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HOME > IMMORTALITY MEDICINE > CHEMICAL POLLUTION IS DESTROYING MASCULINITY



Masculinity Lowered By Chemicals?


Written by Dr. Welsh, Published on 07 October 2018

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Endocrine Disrupting Chemicals in Pesticides and Plastics

Over the last ten years, clinical and ecological research continues to suggest that many chemicals, both synthetic and natural, have the ability to disrupt the hormone balance of the endocrine system, producing various negative effects in all sorts of creatures, including birds, fish, wildlife, and even human beings.

When discussing the hormonal implication of these chemicals, scientists and researchers have labeled these chemicals endocrine disruptors. In today's 21st century world, these products are everywhere in our lives. Some of the most common places where these chemicals exist are pesticides, cosmetics, toys, foods, flame retardants, detergents, metal food cans, and some plastic bottles.

Today, there is a limited body of scientific data available regarding these chemicals, but there is a legitimate concern over how these chemicals may have an impact on human health. In the environment, there are areas which are polluted with endocrine disrupting chemicals to an extent that ecological populations are experiencing deleterious effects directly as a result. These negative health impacts have also been proven in a laboratory atmosphere.

Although it is clear that Endocrine Disrupting Chemicals are a health risk under certain circumstances and concentrations, it can be hard to study the health impact of these chemicals, because people are generally exposed to a number of these chemicals at varying concentrations at the same time. There are government and non-profit organizations dedicated to clarifying the health risks and implications associated with Endocrine Disruptors, two of which are the National Toxicology Program and the National Institute of Environmental Health Science.

These groups support and fund scientific studies aimed at fostering a more complete understanding regarding how these chemicals impact hormone balance in an effort to protect both human beings and wildlife from the negative impact of Endocrine Disrupting Chemicals. In the near and distant future, these programs hope to minimize the domestic and global environmental and health impact of these chemicals and to discover ways to mitigate the negative effects.

What is an Endocrine Disrupting Chemical?

Endocrine Disrupting Chemicals are synthetic or naturally occurring chemicals which have the capacity to interfere with the secretion or functional capacity of hormones produced by the endocrine system. These chemicals have the ability to significantly alter hormone balance in both humans and animals, leading directly to negative health consequences. A number of these Endocrine Disruptors have been strongly correlated with immune, neural, reproductive, and developmental issues in both captive and wild animal populations.

Many researchers also believe that these chemicals and compounds also have the ability to negatively impact human health at existing concentrations. There is some correlation between reduced fertility and Endocrine Disrupting Chemicals. These chemicals also appear to increase the risks of certain health conditions, including several cancers.

In addition to Endocrine Disruptors and Endocrine Disrupting Chemicals, these chemicals are also referred to by a number of other names, including Endocrine Active Compounds, Environmental Hormones, and Endocrine Modulators.

There are forms of chemical pollution that affect various types of hormone balance, but the group of chemicals that have received the largest body of scientific study are those that increase the physiological influence of Estrogen. A number of other chemical disruptors have been identified however, including those that encourage the production of thyroid hormones, androgens, and progesterone, and those that inhibit the production of Estrogens and Androgens.

What is the Importance of the Endocrine System?

Along with the Neurological System, the Endocrine system is the primary way that the body communicates changes from disparate areas of the body. The Endocrine System also plays a central role in the coordination and control of numerous physiological functions. The Endocrine System produces these changes directly through the secretion of hormones from Endocrine Tissues situated throughout the body, including the pancreas, thyroid, pituitary, testes, and ovaries. These hormones then enter the blood stream where they flow to target organs and affect change.

Hormones are able to conduct the complex orchestra of necessary functions which keep us happy and healthy. One example of how hormones function is the complex way that the reproductive system, nervous system, fat, liver, gut, and kidneys work together in order to control and maintain various metabolic functions, including:

  • Reproduction

  • Development and Growth

  • Energy Level of the Body

  • Hormone Homeostasis

  • Response to Injury, Stress, and Outside Influences

Endocrine Disrupting Chemicals interfere with the normally-closed set of signals flowing throughout the body to keep us healthy, leading directly to hormone imbalance which causes a variety of negative consequences.

How do Endocrine Disrupting Chemicals Work?

Animal research has provided us with a lot of insight regarding the impact of Endocrine Disrupting Chemicals. There are a number of different mechanisms through which EDCs have the ability to alter the normal function of the human body.

Endocrine Disruptors have the ability to:

  • Substitute partially or completely for hormones produced naturally by the human body, such as Thyroids Hormones, Androgens, and Estrogens. These chemicals imbalance the system by overstimulating the body with the effects of a particular hormone.

  • Block the normal and healthy function of a hormone by blocking cell receptors and preventing hormones from making their connections. In these cases, the target organ does not receive the full physiological signal, and the body displays symptoms and signs of deficiency. Chemicals that produce these effects are categorized under terms such as Anti-Androgens and Anti-Estrogens.

  • Other Endocrine Disruptors actually have the ability to block or alter the way that hormones and hormone receptors are controlled or created. One example is that there are certain EDCs which can prevent the proper metabolism of hormones by the liver.

What are Some Particular Examples of Endocrine Disrupting Chemicals?

There are a large number of chemicals which have the capacity to alter normal Endocrine Function in a variety of ways. A few well known Endocrine Disrupting chemicals are, PCBs, Dioxin, and the medication Diethylstibesterol (also known as DES), and pesticides like DDT .

