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Short children can gain inches with growth hormone


Written by Dr. Welsh, Published on 12 January 2014

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The Impact of Human Growth Hormone on Adolescent Patients with HGH Deficiency

Human Growth Hormone Replacement Therapy was first utilized for the treatment of children with Idiopathic Short Stature and HGH Deficiency. HGH Injections are a tried and true method to help children with HGH Deficiency live a more normal life.

How does HGH Make You Grow?

Human Growth Hormone is a metabolic hormone which encourages cell division and replication. Healthy individuals have the highest concentration of Human Growth Hormone in their bodies when they are young. HGH causes us to grow bigger and longer, and our bodies make the most of it during puberty.

HGH influences growth because of the way that our bones are structured when we are young. During childhood, our bones are slightly more flexible, and they have not completely hardened. At the center of all of our bones lie structures known as epiphyseal plates. We grow taller because our bones generate more cells at the epiphyseal plates which harden and slowly cause our bones to get longer.

At the end of puberty, these epiphyseal plates close, and no amount of Human Growth Hormone will cause the bones to become longer. This is why pediatric treatment of HGH Deficiency is incredibly important. Once our bodies reach the end of puberty, there is no medical treatment that can recreate that era of physiological development.

Causes of Pediatric Human Growth Hormone Deficiency

HGH Deficiency is one of the many causes of a condition known as Short Stature. Short Stature refers to any individual that is significantly under the normal height for a child or adult of the same gender and age. There are a lot of different reasons why this can happen, and sometimes even doctors are unsure of the ultimate cause. When there is no known medical reason for the condition, it is known as Idiopathic Short Stature.

Often, the reason why a child is not growing as quickly as his or her peers is because the child is producing an insufficient amount of Human Growth Hormone. HGH is secreted by organs known as somatotrophs in the pituitary gland, which is positioned at the very base of the brain. The hypothalamus sends signals for HGH via a precursor hormone known as GH-RH, and the pituitary carries out the order.

Sometimes, children suffer from Human Growth Hormone Deficiency as a result of congenital conditions, but it can also be caused during development by traumatic injuries as well as tumors. Some children with congenital HGH Deficiency suffer from the disorder because their pituitary glands did not develop fully. In the case of this, the hormonal deficiency is often paired with other developmental abnormalities, including cleft palate, cleft lip, and other facial deformities.

Often, there is no clear underlying reason why HGH Levels are abnormally low. If HGH Deficiency is not the result of an undeveloped pituitary, the condition is generally recognized when the parents or their physician notice that the child is growing abnormally slowly. Pediatricians monitor normal growth by measuring the child with every visit and comparing their height to a chart which organizes the height of all children into a growth-curve, where they can easily explain to the parent how their child is growing compared to the average child.

Brain Tumors and Childhood HGH Deficiency

Tumors on and around the pituitary can contribute to Human Growth Hormone Deficiency. Tumors around the pituitary can put pressure on the Somatotrophs that generate the hormone, preventing them from functioning normally, as can tumors on other parts of the pituitary not associated with Human Growth Hormone. Tumors of the Somatotrophs themselves cause an excess of Human Growth Hormone to be produced, leading to gigantism in some cases if left untreated.

Cancer Treatment and Childhood HGH Deficiency

If a child is treated for any cancer of the head or brain, there is a chance that radiation will have a negative impact upon the pituitary gland. This can render the organ unable to produce Human Growth Hormone, or can simply limit the organ's functional capacity.

Brain Trauma and Childhood HGH Deficiency

Any injury which negatively impacts the healthy function of the pituitary gland or hypothalamus can alter the body's ability to produce sufficient levels of Human Growth Hormone.

Chronic Renal Insufficiency

This condition is caused by any disorder which slowly maligns the function of the kidneys. The kidneys play a role in the proper function and activity of Human Growth Hormone in the human body, and can lead to symptoms of HGH Deficiency as a result.

Genetic Conditions which Cause HGH Deficiency

Isolated HGH Deficiency

Sometimes, Human Growth Hormone Deficiency is caused by a simple genetic mix-up which renders the body unable to produce HGH, but has no other impacts on the health and the development of the fetus. There are three gene mutations which cause this form of deficiency:

  • The GH1 Gene carries the blueprint for the body to produce Human Growth Hormone.

  • The GHRHR gene carries the blueprints for the brain to make receptors which help the precursor GH-RH molecule attach to pituitary receptors which send the message to the pituitary to make HGH.

  • A third cause is a malformation of the BTK gene, which is responsible for the production of immune cells known as B-Cells. Researchers are unsure why the BTK abnormality contributes to HGH Deficiency.

SHOX Deficiency

SHOX Deficiency is caused by a genetic mutation which renders the SHOX Gene unable to function. This gene is necessary for a child to experience normal growth, but there are usually no other significant symptoms of the deficiency. HGH Hormone Replacement Therapy counteracts this disorder completely, allowing the child to grow normally.

