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REGULAR INTERMITTENT FASTING IMPROVES COGNITIVE HEALTH AND BRAIN STRUCTURES


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 08 April 2021

Intermittent fasting is a hot topic right now, with people from all walks of life interested in fasting: weight lifters, vegans and millennials. Fasting comes with different benefits than just plain dieting. It has been practiced for thousands of years, across many different cultures.

Some studies have claimed that intermittent fasting promotes faster weight loss (in a healthier way), boosts growth hormone levels and even increases the life span. A group of researchers wanted to find out if intermittent fasting affects brain functions and structures, especially in an anti-aging kind of way. The scientists began their research on mice to get preliminary data.

Research Suggests Intermittent Fasting Improves Brain Functions

The mice were divided into control, intermittent fasting and a high-fat diet group. The control group mice were allowed free access to regular rodent food. The intermittent fasting mice group were allowed free access to rodent food every other day with zero food on the alternate day. The high fat diet mice had free access to high-fat food (45% fat). This diet style continued for 11 months. Water was never restricted. The high fat diet group was supposed to represent the typical Western diet in terms of fat consumption.

After the 11 months, the mice were then subjected to Barnes maze which was designed to test spatial learning and memory. Both short-term and long-term memory retention was tested. After the Barnes maze, the mice were subjected to a fear conditioning experiment with freezing behavior recorded. After fear conditioning, motor coordination and exercise tolerance was evaluated. Here, the mice were placed on an accelerating rotarod to see how long they could stay on it for (tolerance). Other biometrics were taken, such as blood samples for levels of lipids/glucose, western blot analysis and measurements of the brain/hippocampus. This study was a lot of complex work!

Intermittent Fasting Improves Learning and Memory

The Barnes maze and fear conditioning results suggested that intermittent fasting improves learning and memory. In addition, the thickness of a layer of the hippocampus (brain structure) was increased, suggesting improved brain structures. Other benefits demonstrated for the brain was the reduction of oxidative stress as shown by the ratio of certain proteins in the brain. Oxidative stress is known to cause injury to cells and premature aging. If intermittent fasting can reduce oxidative stress, that would certainly cause anti-aging effects and improvement in brain structures and functions.

The high-fat group (typical Western diet) did not show impaired learning and memory (surprisingly!) and no significant difference in oxidative stress. However, they ended up being obese with hyperlipidemia. Their exercise tolerance was significantly worse but no harm to brain structures or functions were observed. The authors are worried about the effects of long-term obesity on the brain and need further research to come to a conclusion.

This study was very complex and the details cannot be delved into here, but the link is available below for your own study. In conclusion, it appears that intermittent fasting may have some seriously awesome benefits which probably translate over to humans as well. It would make sense as to why fasting has been such a popular diet for centuries, if you can call it a diet. Some people may call it a lifestyle.

In fact, the best way to adopt healthy eating is not through diet but rather, through a change in your lifestyle. Make healthy eating and intermittent fasting a habit and youll start seeing the benefits quickly!

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