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ENCLOMIPHENE CITRATE ANDROPAUSE TREATMENT UP FOR FDA APPROVAL


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 28 September 2015

Enclomiphene Citrate May Treat Andropause More Effectively than Bio-Identical Testosterone

Bio-Identical Testosterone has been used for decades in order to treat Low-T caused by Hypogonadism and Andropause. There is a drug currently undergoing Clinical Evaluation which is likely to reach the open market in just a matter of years, known as Enclomiphene Citrate.

Medications similar to Enclomiphene Citrate have long been used as fertility treatments for women, but studies indicate that the treatment can also provide men with a potent boost of Testosterone without a risk of overdose.

Enclomiphene Citrate Affects Men and Women Differently

In women, Enclomiphene Citrate encourages the process of ovulation, but in men, it encourages the release of precursor hormones which stimulate the production of both natural, endogenous Testosterone and sperm.

In fact, these trials provide evidence that Enclomiphene Citrate is even better than Testosterone Injections and Creams at restoring natural Testosterone Levels, all the while promoting healthier hormone balance and circulation in other ways.

How Does Testosterone Replacement Treat Low-T?

Bio-Identical Testosterone Therapy simply replaces the Testosterone that the body no longer produces at sufficient concentrations to sustain male health. Testosterone Therapy can bring Testosterone Levels back to normal, but it comes with side-effects, both inherent in the treatment and related to accidental overdose. Because Testosterone Therapy provides an outside source of Testosterone, the treatment suppresses the body's production of Testosterone Precursors that are responsible for healthy testicles, which leads to fertility issues as well as Testicular shrinkage.

Enclomiphene Citrate is Cheaper than Testosterone

Enclomiphene Citrate is also cheaper than Testosterone, meaning that, if the treatment is found to be effective and gains FDA Approval, and it appears likely that this will be the case, countless men will flock from Bio-Identical Testosterone to Enclomiphene Citrate in order to get more cost effective care that is easier to administer. Unlike Testosterone, which is generally delivered via injection or topical formulation, Enclomiphene Citrate is a simple pill.

Enclomiphene Citrate Clinical Research Study

At this point, Enclomiphene Citrate for Men is in the second stage of its clinical trial, after showing incredible promise in the initial stage of research. The details regarding this second phase will be published in the academic publication Fertility and Sterility.

Of course, the process for FDA Approval is a four stage process, but, based on off-label usage of similar medications, and the effectiveness of the treatment in the first two stages, it seems clear that Enclomiphene Citrate for Andropause and Male Infertility will almost certainly obtain FDA Approval.

Testosterone Deficiency Prevalent in American Society

Low-T, also known as Andropause or Age-Related Hypogonadism, is a prevalent condition among men in the United States. Millions of American males suffer from the condition, and studies suggest that the condition is still under-diagnosed, due to a number of different factors.

Testosterone Deficiency is most well-known for its impact on sexual health, but Low-T affects male health and longevity in a number of different ways. Aside from Low Libido, Infertility, and Erectile Dysfunction, other symptoms of Andropause include depression, anxiety, changes in body composition, loss of Bone Mineral Density, muscle atrophy, and lack of energy.

Low-T is a natural aspect of the process of aging, but not everything that is natural is healthy. Study after study shows that men with naturally high Testosterone tend to be both healthier and more well-adjusted than their peers that have lower levels of Testosterone.

When Does Testosterone Production Peak?

Biologically, our Testosterone Levels peak while we are in our teens and twenties, and start to fall off beginning in the thirties. Every man is impacted by Low-T in their own way, and some experience symptoms more quickly and more severely than others. Testosterone Deficiency is associated with a number of chronic medical conditions, from cardiovascular disease to diabetes to obesity.

The State of Modern Testosterone Therapy

One issue with Testosterone Deficiency as it is treated today is that there are no definite thresholds regarding how low Testosterone Concentrations must fall before a patient is ultimately diagnosed. This is partially because there is still ongoing research regarding Testosterone for Andropause, but also because each patient has his own personal genetic profile as well as their own set of unique lifestyle choices.

