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Human
Growth Hormone May Improve Physical Therapy Outcomes in the Elderly
Human
Growth Hormone Replacement Therapy has been shown to both increase
Bone Mineral Density and Increase Lean Muscle in elderly patients.
New evidence shows that HGH Hormone Replacement may offer another
benefit: Increased healing capacity.
Dr. Robert
Costa, professor of molecular genetics and biochemistry at the
University of Illinois at Chicago, says that he and his staff have
discovered that Human Growth Hormone has the ability to switch on a
gene that is responsible for tissue to regenerate and heal more
quickly. This function of HGH may help to explain one critical factor
of the aging process: The older that we get, the harder that it is to
recover from injury or tissue damage.
Aging
is the Result of Ongoing Physical Breakdown
It is
believed that one of the ways that the body physiologically ages is
through a slow process of degradation, resulting from the body's
reduced ability to heal efficiently. HGH Levels appear to have a
distinct correlation with the speed at which our bodies can heal. Dr.
Costa explains that the gene Foxm1b plays a critical role in the
human body's ability to undergo repair. Foxm1b is turned on directly
by Human Growth Hormone secretion, and as the body releases less HGH,
Foxm1b loses its ability to efficiently restore tissue to a healthy
state after damage or injury.
HGH
Study in Hepatology
The study
in which Dr. Costa participated in was released in the medical
journal Hepatology. Although this study was conducted with
animals, there is sufficient evidence to extrapolate the results of
this animal research to human patients. Dr. Costa's study revolved
around liver regeneration in both young and aging mice. The study
compared two month old mice with twelve month old mice in regard to
their capacity to recover from tissue damage in the liver.
The reason
why the liver was chosen for this study is because of a particular
unique trait: The liver can completely restore itself simply from a
collection of mature liver cells. No other organ in the human body
can completely rebuild itself with such a sparse set of resources.
The
Importance of Foxm1b
Foxm1b is
an important gene which plays a role in every aspect of the
development of all mammalian cells. Foxm1b is active within all cells
upon cell division, throughout the development of the cell, and until
the cell finally surrenders to apoptosis at the end of its life
cycle. Early in life, the Foxm1b gene is highly active, but as
mammals age, the gene becomes less and less responsive.
Foxm1B
Activation Heals Organs
In earlier
research, scientists added the human form of Foxm1b into aging mice
with livers which had been partially destroyed. Humans and mice have
Foxm1b genes that are functionally identical, and serve nearly the
exact same set of purposes within the body. Researchers found that
adding the Foxm1b gene to damaged livers increased the speed at which
the liver recovered from damage. The rate at which recovery occurred
was similar to that of younger mice.
Upon
further analysis, the study also showed exactly how the Foxm1b
regulates the health and function of cells throughout the lifespan,
encouraging them to undergo the process of cellular division more
efficiently and more quickly.
The
Correlation between HGH Exposure and Foxm1b Activation
In this
study, the goal was to test the effect of HGH upon the rate at which
cell division occurs in aging organisms. The previous study already
made it clear that activated Foxm1b has the ability to increase
regenerative capacity, and researchers hypothesized that Human Growth
Hormone may have the capability to activate dormant Foxm1b cells,
thus encouraging increased healing capacity later in the aging
process.
What is
the Role of HGH?
Human
Growth Hormone is one of the most important hormones which regulate
health and function throughout the lifespan. Earlier in life, HGH is
recognized primarily for its ability to spur growth and adolescent
development, but later in life, the role of Growth Hormone is
primarily to maintain optimal health balance and regulate cellular
metabolism.
As the
aging process continues, the body is less able to self-regulate and
repair itself, and this is believed to be at least partially the
result of declining levels of Human Growth Hormone released by the
Human Pituitary.
HGH
Makes Cells Regenerate More Quickly
Dr. Costa
says that there is evidence in the body of endocrinological research
that HGH Hormone Replacement Therapy likely has the capacity to
increase rates of cellular regeneration in aging patients. This is
one of the primary reasons why changes in physical composition occur
as a result of HGH Injections.
Increased
cellular metabolism leads to increased lean muscle mass, increased
bone mineral density, and stronger skin, because the body is
repairing and replacing dying cells quickly and more effectively. Dr.
Costa claims that the ultimate goal of his study is to discover how
Human Growth Hormone functions at the molecular level, in order to
uncover new medical purposes for HGH Replacement Therapy.
Foxm1b
HGH Study Results
The
results of the study were fairly dramatic. When the year old mice
were administered HGH Injection, multiple tests showed that Foxm1b
drastically increased in activity. In addition to this, other
proteins and enzymes responsible for the process of cell division
also became more active as well. At the organ level, the mice
experienced physiological regeneration as a result of Human Growth
Hormone Stimulation.
