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TESTOSTERONE AND OTHER SEX HORMONES IMPACT ASTHMA RESPONSE DEPENDENT ON SEX


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 July 2020


Many conditions affect men and women differently. One of these conditions is asthma. It has long been known that pre-pubertal males tend to have more issues with asthma than females of the same age, but the underlying reasons why have not been so clear.

Recently, researchers from Johns Hopkins have explored the effects of Testosterone concerning asthma. It's critical to understand how men and women differ physiologically because it leads to different risks and different factors that impact potential treatment options.

While this study was conducted in mice, its results are hypothesized to be transferrable to humans. The research was published via the Journal of Immunology last October. While women are less likely to experience asthma than men in adulthood, Testosterone activated inflammation receptors in the lungs in response to exposure to an allergen known as ovalbumin. Obviously, these results give some mixed messages.

Asthma Risk Dependent on Age and Sex

Asthma is an interesting condition because its prevalence changes among males and females depending on age. Prior to puberty, boys are more liable to have issues with asthma than girls. After puberty, however, the situation changes. Then girls and women are more likely to have asthma. This is a clear example of how sex hormones lead to wellness-related sex differences. By exploring the mechanisms behind these differences, we can improve asthma diagnosis and treatment protocols.

A previous study investigated how Estrogen effected lung inflammation in mice. They found that Estrogen triggers inflammation. As we mentioned earlier, post-pubertal girls and women have a much higher incidence of asthma than men of the same age. This data led researchers to hypothesize that Testosterone would provide benefits against lung inflammation. For example, while still in experimental phases, male hormones have been prescribed as a successful treatment for women with asthma.

Mouse Testosterone Asthma Study

In order to learn more about how Testosterone impacts asthma, researchers needed mice that couldn't produce their own sex hormones. By using castrated mice, they could precisely control hormone levels using Testosterone Implants, which slowly and steadily release hormones.

Researchers also had to simulate asthmatic allergic reaction in the mice, because mice don't normally experience allergic asthma. Researchers aerosolized albumin to trigger a lung reaction similar to what humans experience when they have an asthma attack.

Testosterone and Lung Inflammation

Lung Inflammation is triggered by specific immune cells known as Alveolar Macrophages. These microscopic phagocytes absorb and break down debris in the lungs. They also trigger inflammatory activity, including the cascade of symptoms associated with an asthma attack. Researchers expected Testosterone to protect against lung inflammation in the mice.

What they discovered was more complicated. While Testosterone suppressed most markers of inflammation, it activated lung inflammation, specifically in Alveolar Macrophages. Researchers then bred male/female mice without Testosterone Receptors in their Alveolar Macrophages. Here, they discovered a critical sex-difference. Male mice had less inflammation when these receptors were deactivated. Female mice saw no such change. This means that in male mice, Testosterone is more intricately involved in how irritants trigger asthma response.

This provides evidence for why Testosterone can help women with asthma, but those results are sex-specific. This research highlights that a person's individual characteristics are very important to consider when deliberating upon treatment options.

In the future, research like this will likely lead to treatment options that differ for men and women. While an asthma attack looks the same in males and females, the mechanisms which trigger the attack clearly differ, which provides different opportunities for ideal treatment. Antihistamines and Steroids are the go-to treatment for asthma, but males with severe asthma may benefit more from an alternative form of therapy.


TESTOSTERONE THERAPY MAY BENEFIT SOME PROSTATE CANCER SURVIVORS


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 17 May 2020

Testosterone Therapy May Benefit Some Prostate Cancer Survivors

Historically, researchers and doctors hypothesized that Testosterone Replacement Therapy was associated with some risks, including cardiovascular complications, increased Prostate Cancer Risk, and other potentially dangerous health issues. On the other hand, studies published in recent years have provided a growing body of evidence that Bio-Identical Testosterone for Low-T is much safer than previously believed, even among many patients that were once considered most at-risk.

