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THE FACTS ABOUT ACROMEGALY


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 June 2014

The Facts About Acromegaly

Acromegaly is a medical condition which is caused by the excessive release of Human Growth Hormone by the pituitary, or by a tumor. The pituitary gland is a very small gland that rests just behind the eyes underneath the brain. The pituitary gland is often referred to as the Master Gland, because of the various functions that the pituitary gland controls, including reproductive function, metabolism, and growth.

What Causes Acromegaly?

The vast majority of patients with Acromegaly experience the condition as a result of a benign tumor attached to the pituitary gland, which imitates the activity of the Somatotrophs which are responsible for the release of Natural Growth Hormone. Excess HGH production over the course of a long period of time causes the body to grow abnormally. It causes the bones and cartilage in the feet, hands, and face to grow abnormally long and thick. Pituitary tumors that cause acromegaly can also lead to migraines because of the increased pressure in the brain, or pressure on the optic nerve.

How Do Hormones Contribute to Acromegaly?

Acromegaly effects the production and activity of three particular hormones that are very important, and all related to the somatotrophs. These are the hormones which are primarily affected by acromegaly:

Human Growth Hormone - Normally, the human body produces HGH throughout the day, in short bursts known as pulses. The hormone is primarily released during deep sleep and during intense physical activity. When the body produces too much HGH, it impacts the growth of organs and systems all throughout the body, and can impact physical appearance.

Insulin-like Growth Factor-One - The release of this hormone is directly influenced by the release of Human Growth Hormone. HGH circulates through the body, and much of it is processed by the liver into IGF-1. IGF-1 remains active more constantly than Human Growth Hormone, and many symptoms of Acromegaly are caused by a simultaneous rise in these two hormones.

Somatostatins - These hormones play an important role in Growth Hormone and IGF-1 regulation. Under normal circumstances, the human body recognizes the influx of HGH and IGF-1 and the brain releases somatostatins in response to mitigate the release of HGH by the pituitary. Somatostatin Therapy plays an important role in the treatment of Acromegaly.

What are the Symptoms of Acromegaly?

Acromegaly is a complex disorder which affects both health and appearance. Many people don't realize that they are suffering from Acromegaly for many years, because the effects onset slowly, and can often be difficult to notice until the symptoms are already problematic. Often, acromegaly symptoms are written off simply as aging by the patient, and there are many conditions which can imitate some of the symptoms of the condition.

Acromegaly often doesn't become clearly noticeable for many years. It is important to understand that although there are many signs and symptoms, most patients only experience a small number of symptoms. Below are the symptoms that are associated with Acromegaly:

  • Sleep Apnea

  • Diabetes

  • Cardiovascular Issues

  • Hypertension

  • Vision Changes due to Tumor Growth

  • Migraines

  • Cartilage swelling

  • Increased Size of Internal Organs

  • Increased size of Feet, Hands, and Jaw

  • Joint Swelling and Pain

  • Sweating

  • Acne, Increased Oil Production, Thicker Skin, and other Skin Issues

  • Nasal Congestion

  • Goiter

  • Impotence

  • Menstrual Disruption

  • Skin Tags

  • Carpal Tunnel Syndrome

How is Acromegaly Diagnosed?

There are a number of tests that can effectively diagnose and keep track of Acromegaly. The most effective blood test for Acromegaly is Growth Hormone Analysis. Normally, HGH Levels spike and remain in the blood stream for only a brief period of time, but in the case of Acromegaly, Growth Hormone Levels remain excessively high, or reach abnormally high spikes..

Natural HGH Secretions are dependent upon a number of different variables, including when the test is taken, age, and genetics, as well as the last time that you ate. The following are the main means by which Growth Hormone Levels are Tested:

Oral Glucose Tolerance Test - The easiest way to analyze Growth Hormone Levels through a single test is for the patient to fast for a single night and provide blood after drinking a specialized solution of glucose concentrate.

IGF-1 Testing - One can also test for Acromegaly by testing IGF-1, which is released directly as a response to Growth Hormone Secretion. IGF-1 is a byproduct of Acromegaly, and it is exceedingly rare that IGF-1 Levels do not increase to abnormally high levels as a result of Acromegaly. IGF-1 Levels can also be easily tested, because they don't spike like HGH Levels.

