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LEPTIN HORMONE GUIDE THE EFFECTS OF THE SATIETY HORMONE





Leptin Hormone Guide: The Effects of the Satiety Hormone


Leptin Hormone Guide

What is Leptin?

Leptin is a hormone that has many purposes, but primarily it is responsible for the full sensation that we get after the body decides that we've had enough to eat. It is frequently referred to as the “satiety hormone.” Leptin is released by fat cells in an effort to control the way that our body stores fat. In addition to suppressing hunger, leptin also alters the way that our body uses energy.

The fat cells release leptin when they have stored a certain level of fat converted from the calories from the food that we eat. When leptin is released, it enters the blood stream and passes through the body. Leptin travels through the cardiovascular system to the hypothalamus, where it activates special receptors in the arcuate nucleus.

When leptin receptors are activated, it causes the body to increase metabolism, while also reducing signals for hunger. Although this is primarily affected through the brain, there are targets throughout the body which are also responsible for increasing metabolism.

The two hormones, Leptin and Ghrelin, have opposite, component effects upon the body. Whereas leptin controls the feeling of satiation, Ghrelin controls the sensation of hunger. Leptin and Ghrelin receptors are actually located on the same cells, and are two vital hormones responsible for the way that our body both stores and expends energy.

Leptin has a number of different purposes in the body, but the most important of these is considered the regulation of the way that the body stores fat. Our knowledge of how Leptin works is far from complete, but leptin is produced not only by fat cells, but by other organs as well.

Where is Leptin Produced?

The majority of leptin is secreted by white adipose fat tissue by organelles known as adipocytes. Leptin is also secreted from other locations, including the liver, pituitary, bone marrow, epithelial cells, stomach, skeletal muscle, ovaries, placenta, and brown adipose fat tissue.

What Causes Leptin Levels to Fluctuate?

Like other hormones such as Testosterone, Leptin flows through the blood stream both locked into a carrier protein and freely. Because body fat produces leptin, the more body fat that a person carries, the more leptin that they will produce. Perhaps surprisingly, the amount of leptin produced by body fat increases exponentially with the volume of body fat that a person carries.

Leptin concentrations also follow the circadian rhythm under normal circumstances. From around 12am to some point in the early morning, leptin levels remain quite high, which is believed to prevent hunger and promote sleep. Although this is the normal pattern of leptin release and circulation, if a person eats at odd times, such as in the middle of the night, this alters the rhythm of leptin release.

There are many ways that Leptin production is unrelated to body fat as well:

  • Fasting for one to three days leads to a drop in Leptin production, even if body fat remains the same. Related to this, Leptin levels also drop as a response to starvation, encouraging hunger even when the body still has a large amount of body fat. This is actually one reason why crash diets don't work effectively. Starving yourself will eventually cause you to lose weight, but once you lose the weight, your body will not be able to effectively send signals for satiation, causing you to eat more than your body needs and experience hunger even though you are eating a healthy diet.

  • Psychological stress increases Leptin Production.

  • Leptin is affected significantly by sex hormone concentrations in the body. Testosterone is associated with reduced leptin, whereas estrogen is associated with increased leptin. Some hormones released in response to stress, including dexamethasone, also increase leptin secretion.

  • Physical training will cause leptin levels to drop for the duration of time that a person engages in a healthy exercise routine. This makes sense, because physical exercise stimulates metabolism and increases the need for calories to maintain a certain weight.

  • The more insulin that your body produces, the more leptin that your body will produce.

  • For complex reasons, obesity actually leads to an increase in Leptin production.

  • Overweight individuals with obstructive sleep apnea experience increased leptin levels, but CPAP treatment can bring leptin production back to more normalized levels. Short-term sleep deprivation can lead to a reduction in Leptin production, but long term issues with sleep deprivation, such as sleep apnea, can increase leptin concentrations.

Effects of Leptin

After Leptin is released by body fat and other cells, it suppresses hunger primarily through three mechanisms:

  • Encourages the production of α-MSH, which suppresses hunger.

