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Human Growth Hormone May Improve Physical Therapy Outcomes in the Elderly

Human Growth Hormone Replacement Therapy has been shown to both increase Bone Mineral Density and Increase Lean Muscle in elderly patients. New evidence shows that HGH Hormone Replacement may offer another benefit: Increased healing capacity.

Dr. Robert Costa, professor of molecular genetics and biochemistry at the University of Illinois at Chicago, says that he and his staff have discovered that Human Growth Hormone has the ability to switch on a gene that is responsible for tissue to regenerate and heal more quickly. This function of HGH may help to explain one critical factor of the aging process: The older that we get, the harder that it is to recover from injury or tissue damage.

Aging is the Result of Ongoing Physical Breakdown

It is believed that one of the ways that the body physiologically ages is through a slow process of degradation, resulting from the body's reduced ability to heal efficiently. HGH Levels appear to have a distinct correlation with the speed at which our bodies can heal. Dr. Costa explains that the gene Foxm1b plays a critical role in the human body's ability to undergo repair. Foxm1b is turned on directly by Human Growth Hormone secretion, and as the body releases less HGH, Foxm1b loses its ability to efficiently restore tissue to a healthy state after damage or injury.

HGH Study in Hepatology

The study in which Dr. Costa participated in was released in the medical journal Hepatology. Although this study was conducted with animals, there is sufficient evidence to extrapolate the results of this animal research to human patients. Dr. Costa's study revolved around liver regeneration in both young and aging mice. The study compared two month old mice with twelve month old mice in regard to their capacity to recover from tissue damage in the liver.

The reason why the liver was chosen for this study is because of a particular unique trait: The liver can completely restore itself simply from a collection of mature liver cells. No other organ in the human body can completely rebuild itself with such a sparse set of resources.

The Importance of Foxm1b

Foxm1b is an important gene which plays a role in every aspect of the development of all mammalian cells. Foxm1b is active within all cells upon cell division, throughout the development of the cell, and until the cell finally surrenders to apoptosis at the end of its life cycle. Early in life, the Foxm1b gene is highly active, but as mammals age, the gene becomes less and less responsive.

Foxm1B Activation Heals Organs

In earlier research, scientists added the human form of Foxm1b into aging mice with livers which had been partially destroyed. Humans and mice have Foxm1b genes that are functionally identical, and serve nearly the exact same set of purposes within the body. Researchers found that adding the Foxm1b gene to damaged livers increased the speed at which the liver recovered from damage. The rate at which recovery occurred was similar to that of younger mice.

Upon further analysis, the study also showed exactly how the Foxm1b regulates the health and function of cells throughout the lifespan, encouraging them to undergo the process of cellular division more efficiently and more quickly.

The Correlation between HGH Exposure and Foxm1b Activation

In this study, the goal was to test the effect of HGH upon the rate at which cell division occurs in aging organisms. The previous study already made it clear that activated Foxm1b has the ability to increase regenerative capacity, and researchers hypothesized that Human Growth Hormone may have the capability to activate dormant Foxm1b cells, thus encouraging increased healing capacity later in the aging process.

What is the Role of HGH?

Human Growth Hormone is one of the most important hormones which regulate health and function throughout the lifespan. Earlier in life, HGH is recognized primarily for its ability to spur growth and adolescent development, but later in life, the role of Growth Hormone is primarily to maintain optimal health balance and regulate cellular metabolism.

As the aging process continues, the body is less able to self-regulate and repair itself, and this is believed to be at least partially the result of declining levels of Human Growth Hormone released by the Human Pituitary.

HGH Makes Cells Regenerate More Quickly

Dr. Costa says that there is evidence in the body of endocrinological research that HGH Hormone Replacement Therapy likely has the capacity to increase rates of cellular regeneration in aging patients. This is one of the primary reasons why changes in physical composition occur as a result of HGH Injections.

Increased cellular metabolism leads to increased lean muscle mass, increased bone mineral density, and stronger skin, because the body is repairing and replacing dying cells quickly and more effectively. Dr. Costa claims that the ultimate goal of his study is to discover how Human Growth Hormone functions at the molecular level, in order to uncover new medical purposes for HGH Replacement Therapy.

