawing out the medication.

4. Flip the vial of medication with its base facing upwards. Keep the tip of the needle within the liquid.

5. Press down on the plunger, ejecting the air in the needle into the vial of medication. This action will aid in maintaining a balance of external/internal pressure when working with a vial made of glass. It also helps to make later withdrawals of medication much easier.

6. Hold the syringe and vial in one of your hands and then draw the proper dose of medication up into the syringe slowly and carefully. The first diagram provides a demonstration of the proper technique to use when holding the vial.

7. As you hold the vial with its base facing upwards, and while continuing to slowly draw medication into the vial, tap gently upon the side of the syringe. Air bubbles will float to the top of the syringe barrel. Press the plunger extremely gently so that ONLY THE BUBBLES OF AIR are ejected from the needle.

8. Pull the syringe and needle from the vial.

9. Recap your needle. Place the cap of the needle upon your hard, flat, sterile surface and guide your needle into its cap with care. This action makes it much less likely that you will accidentally poke yourself with the needle.

10. When taking an Intramusular injection or a Testosterone injection pull out the drawing needle and dispose of it in a Sharps container approved by OSHA. FDA Regulations legally require you to dispose of sharps and needles in an approved biological medical waste receptacle. If you do not have one of these containers you should give us a call immediately and acquire one. ALWAYS DISPOSE OF YOUR NEEDLES WITH PROPER CARE.

Solution Injection:

Keep medical materials and syringes clean. Do not let any object touch the and of the needle or syringe. If you touch the syringe or needle tip accidently, or contaminate the needle or syringe in any manner, it must be thrown away, and the process must begin again. This ensures that you will not acquire an infection.

1. For Intramuscular or Testosterone injection, take the new administration needle from its package and check for any possible defections. Do not take off the plastic cap until it is time for injection.

2. Twist the administration needle firmly onto the syringe. Keep it in Firmly twist administration needle on to syringe and maintain it on the hard, flat, clean surface in front of you until it is time to begin administration.

3. In the case of the SUBQ form of injection, the small syringe of insulin comes preloaded with an attached syringe that it is not possible to remove. This is the vehicle of administration.

4. Use a fresh swab of alcohol to disinfect the skin around your planned injection site. Let it dry in the air. Discard the wipe. (Notice: Never inject into a site where there are firm knots, bumps, lumps, or pain. Never use an area where the skin is depressed, discolored, scabbed, or broken. If you are not sure if an area is safe, call your physician or another health professional.

5. Take off the cap to the needle and pinch the area of skin where you plan on administering the injection so that you raise it up slightly. Check the second diagram. The easiest and safest areas to administer the needle are located away from your bones, nerves, joints, or any other important or obtrusive area of the body. Turn to the last page to view a diagram of preferable sites for injection. The most accessible areas to perform Intramuscular injections like testosterone are into the quadricep or gluteus maximus. The most accessible area for Subcutaneous injections like GH and HCG is located around the bellybutton on the stomach.

6. Using a swift, firm motion, press the needle into the skin at a ninety degree angle when performing an IM injection or at a forty five degree angle when performing a SUBQ injection.

*The seventh step is meant ONLY FOR INTRAMUSCULAR INJECTIONS! ONLY! For subcutaneous injections move on to Step 8*

7. Intramuscular: As the needle continues to be inserted into the muscle, pull the plunger back very slightly and check for blood in your syringe.*This will occur rarely. If you happen to have this experience, it merely means that you inserted the needle and struck or landed near a blood vessel. If so, pull the syringe and needle out at once and massage the area gently where the needle was inserted with a clean tissue or gauze. Return to the second step and repeat the process after choosing a new site for injection.

8. Administer the medicine by performing a slow and steady plunger push until the point is reached where the syringe is 100% empty. Press a gauze or swab close to the site of injection.

9. Safely yet swiftly pull the needle out from the skin and massage the site of injection gently with gauze or dry cotton.

10. Throw away the syringe immediately into an approved Sharps disposal container approved by OSHA..

11. Store all medication and supplies in a proper and safe place that is out of the reach of strangers and children. Make sure that medical supplies and medicines that require refrigerated storage are put away correctly.

12. After you have accumulated enough medical waste in your OSHA Sharps Disposal container to reach the recommended fill line, you should give your local waste disposal management provider a call and follow the guidelines in your area to dispose of the medical waste responsibly.

The above information is provided to you only for purposes of information. This document is not supposed to be a surrogate for the instruction that your bio identical hormone replacement therapy doctor or any other qualified medical professional can provide more fully. Do not use this information to self-diagnose or self treat a disease or health ailment. Neither should you use it to self-prescribe medication. If you feel that you have or know that you have a medical issue, make contact with a health representative, physician, or health provider as soon as is possible and appropriate.


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Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

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Disclaimer: The board-certified American physician specialists at our reputable medical clinic do not provide prescriptions and HRT treatments unless there is a clinical necessity for the patient at the time of the assessment. Clinically based hormone deficiency is determined by blood testing, physical exam, related symptoms evaluation, medical history documentation, and doctor-patient consultation. These statements presented here at our website have not been evaluated by the FDA.

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