  • Blocks the activity of anandamide, a hormone which encourages hunger via the same mechanism as THC present in marijuana.

  • Blocks the activity of Neuropeptide Y, a molecule released by the hypothalamus and the stomach which encourages hunger.

In spite of the fact that leptin is the hormone that we most associate with hunger, it is actually only responsible for long-term appetite control. Other hormones are responsible for short term and intermediate hunger:

  • PYY3-36 is the reason why we don't feel hungry between meals. This hormone encourages us to eat our meals during single sittings.

  • Cholecystokinin is the hormone which is produced as we eat which inhibits hunger signals. This hormone helps us know when we are full at a particular meal.

Of course, leptin does play a role in the way that these hormones function. Animal research involving leptin clearly shows how the hormone contributes to diet control, as animals which have their ability to produce leptin removed gain weight uncontrollably as a result of a loss of their ability to become full.

Caloric restriction and fasting both have an inhibitive effect upon the production of Leptin. In addition to this, the body is more reactive to the absence of food, rather than its overabundance, so Leptin production will change faster and more dramatically when the body is not getting enough food. This also means that once food access is restored, hunger response won't return to normal as quickly as it was first altered.

Changes in leptin production resulting from abrupt changes in food access appear to be correlated with changes in food intake and diet rather than the energy available that is locked in body fat. This means that leptin suppression due to hunger is not mitigated by existing body fat.

How Does Leptin Control Diet?

Leptin encourages eating and changes in metabolism by triggering receptors in the mediobasal hypothalamus. It used to be believed that blood sugar directly controlled metabolism and eating patterns, but it is clear today that leptin is the mediator of this process.

As we mentioned earlier, Neuropeptide Y activity encourages hunger. There are neurons which produce this hormone in the arcuate nucleus, and as leptin passes through the body, it binds to these neurons, preventing the release of this potent hunger hormone, promoting a disinterest in food. There is also evidence that when Leptin levels are in balance, this makes it easier to eat a healthy diet and not be tempted by the allure of calorie-dense foods.

Prior research has shown that Neuropeptide Y plays an important role in the way that animals eat, including humans. When Neuropeptide Y is artificially introduced to the brain, it automatically triggers the animal to seek out food. The opposite is also true. If the neurons which produce Neuropeptide Y are destroyed, the mice ill become disinterested in eating and become drastically underweight.

Leptin also encourages the release of a peptide known as α-MSH which promotes the feeling of satiety, and genetic abnormalities which limit α-MSH have been shown to increase hunger response and increase the risk of obesity considerably.

Melatonin Affects Leptin Production

In a vacuum, elevated melatonin leads directly to reduced production of leptin. On the other hand, if insulin is in circulation, melatonin leads to an increase in leptin production. This interaction is important because it prevents us from becoming hungry while we are asleep, which can disturb sleeping patterns.

This is why it is generally encouraged to eat a healthy dinner a few hours before bed. This way, your stomach isn't full while you are asleep, but your digestive system is still somewhat active, which means that you have insulin and melatonin in your blood stream, which encourages healthy sleep.

By the end of the night, when insulin levels drop, Leptin levels start to fall as well, as melatonin levels are still elevated. This, in combination with an increase in cortisol and other factors, helps set the stage for you to wake up refreshed and hungry.

Leptin and Diabetes

Preliminary animal research shows that combining leptin with insulin improves metabolism and stabilizes blood sugar more effectively. This combination also helped promote healthier body composition while also balancing cholesterol.

Leptin and the Cardiovascular System

Leptin has an impact on the activity of T-Cells in the immune system. Leptin promotes the health of the heart tissue and healthy leptin levels reduce the inflammatory activity which promotes atherosclerosis. There is also evidence that elevated Leptin levels can help control blood pressure if prescribed medically.

Leptin and the Reproductive System

Leptin does not play any predominant role in human fertility, but it is important and necessary to create the conditions which promote fertility. The regularity of the menstrual cycle depends upon proper metabolism, and is dependent upon the normalized flow of energy through the body, which leptin plays a part in regulating.

