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Melatonin The Sleep Hormone How It Impacts Your Health


Melatonin Hormone Guide

What Is Melatonin?

Melatonin is a hormone that is released by the pineal gland which encourages sleep and helps to preserve the natural human circadian rhythm. Melatonin is also produced by animals and many plants.

Human beings are naturally designed to be awake during daylight and to become sleepy once the sun goes down. That is because we are diurnal creatures. Although the average person sleeps eight hours per night, we have just begun to really understand why we sleep, and the processes behind it, in recent years.

Although we have been keenly aware of the connection between light/dark and the sleep cycle, we are only now becoming aware of the mechanisms which promote this cycle, and melatonin is one of the keys to this cycle.

It used to be believed that Mmlatonin was the primary mechanism which controlled the circadian rhythm, but today it is clear that melatonin is a tool that the body uses to change the body's physiological patterns to induce sleep, as controlled by the central nervous system.

How Do Light and Dark Promote Patterns of Wakefulness?

Our brains actually process the presence or absence of light through the eyes in order to send information to the brain regarding the sleep cycle. The eyes absorb light, and this information passes from the eyes to the hypothalamus. The hypothalamus has a particular region known as the suprachiasmic nucleus which reacts to sunlight and other factors in order to either promote a state of wakefulness or sleepiness by manipulating body temperature, hormone release, and other factors which promote a normal sleep cycle.

Think of the suprachiasmic nucleus as a clock. Under normal circumstances, human beings usually wake up around the same time each day, and the appearance of sunlight plays a central role in establishing that set pattern. For example, when the suprachiasmic nucleus senses sunlight, it responds by promoting the secretion of cortisol and increasing ambient body temperature. In addition to this, the suprachiasmic nucleus also suppresses the release of melatonin, a hormone which encourages the body to go into a sleep state. Once the sun goes down, the body stops suppressing melatonin release, which encourages sleepiness.

Melatonin is often taken as a supplement in order to help promote sleep. This can be effective for many patients, but should only be used for a brief period of time, because long-term use can affect the body's hormone patterns.

Of course, anyone that experiences significant issues with sleep should talk to a professional in order to get the appropriate treatment, but for mild or temporary sleeplessness, melatonin is often a fine option.

Where Does the Body Make Melatonin?

Melatonin is produced by the pineal gland, which is about the size of a bean and is situated in the central portion of the brain. Under normal circumstances, the pineal gland does not produce Melatonin during the day, but as the sun goes down and the suprachiasmic nucleus no longer receives sufficient light signal, this causes the body to start producing Melatonin.

After the pineal gland produces melatonin, it immediately begins to circulate through the blood stream. For people with normal sleeping patterns, this generally happens at about nine o'clock at night. This is why, a couple of hours after the sun falls down, you naturally enter a state of sleepiness, which inhibits your alertness and causes you to seek out a comfortable place to rest.

Once the body starts to release melatonin, it will continue to do so until sunlight, when melatonin levels will drop, encouraging wakefulness, until around nine o'clock in the morning, when the pineal gland completely deactivates and melatonin production halts. During the day, the body produces almost no melatonin.

Of course, time is not the only factor with regard to melatonin, light is also important. If it is the appropriate time, but the body still senses bright light associated with daytime, then the pineal gland will be activated but will not produce melatonin. In many cases, light produced indoors, especially white light with a lot of blue waves, will be interpreted by the brain as sunlight. This is why it's important to turn off computers and televisions about an hour before bed in order to promote a healthy sleep cycle.

Melatonin is processed by the liver, and is filtered quickly. Ninety percent of Melatonin is processed by the liver the first time it passes through the organ.

How Much Melatonin Does the Body Release at Night?

Dependent on a wide variety of factors, different people produce different levels of melatonin. There does appear to be a strong correlation between age and melatonin production, where children produce the greatest concentrations of melatonin, and older adults produce less over time. This is both why children tend to sleep longer and deeper, and why adults tend to sleep for shorter periods of time. Older adults that have issues sleeping produce less melatonin than their peers on average.

How Much Melatonin Should I Take To Sleep?

Melatonin is a common supplement, and is actually the only hormone in America that can be obtained without a prescription. Because melatonin is present in many animal and plant-based foods, it is considered a nutrient, rather than a hormone, and is not regulated under the same rules as pharmaceutical drugs and other Bio-Identical Hormones. Supplements do not require FDA-Approval, and are not subject to regulations which are as strict as those intended for medications.

For this reason, it is important to source melatonin responsibly. An issue with many over-the-counter melatonin products is that they often provide much more melatonin than the body naturally has the capability to producein some cases twenty times more than the pineal gland secretes to promote sleep!

A few noted side-effects of melatonin supplementation are depression, fatigue, and vivid dreaming.

There has been quite a bit of animal research conducted with regard to melatonin, and there is evidence that melatonin affects blood pressure, and long-term or heavy use can potentially affect fertility. Because of the potential impact of melatonin upon blood pressure, those that are at high risk of cardiovascular disease, heart disease, stroke, kidney disease, or hypertension should always talk to their doctor before using melatonin. Melatonin may also exacerbate sleep apnea.

The best way to use melatonin is to use it to establish a healthy and natural circadian rhythm. This means that it should be taken an hour or so before you are ready to go to bed, so that you can get comfortable and fall naturally to sleep. Also, it is important to take a physiologically natural dose of melatonin in order to prevent side-effects and help your body stay in a normal rhythm.

It is important to note that our knowledge of melatonin (as is true with many other hormones), is incomplete, and more potential treatments or more effective usage protocols may be adopted in the future.

Is Melatonin Dangerous?

Although there are potential concerns regarding melatonin's effect upon mood and cardiovascular health, there has never been a case of melatonin overdose, and there is no evidence that Melatonin overdose produces any toxic effects.

