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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2021

Belly fat is stubborn and frustrating. Resculpting the body to get rid of body fat is not a simple and easy task, though it is certainly not impossible. One of the reasons why it is so hard to burn belly fat is that your body primarily uses the midsection as its storage unit for fat. Hormone Balance helps us avoid the buildup of belly fat. It's also true that, as we get older, we become more prone to hormone imbalance as levels of HGH and Testosterone fall into decline. In women, the changes associated with Menopause also contribute heavily to increased body fat. What it comes down to is that the older that you get, the harder that it becomes to stay lean. Body fat can become especially stubborn when folks reach their forties and fifties. This is the period when the decline of important hormones often becomes noticeable and problematic.

Sources of Hormone Imbalance Associated with Belly Fat

Hormone Imbalance is often multifaceted, and the accumulation of body fat is often the result of multiple sources of imbalance. The following are several hormones and how they are associated with belly fat: Testosterone – Testosterone is intimately associated with masculinity and male optimal function. Testosterone helps maintain muscle mass. The more lean muscle that you have, the higher your basal metabolism, which protects against body fat. Testosterone Levels decline when men get older, which reduces metabolism and muscle mass and makes it easier for belly fat to stick around.

Estrogen – Estrogen is most important for women but also plays a critical role in men's health (in small doses). Men produce Estrogen from body fat. The more fat accumulates, the more Estrogen that they will make. Unfortunately, Estrogen is also a limiting factor on Testosterone Production. This is one of several feedback loops associated with obesity. Belly Fat increases Estrogen, which Suppresses Testosterone. Lower Testosterone makes it easier to gain weight which further increases the influence of Estrogen.

Insulin – Insulin is the tool that the body uses to capture free glucose from the bloodstream and transport it to fat cells for storage. Insulin resistance leads to weight gain because the increased concentrations of Insulin in the bloodstream make it harder to free energy stored as body fat.

DHEA – DHEA is a precursor hormone produced by the Adrenal Glands, which is integral to the production of Estrogen and Testosterone. Healthy DHEA activity helps ward off belly fat by promoting healthy Sex Hormone Production and improving the body's responsiveness to Insulin.

Cortisol - Cortisol is the body's key stress hormone, associated with both physical and psychological stress. Cortisol initiates fight-or-flight response and stimulates activity. Cortisol is critical to health but also very prone to imbalance. Chronic Stress causes Cortisol Levels to skyrocket, depleting the building blocks that would normally be available to produce Testosterone and other hormones that are important to stave off body fat. Cortisol both increases appetite and increases Insulin, meaning that you eat more calories, and your body is more prone to storing them as fat.

Ghrelin – Ghrelin is the hormone most directly associated with the sensation of hunger. Ghrelin is responsible for increasing appetite, and high levels of Ghrelin also encourage you to both eat more and store more calories as fat. Crash diets significantly increase Ghrelin production, which contributes to the long-term failure of extreme diets. Ghrelin increases the production of HGH, which helps break energy free from body fat. Intermittent Fasting and other diets which allow for moderate Ghrelin activity are good for weight loss, but extreme diets are counterproductive.

Adiponectin – Adinopectin stimulates weight loss and the breakdown of body fat. Obesity reduces Adinopectin activity. Adiponectin Levels are adversely affected by high levels of Insulin, blood sugar, and body fat. The body's fat-burning power is directly correlated with healthy glucose/Insulin dynamics.


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 02 April 2021

While pretty much everyone knows that Testosterone is critical to male health and physiological function, most people aren't aware of the actual relationship between Estrogen and the male body. While women produce far more Estrogen than men, the colloquial feminine hormone is still very important for men's health. On the other hand, too much Estrogen can lead to very real problems for guys.

How Is Estrogen Important for Men?

Estrogen is actually a shorthand for three hormones called Estriol, Estradiol, and Estrone. Estradiol is the most important to men and is intricately involved in sexual ability and function. Testosterone and Estrogen are in delicate balance in both sexes; it's just that the balance of power with these hormones is vastly different between men and women. Men produce a little Estrogen and a lot of Testosterone. Women make a little Testosterone and lots of Estrogen. Specifically, men should produce around fifteen times more Testosterone than Estrogen. The ratio of Testosterone vs. Estrogen is more important than the values themselves.

How Do Men Make Estrogen?