Acromegaly Imaging Tests for Tumor Identification

Once the case for Acromegaly has been established, the physician will generally recommend imaging scans in order to identify the tumor. This can be completed using a CT Scan or an MRI. These tests provide a high-resolution image of the brain which can be monitored for tumors or other abnormalities. These Imaging Scans are outpatient procedures that do not require any patient preparation.

Health Tests Performed After Acromegaly Diagnosis

After Acromegaly has been diagnosed via HGH/IGF-1 Levels and a visual confirmation on the tumor, there are other tests that will be necessary to assess the health of the patient. Patients will usually undergo vision testing, chest X-Ray, and ECG to monitor the extent to which Acromegaly has affected the health. None of these tests require a stay at a hospital, and none of these tests even necessarily require a trip to the hospital, though they may be performed at one.

The technicians and specialists that perform these tests will forward the results directly to your primary care physician, who will explain the results in detail and use all of the information available to inform you of your current condition and what steps can be taken to improve your health.

Why Is It Important to Control and Treat Acromegaly

Until the tumor is surgically or medically removed, the condition is chronic, but proper treatment can cancel out the health modulating effects of the tumor. Through proper treatment, you can improve your health significantly and significantly reduce the risks associated with the condition.

Most patients begin treatment almost immediately after they have received diagnosis, and your healthcare provider can take steps to control the various factors at play with regard to Acromegaly, including controlling IGF-1 Levels, HGH Levels, treating the symptoms of the disorder, and treating the tumor itself.

Medical Conditions Associated with Acromegaly

Part of effectively treating Acromegaly is being aware of the increased risk of a number of different disorders and treating them accordingly. These conditions include:

  • Colon Cancer and Colon Polyps

  • Sleep Apnea

  • Diabetes

  • Cardiovascular Disease

  • Hypertension

Take Control of Your Acromegaly Treatment to Maximize Health Outcomes

It's vitally important to maintain awareness of your Growth Hormone and Insulin-Like Growth Factor-One Levels in order to effectively treat your condition. Your physician will provide you with somatostatins and other medical treatments designed to treat your hyperpituitarism as well as the medical conditions related to the disorder.

Every day that you go untreated, your health becomes that much more at risk. If you get treatment quickly enough, you can even reverse or at least mitigate some of the symptoms, including Hypertension, Sleep Apnea, Fatigue, Joint Pain, Sweating, Cartilage Swelling, and Headache.

Acromegaly Treatment Options

The most effective way to treat Acromegaly is by taking steps to get rid of the tumor. There are also treatments that can reduce the activity of the tumor until you can get access to treatment that will eliminate it.

  • Surgery for Acromegaly - The most direct way to treat a Pituitary Somatotroph Tumor is through surgery. Because the pituitary is located beneath the brain, it is often possible to remove the tumor with minimal risk, and in doing so, return IGF-1 and Growth Hormone Levels to normal, as well as eliminate Intracranial Hypertension.

This can be achieved through a method known as transsphenoidal surgery. In this procedure, the surgeon enters the brain cavity through the upper lip or through the nose and removes the tumor without having to open the skull.

  • Radiation Treatment for Acromegaly - This form of treatment is paired with surgery in the instance that the pituitary tumor is not removed completely, and prescription medications are not effectively eliminating the remains of the tumor.

  • Prescription Acromegaly Treatment - There are a number of medications that can suppress the Pituitary's ability to produce Human Growth Hormone before surgery, and also help eliminate any tumor remnants that are not fully eliminated through surgery.

Acromegaly and Human Growth Hormone

Acromegaly is a Pituitary Condition

Even though HGH Abuse can lead to symptoms that are normally associated with Acromegaly, it is important to point out that Acromegaly is a specific medical disorder which is caused by a tumor on the pituitary gland, and although long term abuse of Human Growth Hormone can lead to symptoms similar to Acromegaly, the two conditions are unique to one another.

Can HGH Injection Therapy lead to Acromegaly?

No. The goal of Human Growth Hormone Injections is to restore optimal, youthful HGH and IGF-1 Levels in the blood stream, not to introduce more of the hormones than the body is capable of handling in a healthy way. Acromegaly-like symptoms are the result of a long-term flood of Human Growth Hormone, and cannot be triggered by Restorative Doses of HGH.