Melatonin Research

Many people have taken melatonin and report that it does indeed help them sleep. It is unclear if melatonin is better than placebo at inducing sleep however. Some studies have shown that Melatonin is no more effective than sugar pill, but there is evidence that melatonin produces other benefits.

For example, melatonin does have the ability to help patients realign their circadian rhythm to a normal schedule. Continuing study needs to be performed, however, to compare the benefits of melatonin to sunlight exposure in promoting healthy sleep patterns. Even so, Melatonin can be very useful for individuals that are exposed to bright light, such as the light of a computer screen, after sundown.

Melatonin has been shown to be highly effective at restoring sleep patterns and promoting sleep both for individuals that work odd hours, and for people suffering from jet lag.

Melatonin does not seem to have an impact on average length of sleep, but it does appear to help patients sleep more soundly, and fall asleep more quickly. Patients that have trouble getting themselves in bed at night may find melatonin very effective. The jury is still out, however, as there are some studies that show otherwise.

The biggest benefit of Melatonin is that it can alter an individuals circadian rhythm, helping them to reset the clock when their bodies are out of sync with their lives. Supplemental melatonin provides this benefit for around six hours.

Individuals should not take Melatonin in the hours just after they have woken up, because it can lead to fatigue and cognitive disruption when taken during a period when the body has just had a large amount of sleep.

Melatonin for Insomnia

The body of research regarding Melatonin and Insomnia is small, and there have been mixed results. In one particular study of men and women over the age of fifty, melatonin appeared to improve both sleep quality and the time that it took to fall asleep. Other studies have shared the result of improved sleep onset, but melatonin did not help insomnia patients maintain energy levels in the daytime, and did not help patients stay asleep through the entire night.

Before more conclusive evidence can be drawn, more elaborate research will need to be performed in order to assess the effectiveness of melatonin as an insomnia treatment. Also, there are no set guidelines for how much melatonin to take to treat various conditions.

Melatonin and Jet Lag

Jet lag is a condition that occurs when an individual changes time zones rapidly, causing their normal sleep schedule, as governed by day-night cycles, to be disrupted. The more time zones that an individual travels, the more time that it will take to recover. As a result, people feel fatigued when they would normally be rested, and they also become hungry at off-times.

There are a number of things that can make jet lag worse. For example, many people don't sleep well on planes. Also, caffeine and alcohol can further alter sleep cycle. The circadian rhythm is important, and when individuals with set rhythms become disrupted, it can completely change their ability to go about their day.

A recent survey of people that regularly travel on business showed that around 50% of these individuals routinely have jet lag as a result of long-distance flights. As a result of this jet lag, they claimed that their productivity and performance were directly impacted. For reasons that are unclear, women were more affected by jet lag than their male peers.

Perhaps because melatonin is available as a cheap over-the-counter supplement, there has not been extensive study regarding its benefits with regard to jet lag. However, studies conducted thus far have shown that melatonin is highly effective at mitigating or completely preventing jet lag. Traveling forward in time or traveling 5+ time zones in a trip were correlated with the greatest degree of benefit.

Melatonin and Delayed Sleep Phase Syndrome

There are other conditions which impact circadian rhythm as well. For example, Delayed Sleep Phase Syndrome is a condition in which patients have major issues falling asleep at normal times, sometimes unable to sleep before sunrise.

This condition affects people of all ages, but is most common among teens. Research shows that melatonin can be an effective method to treat this condition and promote healthy sleep, but for many patients, simply exposing oneself to bright light when one wishes to be awake is equally beneficial.

Melatonin and Libido

In animals, melatonin plays a role in sex drive. Melatonin has the ability to suppress both Follicle-Stimulating Hormone and Luteinizing Hormone, which are important for the maintenance of libido as well as the production of sperm. The way that a species responds to melatonin depends on whether they are sexually active during the day or at night.

Animals that mate at night breed better while melatonin levels are high and daytime breeders mate most effectively when melatonin levels are low. Taking melatonin can negatively affect fertility in some individuals, but there is also evidence that it can promote fertility and libido in others. More research needs to be done to more accurately show how melatonin affects human fertility and libido.

Melatonin and Leptin

Leptin is one of the hormones that controls our hunger. High levels of Leptin produce the sensation of satiety. Leptin levels are affected by melatonin in a complex way. Melatonin interacts with Leptin and Insulin, helping to reduce hunger during sleep. If Melatonin and Leptin interact outside of the presence of Insulin, this causes Leptin levels to decline, however.

Melatonin and the Immune System

In addition to sleep, sex drive, and hunger, melatonin also has an impact on the function of the immune system. The research is limited in this regard, but melatonin does seem to have antiinflammatory properties. Researchers are attempting to discover if melatonin can be used as a way to mitigate inflammation. It is believed that Melatonin promotes the synthesis of cytokines which limit inflammation. In the near future, melatonin may be an important part of fighting both viruses and bacterial infections, and it also may benefit many people with cancer.

Melatonin and Dreaming

In some cases, people that take melatonin supplements report intense dreams. Studies have shown that a 50 milligram dose of Melatonin appears to increase the number of dreams because it lengthens the period of time that an individual spends in REM-Sleep, the period where dreams are most common.

Melatonin and Autism

Melatonin is useful for patients with Aspergers and Autism, because it helps them sleep longer and deeper.

Melatonin and Aging

There is some evidence that suggests that melatonin may be a useful anti-aging tool. It has long been known that children produce higher levels of melatonin later in the night, and older individuals reach peak melatonin much earlier. It is hypothesized that this is one of the reasons why younger and older individuals often have such different sleeping habits. It is also hypothesized that this is why adults don't sleep as long, and why they are more prone to sleep dysfunction.

Animal research studies have also shown that exposure to exogenous melatonin changes the expression of thirteen separate genes in geriatric mice, reverting their expression to those associated with youth. The antioxidant properties in melatonin also may have a neuroprotective effect, which promotes neurological health deeper in to the lifespan, while also reducing inflammation. Both of these aspects have a significant impact on longevity.