Men make Estrogen via an enzyme named aromatase. Aromatase is abundant in fat cells. This is important because obesity is one of the leading causes of sex hormone imbalance in men. The more body fat a man carries, the more Estrogen that his body produces. The hypothalamus uses circulating Estrogen Levels as a means to modulate Testosterone Production. Perhaps ironically, the more Estrogen that your body is converting, the less your brain signals for the production of Testosterone, which can lead to symptoms of Testosterone Deficiency. In some cases, men may not produce enough Estrogen via aromatase. This can lead to issues with fertility and also contribute to metabolic problems and abnormal bone development.

Causes of High Estrogen

Elevated Estrogen is caused by many different factors. As mentioned above, weight gain leads to increased Estrogen. Men are also likely to produce more Estrogen due to stress and aging, though aging sometimes leads to lower Estrogen production. Certain tumors can also increase Estrogen expression. Endocrine Disrupting Chemicals can also increase Estrogen or suppress Testosterone production. These chemicals can reproduce the effects of Estrogen. Steroids can also increase Estrogen Levels because some excess Testosterone is turned into Estrogen.

Symptoms of Elevated Estrogen Levels

  • Gynecomastia
  • Pulmonary Hypertension
  • Depression
  • Weight Gain
  • Migraines
  • Erectile Dysfunction
High Estrogen is also evidence that a man is at high risk of several dangerous conditions, including prostate cancer, breast cancer, stroke, blood clots, and diabetes. Elevated Estrogen is also a symptom of Prostate Cancer.

Causes of Estrogen Deficiency

Because Testosterone Production and Estrogen Expression are strongly linked, Testosterone Deficiency can also lead to symptomatic Low Estrogen Levels. There are several conditions that also suppress the production of Estrogen, including anorexia, hemochromatosis, autoimmune disorders, and cardiovascular issues. Low Estrogen is often a symptom of other health issues.

Symptoms of Estrogen Deficiency

  • Insulin Resistance
  • Weight Gain
  • Osteoporosis
  • Bone Loss
  • Late Puberty
  • Heart/Arterial Disease
  • Trouble Ejaculating
  • Depression


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 24 March 2021
Healthy HGH Levels are critical to achieving and maintaining a state of ideal wellness and vitality. While HGH Deficiency is uncommon during early adulthood, it becomes more common as men and women get older. Until recently, all FDA-Approved Growth Hormone Therapy Treatments required daily injections to maintain effectiveness. This is different from other hormone treatments such as Testosterone Therapy. With Testosterone, some formulations only require administration once every 2-4 weeks. Luckily, as medical science advances, new treatment options evolve. In late 2020, a new form of HGH Treatment was approved, which only requires injections on a weekly basis: Sogroya (generic name somapacitan). Sogroya is derived from the same base of Bio-Identical Human Growth Hormone as other brands of HGH Injection. Unlike other available treatment options, somapacitan is specially formulated to release slowly into the bloodstream. Other Therapeutic Growth Hormone options are metabolized quickly after injection. Sogroya is the end-result of the scientific innovations of Novo Nordisk.

How to Use Sogroya

Sogroya is delivered the same way as older HGH formulations. Sogroya is administered subcutaneously, just below the top layer of the skin. This type of injection is nearly painless, and there are HGH Injection Pens that make the process even simpler. Sogroya is developed to be used with a Pen.

Who Qualifies for Sogroya?

Sogroya is indicated for adults that have been clinically diagnosed with Human Growth Hormone Deficiency. Most other forms of HGH Therapy are available for all ages, but Sogroya is only intended for adult patients. In the future, Sogroya availability may be expanded to all ages, but more testing is required. Human Growth Hormone Deficiency is diagnosed by measuring Serum IGF-1 Levels in the blood. Baseline HGH cannot be easily measured because it is released in short bursts, but IGF-1 Levels remain fairly constant in the bloodstream, providing the prescribing doctor with a means to accurately estimate HGH Levels and make a diagnosis.

Benefits of Sogroya

Sogroya provides the same benefits to patients as older forms of HGH Therapy. For patients with Clinical Growth Hormone Deficiency, Sogroya can increase muscle mass, improve cognition, ward off fatigue, and encourage weight loss via the breakdown of body fat. There is also strong evidence that HGH Treatments like Sogroya can improve immune health and enhance the body's natural healing processes. While Sogroya is not without risks, those risks are comparable to other available brands of Growth Hormone Injection.

Interested in Sogroya? Contact our Licensed Hormone Clinic for More Information!

Sogroya HGH Therapy represents an exciting step forward in the treatment of Hypopituitarism. If you are interested in switching your Growth Hormone Prescription to Sogroya, our Board-Certified Hormone Specialists may be able to help. If you've never been diagnosed with HGH Deficiency, we can help you undergo the prerequisite testing necessary to see if you qualify!

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Correctly performed testosterone therapy can be your ticket to health.

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If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

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