This means that part of diagnosing Low-T is up to the discretion of the prescribing physician, because it is up to his or her expertise to determine if the severity of the symptoms and the underlying hormone levels warrant therapy.

This also means that Testosterone Therapy is prescribed to meet our standards for what healthy Testosterone Levels should be, rather than the body's natural processes to provide youthful Testosterone. This is where Enclomiphene Citrate can be both useful and perhaps even superior to Testosterone Therapy for many patients.

Enclomiphene Citrate and Andropause

Andropause is a form of Secondary Hypogonadism, meaning that the testes are still fully capable of producing their own Testosterone, they just aren't receiving the same signals that they did when the patient was younger. Enclomiphene Citrate restores this youthful signaling, allowing the body to make just as much Testosterone as it needs to meet the needs of the body. Enclomiphene Citrate encourages youthful production of Testosterone, without the risk of overdose (or under-dose) that is sometimes associated with Testosterone Treatment.

Why is Enclomiphene Citrate Superior to Testosterone?

Bio-Identical Low-T Treatments restore Testosterone quite capably, but they do so without taking into account the other hormones and processes of the male body which depend upon Luteinizing Hormone, Follicle-Stimulating Hormone, and Gonadotropin-Releasing Hormone to take place.

When Bio-Identical Testosterone is administered, the body fully absorbs and utilizes the Testosterone, but the three precursors listed above, LH, FSH, and GnRH, no longer get produced in sufficient quantities. This condition does not have a significant impact on health and wellness, but it has a tremendous impact on both male fertility and the condition of the testes themselves.

Doctors Often Prescribe Testosterone to Men that Want Children

Many men take Testosterone without realizing the fertility risk associated with Standard Testosterone Therapy. This is because many general practitioners prescribe Testosterone for Low-T without fully recognizing the downsides associated with the treatment, and thus, they don't relay that information effectively to their patients.

Often, we think of Testosterone Treatment as a therapy for men in the latter stages of their life, but Age-Related Low-T can affect male health even as soon as the early thirties, and many men start taking Testosterone while they are still interested in having children, without recognizing the suppressive effect that the treatment has on a man's ability to produce sufficient sperm for conception.

This lack of knowledge on the part of many physicians is not anecdote, there are studies to back it up. A recent poll by the American Urological Association discovered that fully a quarter of urological specialists were not aware that Testosterone inhibited fertility, and would prescribe Bio-Identical Testosterone Treatments like Axiron to men that were vocally interested in having children in the near future.

Fertility Suppression Due to Low-T Treatment Temporary

Luckily, the fertility risks associated with Bio-Identical Testosterone are short-term, and fertility returns to pre-treatment levels after therapy is suspended, but this still means that many men that would greatly benefit from Testosterone Therapy don't get the opportunity for treatment because of their desire for children.

Clomid vs. Enclomiphene Citrate

In the very near future, there will be a new option available for these men, so they can protect their health and their sexual function while also promoting the healthy production of sperm. Enclomiphene Citrate is a component of a medical treatment that has long been on the market in generic form known as Clomiphene Citrate.

This treatment is also available under the brand name Clomid. The treatment was originally designed to improve fertility in women, but also shows some effectiveness at restoring Testosterone Levels in males. In women, Clomid and Enclomiphene encourage the production of female sex hormones, but in men, the medical treatments encourage the production of Testosterone and sperm.

Clomid is a combination of two active compounds, Enclomiphene Citrate and Zuclomiphene. The benefits of Clomid on Male Sexual Health are primarily the result of the Enclomiphene component of the medication.

The issue with Off-Label prescription of Clomid is that Zuclomiphene does increase the level of Estrogen in the body by a slight amount, meaning that the ideal form of the medication would omit Zuclomiphene entirely. Because of the Estrogenic effects of Zuclomiphene, Clomid is often prescribed in combination with Arimadex in order to counteract those effects and optimize treatment.