Melatonin and Diabetes

Diabetes and Melatonin Levels appear to be correlated. Individuals that produce less melatonin than their peers appear to be more likely to develop Type-Two Diabetes. This could be because people that produce enough melatonin have greater issues controlling insulin, and also because less melatonin means that the body doesn't rest as well, which has a tremendous impact on hormone health.

Melatonin and ADHD Treatment

Research has shown that patients taking medications such as Adderall for ADHD find it easier to sleep at night if they take melatonin before bed. Preliminary studies have shown that this benefit of melatonin does not decrease over the course of three months of treatment.

References:

Is There a Connection Between Melatonin and Fertility?

http://www.wisegeekhealth.com/is-there-a-connection-between-melatonin-and-fertility.htm

Melatonin and Sleep

http://sleepfoundation.org/sleep-topics/melatonin-and-sleep

Wikipedia: Melatonin

http://en.wikipedia.org/wiki/Melatonin

19 August 2014

Andropause A Mid-Life Hormone Crisis


Andropause FAQ

What is Andropause?

Andropause is a medical state that is a natural result of aging, in which symptoms of aging manifest resulting from a decline in Testosterone Production and other male hormones such as dehydroepiandrosterone, also referred to as DHEA.

Andropause is a universal factor of the male condition, although each male will physiologically react to the condition in their own way, and some men will display symptoms much earlier than others.

How Fast do Testosterone Levels Decline Over Time?

From the age of puberty to around the late twenties, males are flush with Testosterone, which contributes to optimal health and wellness. Around the late twenties or early thirties, however, these levels start to drop, at a rate of around 1%-2% per year. This decline is slow and without symptoms at first, but as the decline becomes more severe, the changes start to become apparent.

How Can I Qualify for Andropause Treatment?

In order to be prescribed Testosterone Treatment for Andropause, or other effective treatments, you must undergo clinical evaluation. Many men have Low Testosterone without displaying symptoms. In order to qualify for Low-T treatment, you must not only have clinically low levels of Testosterone, but you must also display symptoms of the condition.

There are many conditions which may prevent you from qualifying for treatment, including prostate cancer and severe sleep apnea.

What Blood Tests Are Necessary In Order to Diagnose Andropause?

Although your doctor may order a variety of tests in order to fully assess your overall health and hormone balance, for Age-Related Low-T, the most important test is the Free Testosterone Test. Free Testosterone is also referred to as Bioavailable Testosterone, and refers to the amount of Testosterone that is available for use by the body, and not currently being used.

With a saliva or blood sample, it is possible to take a snapshot of your current Free Testosterone Levels.

What is Total Testosterone?

Total Testosterone refers to all Testosterone that is circulating through your blood stream. This includes both Free (Bioavailable) Testosterone and bound Testosterone.

Why Is the Total Testosterone Test Insufficient for the Diagnosis of Andropause?

The vast majority of patients with Symptomatic Andropause have clinically normal Total Testosterone Levels, meaning that if Total Testosterone alone is evaluated, most patients with Andropause will appear to have normal Testosterone Levels, because the wrong factor is being measured. Recent research has shown that among men with Andropause, only 13% show depressed Total Testosterone Levels, whereas nearly three out of four of those patients had Low Free Testosterone Levels.

Because many physicians only measure Total Testosterone when evaluating Andropause, symptoms of Testosterone Deficiency are often diagnosed mistakenly as resultant from chronic fatigue, stress, depression, and other factors. Many of the treatments for these conditions actually have a depressant effect upon Testosterone, which could actually exacerbate symptoms in the long run.

By Fifty, What Percentage of Men Have Abnormally Low Free Testosterone Levels?

Among men over fifty, it is approximated that roughly half of men have Free Testosterone Concentrations that would be considered clinically low for men between the ages of thirty and forty.

What Are Other Names for Andropause?

Andropause is often referred to by a number of different names. For the sake of simplicity, it is often referred to in the media as Low-T, although Low-T is a broader term which simply refers to any physiological state in which Testosterone Levels are inadequate to meet the needs of the body. Another informal term for Andropause is Manopause, used to further emphasis the physiological connection between Menopause and Andropause.

Andropause is also sometimes referred to as Age-Related Testosterone Deficiency, which is a more adequate representation of the condition, because Andropause is an age-dependent chronic condition. Other similar names include Partial Androgen Deficiency in Aging Males, Androgen Deficiency of the Aging Male, and Symptomatic Late Onset Hypogonadism.

Because Andropause has not been fully accepted as a medical condition by the World Health Organization or the Food and Drug Administration, there is not a codified set of terms related to the condition, although there is a large amount of on-going study, and the condition is widely recognized by medical professionals and medical research institutes both nation- and worldwide.

What Causes Andropause?

Andropause is caused by a combination of hereditary factors and lifestyle choices, also known as Internal and External Causes. Internal causes are genetic.

Before Andropause occurs, the body enters a state of Hypogonadotrophic hypogonadism. During this period, the body produces less Testosterone than is produced by younger, healthier men. Hypogonadotrophic hypogonadism is a state in which the brain does not respond adequately to signals that Testosterone Levels are insufficient to promote the optimal health of the human body. Hypogonadotrophic hypogonadism generally takes place around the age of forty.

Testosterone production will continue to decline over time, eventually to a point at which the pituitary and the hypothalamus respond by producing elevated concentrations of Gonadotropin-Releasing Hormone and Luteinizing Hormone in an effort to rebound declining Testosterone. This is effective for a brief period of time, but the body eventually reverts to a state of decline once again.

This is the period at which Andropause takes place. Hypogonadotrophic hypogonadism refers to the early state at which GnRH and LH Levels are low in combination with Testosterone. Andropause refers to the period at which Testosterone Production remains inhibited in spite of increased LH and GnRH levels.