There are other chemicals, commonly plasticizers and pesticides, which have been shown to have Endocrine Disrupting effects in animal studies, such as Bisphenol A (also known as BPA). Bisphenol A is a synthetic chemical that is in many plastic products such as bottles, which leach from certain products when exposed to heat. BPA has many industrial applications, including the creation of beverage and food containers, and well as an ingredient of resins used in dental sealants.

Another large group of Endocrine Disrupting Chemicals are known as phthalates. The industrial application of these synthetic chemicals is to improve the flexibility or soften plastics made from polyvinyl chloride. One common phthalate is DEHP. This chemical is used in the production of a large number of polyvinyl products such as food packages, clothes, car products, building materials, children's products, and medical tools. Scientists with the National Toxicology Program have found that there may be a link between DEHP and developmental issues in young children, especially male infants which are seriously ill.

Some of the most common forms of naturally occurring Endocrine Disrupting Chemicals are known as Phytoestrogens. These chemicals are naturally produced in some plants, and have the ability to partially mimic the effects of Estrogen under some circumstances. Some of these chemicals can be found in foods and other products produced from soy, such as daidzein and genestein.

Representatives of the National Toxicology Program recognized the importance of evaluating the risks of Endocrine Disrupting Chemicals upon human reproduction, and created The Center for the Evaluation of Risks to Human Reproduction. This group analyzes various products for signs that they may impact normal fetal and childhood development. The Center has determined that seven Phthalate compounds have Endocrine-Disrupting Effects, as well as one particular Phytoestrogen known as Genistein. Genistein is an ingredient in infant formulas derived from soy.

How do People become Exposed to Endocrine Disrupting Chemicals?

There are a number of ways that individuals of all ages can become exposed to EDCs. It can enter through their dietary choices, the medicines they are prescribed, and even the make-up they put on their face. Exposure can occur directly through the skin, through the digestive system, and through breathing.

Many chemicals which have these Endocrine Disrupting qualities take a long time to degrade or otherwise dissipate, such as the pesticide DDT. For this reason, many EDC Chemicals can be a health risk for long after they are initially used.

What is the Current State of Endocrine Disrupting Chemical Research?

The National Institute of Environmental Health Science has spent over thirty years researching the impact of medical Diethylstilbestrol on human patients. This chemical was used from the 1940s to the 1970s because medical professionals mistakenly believed that the chemical had the ability to reduce the risk of miscarriage for patients at serious risk.

In 1972, it was discovered that daughters born to mothers that were treated with DES had a significantly increased risk of experiencing a very uncommon form of vaginal cancer. In addition to this, DES produced many other changes in children of both sexes born to mothers that took the drug. The National Institute of Environmental Health Science performed extensive animal studies which proved the link between exposure to DES and the development of birth defects and increased cancer risk.

Leading directly from this initial, stunning series of discoveries, scientists with the NIEHS have continued to study other chemicals which interact adversely with estrogen receptors. Scientists continue to broaden the body of knowledge regarding Endocrine Disrupting Chemicals in a number of different ways, including:

  • Creating new tools and models to reveal new information about how Endocrine Disruptors function

  • Uncovering new techniques to discover which chemicals produce Endocrine Disrupting Effects

  • Studying the impact of EDC exposure throughout the lifespan, and how it impacts health

  • Studying the effects of EDCs in existing human patient populations

  • Creating new tests and biological markers in order to measure both toxicity level and exposure to these chemicals

  • Animal studies created to assess the effects of EDC exposure

  • Developing ways to treat patients exposed to EDCs or learn ways to prevent exposure

When are Endocrine Disrupting Chemicals Most Dangerous?

Scientific studies show that EDC exposure produces the highest level of risk before a child is born, or in the period after birth in which the organs of the child's body are still developing. In animal studies, there are a number of different issues related to early EDC exposure, including increased cancer risk and reduced fertility, which may not become an issue until a much later point in the lifespan.

In one case, researchers found that animal subjects which were exposed to synthetic BPA or natural, human Estradiol during prenatal development as well as Estradiol during adulthood were much more likely to develop a particular prostate cancer precursor. This study provides evidence that both natural and synthetic estrogen exposure have the ability to impact the way that the prostate behaves at the genetic level, which increases the risk of prostate disorders and cancer.

Low Level Endocrine Disrupting Chemical Disruptor Exposure

Researchers have found that there is credible evidence that EDCs can impact the physiological function of animals even at very low doses. These doses are significantly below what has traditionally been believed to impact health and physiology.

Even though there has been a limited amount of study in regard to the direct impact of EDCs upon human health and function, the body of animal evidence is quite large, and Endocrine Disrupting Chemicals have the ability to cause the following issues in animal populations:

  • Abnormal development of male reproductive organs

  • Drop in male fertility

  • Increased female-to-male birth ratio

  • Increased incidence of sexual issues in female animals, including fertility complications and premature puberty

  • Increased incidence of breast, prostate, and ovarian cancer

  • BPA may also negatively impact diabetes and obesity.

Can Endocrine Disruptors in Pesticides and Plastics Affect Future Generations?

Evidence suggests that Endocrine Disrupting Chemicals not only have a negative impact on individual exposure, but EDC exposure may have a hereditary risk as well. There is some research that provides evidence that a patient exposed to Endocrine Disruptors may pass on their genetic abnormalities to future generations. In laboratory animals, the increased risk of cancer passed on three generations after initial exposure.

Another study found that male laboratory rats exposed to two particular EDCs were found to carry on abnormalities to almost every male in proceeding generations. The researchers hypothesize that these EDCs have the ability to alter gene expression without directly causing genetic mutation.

EDC research is a vastly expanding field, and as our knowledge of the effects of these chemicals continues to grow, it will help us to prevent or mitigate the effects of these chemicals on both human and animal populations.

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