Enclomiphene Shown to Be Effective in Stage-2 FDA Trial

In the second stage of clinical research for Enclomiphene Citrate, medical specialists from the Houston campus of the Baylor College of Medicine and Repros Therapeutrics provided 73 male patients with Enclomiphene Citrate for the treatment of Low-T caused by inhibited stimulation of the testes. This is most commonly the result of natural aging, but there are other factors which can impede the release of precursors from the pituitary and hypothalamus as well.

The study went according to the hypotheses supported by Off-Label use of the medication. The researchers found that Enclomiphene Citrate was incredibly effective at increasing Free and Total Testosterone to youthful levels, as well as LH and FSH Levels, which are necessary for proper sexual function.

As a result, Enclomiphene Citrate had no inhibitive effect upon the production of sperm, and perhaps even improved fertility among patients, though this is unclear.

Enclomiphene Works Better Than Clomid for Men

The lead researcher of the study, Dr. Ron Wiehle, explains that Enclomiphene Citrate works via the same mechanism as Clomid, which is prescribed Off-Label, but appears to do so with improved consistency. Further research could prove or disprove that notion, but because Clomid is no longer under patent, there is no financial incentive to study its effects.

On the other hand, Enclomiphene Citrate is still under patent, and is potentially effective for a greater subset of the male population, which provides the motivation for funding and research by private pharmaceutical manufacturers such as Repros Therapeutrics.

Enclomiphene Slightly Reduces IGF-1 Levels

Prior research shows that Enclomiphene Citrate does have a slight suppressive effect upon IGF-1 Production in men. This means that Enclomiphene is likely not a good option for men that simulataneously suffer from significant HGH Deficiency and Testosterone Deficiency simultaneously. This does mean, however, that Enclomiphene Citrate is safer for the prostate than Testosterone Therapy. Further study is needed to elucidate the impact of Enclomiphene upon IGF-1.

Enclomiphene to Be Marketed as Androxal

Although Enclomiphene Citrate is not available on the open market quite yet, the plans are to sell and distribute the medication under the brand name Androxal. Androxal will be specially formulated for male use, to provide the optimal amount of medication to restore the youthful cascade of male hormones necessary to restore vitality and sexual potency.

One reason why there is so much interest in Enclomiphene Citrate is that men in America are choosing to have children later and later in the lifespan, meaning that the segment of the population that experiences symptoms related to Low-T while also being interested in having children continues to grow.

Interested in Enclomiphene Now? Talk to Your Doctor About Clomid!

Although Enclomiphene Citrate is not currently on the market, you can still talk to your doctor about Clomid (Clomiphene Citrate), and find out if you are a candidate for treatment. Clomid is designed and certified for use by women, but there are many physicians all across the country that are highly experienced with the treatment regimen. Clomid may never gain enough traction for FDA-Approval, but the treatment has been used effectively for decades.


HUMAN GROWTH HORMONE DEFICIENCY IMPACT ON SLEEPING HABITS


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 July 2014

How Does Human Growth Hormone Deficiency Impact Sleeping Habits: A Clinical Study

Researchers have long been aware that HGH Deficiency is strongly correlated with an increased incidence of sleeping problems, and in recent years, more time and effort have gone into exploring that correlation.

How Were Patients Selected for this HGH Sleep Study?

One study, published in 2010, analyzed thirty patients with Abnormally Low Growth Hormone Levels from four different University medical centers: the University of Pisa, Italy, the University of Liege in Belgium, the Free University of Brussels, and the University of Chicago. Patients were diagnosed with Human Growth Hormone Deficiency using a method known as the Insulin Tolerance Test. Patients were selected for this study if they showed less than three micrograms per liter after drinking Glucose Solution. Twenty-four of the patients suffered from Adult-Onset Hypopituitarism, while six were diagnosed early in life with Childhood-Onset Hypopituitarism.

Patients that were selected for study had not taken Bio-Identical HGH Injections for a minimum of six months before they were selected, and some participants had never used Bio-Identical Human Growth Hormone Injections. Subjects were screened for a number of conditions, and were turned away if they showed any signs of Diabetes, Hyperprolactinemia, Psychiatric/Neurological Disease, chronic infection, heart problems, kidney problems, liver disease, or drug/alcohol abuse.