Turner Syndrome

This condition only impacts females. Turner Syndrome belongs to a class of genetic abnormalities ranging from partial to total deletion of the second X Chromosome. The physical symptoms include short stature, webbed neck, low ears, and broad chest. Other symptoms include sexual dysfunction, vision abnormalities and diabetes as well as weak memory and weak mathematic and spacial reasoning. HGH Injections can alleviate the symptoms of this disorder associated with a lack of circulating Human Growth Hormone.

Prader-Willi Syndrome

This condition is caused by a mutation in which seven genes on Chromosome 15 are deleted, including the instructions needed to make Human Growth Hormone. This condition leads to obesity, reduced muscle tone, powerful and constant hunger, sexual immaturity, and mental disability. Human Growth Hormone Shots can alleviate issues related to this condition which are caused by HGH Deficiency.

How does HGH Hormone Replacement Therapy Work?

Human Growth Hormone HRT is a very simple treatment in concept. The best way to restore normal HGH Balance in children with Human Growth Hormone Deficiency is to directly inject Bio-Identical HGH into the body that for whatever reason, the child's body is unable to produce, or unable to produce sufficiently.

Early forms of HGH Hormone Replacement used real Human Growth Hormone drawn from organ donors, but the risks of this form of collection outweighed the benefits, stirring researchers and scientists to figure out a way to create the vital hormone in a laboratory environment.

Today, all HGH Injections in the United States are created using a technique known as Recombinant-DNA Technology. This means that researchers found a way to encourage other organisms to produce Human Growth Hormone by slightly altering their DNA so that they produce biologically pure HGH which can be collected for medical treatment. Researchers actually found a way to make a particular, harmless strand of E. coli generate the Human Growth Hormone molecule as a result of its natural organic processes.

How is Human Growth Hormone Delivered?

Bio-Identical HGH is administered to the child through a technique known as Subcutaneous Injection. Luckily, Subcutaneous injections are generally considered to be the most painless form of injection. Rather than Intravenous Injections which pierce into sensitive veins and Intramuscular Injections which plunge directly into meaty muscle tissue, Subcutaneous Injections are delivered just below the top layers of the skin using the same form of needle which is used for Insulin Injections.

All children have their own particular issues with needles, but the vast majority of children can handle the minor pain of an HGH Injection with ease, especially when they can easily recognize that HGH will help them grow taller like their friends.

HGH Hormone Injections work quickly for children with Growth Hormone Deficiency. The child will begin growing more quickly just in a manner of months.

Most people associate Human Growth Hormone Deficiency simply with an inability to grow taller, but there are a number of medical issues that are related to the condition.

Other Benefits of HGH for Children

Human Growth Hormone Replacement Therapy produces a number of physical as well as psychological benefits. HGH plays a major role in metabolism, so your child will generally experience increased energy levels which help them play and act like other children. HGH Hormone Replacement Therapy also has a direct impact upon the strength of the child, because Human Growth Hormone not only improves the length of the body but also the size of the organs of the body, including the muscles. HGH Injections also directly reduce body fat in pediatric patients, and can reverse the obesity associated with Pediatric HGH Deficiency.

Side-Effects of HGH for Children

Because Pediatric HGH Injections are intended to reverse an abnormal absence of Human Growth Hormone in the child's body, there are very few side-effects associated with this form of treatment, and Pediatric HGH Replacement Patients experience the lowest incidence of side-effects of any group that takes this form of treatment.

If side-effects do occur, they are generally itching or rashing at the injection site, and are associated with the delivery of the medication, not the actions of the Human Growth Hormone once inside the human body. Irritation at the injection site can be alleviated by changing injection sites more frequently or adjusting the dose slightly to prevent the irritation.

Treatment throughout the Lifespan

Many patients that take Bio-Identical Human Growth Hormone as children choose to continue to take the treatments once they reach adulthood. Patients that take Human Growth Hormone as children generally have under-functioning pituitary glands or other medical conditions which necessitate the use of HGH into adulthood. Although many people think that HGH is simply associated with the process of growth and puberty, the hormone actually plays a role in the health of an individual throughout the lifespan.

After puberty is over and the epiphyseal plates close, HGH still plays a crucial role in normal adult health. HGH Deficiency prevents the muscles from becoming sufficiently strong, and HGH Deficiency is highly correlated with obesity. Human Growth Hormone is also an important part of heart health and cholesterol balance, so adults that stop HGH Hormone Replacement Treatment after childhood are at an elevated risk for hypoglycemia, heart attack, and cardiovascular disease later in life because they are naturally predisposed to elevated levels of both triglycerides and LDL Cholesterol. This form of HGH Deficiency also significantly weakens the bones, leading to a greatly increased risk of breaks and fractures associated with Osteoporosis and Osteopenia.

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