This hormonal change is absolutely normal, in that it is a natural progression of male hormone balance, which bears some similarities to menopause, hence the name. One significant way that Andropause and Menopause differ is that there is more variation as to when men begin to experience their change. Women will reach menopause at some point between the early 40s and late 50s, whereas some men will begin to experience symptoms before or even after that period.

What Are Lifestyle Factors Which Encourage Symptoms of Andropause?

Although the human body has a baseline of Testosterone Production dependent on age and genetics, this production can be affected by lifestyle choices which further suppress Testosterone Levels in the body. The following are some factors which can inhibit the body's natural ability to release Testosterone:

  • Inadequate Sleep

  • Poor Diet

  • Sedentary Lifestyle

  • Medications

  • Overindulgence of Alcohol

  • Stress

  • Illness

What Are the Symptoms of Andropause?

Andropause is a complex condition which affects male health in a wide variety of ways. The following are some symptoms associated with Age-Related Testosterone Deficiency:

  • Insomnia

  • Head and Back Aches

  • Reduced Sex Drive

  • Depression

  • Mood Instability

  • Hot Flashes

  • Hypersensitivity

  • Irritability

  • Social Withdrawal

  • Anger

  • Unhealthy Changes in Body Composition

  • Fatigue

  • Loss of Bone Mineral Density

What Are Some Effective Andropause Treatments Available?

Men with Andropause can benefit significantly from Hormone Replacement Therapy. There are a number of options available to Andropause patients, including:

  • Testosterone Patches

  • Testosterone Creams

  • Testosterone Gels

  • Injectable Testosterone (Testosterone Enanthate, Testosterone Cypionate, etc.)

  • Testosterone Pellet Therapy

  • Clomiphene Citrate

What is the Difference Between Andropause and Primary Testosterone Deficiency?

Most men suffering from symptoms related to Andropause have perfectly functioning testes, but do not receive sufficient signaling from the hypothalamus to produce enough Testosterone to meet the needs of the body.

Andropause is a form of secondary hypogonadism related to age. The older that men get, the less efficient that their bodies are at producing Testosterone. Primary Testosterone Deficiency is Low-T that is the result of a direct malfunction of the testes which prevents the body from being able to produce Testosterone at normal levels.

Both of these forms of Testosterone Deficiency can be treated with Bioidentical Testosterone Therapy, but there are more off-label options available to patients that suffer from Andropause and other forms of Secondary Hypogonadism, such as Clomiphene Citrate.

Testosterone production is actually the result of a cascade of signals that begins at the hypothalamus. The hypothalamus releases a hormone known as gonadotropin-releasing hormone (GnRH), which circulates to the pituitary, stimulating the production of Follicle-Stimulating Hormone and Luteinizing Hormone, which both contribute heavily to the healthy function of the male reproductive system. Luteinizing Hormone stimulates the production of Testosterone and other male sex hormones, while Follicle-Stimulating Hormone promotes the healthy production of sperm.

What Are Some Health Risks Associated with Andropause?

Andropause is correlated with a number of health conditions which can severely impact health and wellness, including:

  • Diabetes

  • Hypertension

  • Obesity

  • Chronic Fatigue

  • Heart Attack

  • Stroke

There is even evidence that Andropause leads to an increased risk of Alzheimer's and other neurological disorders.

What is the Goal of Andropause Treatment?

The ultimate goal of Andropause Treatment is not to flood the body with Testosterone, but simply to restore Testosterone Levels in the body to normal, physiological levels. In general, Testosterone Replacement Therapy Treatments aim to restore Testosterone Concentrations to what would be considered mid-normal for a man in his twenties.

In restoring Testosterone Levels to these physiologically normal levels, it is possible to significantly mitigate the symptoms of Andropause, helping men live healthier lives.

What Are the Benefits of Andropause Treatment?

  • Higher Quality of Life

  • Fewer Mood Swings

  • Reduced Irritability and Anxiety

  • Preserved Bone Mineral Density

  • More Energy

  • Enhanced Muscle Health

  • Increased Metabolism

  • Improved Capacity to Burn Fat

  • Increased Libido

There is preliminary evidence that shows that Testosterone Treatment also improves cardiovascular health, but more research is needed.

Does Andropause Treatment Cause Cancer?

There is no evidence that Testosterone Therapy for Andropause causes cancer, but the treatment can exacerbate existing forms of cancer, including breast and prostate cancer, and should not be prescribed to individuals that have or are at high risk of these or other forms of cancer.

How Can I Treat Infertility Related to Andropause?

Unfortunately, Testosterone alone is not capable of restoring fertility. This is because Bioidentical Testosterone actually suppresses the ability of the testes to produce Testosterone and sperm for the duration of therapy. This is temporary, and testosterone production will return after therapy has been suspended, but for patients interested in having children, Testosterone Treatment alone will not be sufficient.

Testosterone can, however, be combined with Human Chorionic Gonadotropin (HCG) in order to simultaneously increase Testosterone Concentrations in the body while simultaneously preserving fertility and the normal function of the Testes. In the male body, HCG acts as a functional analogue of Luteinizing Hormone, both preserving the body's ability to make some of its own Testosterone while also preserving the fertility of the patient.

Clomiphene citrate (brand name: Clomid) is sometimes prescribed to men with Testosterone Deficiency/Andropause that are interested in Testosterone Restoration which also preserves fertility. Clomiphene increases Testosterone and Sperm Production by inhibiting negative feedback mechanisms which can limit the healthy production of Testosterone.

Is It Possible to Use Erectile Dysfunction Medications During Andropause Treatment?

Yes, but you may not have to in the long run. Andropause is one of the main causes of Erectile Dysfunction as men grow older, and many men with Age-Related Testosterone Deficiency report that as a result of Testosterone Replacement Therapy, they no longer rely as heavily on Erectile Dysfunction Medications. Many patients even report that they no longer need to use such medications.