The
damaged livers repaired more quickly as a result of treatment,
healing at a rate which was comparable to that of healthy, youthful
mice. The rate of efficiency of cellular division reached its peak
after only 2 short days, and the liver was completely rehabilitated
after only a single week. As opposed to aging mice in the
experimental group, control mice which were not administered HGH did
not experience total regeneration until at least one month after the
damage occurred.
This means
that, in the case of mice, HGH Hormone Replacement has the capacity
to increase the rate at which liver rehabilitation takes place by
over 400%. Of course, mice have metabolic processes which are much
faster than our own (and thus, live shorter lifespans), but this
study is proof of concept. Human Growth Hormone HRT can, and likely
does, have the capacity to increase rate of healing in aging
patients.
In mice
that did not receive supplemental HGH, the Foxm1b gene stayed
relatively dormant, limiting the rate at which cellular regeneration
could take place. Without the rapid increase in cell regeneration
spurred by Human Growth Hormone, the liver could only repair itself
at a slow and limited pace.
Foxm1B
Deactivation Blunts the Effect of HGH
Further
testing examined the function of HGH upon Foxm1b activation from the
opposite perspective. In a second group of mice, the rodents were
genetically altered so that their livers contained Foxm1b genes that
were totally inactivated. In this second experiment, mice acted
physiologically according to Dr. Costa's hypothesis. When the Foxm1b
gene is inactivated, it prevents HGH injections from having any
appreciable effect upon cellular metabolism and physiological
recovery.
Dr. Costa
explains that the results of the research conducted by his academic
team show that Foxm1b is a necessary ingredient which is required to
encourage the regeneration of the liver after damage occurs. There is
also strong reason to believe that Human Growth Hormone Replacement
Therapy has the capability to increase the rate of physiological
response in other tissues throughout the body as well.
Future
Research will Improve our Knowledge of Foxm1b
Although
Dr. Costa finds the results of his study promising, he still urges
caution regarding the use of Human Growth Hormone Replacement
Therapy. He explains that his study only explores the short term
benefits of HGH Injection, but does not offer any information
regarding the long term benefits or consequences of Human Growth
Hormone Usage.
This study
increases our knowledge of the mechanisms by which Human Growth
Hormone can benefit the body at a molecular level, but Dr. Costa
encourages further research and evaluation to take place before his
data can be extrapolated fully to human patients.
Human
Growth Hormone May Be Useful in Encouraging Physical Rehabilitation
in Aging Patients
In the
future, many are confident that HGH Injections can be utilized in
elderly patients to increase physiological healing capacity and
resiliency. There is hope that Human Growth Hormone can be used in
urgent care situations in order to increase the speed of the healing
process in order to more fully preserve the health of the elderly
patient.
The
Future of HGH Hormone Replacement Therapy
Perhaps in
the future, a combination of therapies will become available in order
to preserve health into old age. Since older patients tend to be more
sensitive to Human Growth Hormone, it may be found that Sermorelin
Acetate Injections can be a long-term solution to Age-Related HGH
Deficiency which minimizes the risk of overdose and side-effects,
while Growth Hormone Injections can be utilized in a rehabilitation
setting to increase the effectiveness of the healing process while
also stimulating cellular metabolism more directly.
Although
Human Growth Hormone cannot be prescribed as an Anti-Aging Solution,
in the future, as our knowledge of the benefits of the hormone become
more complete, many restrictions on the use of the hormone will
likely be lifted, and HGH can be utilized more fully as a tool of
health optimization.
HGH May
Be Beneficial in the Physical Rehabilitation Outcomes of Patients of
All Ages
Although
this study is primarily concerned with the concept of Human Growth
Hormone as a tool to improve rehabilitation outcomes for older
patients with low levels of innate Human Growth Hormone, there are
also studies which show that Human Growth Hormone has the potential
to benefit adults of all ages that are going through the process of
physical rehabilitation and therapy.
In the
case of cartilage repair, for example, it appears that Human Growth
Hormone and IGF-1 have the capability to restore healthy cartilage
tissue, minimizing pain and limited range of movement which is
sometimes associated with cartilage surgery and damage. In addition
to this, HGH Hormone Injections may also benefit patients that have
recently undergone surgery, whether they are suffering from HGH
Deficiency or not. Side-effects of Human Growth Hormone use are
primarily associated with long-term use at abusive levels.
There are
some that hypothesize that patients of all ages may be able to
directly benefit from short term therapy using Human Growth Hormone
in order to spur tissue regeneration and shorten downtime from injury
or surgery.
Time will
only tell, but it appears that in future years, HGH will find
increased acceptance as a medical treatment, and medical
professionals will gradually uncover more and greater benefits of HGH
Hormone Replacement Therapy as a legitimate medical treatment.
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