Also, patients that had traveled three time zones or more in the previous two weeks were excluded, as were people that were shift workers in the prior three months. Finally, participants had to be off of sleeping medications for a minimum of 90 days.

Adult-Onset HGH Deficiency Causes

The source of Hypogonadism varied from patient to patient. In twelve of the thirty patients, Adult-Onset Hypopituitarism was the result of a pituitary issue that did not involve other parts of the endocrine system. Ten patients had their pituitary removed via surgery. One patient experienced the death of a pituitary tumor which suppressed HGH Levels, and one patient suffered from the same issue, but from the stalk of the pituitary. None of these patients suffered from Diabetes Insipidus.

The second group of patients had pituitary issues that could have been partially the result of hypothalamic insufficiency. Two patients had a tumor removed from the pituitary and suffered from Diabetes Insipidus. One patient received radiation therapy to remove a pituitary tumor. Two patients experienced HGH Deficiency as a result of Craniopharyngioma. One patient had a pituitary tumor break down while also suffering from Diabetes Insipidus. There were two patients that had lesions both of the hypothalamus and the pituitary, resulting from histiocytosis and neurosarcoidosis, respectively.

Childhood-Onset HGH Deficiency Causes

In the Childhood-Onset Hypopituitarism group, six of the ten patients experienced their deficiency as a result of a known genetic predisposition to HGH Deficiency. One patient suffered from Hypothalamic Insufficiency that led to HGH Deficiency. Three others suffered from Hypopituitarism resulting from the appearance or removal of tumors from the Pineal Gland, the Olfactory Duct, and a Brain Tumor, respectively. Finally, the tenth participant suffered from HGH Deficiency resulting from Brain Thrombosis.

More HGH Patient Information

Among the thirty patients, 28 of them had received Bio-Identical Hormone Deficiency Treatment in the past for their Pituitary Insufficiency. There were 24 male patients and 6 female patients in the study. Each female HGH Deficiency subject was taking Estrogen Replacement Therapy, with 4 of those 6 taking progesterone as well.

Sixteen of the patients were simultaneously suffering from Testosterone Deficiency, and were either replacing their Testosterone with Intramuscular Testosterone Injections, or Topical Testosterone Products.

Twenty-one patients were taking Thyroxine for Thyroid Deficiency and twenty-four were taking cortisone acetate or hydrocortisone for adrenal hormone deficiency. Finally, seven patients were taking desmopressin.

HGH Deficiency: Experimental vs. Control

Every patient in this Hypopituitarism Sleep Study had their own personal control with normal HGH Levels. Experimental Group Patients averaged around 72 micrograms per deciliter, whereas control patients had an average of 194 micrograms per deciliter. All experimental patients had normal levels of potassium, sodium, and glucose. Overall, patients had Thyroxine Levels which averaged 86% of normal.


Each patient was matched with a control based upon Body Mass Index, Age, and Gender. The results of this study indicate that Human Growth Hormone Deficiency is strongly associated with daytime fatigue, inhibited sleep quality, and too much high-intensity Slow Wave Sleep. Strangely enough, this increased level of Slow Wave Sleep is not normally associated with most sleeping disorders, which are the result of inhibited Slow Wave Sleep.


There are a number of mechanisms by which this abnormal sleeping condition could lead to issues with sleep health and quality. There is evidence that Growth Hormone-Releasing Hormone enhances Delta Activity, because in healthy brains, HGH and IGF-1 serve as a negative feedback mechanism to limit Human Growth Hormone Production. There is animal research which supports this theory.


How Did HGH Deficiency Effect the Sleeping Patterns of Younger Patients?


Researchers also hypothesize that the hormone imbalance caused by the overproduction of Growth Hormone-Releasing Hormone could cause the body to continue to release signals for Slow Wave Sleep even while awake, which could lead to issues with daytime tiredness. This is especially pronounced among the youngest patients, as those with elevated levels of Slow Wave Sleep were more tired during the day than their counterparts. Among the thirty participants, exhaustion was the single complaint most reported in Self-Reported Quality of Life Scales.