There is research that shows that taking Erectile Dysfunction medications with Testosterone Therapy has the ability to resolve ED issues in 95% of patients.

What Are the Potential Side-Effects of Testosterone Therapy for Andropause?

As with any form of medical treatment, there are risks associated with Testosterone Restoration. The following are some of the risks associated with Andropause Treatment:

  • Oily Skin, increased prevalence of acne

  • Male-Pattern Baldness

  • Headaches

  • Prolonged/Frequent Erections

  • Gynecomastia (increased breast tissue can be treated with estrogen-blockers such as Arimadex)

  • Increased Red Blood Cell Count (can be treated via blood donation)

  • Accidental long term overdose can lead to Heart Disease

All patients that take Testosterone will experience the following symptoms resulting from therapy:

  • Reduced Fertility

  • Testicular Shrinkage

These symptoms are temporary, and will slowly return to a normal state after treatment has ended. Combining Testosterone with HCG can prevent these symptoms, as can Low-T Treatment with clomiphene citrate.

How Can I Mitigate the Effects of Andropause Through Lifestyle?

What Should I Avoid the Onset of Andropause Symptoms?

Stop Smoking and Using Tobacco Andropause has a negative impact on cardiovascular health, and smoking only exacerbates the risk of cardiovascular complications. Also, smoking reduces normal erectile function because nicotine encourages vasoconstriction, which reduces the ability of the body to rush blood flow to the potential erection.

Don't Abuse Alcohol Alcohol promotes the body's production of estrogen, which depresses testosterone production. Also, alcohol reduces zinc levels in the body, which reduces the ability of the body to adequately control estrogen production.

What Should I Do to Delay the Onset and Severity of Andropause Symptoms?

Lose Weight Adipose body fat has the natural ability to promote elevated estrogen levels which suppress testosterone production in men. By losing weight, it is possible to promote a healthier testosterone balance.

Eat Healthier Your body also needs a well-rounded diet rich in nutrients in order to promote optimal hormone balance and mitigate the effects of Andropause. Although the body needs some fat, diets that are high in fat will expose the body to more estrogen. Also, organic foods can help improve Testosterone levels, because many common pesticides have estrogenic qualities. Finally, a diet rich in cruciferous vegetables such as cauliflower and broccoli promotes healthy testosterone balance as a result of naturally occurring antioxidant compounds such as indole-3-carbinol.

Make a Concerted Effort to Improve Sleeping Habits The body produces Testosterone primarily at night. By taking the steps to make sure that you get all the sleep your body needs, you protect your body's natural ability to produce Testosterone.

Take Zinc Supplements Zinc is a very important nutrient which promotes the body's ability to produce its own Testosterone while also inhibiting the body's ability to produce estrogen and other aromatase compounds which suppress Testosterone production.

Manage Stress More Effectively In order to promote healthy Testosterone Production, it is important to control one's stress. Stress increases the production of cortisol, which is another cholesterol-based hormone. The body has a limited amount of these resources, and if you have too much stress, your body will divert resources from Testosterone production to Cortisol production.

What is the Average Dosage for Testosterone Restoration for Andropause?

When men are in their twenties, they generally produce between four and seven milligrams of Testosterone. Because not all Testosterone is absorbed during topical Testosterone Therapy, the initial dosage is generally between ten and twenty milligrams each day in order to bring Free Testosterone Production back to normal.

Because of potential issues related to elevated Testosterone Levels, it is prudent to start with a small dose in order to provide benefits with the lowest risk of side effects. Generally, patients will stay on this starter dose for around three or four months, then come back for further evaluation. Their dose will remain the same or be adjusted based on further testing as well as an evaluation of the effectiveness of treatment.

References:

Andropause: The Male Menopause

http://www.bodylogicmd.com/for-men/andropause

Frequently Asked Questions about Andropause (Male Menopause) and Testosterone Replacement Therapy

http://www.apothecaryoptions.com/pdf/atrfaq.pdf

Wikipedia: Andropause

http://en.wikipedia.org/wiki/Andropause

19 August 2014

Ghrelin The Hunger Hormone


Ghrelin Hormone Guide

What is Ghrelin?

Ghrelin is the primary hormone in the human body which regulates the sensation of hunger. It is considered a partner to a hormone known as Leptin, which controls satiation. Whereas Leptin is produced primarily by adipose fat tissue, Ghrelin is released by special cells throughout the digestive system. After Ghrelin is released, the hormone circulates through the body and activates at sites throughout the nervous system, in particular, the hypothalamus.

Like Leptin, in addition to impacting hunger signals, Ghrelin also has a role in metabolism and the usage and storage of energy.

When is Ghrelin Released?

Ghrelin is produced by the stomach when the stomach is empty, and the release of the hormone is suppressed when the stomach is stretched. The primary influence of Ghrelin is upon the hypothalamus, where it triggers the sensation of hunger and encourages the stomach to release acid in preparation of its next meal. It also readies the entire digestive system to process and move food through the system.

Leptin and Ghrelin both trigger activity upon the same receptors in the hypothalamus, although Ghrelin encourages hunger and Leptin suppresses it.

Ghrelin also alters the sensitivity of a certain pleasure center of the brain known as the ventral tegmental area, an area which plays a major role in both addiction and sexual libido. In particular, Ghrelin has a powerful influence on both acetylcholine and dopamine production.

Ghrelin is just one of many hormones that help human beings (and other animals) establish a routine pattern of energy distribution. It encourages the body to intake calories which will be converted into energy by stimulating hunger, and also alters the way that the body uses energy, in terms of immediate heat generation, adipose fat storage, and the process of the ATP cycle.

Ghrelin and Leptin Ideally Create Metabolic Homeostasis

When Ghrelin and Leptin are interacting as they should, it helps to promote an ideal physiological state, but when these hormones get out of their natural rhythms, it can lead to increased body weight and reduced metabolism, as well as powerful sensations of hunger which encourage eating junk food and other foods dense in calories.