Foxm1b HGH Study Results

The results of the study were fairly dramatic. When the year old mice were administered HGH Injection, multiple tests showed that Foxm1b drastically increased in activity. In addition to this, other proteins and enzymes responsible for the process of cell division also became more active as well. At the organ level, the mice experienced physiological regeneration as a result of Human Growth Hormone Stimulation.

The damaged livers repaired more quickly as a result of treatment, healing at a rate which was comparable to that of healthy, youthful mice. The rate of efficiency of cellular division reached its peak after only 2 short days, and the liver was completely rehabilitated after only a single week. As opposed to aging mice in the experimental group, control mice which were not administered HGH did not experience total regeneration until at least one month after the damage occurred.

This means that, in the case of mice, HGH Hormone Replacement has the capacity to increase the rate at which liver rehabilitation takes place by over 400%. Of course, mice have metabolic processes which are much faster than our own (and thus, live shorter lifespans), but this study is proof of concept. Human Growth Hormone HRT can, and likely does, have the capacity to increase rate of healing in aging patients.

In mice that did not receive supplemental HGH, the Foxm1b gene stayed relatively dormant, limiting the rate at which cellular regeneration could take place. Without the rapid increase in cell regeneration spurred by Human Growth Hormone, the liver could only repair itself at a slow and limited pace.

Foxm1B Deactivation Blunts the Effect of HGH

Further testing examined the function of HGH upon Foxm1b activation from the opposite perspective. In a second group of mice, the rodents were genetically altered so that their livers contained Foxm1b genes that were totally inactivated. In this second experiment, mice acted physiologically according to Dr. Costa's hypothesis. When the Foxm1b gene is inactivated, it prevents HGH injections from having any appreciable effect upon cellular metabolism and physiological recovery.

Dr. Costa explains that the results of the research conducted by his academic team show that Foxm1b is a necessary ingredient which is required to encourage the regeneration of the liver after damage occurs. There is also strong reason to believe that Human Growth Hormone Replacement Therapy has the capability to increase the rate of physiological response in other tissues throughout the body as well.

Future Research will Improve our Knowledge of Foxm1b

Although Dr. Costa finds the results of his study promising, he still urges caution regarding the use of Human Growth Hormone Replacement Therapy. He explains that his study only explores the short term benefits of HGH Injection, but does not offer any information regarding the long term benefits or consequences of Human Growth Hormone Usage.

This study increases our knowledge of the mechanisms by which Human Growth Hormone can benefit the body at a molecular level, but Dr. Costa encourages further research and evaluation to take place before his data can be extrapolated fully to human patients.

Human Growth Hormone May Be Useful in Encouraging Physical Rehabilitation in Aging Patients

In the future, many are confident that HGH Injections can be utilized in elderly patients to increase physiological healing capacity and resiliency. There is hope that Human Growth Hormone can be used in urgent care situations in order to increase the speed of the healing process in order to more fully preserve the health of the elderly patient.

The Future of HGH Hormone Replacement Therapy

Perhaps in the future, a combination of therapies will become available in order to preserve health into old age. Since older patients tend to be more sensitive to Human Growth Hormone, it may be found that Sermorelin Acetate Injections can be a long-term solution to Age-Related HGH Deficiency which minimizes the risk of overdose and side-effects, while Growth Hormone Injections can be utilized in a rehabilitation setting to increase the effectiveness of the healing process while also stimulating cellular metabolism more directly.

Although Human Growth Hormone cannot be prescribed as an Anti-Aging Solution, in the future, as our knowledge of the benefits of the hormone become more complete, many restrictions on the use of the hormone will likely be lifted, and HGH can be utilized more fully as a tool of health optimization.

HGH May Be Beneficial in the Physical Rehabilitation Outcomes of Patients of All Ages

Although this study is primarily concerned with the concept of Human Growth Hormone as a tool to improve rehabilitation outcomes for older patients with low levels of innate Human Growth Hormone, there are also studies which show that Human Growth Hormone has the potential to benefit adults of all ages that are going through the process of physical rehabilitation and therapy.

In the case of cartilage repair, for example, it appears that Human Growth Hormone and IGF-1 have the capability to restore healthy cartilage tissue, minimizing pain and limited range of movement which is sometimes associated with cartilage surgery and damage. In addition to this, HGH Hormone Injections may also benefit patients that have recently undergone surgery, whether they are suffering from HGH Deficiency or not. Side-effects of Human Growth Hormone use are primarily associated with long-term use at abusive levels.