How Did HGH Deficiency Effect the Sleep of Older Patients?

Among older Hypopituitarism patients, the most significant issue appeared to be a lack of sufficient REM Sleep, which is strongly correlated with Human Growth Hormone Deficiency. Lack of REM-Sleep is associated with a number of medical issues, including issues with memory. In this study, older patients with Human Growth Hormone Deficiency were more likely than their control counterparts to suffer from memory issues. As the body of research continues to grow, it becomes increasingly clear that memory is strongly correlated with sufficient REM-Sleep in adult patients.

Another issue that Older Adult Hypopituitarism Patients experienced was that they slept less than their control counterparts, and also slept less soundly and experienced a higher level of sleep fragmentation. It is true that older men and women experience less REM sleep as they grow older, as well as shorter sleep, and more frequent rousing from sleep, but experimental patients experienced these sleep issues at a rate higher than their control peers, and HGH Deficiency appears to be a powerful mechanism which inhibits healthy sleep among these patients.

Older Adult HGH Deficiency patients simultaneously experienced Slow Wave Sleep of high intensity and long duration earlier in the sleep cycle, and had more issues staying asleep later in the sleep cycle. This is a strange issue, because enhanced Slow Wave Sleep is usually correlated with longer, steadier sleep.

Pituitary Insufficiency Vs. Combination Hypothalamic-Pituitary Insufficiency

So, for patients that only experienced pituitary issues with no hormone imbalance resulting from hypothalamic insufficiency, Slow Wave Sleep was longer, but didn't provide sleep benefits for other reasons. This was not the case for patients that were suffering from Hypothalamic issues in addition to Pituitary Insufficiency. Patients that had diminished GH-RH response had issues with Non-REM Sleep, not reaching a sufficient depth of sleep for optimal health. There is significant evidence from other studies that shows that GH-RH Deficiency is associated with an inability to sleep deeply.

For participants that were suffering from Pituitary issues in which Hypothalamic Insufficiency was not ruled out, the results were a mix between the two classes of Hormone Deficiency.

How Did this HGH Sleep Study Compare to Previous Studies?

Interestingly enough, the results of this study were different from another study released twenty years previously, which studied patients with Isolated Growth Hormone Deficiency. There are a number of reasons for this, however. In the older study, participants were controlled on age and sex, but not with regard to Body Mass Index.

There were other aspects which were insufficiently controlled as well. Patients were not monitored for how long they slept, nor when they went to sleep. The earlier study also allowed for naps, and patients were not limited in their activity in the previous study.

In this earlier study, patients slept much longer, ranging from 7:45 of sleep to 11:44 among the eight patients. Increased need for naps and longer periods of sleep are generally associated with fitful sleep which is not sufficiently deep. Because of these various differences, the results in the newer study were different.

Another older study found no significant difference between patients with Adult-Onset Human Growth Hormone Deficiency and otherwise healthy patients, but the patients were not matched to their controls with regard to sleeping habits, age, gender, and other characteristics, which led the study to be unable to register sleep differences between HGH Deficiency patients and healthy patients.

Could Other Hormone Deficiencies Have Impacted Sleep Quality?

Almost all of the patients in this Growth Hormone Deficiency Study received some form of Hormone Replacement Treatment, such as Estrogen, Testosterone, Thyroxine, Cortisone, or Hydrocortisone, although none of the patients were receiving Growth Hormone Therapy.

There is no way to rule out that any of these treatments or other underlying hormone deficiencies could have an impact on their sleeping patterns and habits as well. In spite of this, the fact that older patients experienced greater issues with sleep than their younger counterparts does provide strong evidence that HGH / GH-RH Deficiency do have a powerful impact on sleep quality.

HGH Study Conclusion

Based on the results of this study, there is strong evidence that Human Growth Hormone Deficiency impacts health in a number of ways related to sleep, including increased feelings of exhaustion and sleepiness during the day, caused by inhibited sleep quality during the night.