HGH Abuse and Overdose Does Not Lead to Acromegaly Symptoms for a Long Period of Time

Also, like the condition of Acromegaly itself, it can take years of excess HGH and IGF-1 Levels before it becomes physically apparent that the patient is suffering from such a condition, whether it is from the disease of Acromegaly or the decision to abuse Bio-Identical HGH.

If a patient does begin to show Acromegaly-like symptoms, such as joint stiffness, carpal tunnel syndrome, or increased soft tissue production, there is still time to mitigate or prevent long-term damage to physiological health by suspending Injectable Growth Hormone Abuse.

Famous People with Acromegaly

Today, Acromegaly is recognized more quickly than it was in the past, and treated more promptly, but over the last fifty years there have been a number of celebrities that are known for having Acomegaly, the most famous of which is Andre the Giant. Andre the Giant was 7 foot 4 inches and weighed as much as 520 pounds. He first reached celebrity status as a star of the World Wrestling Federation, and later had a notable acting career, starring in films such as The Princess Bride and Conan the Destroyer.

Although he was largely seen as a beloved character, he dealt with an immense amount of pain from his condition which led him to alcoholism. In spite of his propensity for drinking and his wrestling persona, he was widely regarded as an incredibly kind and gentle person.

Other Celebrities with Acromegaly:

  • WWE star Big Show, also known as Paul Randall Wight, Junior

  • UFC Fighter Antonio Silva

  • Richard Kiel, most famously known for his role as Jaws for the James Bond Franchise

  • Carel Struycken, who starred as Lurch in the Adams Family films


THE FACTS ABOUT PSORIASIS: SYMPTOMS AND CAUSES


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 June 2014

The Facts About Psoriasis

What Is Psoriasis?

Psoriasis is a medical condition that impacts around three percent of people in the United States. There are over five million men and women with psoriasis across the nation. Psoriasis is characterized by inflammation and scaling of the skin, and is mainly seen in adult patients, though psoriasis can also become an issue during childhood and adolescence. There is no gender divide with this condition, as both women and men are equally likely to experience the condition.

How Does Psoriasis Impact Skin Health?

The mechanism which causes scaling and inflammation is that new skin cells, which normally mature beneath the skin and rise to the surface, move to the surface before they have sufficiently developed. It normally takes a newborn skin cell around thirty days to reach the top layer of the skin, but in the case of Psoriasis, this process of turnover can take place in just a matter of days.

What Are the Symptoms of Psoriasis?

In the most common form of the condition, Psoriasis leads to high levels of inflammation, and the skin becomes red and topped with scales. The areas where scaling develops are called plaques, and they can lead to soreness and severe itching. Common areas where Psoriasis appears on the body are the soles of the feet, palms, face, lower back, scalp, knees, and elbows, although these patches can appear anywhere on the body.

Other areas where Psoriasis can appear are inside the mouth, on the genitals, and underneath the toenails and fingernails. If Psoriasis occurs on the joints, it can lead the inflamed area to become cracked and this can lead to bleeding. The psoriasis can also inflame the joints, which leads to arthritis symptoms. If this occurs, it is referred to as Psoriatic Arthritis.

How Can Psoriasis Negatively Impact Quality of Life?

People that have Psoriasis can experience life-altering issues resulting from the pain and itching associated with Psoriasis. Also, Psoriasis can limit movement in some cases, leading to limited disability.

Some patients experience severe pain and itching, which prevents them from living and appreciating their day to day life, causing sleep to be restless, making bathing a painful chore, and even making walking difficult. Patients that have Psoriasis Plaques on the feet and hands can have issues with any activity that involves those body parts, and they may not be able to participate in some sports or even have jobs in some careers. This can even inhibit their ability to care for their loved ones.

In order to mitigate the symptoms of Psoriasis, it can require frequent trips to the doctor, and the cost to treat the medical disorder is very high, as a result of the chronic nature of the condition. Psoriasis also impacts self-perception, because they are embarrassed about the way they look as a result of their condition. This can lead them to become withdrawn, or make it harder for them to enter romantic relationships. These issues can lead to social isolation, depression, and other psychological issues related to their poor self-image.

What Causes Psoriasis?

Psoriasis is a medical condition that results from an overactive immune system, and it is related to the body's production of T-Cells. T-Cells are powerful immune cells which fight disease and infection. When a person has Psoriasis, the body activates T-Cells for no reason and this causes a cascade of immune response which both causes immature skin cells to rise prematurely while also causing high levels of inflammation.