There are some that hypothesize that patients of all ages may be able to directly benefit from short term therapy using Human Growth Hormone in order to spur tissue regeneration and shorten downtime from injury or surgery.

Time will only tell, but it appears that in future years, HGH will find increased acceptance as a medical treatment, and medical professionals will gradually uncover more and greater benefits of HGH Hormone Replacement Therapy as a legitimate medical treatment.

07 July 2013

Study Shows New Method Of Growth Hormone Dosing Improves Height

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Study Shows New Method Of Growth Hormone Dosing Improves Height
ScienceDaily (Jun. 7, 2005) A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short stature.
The groundbreaking study, presented at The Endocrine Society 2005 meeting in San Diego, Calif., challenges traditional approaches to growth hormone (GH) administration based upon weight.
The authors described a new dosing approach based on the serum levels of insulin-like growth factor-I (IGF-I), the growth hormone GH-dependent hormone that mediates the actions of growth hormone on the growth of children.
In the study, Dr. Pinchas Cohen, lead investigator and professor and chief of pediatric endocrinology at UCLA's Mattel Children's Hospital, along with his UCLA colleagues and collaborators from four institutions, randomized pre-pubertal children with growth hormone deficiency or short stature to one of three treatment arms: a conventional dose of growth hormone according to weight, or to one of two dosing arms where the dose was adjusted to achieve an IGF-I level that was either at the mean for age and gender, or at the upper limit of normal.
Study results showed that the change in height in children whose growth hormone dosage was increased to achieve a higher IGF-I level grew 50 percent better than children receiving fixed doses of growth hormone or whose IGF was maintained at the mean. Furthermore, the higher IGF-I arm resulted in a substantial improvement in the growth of both growth-hormone deficiency patients and patients with idiopathic short stature.
"We feel confident that IGF-based growth hormone dosing could become a novel paradigm in treating growth hormone deficiency, resulting in improved height increases for these children. The growth hormone dose targeted to achieve the higher IGF-I level produced especially meaningful increases in height compared to conventional weight-based methods of determining doses," Cohen said. "Also, the dramatic range of sensitivity to growth hormone in the study population substantiated the rationale for IGF-based dosing. This approach has important implications for both the safety and efficacy of GH."
###
This study was supported by an unrestricted grant from Novo Nordisk. Cohen is an investigator for Novo Nordisk and has received speaking honorariums from the company.
Source Science Daily
Adapted from materials provided by University Of California - Los Angeles Health Sciences.
25 June 2012

How To Lose Weight With Human Growth Hormone

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Losing Weight with HGH a Scientific Study

A new study conducted by the medical department of St. Louis University shows that Human Growth Hormone is likely highly beneficial in aiding obese men and women in the fight to lose weight.

HGH Injections Lead to Weight Loss

Patients who participated in the clinical study were able to drop around five pounds over the course of the study in comparison to placebo participants. It seems as though Human Growth Hormone Replacement Therapy is an incredibly useful tool in the fight against obesity and the physical illnesses which occur as a result. In addition to this, HGH Treatments also help provide obese patients with the initial energy that they need to begin and maintain a healthy exercise program.

The leader of the HGH Hormone Treatment study was medical professor Stewart Albert, of the St. Louis Department of Internal Medicine and Endocrinology. In order to share his discovery with the scientific community, Professor Albert and his department chair Arshag Mooradian travelled to the 2003 ENDO conference, which was the eighty fifth annual congregation of the Endocrine Society. This conference took place from June nineteenth to twenty-second in Philadelphia, Pennsylvania.

The ENDO conference is the largest meeting of Endocrinology professionals and academics in the world. The primary purpose of ENDO is to display advances in Endocrine research which took place in the previous year. This is the Endocrinology communitys best opportunity to enhance the level of discourse as well as provide networking opportunities in order to advance the science.

HGH as an Obesity Cure: Symptoms of Obesity

One of the primary reasons why the results of this study are so important is because of the epidemic level of obesity in American society today. As many as thirty percent of Americans are afflicted with obesity. Perhaps even more alarming, eighteen percent of children aged from 12-19 in America suffer from obesity, a stunning increase from just five percent thirty years earlier. Below are a number of risks associated with obesity:

  • High Blood Pressure Obesity makes the heart have to work harder to achieve the normal distribution of blood throughout the body. In addition to this, issues such as cholesterol blockage in the arteries cause the arteries to become restricted, increasing blood pressure tremendously as a result.