If a woman frequently enters a state of starvation, whether purposefully or unintentionally, the menstrual cycle will go into dormancy. Also, if a woman engages in heavy exercise, they also risk entering this state, even if they consume enough calories to meet the demands of their body. On the other hand, menstruation is only affected by low body mass in extreme cases.

In both sexes, Leptin encourages the hypothalamus to produce Gonadotropin-Releasing Hormone, the precursor to Luteinizing Hormone and Follicle-Stimulating Hormone necessary to encourage both sex hormone production as well as sperm production.

Leptin and Pregnancy

During pregnancy, leptin is produced by the placenta, and it continues to be produced in greater concentration throughout pregnancy before returning to baseline after the child is born. This is because leptin has an inhibitory effect upon contractions, allowing the child to develop within the womb. When leptin levels fall, this encourages contractions and helps to stimulate childbirth. Elevated leptin levels also contribute to the condition of morning sickness that commonly takes place during pregnancy.

Leptin and Puberty

There are two hormones which determine when an individual enters puberty: kisspeptin and leptin. In the period just before puberty, leptin levels start to rise, and once they reach a certain point, puberty is triggered. Childhood obesity can lead to early puberty, because adipose fat cells produce leptin, and cause leptin levels to reach the triggering point much faster than in children with normal levels of body fat. There is also evidence that girls that enter puberty early don't grow as tall as their peers, because the increase in estrogen production promotes the closure of the growth plates.

Leptin and Bone Mineral Density

Leptin also appears to help promote healthy bone mineral density. When the brain receives sufficient satiation signals, it then signals the bones to undergo metabolic changes which promote cortical bone growth and inhibit cancellous bone. Cancellous bone is the softer tissue in the core of the bone, and cortical bone is the hard casing which covers the cancellous bone. Thus, leptin plays a role in bone maturation during puberty because the bones become thicker and harder, allowing them to carry more weight.

After puberty, leptin still plays a role in bone metabolism, because once it activates at its receptor sites on the hypothalamus, is alters the production of a number of other hormones and peptides associated with the regulation of bone mineral density. There is also some evidence that Leptin directly contributes to increased bone mineral density by playing an intermediary role between metabolism and the release and activation of Insulin-Like Growth Factor-One. As a result of this connection, there may be treatments in the future which utilize leptin in order to enhance the natural healing processes of bone tissue after breaks and fractures.

Leptin and the Brain

Although the primary trigger point for leptin is the hypothalamus, there are also receptors for the hormone at other locations within the brain. One of the largest receptor sites outside of the hypothalamus is the hippocampus.

Research has clearly shown that Leptin Deficiency has a negative impact on the normal function of neurons as well as brain proteins. In animal studies, normal neurological function in this instance can be restored by providing injections of leptin.

In humans, Leptin Deficiency is associated with neurological and cognitive changes that are associated with HIV, depression, and anorexia. There is even evidence in rats that leptin deficiency may play a role in Alzheimer's, and that providing leptin therapy may be able to increase cognitive ability and reduce the negative effects of the disease by limiting the concentrations of hyperphosphorylated tau and b-amyloid, which are two of the main factors which make Alzheimer's such a devastating neurological disorder.

Leptin and the Immune System

Leptin is intricately related to the immune system response of inflammation, and leptin has a regulatory effect upon a number of factors which affect immune health, including body fat, caloric restriction, stress, sleep, and Testosterone levels. It is hypothesized that the primary mechanism which links Leptin to immune health is that Leptin helps control the activity of cytokines released by adipose tissue.

Leptin is actually structurally similar to cytokines both in function and its molecular composition. There is evidence that Leptin plays an active role in the way that the body handles and manages stress, but the direct mechanisms are not completely understood. There is also a positive correlation between white blood cell count and leptin levels.

Diseases Associated with High Leptin Levels

There are a number of medical conditions which are associated with abnormally high leptin levels, especially those associated with inflammation. Among these are cardiovascular disease, chronic fatigue, and hypertension.