Leptin controls the way that the body responds to food via signals from body fat, while Ghrelin controls the way that the body responds to food from the stomach itself. There are a number of pathways through which Ghrelin achieves this, some of which are not fully understood at this time. There are also synthetic molecules which imitate the function of Ghrelin which have the ability to both promote weight gain and increase appetite by activating receptor sites on the arcuate nucleus.

Insulin, Leptin, and Ghrelin

The ability of Ghrelin receptors to accept stimulation is affected both by the influence of insulin and Leptin. Also, Ghrelin encourages eating full meals because it suppresses the body's ability to feel the stomach stretch until toward the end of the meal when Ghrelin levels decline.

In addition to directly controlling hunger, Ghrelin also promotes the release of pleasure hormones which encourage an individual to regularly eat, but can also promote overeating as well as addiction if a patient lacks willpower and self-control. In fact, alcohol dependency requires Ghrelin to activate receptors on the hypothalamus, and this is also one of the influences which encourage people to prefer certain foods over others.

Ghrelin and Eating Habits

Ghrelin is a powerful hormonal force which controls both feeding and appetite in animals, including humans. Ghrelin levels drop after we eat a meal, and slowly rise over time, increasing our hunger and desire to eat. Ghrelin peaks immediately before eating and drops to its lowest levels after the meal has concluded.

Ghrelin Injections, and the injection of Synthetic Ghrelin Analogues, have the ability to increase hunger and appetite dependent upon the dose of the hormone that is administered. This means that the more Ghrelin that is administered, the more calories that a patient will consume over time. This does not make individuals eat more at every meal, however. It makes them become hungry again much more quickly than they normally would, so they eat more meals each day.

In animal species, the administration of Ghrelin causes the animal to search for food more aggressively, and increases the prevalence of any activities related to meal habits, including hoarding, foraging, or sniffing out food.

Ghrelin and Metabolism

Body mass is controlled through metabolism. At its simplest, this simply means that weight is controlled by adjusting how calories are taken in and how calories are burned from day to day. The more Ghrelin that an animal produces, the more they will weigh, as a general rule. Based on this information, it is believed that Ghrelin acts as an intermediary between adipose fat deposits and the brain.

Ghrelin is dependent upon the weight of the individual. The less than a person weights, the more Ghrelin that their body will produce, while on the other hand, the more that a person weighs, the less Ghrelin that they will produce. This may be one reason why many people that are overweight don't eat as often as their peers, but eat larger meals as a result of their lack of self control.

Under normal circumstances, Ghrelin works in the body as a means to keep weight at an average healthy level, mediating the body's use of energy and its mass.

Ghrelin and the Digestive System

Ghrelin acts as an anti-inflammatory in the digestive system and prevents cells from spontaneously dying during times of internal stress and inflammation. Ghrelin generally promotes the activity of other anti-inflammatory hormones and compounds while limiting the activity of those that cause inflammation. For this reason, researchers hypothesize that medically administered Ghrelin may one day be useful in promoting gastrointestinal health during these times of stress. Ghrelin also appears to help the interior of the digestive system rehabilitate itself after damage and injury.

In the case of pancreatic and gastrointestinal cancers, elevated Ghrelin levels can exacerbate the illness.

Ghrelin and the Pancreas

Ghrelin and insulin are related hormones, and the presence of one impacts the activity of the other. There are Ghrelin receptors on the pancreas, and when Ghrelin activates these points, it slows down the release of insulin in response to the presence of glucose. This means that Ghrelin slows down the rate at which the body processes sugar as it circulates through the body.

Ghrelin and Heart Health

Ghrelin is beneficial to heart health because it inhibits the formation of fatty deposits in the arteries, and it also encourages the healthy function of the endothelium, the inner lining of the blood vessels.

Ghrelin, Memory, and Learning

The hippocampus is the center for learning in the brain. Ghrelin plays a role in all of this, and also encourages the production of Human Growth Hormone. Ghrelin circulates through the blood stream and passes through the blood-brain barrier at the hippocampus, and encourages the development of new connections in the brain

There is some evidence that the brain is able to retain information at the highest levels when Ghrelin levels are higher, which means that when people are full, they may have slightly more trouble learning than when they are hungry. From an evolutionary perspective, it does seem beneficial to have additional horsepower in the brain when the body requires food, and for the mind to slow down after a meal has been found and consumed. This process is apparent in animal studies, and it is hypothesized that in humans this same mechanism is at play, at least to a certain extent.

Ghrelin and Depression

Animal research has shown that Ghrelin promotes a healthier psychological profile and inhibits depression. Lab mice which don't produce Ghrelin experience greater levels of anxiety when they are exposed to both physical and psychological stress. Under normal circumstances, Ghrelin has the ability to interact with the hypothalamic-pituitary-adrenal axis in a way that reduces the effects of stress.

Also, animal studies have shown that Ghrelin acts like an anti-depressant in laboratory mice, as rodents with elevated levels of the hormone showed fewer signs of stress than their peers without Ghrelin. Furthermore, rodents that were unable to produce Ghrelin were less likely to interact with other rats around them.

When these lab rodents were provided an anti-depressant, it counteracted the social inhibition experienced resulting from a lack of Ghrelin, which suggests that Ghrelin helps ward off depression by some underlying mechanism.

Ghrelin and Sleep

Elevated Ghrelin Levels are associated with shorter periods of rest, and this is also associated with being overweight. The more Ghrelin that is present in the blood stream, the less sleep that an individual will experience. Also, those that sleep well through the night are less likely to experience obesity, and their Ghrelin levels tend to be lower.