The mechanism by which Human Growth Hormone Deficiency impacts sleep quality depends on multiple variables, and the age of the patient and the cause of HGH Deficiency both seem to be very important signifiers.

How Does This Study Relate to Age-Related Hypopituitarism and Somatopause?

It's important to note that this study almost universally involved patients with damaged or otherwise non-functional Somatotrophs. Age-Related HGH Deficiency is most commonly the result of an underlying GH-RH Deficiency.

Patients in this study that were unable to produce sufficient GH-RH experienced issues with their ability to achieve deep sleep, which is in line with the experiences of patients that suffer from HGH Deficiency resulting from the aging process.


WHAT IS ADRENAL FATIGUE


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 June 2014

What is Adrenal Fatigue, and How Does It Impact Physical and Mental Health?

Adrenal Fatigue is a medical condition that occurs when the body's ability to produce adrenal hormones is suppressed, preventing the body from functioning optimally. The body has a limited ability to produce certain hormones over time, and if the body produces too much of certain hormones over an extended period of time, it can sometimes no longer meet the needs of the body.

What Causes Adrenal Fatigue?

Adrenal Fatigue has many causes, and most are related to any issue which chronically puts physiological stress upon the body. High levels of psychological stress can lead to Adrenal Fatigue, as well as constant stress over a long period of time. Adrenal Fatigue can also occur as a result of physical stress from a variety of sources, including pneumonia, bronchitis, the flu, and chronic infections. Respiratory System infections are more likely to lead to Adrenal Fatigue than other forms of infection.

Adrenal Fatigue Is Caused By Exhausted Adrenal Glands

The primary symptom of Adrenal Fatigue is the reduced function of the Adrenal Glands that does not see improvement, even with sufficient rest. Adrenal Fatigue is a complex condition that is associated with a number of different disorders. Think of it as a symptom of other issues that are causing problems for the body or mind.

Adrenal Fatigue often goes undiagnosed, and people often mistake the symptoms of Adrenal Fatigue for psychological symptoms such as mild depression, exhaustion, or a general lack of well-being. People that have Adrenal Fatigue will often try to self-medicate their condition subconsciously by drinking a lot of cola or coffee or using stimulants to keep themselves energized enough to get by.

What Are Other Terms for Adrenal Fatigue?

Over the course of the 20th Century, Adrenal Fatigue has gone by a number on names, including Adrenal Apathy, Adrenal Neurasthenia, Neurasthenia, Sub-Clinical Hypoadrenia, and Non-Addison's Hypoadrenia. There are millions that suffer from Adrenal Fatigue in the United States and across the globe, but the condition is not distinctly considered a medical syndrome by most medical groups, and is simply considered a collection of connected symptoms.

How Can Adrenal Fatigue Impact My Life?

Adrenal Fatigue can significantly impact both your health and your general sense of well-being. Although the excess production of Adrenal Hormones such as Cortisol can have detrimental impacts on your health and wellness, so can too little of these hormones. Adrenal Hormones activate your body, getting you ready to seize the day, but they are not intended to remain at high levels 24/7.

Adrenal Hormone Production also spikes when you reach an impasse where your body activates the fight-or-flight response, helping you make split second decisions that could benefit you or even save your life. Obviously, nature never intended for Adrenal Hormones like Cortisol to remain at elevated levels for an extended period of time, and your Adrenal Glands eventually wear down and can lose their ability to produce enough of these hormones when they are actually needed.

In the case of severe Adrenal Fatigue, it can become difficult to even rouse yourself from bed for more than a brief period each and every day.

Adrenal Fatigue is a condition which can increase in severity over time, causing the symptoms to become more problematic. Every system of your body is impacted by diminished Adrenal Hormones, and this effects the core functions of your body. It can diminish your libido, strain your cardiovascular system, affect electrolyte and fluid balance, slow down protein synthesis and cause you to gain weight more quickly. It can also lead to diabetes and other conditions related to carbohydrate balance.