For generations, scientists have believed that Testosterone increases the likelihood and severity of Prostate Cancer. In fact, the 1941 Nobel Prize for Medicine was awarded for research which demonstrated how Testosterone Suppression positively impacted Prostate Cancer Outcomes.

A recent large-scale study calls this notion into question, however. In March, researchers produced evidence at the Congress of the European Association of Urology which suggests that certain patients with a history of prostate cancer can benefit greatly from Bio-Identical Testosterone Therapy. This study focused on patients with Prostate Cancer in remission that were at low risk of recurrence. If this research is further confirmed to be true, it will change the way that doctors think about the use of Testosterone Creams, Patches, and Injections for patients with past experience with Prostate Cancer.

Testosterone Suppression Benefits Prostate Cancer PatientsBut at What Cost?

While there is no dispute that Testosterone Suppression Treatments do protect patients from Prostate Cancer recurrence, there are serious downsides. Research published around the turn of the century unequivocably shows that, while patients have improved outcomes with regard to Prostate Cancer risk, Low Testosterone Levels significantly increase the risk of cardiovascular health issues, leading to a significant increase in mortality risk.

Our bodies are heavily reliant on hormones to maintain optimal health, and major changes in Hormone Balance can have severe and dramatic effects on wellness. Testosterone is essential for maintaining healthy metabolism and cardiovascular function. Patients treated with drugs which suppress Testosterone Levels were directly more likely to have increased deposits of body fat around the mid-section, unhealthy cholesterol levels, and complications associated with diabetes and high blood sugar. Androgen Suppression also led to a decline in quality of life related to Erectile Dysfunction and loss of libido.

Because of this collection of complicating issues, many doctors began to hypothesize that the benefits of Testosterone Therapy likely outweigh the risks for many patients at minimal risk of recurrence post-treatment.

Cal-Irvine Testosterone Study for Prostate Cancer Survivors

In a long-term study conducted from 2008-2011, Thomas Ahlering and his staff at Cal-Irvine studied the effects of Testosterone Therapy upon 152 patients treated for Prostate Cancer via robotic prostate removal. The goal was to help patients experience improved sexual health after prostatectomy. The study analyzed the health outcomes of 834 total patients. Around three years after prostate surgery, patients returned for inspection. Researchers searched for signs of Prostate Cancer recurrence as evidenced by an increase in Prostate Specific Antigen Levels. Elevated PSA Levels are the prime non-invasive indicator of prostate cancer.

Fascinatingly enough, researchers found that patients that received Testosterone Therapy were 1/3rd as likely to experience the return of Prostate Cancer. Five percent of patients undergoing Low-T Treatment showed signs of Prostate Cancer, whereas 15% of those that did not receive therapeutic Testosterone showed signs of the disease.

The significance of the Effective Treatment of Prostate Cancer with Testosterone Therapy

Thomas Ahlering was surprised by the results of the study. He only sought to confirm the safety of Testosterone for Sexual Health among Prostate Cancer survivors, but it appears that Testosterone can have a major impact on overall mortality risk. He explains that Testosterone isn't stopping the progression of Prostate Cancer, but it slows the development of the cancer, extending remission by an average of 1.5 years. This is combined with the highly beneficial impact of Testosterone upon sexual wellness, triglyceride levels, cholesterol, body composition, and insulin sensitivity.

If further study demonstrates the safety and effectiveness of Testosterone Therapy for Prostate Cancer Survivors, then Low-T Treatments may become the norm for these patients in the near future. Numerous studies published in the last decades have increased awareness of the overall safety profile of Bio-Identical Testosterone Treatments for various segments of the male population. When used appropriately and monitored closely, Low-T Therapy appears to be a potential boon for millions of aging men across America, as well as patients with issues which impair their healthy Testosterone Production.