There is a genetic component to Psoriasis, and scientists have been able to link particular genes to the condition, based upon their study of certain family lines which are heavily impacted by the condition. Not all patients with Psoriasis have a family history, however.

What Causes Psoriasis Skin Flare-Ups?

Most people with psoriasis experience periods where their skin health becomes more problematic. These periods are known as flares. Psoriasis will temporarily become much worse, before recovering somewhat. There are a number of issues that can cause these flares to occur, including weather changes that lead to drier skin, stress, and infection.

There are also some medications that can exacerbate Psoriasis, including lithium and blood pressure medications known as Beta-Blockers. Finally, Psoriasis is more likely to flare up in areas of the skin that have experienced damage or irritation from issues such as infection, sunburn, scratches and lesions.

How Do Doctors Diagnose Psoriasis

Sometimes, Psoriasis can be problematic to diagnose, because it shares symptoms with a number of other skin conditions, such as Sebhoerric Dermatitis. The best way to clinically diagnose Psoriasis is by taking a small patch of the inflamed skin and looking at it through a microscope.

What Are the Types of Psoriasis?

There a number of kinds of Psoriasis. Below is a partial list:

  • Plaque Psoriasis - Characterized by inflamed, red skin covered in shiny scales.

  • Guttate Psoriasis - Characterized by small, round areas of inflamed skin on the scalp, limbs, and trunk. This form of the disease is commonly a reaction to strep throat or other infections of the upper respiratory system.

  • Pustular Psoriasis - Characterized by the formation of blisters which are not the result of infection. These blisters are filled with puss, and can be caused by stress, infections, medicines, and contact with particular chemicals.

  • Inverse Psoriasis - Characterized by inflamed areas along skin folds, such as the armpits, beneath the breasts, or around the genitals. Sweating and friction can exacerbate this form of Psoriasis.

  • Erythrodermic Psoriasis - Rapid and widespread appearance of Psoriasis that is commonly caused by corticosteroid medicines or significant sunburn. This form of Psoriasis can also occur as an extension of other forms of Psoriasis which are not effectively controlled. This is the most severe form of the condition, and requires an immediate visit to a medical professional.

What is Psoriatic Arthritis?

Psoriatic Arthritis is a medical condition that is related to and caused by Psoriasis, itself. In this case, Psoriasis penetrates into the skin and causes lesions and inflammation of the joints. Patients can experience both forms of Psoriasis simultaneously, or either alone at any particular time.

How Can Psoriasis Be Effectively Treated?

There are a number of methods that physicians use to mitigate the symptoms of Psoriasis, dependent upon the specific characteristics of the disease, including the locations of inflammation, the form of psoriasis, the surface area of inflammation, the severity of the psoriasis, and the way that the patient has responded to previous treatment.

The following are some common means by which Psoriasis can be treated:

  • Injectable and Oral Psoriasis Medication

  • Phototherapy via Light Exposure

  • Topical Medications

Like any medication, the treatments listed above can lead to side-effects, some minor, some more significant. Always talk to your physician and pharmacist about potential side-effects so you can be armed with the knowledge to recognize them.

There are some issues that make Psoriasis hard to treat. For one, the body can develop a resistance to certain forms of treatment, limiting their effectiveness over time. This is especially true of corticosteroids delivered topically.

Second, every patient responds differently to treatment, and the same medication or therapy may be highly effective for one patient while producing no benefit in a second patient. As a result of this, physicians often switch from therapy to therapy until they find one that works effectively with few or no side effects.


MARK CUBAN TO FUND STUDY ON HEALING POWER OF HGH


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 06 May 2014

Mark Cuban to Finance Medical Study to Prove Benefits of HGH for Rehabilitation

Medical researchers have long understood the potential benefits of HGH Hormone Replacement Therapy to patients suffering from Age-Related Human Growth Hormone Deficiency, but we are just beginning to learn about a wide variety of other potentially beneficial uses for HGH Shots.

There has been growing evidence that HGH Injection Therapy can be useful for rehabilitation, and Mark Cuban, the owner of the Dallas Mavericks, is interested in finding out the real benefits and drawbacks of HGH for Injury Rehabilitation, and is willing to contribute large sums of money to find out the truth of the matter.