Ghrelin and Fear Response

Humans and animals have a tendency to experience latent fear as a result of past experiences of stress. Ghrelin plays a role in this, as the body releases Ghrelin in response to such fear, which makes the source of the fear easier to retain. Stress affects Ghrelin concentrations even when the body is not producing adrenal hormones such as cortisol. When Ghrelin stimulation is inhibited, this suppresses the brain's tendency to learn what to fear more effectively under stress, although it does not affect adrenal response to stress.

In the future, there will likely be medications that use synthetic Ghrelin or Ghrelin analogues as a means to limit the effects of mental disorders caused by stress.

Ghrelin and Dopamine

Dopamine is the primary pleasure hormone that is produced by the body. Ghrelin increases the level of dopamine that is present in the substantia nigra, which is the reward center of the brain. Upon eating or engaging in any other pleasurable activity, this enhances the sensation of pleasure.

Ghrelin and Reproductive Health

Ghrelin inhibits the release of precursor hormones which produce sex hormones and sperm, whereas Leptin encourages the production of these hormones. It is unclear to what extent that this may limit fertility. From an evolutionary standpoint, it makes sense that during times of hunger, reproduction would be a secondary concern, whereas during periods of satiation and abundance, sex drive and function would increase.

Prenatal Health and Ghrelin Production

During the fetal stage, the developing lungs produce Ghrelin in order to accelerate the growth of the organ. Also, there is a connection between the concentration of Ghrelin in the umbilical cord and the weight of the child at birth.

Ghrelin, Obesity, and Anorexia

As we mentioned earlier, individuals that are overweight or obese do not produce as much Ghrelin as their thinner counterparts. For this reason, it does not seem that Ghrelin is a contributor to weight gain, although its high or low levels can affect other aspects of physiological health. The exception to this is patients that suffer from Prader-Willi syndrome. Among these patients, Ghrelin levels do promote obesity.

Individuals that suffer from anorexia have exceptionally high blood-concentrations of Ghrelin. The issue is that their bodies override these normal physiological cues to eat. Clinical research has shown that by introducing exogenous Ghrelin intravenously, it is possible to increase calorie intake among patients with anorexia by as much as 36%.

Under normal, healthy circumstances, Ghrelin levels are low around bedtime and increase slowly through the course of the night. Overweight and obese individuals are more likely to experience elevated Ghrelin levels at inappropriate times, which is evidence toward the hypothesis that obesity is a condition that is exacerbated by an incorrect circadian rhythm.

Being in front of a computer screen or other source of abundant light during the late evening can interrupt the natural rise and fall or Ghrelin levels at night. Also, individuals that don't get enough sleep at night produce more Ghrelin, because sleep naturally has a depressant effect upon the hormone. Poor sleeping habits promote the suppression of leptin and the release of Ghrelin, which promotes overeating.

Potential Medical Uses of Ghrelin in the Future

  • Ghrelin may also prove to be an effective means to promote the normal muscle activity of the stomach in individuals suffering from gastroparesis.

  • In animal research, Ghrelin has proven effective at reducing the number and severity of seizures that afflicted animals experience. This may cross over into humans.

  • Ghrelin will soon be used as a treatment for many forms of wasting disease, and may assist patients being treated for kidney failure.

Ghrelin and Appetite: A Research Study

New research shows that elevated levels of Ghrelin promote poor dietary choices, which is why many people may be more prone to eating unhealthy foods packed with calories like cookies and cake.

Simply having elevated Ghrelin in circulation is as powerful of an influence on diet as the act of fasting, both of which encourage desire for calorie-dense foods. Ghrelin reaches very high levels during the act of fasting, but the administration of synthetic Ghrelin can mimic the physiological and psychological desires associated with such a fast, even if the patient does not engage in the activity.

This is because of the way that Ghrelin interacts with the reward centers of the brain. In this study, it was found that synthetic Ghrelin significantly increased the activity in the area of the brain which activates in response to pleasure.

The main researcher in this study, Dr. Goldstone, was interested in seeing how the administration of Ghrelin via injection compared to the act of fasting in relationship to dietary choice.

His study involved eighteen patients, all around the age of 23, all of which were of average weight. They were required to fast the night before and come in without breakfast, and they visited the medical location on three occasions, all of which were at least seven days between.

Each visit, patients either stayed on the fast or ate a meal of 730 calories. After they were fed or required to remain on their fast, they were administered with an injection of either Ghrelin or saline. In order to ensure that the patients' bodies reacted to the Ghrelin injection, they were tested for elevated HGH levels, which rise at the same time that Ghrelin Levels rise in the blood stream.

Ghrelin Research Procedures

Rather than eating after the injection, the subjects were shown various images of foods, sixty of which were low calorie foods, and sixty of which were foods with high calories. Interspersed among these pictures were photos of things seen around the house, to act as a control. During this rating process, their brains were scanned in an MRI machine, meaning that the patient could both provide a qualitative response while the researchers also measured the neurological response to the food stimulus.

How Does Ghrelin Affect Desire for Food?

What researchers discovered was that Ghrelin had no effect on the participants' interest in foods with low calories, while it did increase the desire for foods with a lot of calories. In particular, Ghrelin increased the desire for sweets the most.

One particular area of the brain that was closely monitored during these tests was the anterior orbital frontal cortex, which is the location of the brain that stores the desire that the brain has for particular foods. He found that satiated individuals that received saline did not experience high levels of activation in this area, whereas those that received Ghrelin still experienced activity in this area even when the patient was fed prior to the imaging session.

Does Ghrelin Contribute to Obesity?

Ghrelin may not directly cause obesity, but it does prevent the body from changing its pattern of nutrition intake. Ghrelin levels remain low as long as the obese patient stays at his or her stable weight, but as soon as he or she tries to lose the weight, Ghrelin levels increase dramatically. It is believed that one day, there will be treatments available which block the body's production of Ghrelin during dieting in order to promote weight loss and treat obesity.