It's important to question the perceived norms regarding Testosterone Therapy so that patients can receive the best results with the best outcomes. For now, patients who've had their prostates removed appear to be in the clear for safe and effective use of Testosterone. In the future, it is inevitable that more groups will be approved for such treatment.

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If you're interested in learning more about the fantastic benefits of Testosterone Replacement for Low-T, our Licensed and Board-Certified HRT Clinic provides Free Consultation to potential clients. Our Hormone Specialists have helped men across the United States experience improved well-being and health outcomes via Testosterone Restoration. We also offer a variety of forms of Hormone Optimization designed to meet the needs of both men and women, including HGH Therapy, Sermorelin Acetate for Somatopause, Thyroid Treatments, and Physician-Mediated Weight Loss Plans.

We specialize in the treatment of Age-Associated Hormone Issues in patients thirty and older. Our goal is to restore Hormone Levels associated with early adulthood to counteract the detrimental symptoms associated with Hormone Decline and Imbalance so that patients can experience elevated quality of life. We work with Quest Diagnostics and LabCorp to extend our logistical capacity for fast and accurate assessment and treatment all across the United States. We work with reputable pharmacies that provide effective and affordable HRT Products and Services! We can help you overcome the demoralizing effects of Hormone Imbalance so that you can live a better life!


WHAT ARE NORMAL TESTOSTERONE LEVELS FOR MEN AND WOMEN THROUGHOUT LIFE?


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 15 October 2018

What Are Normal Testosterone Levels for Men and Women Throughout Life?

Testosterone Levels are dependent upon a variety of diverse factors. Most logically, Testosterone is dependent upon gender, but it is also contingent on age, health, lifestyle, and genetics. Males almost always have more Testosterone than women unless influenced by external factors such as Hormone Therapy or Hormone Suppression.

Testosterone belongs to a collection of critical hormones known as Androgens. Androgen is the catch-all term for sex hormones that are associated with male function and form. Although Androgens are expressed in higher concentrations in men, women also produce Androgens like Testosterone, though in much lower levels.

The opposite is also true. Men need Estradiol and other Estrogens for normal function but produce far less of the feminine Hormones. The majority of Testosterone produced by a woman's body is transformed into Estradiol. While the Adrenal glands produce small amounts of Testosterone for both men and women, the testes and ovaries are responsible for the majority of Testosterone secretion.

What Does Testosterone Do for Men?

Testosterone is central to the development of primary and secondary sex characteristic in men. It's responsible for the formation of the sex organs during fetal development and is responsible for spurring the maturation of the sex organs during puberty. Testosterone also plays an essential role in libido, metabolism, strength, energy level support, and reproduction.

What Does Testosterone Do for Women?

For women, Testosterone encourages fertility and facilitates libido while also promoting the creation of red blood cells and maintaining Hormone Homeostasis. Both sexes report issues with fertility and sex drive associated with Low Testosterone Levels.

What Are Healthy Testosterone Levels?

Testosterone is incredibly important, and the body thrives when Testosterone Levels are in the healthy range. While it is possible for men and women to have naturally high Testosterone Production, Low-T is the far more prevalent condition, and most people have Testosterone circulating within the healthy range, though men and women are more prone to issues related to diminishing Testosterone as they age. Testosterone is calculated using nanograms per deciliter by most physicians. Testosterone Levels are assessed via blood sample.

Abnormally Low Testosterone Levels during gestation can interfere with male fetal development. Suppressed Testosterone Levels during adolescence can delay or slow pubertal development. High Testosterone in boys can trigger early puberty.