  • Type-2 Diabetes This may be the most detrimental long-term affliction associated with obesity. This form of diabetes is a direct result of obesity and a diet too full of carbohydrates and sugars. The body slowly becomes immune to insulin, and it is no longer able to regulate blood-glucose levels without the help of insulin injections. The body slowly begins to atrophy if medication is not prescribed perfectly, and the risk of other afflictions associated with obesity increase significantly even if obesity is eventually resolved.

  • High Cholesterol Obesity is directly correlated with elevated levels of triglycerides and unhealthy LDL cholesterol. Cholesterol has a nasty habit of clogging up arteries and veins throughout the body, increasing blood pressure, preventing the heart muscle from contracting powerfully, and preventing areas of the body from obtaining proper levels of oxygen.

  • Sleep Apnea Obesity causes fatty tissue to obstruct air pathways, making it hard to breathe while in a sleeping position. This leads to poor sleep and in rare cases can even lead to suffocation

  • Stroke Strokes occur as a result of cholesterol and fatty lesions in the arteries and veins which clog up blood pathways in the brain. If not discovered immediately, strokes can permanently damage and kill off neurons and brain tissues, leading to limitless potential afflictions dependent upon where the stroke occurs.

  • Fatigue Fatigue is the result of many factors in relation to obesity. Excess levels of fat and the overconsumption of sugars and carbohydrates lead to a breakdown in the ability of the human body to produce and process Human Growth Hormone. Without sufficient HGH production, the body does not break down fatty tissue and convert it into energy efficiently, which leads to fatigue. Also, fatty tissue has the ability to convert Testosterone into estrogen and other derivatives of the feminine hormone. If Testosterone levels drop, then the muscles begin to atrophy as a result. Smaller, weaker muscles are less resistant to exhaustion and the body loses its ability to withstand muscular stress.

  • Gallstones Gallstones are masses of cholesterol that build up within the gallbladder. These growths can be as small as a rice grain or even as large as a golf ball. Obesity leads to increased size and manifestation of gallstones because the body sometimes has issues with dealing with the excess cholesterol circulating through the bodies of obese patients. Although gallstones can often pass undetected, they can also grow large and painful within the body and can become lodged. In this case, surgery is often the only option. Gallstones are not extremely dangerous if treated promptly, but can lead to debilitating abdominal and/or shoulder pain, as well as vomiting and nausea.

  • Heart Attacks All of the above stressesincreased blood pressure, an overworked heart, high cholesterol, and clogged arteries all contribute to a highly elevated risk of heart attack. If the heart cant build up enough pressure to circulate blood throughout the body efficiently, or if blood clots or artery clogging prevent the heart from receiving enough blood to function, then the organ begins to die, which dependent upon the severity of the heart attack will significantly reduce the hearts ability to function, or kill off the heart, and therefore the patient, as a result.

Answering Questions about HGH

The primary researcher, Dr. Albert, believes that there is great promise in using HGH Hormone Replacement Therapy as a treatment for obesity. Although he is certain that HGH Shots can be a useful technique, it is not yet clear to the doctor what the most efficient protocol should be when using HGH for weight loss. Also, there are questions as to whether Human Growth Hormone should be combined with other drugs in order to maximize weight loss benefits.

Obesity Reduces HGH Secretion

What is clear regarding Dr. Alberts study is that when individuals suffer from obesity, their Human Growth Hormone production drops significantly. Also, HGH is proven to play a major role in metabolism and appetite. After Human Growth Hormone is secreted by the pituitary or injected into the bloodstream, the molecule is converted into Insulin-like Growth Factor One by the liver. This HGH Derivative plays a central role in the breakdown of adipose fatty tissue, contributing to healthy body weight.

If weight gain outpaces the effectiveness of Human Growth Hormone in burning fat, then fatty tissue actually has the ability to send messages to the pituitary, preventing it from producing adequate levels of HGH. Reduced levels of Human Growth Hormone are directly connected with further fat accumulation and muscle atrophy, which greatly increase the physiological strain induced by physical activity while also reducing the benefits of exercise.