References:

Hormone Ghrelin Ups Desire for High Calorie Foods

http://www.webmd.com/diet/news/20100622/hormone-ghrelin-ups-desire-for-high-calorie-foods

Wikipedia: Ghrelin

http://en.wikipedia.org/wiki/Ghrelin

Your Hunger Hormones: How They Affect Your Appetite and Your Weight

http://www.webmd.com/diet/features/your-hunger-hormones

19 August 2014

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The Effects Of Cortisol On The BodyThe Effects of Cortisol on the Body
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A Medical Doctor Tries Human Growth Hormone In 1992A Medical Doctor Tries Human Growth Hormone in 1992
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Estrogen Hormone Replacement Therapy And Alzheimers DiseaseEstrogen Hormone Replacement Therapy and Alzheimers Disease
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A Medical Doctor Tries Human Growth Hormone In 1992A Medical Doctor Tries Human Growth Hormone in 1992
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Hgh Is Illegal If Bought Outside Of The 50 United StatesHGH is illegal if bought outside of the 50 United States
Getting Started With An Hgh ProgramGetting Started with an HGH Program
Introduction To Human Growth HormoneIntroduction to Human Growth Hormone
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How To Age Rapidly Or NotHow to age rapidly or not
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Hrt, Hormone Replacement TherapyHRT Hormone Replacement Therapy
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Study Shows New Method Of Growth Hormone Dosing Improves HeightStudy Shows New Method Of Growth Hormone Dosing Improves Height
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Video: Truth About SteroidsVideo: Truth About Steroids
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Anti-ageing Clinics Distribute Human Growth HormoneAnti-ageing clinics distribute human growth hormone
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Diet Science
The Ideal Balanced Diet The Reality Of Healthy EatingThe Ideal Balanced Diet The Reality of Healthy Eating
The Role Of Magnesium For Good HealthThe Role of Magnesium for Good Health
How Safe Is Msg?How Safe is MSG?
Xylitol Alternative Low-calorie SweetenerXylitol Alternative Low-Calorie Sweetener
How To Increase Lean Muscle Mass And StrengthHow to increase lean muscle mass and strength
Insomnia GuideInsomnia Guide
The Importance And Purpose Of StressThe Importance and Purpose of Stress
Alcohol Appears To Impact Sperm QualityAlcohol Appears to Impact Sperm Quality
A Pound Of Muscle Vs A Pound Of Fat The Truth About Weight LossA Pound of Muscle vs a Pound of Fat The Truth about Weight Loss
Hidden Sources Of Sugar In Common FoodsHidden Sources of Sugar in Common Foods
How Is Sleep Apnea Diagnosed And TreatedHow Is Sleep Apnea Diagnosed and Treated
What Is Sleep Apnea And How Does It Impact HealthWhat is Sleep Apnea and How Does It Impact Health
Twenty Simple Weight Loss Tips That Can Change Your LifeTwenty Simple Weight Loss Tips that Can Change Your Life
Consumers Of Processed Meat Put Themselves At RiskConsumers of Processed Meat Put Themselves At Risk
Four Reasons Why Healthy Sleep Encourages Weight LossFour Reasons Why Healthy Sleep Encourages Weight Loss
Sixteen Common Foods That Increase The Cancer RiskSixteen Common Foods That Increase The Cancer Risk
Should You Consider Intermittent FastingShould You Consider Intermittent Fasting
Juicing Pros And ConsJuicing Pros and Cons
The Truth About The Zone DietThe Truth About the Zone Diet
The Truth About The Schwarzbein PrincipleThe Truth About the Schwarzbein Principle
The Truth About The Realage DietThe Truth About the RealAge Diet
The Truth About The Origin DietThe Truth About the Origin Diet
The Truth About The Eat Right, Live Longer DietThe Truth About the Eat Right Live Longer Diet
Nine More Natural Ways To Relieve AnxietyNine More Natural Ways to Relieve Anxiety
Facts About Omega-3 Fatty Acids Ala, Dha, And EpaFacts About Omega-3 Fatty Acids ALA DHA and EPA
Twelve Ways To Control CravingsTwelve Ways to Control Cravings
What Makes Vitamin C So Important To Health And Longevity?What Makes Vitamin C So Important to Health and Longevity?
Metabolism Boosting Tips For Losing Weight And Feeling GreatMetabolism Boosting Tips for Losing Weight and Feeling Great
Poor Sleeping HabitsPoor Sleeping Habits
Amazing Health Benefits Of L-citrulline And WatermelonAmazing Health Benefits of L-Citrulline and Watermelon
The Effects Of Cortisol On The BodyThe Effects of Cortisol on the Body
Chemical Pollution Is Destroying MasculinityChemical Pollution Is Destroying Masculinity
How To Age Rapidly Or NotHow to age rapidly or not
How To Lose Weight With Human Growth HormoneHow To Lose Weight With Human Growth Hormone
Anti-aging Cell Regeneration And Longevity RecommendationsAnti-Aging Cell Regeneration And Longevity Recommendations
Dont Eat Before You Sleep Increase HghDon't Eat Before you Sleep Increase HGH
L-carnitine: Improves Cognitive Function In CentenariansL-Carnitine: Improves Cognitive Function in Centenarians
Restrict Your Calories 30% And Live 30% Longer?Restrict your calories 30% and live 30% longer?
Vitamin-d Longevity VitaminVitamin-D Longevity Vitamin
Whats The Healthiest Diet?What's the Healthiest Diet?
What Is A Nutraceutical?What is a Nutraceutical?
Flax Seed Oil: Longevity And Anti-aging MedicineFlax Seed Oil: Longevity and Anti-Aging Medicine
Knowing Two Languages Can Postpone DementiaKnowing two languages can postpone dementia
Mind, Not Matter, Rules, Leading Thinker SaysMind Not Matter Rules Leading Thinker Says
Healthy Living Can Add 14 Years To Your LifeHealthy Living can add 14 years to your life

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