Two Year Study Will Test the Effectiveness of HGH

Mark Cuban has already made a major financial contribution with the intention of funding a clinical study at a prominent university. According to his description, the medical study will be conducted over the course of two years and will evaluate the potential ability for Human Growth Hormone Injections to speed up the rate of rehabilitation after an injury. The study will monitor patients from before their operation until long into their recovery process.

Human Growth Hormone Has Long Been Used by Athletes

HGH Injection Therapy has long been used by athletes of all kinds for the purpose of performance enhancement, and there are even rumors abound that many athletes travel overseas to Europe, because medical facilities in Europe often utilize Subcutaneous HGH Therapy in their treatment processes, which many believe speed up the healing process.

HGH Injections Currently Only Legal for a Few Limited Treatments

In the United States, Recombinant HGH is a highly regulated form of medical treatment, and can only be used legally in the country for a few explicit purposes: Human Growth Hormone Deficiency, Idiopathic Short Stature in Children, and HIV/AIDS-Related Wasting. Overseas, some alternative uses for HGH are often encouraged, and off-label use of the medication is considered legal practice. Since HGH was lumped in with Anabolic Steroids in the late 1980s and early 1990s, HGH Prescriptions are highly limited.

With this medical study, Mark Cuban aims to discover the real potential benefit of Human Growth Hormone Injections. There is a large amount of anecdotal evidence regarding the use of HGH for Rehabilitation, but there has been inconclusive medical study to provide a definitive answer. Cuban looks to provide that answer once and for all.

Players Should Be Able to Use All Effective Medical Tools Available to Recover from Injury

Although Mark Cuban leaves no indication that he believes that Human Growth Hormone should be used as a Performance Enhancing Drug, he sees no reason to deny players that ability to use the treatment as a legitimate medical therapy, especially one that is highly useful and beneficial for athletes prone to muscle and joint injuries.

He believes that if Human Growth Hormone Injections can limit the muscle atrophy associated with medical surgery, it should be available to players that have their rehabilitation times lengthened by such atrophy. He believes that reduced recovery times are good both for the player and for professional basketball itself. Cuban feels that if there is no downside, the players should be afforded the opportunity to use the treatment.

What We Know About This Future Study

Cuban does not go into specific details about the study. He does not name the University, and he does not mention the specific injury, but he does explain that the injury affects well over one hundred thousand patients annually. He implies that both groups will go through the exact same treatment regimen, except one group of patients will undergo routine rehabilitation with HGH Injections, and the other group will undergo routine rehabilitation with placebo injections.

Besides the use of injections, the experiment will not negatively impact the normal rehabilitative process, and will provide a clear image of the effects of HGH on Injury Rehab. If the treatment does improve recovery times, it not only benefits NBA Players, it benefits millions of potential patients all across the United States.

Study Awaits DEA and FDA-Approval

Mark Cuban refused to release any overly-specific information regarding the medical study, because it still awaits FDA and DEA-Approval, although at this time he believes there are no roadblocks to approval.

Also, even though he did not mention the university in particular that would conduct the research, he did express that it was a very well-regarded medical institution. At this stage, Cuban is unsure when the study will actually start, because of the need for federal approval.

Mark Cuban Has Long Been an Advocate for Judicious Use of HGH If Deemed Beneficial

Today, Human Growth Hormone is fully banned as a Performance Enhancing Drug by the National Basketball Association. This means that the drug cannot be used by healthy players to attempt to improve their game, but it also means that injured players are not allowed to use the Bio-Identical Hormone as a medical treatment.

Cuban is interested in providing players this opportunity if research suggests that it is beneficial, and discussed this in a recent Board of Governors meeting. He believes that if HGH Injections prove beneficial for Injury Recovery, they should be allowed for use by injured players. After talking about the subject at the meeting, a number of universities contacted him to discuss potential research opportunities.

Motivations for Supporting HGH Research

Mark Cuban says that his main goal in financing this study is to uncover the truth about Human Growth Hormone. He believes that the NBA's current position toward Human Growth Hormone is just a marketing position, and wants to discover the reality for the players, the league, and society at large.

He admits that it benefits him as an NBA owner if Recombinant HGH can increase recovery times, but in this case, what benefits him, personally has the potential to benefit everyone, which has encouraged his desire to see the truth about HGH for Healing.

Source:

http://espn.go.com/dallas/nba/story/_/id/10725677/mark-cuban-dallas-mavericks-helping-fund-study-hgh-use


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