Mimicking Healthy HGH Levels

In the St. Louis University study, researchers administered Human Growth Hormone injections in order to restore blood-serum HGH to levels which would be normal for healthy men or women of an identical height and physiological profile. The researchers divided patients into two distinct groups. The first group was a control group that was injected with saline solution in order to mimic the HGH injection process. The second group was delivered a physiologically appropriate level of Human Growth Hormone. They delivered these HGH and placebo shots every night over the course of six months.

HGH and Weight Loss

In the end, the Human Growth Hormone injections produced significant results. Over the course of the six month clinical period, patients who underwent HGH Hormone Replacement Therapy lost an average of 5 pounds as a direct result of their injections. It should also be noted that all weight loss could be attributed to a reduction in adipose fat. Muscle mass did not deteriorate as a result of HGH Hormone Injections.

Another benefit of HGH Injections was that the weight loss that obese patients achieved was found to be incredibly targeted. The majority of adipose tissue was eliminated from around the midsection. Fat accumulation in the midsection is highly correlated with negative health conditions associated with obesity. Reducing excess fat around the midsection can lead to a lifelong reduction in the risk of heart disease, according to Dr. Albert.

HGH Study Parameters

The St. Louis Study involved 39 participants who weighed in at around forty percent overweightwell within the range of obesity. Every patient met with a dietary specialist once a month throughout the course of the study and was motivated to drop the pounds slowly through a mixture of physical activity and dropping their intake of calories by 500 per day.

Although it is clear that Human Growth Hormone Shots caused patients to lose weight at a faster rate, the researchers are not sure exactly by what mechanism this weight loss occurred. Dr. Albert says he is not sure whether he should attribute weight loss to a reduction in appetite or as a result increasing the ability of patients to build muscle mass and exercise effectively. He also posits that weight loss could easily be the result of a combination of both factors.

Original uses of HGH

Bio-Identical Human Growth Hormone Injections have been used for multiple generations as a treatment for Childhood HGH Deficiency and Idiopathic Short Stature. There is growing interest in off-label use of Human Growth Hormone as a means to encourage weight loss and muscle building in patients who suffer from Adult Human Growth Hormone Deficiency.

The levels of Human Growth Hormone used in Adult Human Growth Hormone Replacement Therapy are significantly lower than those utilized in the treatment of youth patients. This is because Human Growth Hormone levels peak during puberty. This is the period in which Human Growth Hormone encourages rapid height development. After this point, the body still produces a significant level of Human Growth Hormone, but not nearly at the same levels as during puberty.

HGH for Hypopituitarism

After the age of thirty, or sometimes earlier in the case of patients who struggle with obesity, endogenous Human Growth Hormone production declines at a rapid pace, and there is a growing body of evidence which suggests a multitude of ways in which this HGH Deficiency affects the body in incredibly negative ways.

Another aspect of this study which makes it important is that none of the patients who were subject to HGH Hormone Replacement Therapy experienced symptoms which made them decline further treatment. In earlier clinical trials, Doctors often made the mistake of administering doses of HGH that were too high and often resulted in patients who made the decision to stop therapy.

Avoiding HGH Side Effects

The key to useful and effective Human Growth Hormone Replacement Therapy is that the dose must be low enough to discourage side effects while also encouraging positive benefits such as weight loss and muscle development. The most effective way to do this is to determine normal healthy Human Growth Hormone levels and mimic them as precisely as possible.

HGH and Other Weight Loss Factors

Although the benefits of Human Growth Hormone Injection Therapy show immense promise, it is still important to remember that Hormone Replacement would only be one factor in a complete weight loss regimen. Any successful diet therapy will also feature diet restriction, nutrition optimization, and increased physical activity.

An important rule of thumb is that reducing 500 hundred calories per week through a combination of exercise and dietary restriction will produce weight loss amounting to one pound per week.

The Future of Human Growth Hormone for Weight Loss

HGH Replacement Therapy has the ability to increase weight loss both by reducing appetite and encouraging metabolism. With further study, scientists will learn how to optimize Human Growth Hormone HRT in order to achieve maximum weight loss results while maintaining overall good health. Its only a matter of time.

26 January 2016

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Diet Science
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