Normal Testosterone Levels by Age

Early Development In Boys In Girls

0-5 Months Years 75-400 ng/dl 20-80 ng/dl

6 Months-9 Years Less than 20 ng/dl Less than 20 ng/dl

10-11 Years Less than 130 ng/dl Less than 44 ng/dl

During Puberty In Boys In Girls

12-13 Years Less than 800 ng/dl Less than 75 ng/dl

14 Years Less than 1200 ng/dl Less than 75 ng/dl

15-16Years 100-1200 ng/dl Less than 75 ng/dl

During Adulthood In Men In Women

17-18 Years 300-1200 ng/dl 20-75 ng/dl

19+ Years 240-950 ng/dl 8-60 ng/dl

Tanner Scale for Measuring Adolescent Development

While the guidelines above are generally correct, many physicians choose to evaluate Testosterone Levels in children and adolescents according to visual phase of development. In order to do this, doctors refer to a clinical schema known as the Tanner Scale. This scale is useful because children reach puberty and mature at different rates.

Stage I on the Tanner Scale is associated with the period before puberty, and Stage II is reached when visible signs of puberty first appear. The following provides information regarding the Testosterone Levels related to Tanner Stage in both boys and girls:

Tanner Stage In Boys In Girls

Stage I Less than 20 ng/dl Less than 20 ng/dl

Stage II 8-66 ng/dl Less than 47 ng/dl

Stage III 26-800 ng/dl 17-75 ng/dl

Stage IV 85-1,200 ng/dl 20-75 ng/dl

Stage V 300-950 ng/dl 12-60 ng/dl

What Are the Symptoms of Testosterone Deficiency in Men?

  • Low Sex Drive

  • Thin, Easily Damaged Skin

  • Issues with Concentration and Memory

  • Fatigue

  • Thinning Hair on Head, Face, and Body

  • Weight Gain

  • Depression and Anxiety

What Are the Symptoms of Testosterone Deficiency in Women?

  • Low Fertility

  • Osteopenia/Osteoporosis

  • Low Libido

  • Missed or Irregular Periods

  • Sexual Lubrication Issues

Polycystic Ovary Syndrome and Testosterone Levels

One of the most common reasons for excessive Testosterone in women is Polycystic Ovary Syndrome. Women struggling with PCOS experience elevated Testosterone Levels, which can lead to issues such as the development of facial and body hair, acne, oily skin, and absent or irregular periods.

Steroid Use and Testosterone Levels

Steroids are anabolic organic compounds which share similarities with Testosterone. Steroids are commonly used to increase body mass and build muscle. They are often utilized illicitly by men and women looking to bulk up. Steroid use and abuse can have a dramatic effect on natural Testosterone Production.

When guys abuse steroids, it can cause Testosterone Levels to drop precipitously, leading to low libido, temporary infertility, increased body/facial hair, acne, and testicular shrinkage.

In women, Steroid abuse can disrupt fertility and period timing while also causing baldness, acne, unfortunate hair growth, and deepening of the voice.

Testing for Testosterone-Related Issues in Men and Women

If an individual believes that they are having issues related to Low-T or Elevated Testosterone Levels, they should strongly consider reaching out to a doctor or Hormone Specialist for evaluation.

When evaluating for Testosterone Abnormalities, it is common for physicians to follow some general guidelines. For example, opiates have a dramatic effect upon the body's ability to produce Testosterone, so they will likely ask about prior opiate use along with the use of steroids. Men will often be measured for waist circumference, BMI, prostate/testicle size, and evaluated for signs of baldness. Women will be assessed for symptoms of masculation and also for acne and menstrual function.

How Are Testosterone Levels Tested?

Free and Total Testosterone Levels are evaluated using a blood test. To provide the most accurate results, Serum Testosterone is best tested during the morning hours, which gives the doctor the best idea regarding your peak Testosterone Production. The established Low-T Threshold for men varies depending upon the source, but most medical professionals consider Testosterone Deficiency to be associated with Testosterone Production lower than 230-350 ng/dl. Healthy women should have Testosterone Levels registering at 15-75 ng/dl.


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If your doctor only prescribes testosterone by itself, you will probably have a rough ride. The tendency is for you to feel great the first couple months, while you increase testosterone levels, followed by a slow deterioration, once your estrogen creeps up.

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