When your body doesn't produce enough Adrenal Hormones, your various systems and organs have to adapt to this biological change, and function at a sub-optimal level. Your body can function in a state of Adrenal Fatigue, but health will deteriorate in a number of different ways at the same time.

What Is the Underlying Cause of Adrenal Fatigue?

The definition of Adrenal Fatigue is quite simple, even though its causes are quite complex. Adrenal Fatigue simply means that the body is no longer producing enough Adrenal Hormones to keep up with the stress signaling of the body. If stressors are controlled, the body can boost Adrenal Function and regain Adrenal Hormone Balance, restoring the body to an enhanced state of Homeostasis.

The Adrenal Glands are responsible for the response to all forms of stress, whether they be psychological, emotional, or physical. When the Adrenal Glands activate, it leads to a cascade of hormonal changes which improve the body's ability to manage stress. Among the functions that are influenced by increased Adrenal Hormones are muscle tone, heart rate, immunity, and metabolism.

As we said, Cortisol and other Adrenal Hormones are activated under all forms of stress, whether you are defending yourself in a fight, mourning the loss of a loved one, fighting the flu, or just worried about your job. If the amount of stress that you experience is overwhelming, then you will start to tax your Adrenal System and will have physiological issues related to Adrenal Fatigue.

In a state of Adrenal Fatigue, you are still able to produce Adrenal Hormones, just not as much as your body needs to preserve normal function. Over-stimulation negatively impacts your Adrenal Health, and this leads to Hormone Imbalance which negatively impacts your health.

Adrenal Fatigue can be caused by chronic stress, or by single events that put a tremendous strain on your body or mind.

Who Is Most Likely to Experience Adrenal Fatigue?

Adrenal Fatigue is a condition that can affect anyone at any age. This condition is a stimulus-response at its core, and it doesn't matter how healthy you are, psychological stress and illness can put the weight of Adrenal Fatigue on your shoulders. Our Adrenal Glands have a limited capacity at any age or in any health state.

Although Adrenal Fatigue can happen to anyone, there are a number of environmental factors that can increase the risk of Adrenal Fatigue, including:

  • High Levels of Pressure and Expectation

  • Poor Sleep

  • Drug Abuse

  • Alcohol Abuse

  • Poor Nutrition

  • Infection-fighting

  • Chronic Illness

  • Relationship Stress

  • Personal Stress

  • Pregnancy

How Prevalent is Adrenal Fatigue?

Because Adrenal Fatigue isn't clinically recognized as a unique disorder, and is usually lumped in with other medical conditions, there is not sufficient data to say exactly how many people today suffer from the condition, although it can safely be considered to be at least somewhat common, if not more so.

In the late 1960s, a physician named Dr. John Tinterra was an Adrenal Specialist who was clinically active in the treatment of diminished Adrenal Function. He explained that, in the late 1960s, more than one in seven people were struggling with severe Adrenal Fatigue, although a much greater number of people were dealing with at least minor issues related to Inhibited Cortisol Production.

How Do I Know If I am Suffering From Adrenal Fatigue?

There are a number of symptoms associated with Adrenal Fatigue. Because Adrenal Fatigue is a complex disorder, it is the collection of symptoms which indicates the condition, rather than any particular, single symptom. Answer the following questions:

  • Do you feel exhausted with no clear cause?

  • Is it hard for you to rouse yourself from bed, even when you got adequate sleep the night before?

  • Do you have trouble recovering from illness or stress?

  • Do you frequently crave sweets and salty foods?

  • Do your energy levels peak during the late evening?

If you answered Yes to more than one of these questions, there is a significant chance that you may be suffering from Adrenal Fatigue, and you could greatly benefit from seeing a qualified, licensed medical professional regarding your health and hormone balance.

What Are Some Medical Conditions Commonly Related to Adrenal Fatigue?

Any medical issue that causes high levels of physiological stress can lead to Adrenal Fatigue. Patients experiencing chronic medical issues such as cancer or arthritis are particularly susceptible to depleted function of the Adrenal Glands. If you are suffering from a chronic medical condition, and you find it very difficult to get up and about, there is a very high likelihood that Adrenal Fatigue is affecting your energy levels.

There are also medications that can suppress adrenal activity, such as corticosteroids. Corticosteroids are synthetic hormones which imitate the function of the Adrenal Hormones, and the body will produce less of its own Cortisol and other hormones as a direct result. They are generally prescribed when the body is not producing sufficient Adrenal Response, but once treatment has been suspended, it can lead to symptoms of Adrenal Fatigue.

Adrenal Fatigue and Human Growth Hormone

Adrenal Fatigue can lead to HGH Deficiency if left untreated. The body primarily produces Natural Human Growth Hormone during sleep and during intense physical activity. Because Adrenal Fatigue can sap the body of energy, it is no longer as simple of an endeavor to go out and get sufficient exercise. Also, Adrenal Fatigue has a tremendous impact on sleep quality, which often prevents sufferers from reaching the deep phases of sleep necessary to encourage sufficient HGH Production.

For Patients suffering from HGH Deficiency or Hypopituitarism, Injectable HGH can alleviate the effects of the condition and improve Adrenal Balance, improving overall health.

Adrenal Fatigue and Testosterone in Men

Adrenal Fatigue is associated with a number of symptoms that can contribute to Low Testosterone. Clinical research shows that men that experience Adrenal Fatigue are more likely to suffer from Testosterone Deficiency. This is because Cortisol and Testosterone are both steroid hormones, and are both built from the same ingredients. If the body has been producing high levels of Cortisol, then the body no longer has enough raw ingredients to produce the sufficient amount of Testosterone to meet the needs of the body.

Testosterone Deficiency exacerbates the symptoms of Adrenal Fatigue, and the opposite is also true. This can lead to drastic changes in metabolism which lead to weight gain and muscle atrophy, while making fatigue even more pronounced. This can also affect sexual ability and libido, diminishing a man's ability to engage in fruitful, productive sexual activity.

Andropause and Hypogonadism can also lead to Adrenal Fatigue, as the reduced natural production of Testosterone can increase the body's Adrenal System activity due to physiological stress and Hormone Imbalance, which can inhibit the normal and healthy function of the body. For men with Age-Related Low-T, Testosterone Replacement with Creams, Patches, and Injections can help patients restore normal Sex Hormone and Adrenal Balance.


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NORDITROPIN VIALS OR PEN

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Norditropin Pen System is activated with first usage and can be used for three weeks without any refrigeration, Pen will last 4 weeks with refrigeration after which potency might begin to degrade. Pens not being used must be refrigerated.



TESTOSTERONE CYPIONATE VIALS

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OMNITROPE VIALS OR OMNITROPE PEN

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Omnitrope Comes with multi-dosage vials which you mix with Bacteriostatic water to activate. Refrigeration between usage is always required. Mixed and unmixed vials must be refrigerated.



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Tev Tropin comes with multi-dosage vials which you mix with bacteriostatic water to activate. Refrigeration between usage is always required. Mixed and unmixed vials must be refrigerated.

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Testosterone Therapy Benefits

Correctly performed testosterone therapy can be your ticket to health.

Three sided solution: Testosterone + HCG + Arimidex

If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

High estrogen negates a lot of the positives from testosterone therapy, resulting in the same symptoms of low testosterone you had in the first place!

The solution is to add a drug called Arimidex. It's called an aromatase inhibitor, which essentially blocks the conversion of testosterone to estrogen. It has the effect of increasing testosterone levels, while keeping your estrogen low.

Once you have your testosterone and estrogen solved, it's time to stop the next inevitable decline? Shrinking testicles.

This is where HCG (human chorionic gonadotropin) comes in. It prevents both infertility and testicle shrinkage. Your testicles shrink because your body thinks it doesn't need to make testosterone anymore.

For some, small testicles may seem like just a cosmetic problem. But HGC does more than increase testicle size, it also increases adrenal function, which can have positive effects on well-being, libido, and energy.





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