Elevated levels of leptin are correlated with overeating, the mass of adipose fat cells, and overall body composition, but leptin is not connected in any way to physical activity. Exercise does not stimulate or suppress the production of leptin directly. For this reason, it is hypothesized that leptin is designed to activate only with regard to inflammation related to adipose fat. Leptin promotes the formation of new blood vessels, promotes inflammation, and encourages cellular metabolism.

Based on these factors, it is believed that the elevation of leptin levels due to overeating is a mechanism designed to limit the stress on fat cells caused by abrupt changes related to increased caloric intake. When the fat cells no longer have enough room to absorb all the calories being delivered, this causes the body to begin to store fat in the muscles, arteries, and organs, which is dangerous.

So in this sense, leptin triggers satiation in order to prevent the body from eating so much that the fat cells can no longer make room for it all, but obesity causes the body to produce too much of the hormone, which can have negative effects. Like other inflammatory/stress hormones, the body needs leptin, but there are serious issues which can result when the hormone is allowed to remain at abnormally high levels for too long.

References:

The Facts on Leptin: FAQ - The Truth about the Hormone Leptin and Obesity

http://www.webmd.com/diet/features/the-facts-on-leptin-faq

Serum Leptin Levels in Males with Delayed Puberty during Short-Term Pulsatile GnRH Administration.

http://www.ncbi.nlm.nih.gov/pubmed/10090130

Wikipedia: Leptin

http://en.wikipedia.org/wiki/Leptin

19 August 2014



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Stem Cell Therapy
mesenchymal stem cells: the future of rehabilitationMesenchymal Stem Cells: The Future of Rehabilitation
gh-rh alzheimers treatmentGH-RH Alzheimers Treatment
stem cell therapy nanog for immortalityStem Cell Therapy Nanog For Immortality
Vitamins and Minerals
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vitamin d the sunlight vitaminVitamin D The Sunlight Vitamin
the vitamin that isnt a vitamin and why you need itThe Vitamin That Isnt A Vitamin And Why You Need It

Resveratrol
the versatility of resveratrolThe Versatility of Resveratrol
study displays the benefits of resveratrolStudy Displays the Benefits of Resveratrol
cardiovascular benefits of resveratrolCardiovascular Benefits of Resveratrol
best sources of resveratrolBest Sources of Resveratrol
Grow Tall with HGH
are performance enhancing drugs the future of medicineAre Performance Enhancing Drugs the Future of Medicine
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short children can gain inches with growth hormoneShort children can gain inches with growth hormone

Essential Vitamins and Minerals
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the benefits of vitamin b1The Benefits Of Vitamin B1
vitamin c what are the benefitsVitamin C What Are the Benefits
vitamin e: the controversial vitaminVitamin E: The Controversial Vitamin
vitamin a: crucial for vision, necessary for healthVitamin A: Crucial for Vision Necessary for Health
Growth Hormone Therapy
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Hollywood Uses HGH
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Nutraceuticals
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restrict your calories 30% and live 30% longer?Restrict your calories 30% and live 30% longer?
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flax seed oil: longevity and anti-aging medicineFlax Seed Oil: Longevity and Anti-Aging Medicine

HGH Side Effects
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HGH Natural Sources
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hgh releasersHGH Releasers
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Body Building with HGH
a typical somatropin hgh treatmentA Typical Somatropin HGH Treatment
get motivated to exercise and increase your hgh levels naturallyGet Motivated to Exercise and Increase Your HGH Levels naturally
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exercise to increase your hgh production!Exercise to Increase your HGH Production!
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Brands of HGH
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sermorelin growth hormone releasing hormone analogSermorelin Growth Hormone Releasing Hormone Analog
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HGH Overview
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types of psoriasis treatmentTypes of Psoriasis Treatment
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my own experience with human growth hormone (case study)My Own experience with Human Growth Hormone (case study)
introduction to human growth hormoneIntroduction to Human Growth Hormone
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what is human growth hormone?What is Human Growth Hormone?
when the hgh revolution beganWhen the HGH Revolution Began
can laughter increase human growth hormone?Can laughter increase Human Growth Hormone?
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HRT Videos / TV
part 1: suzanne somers on hormone therapy for menopause, part 1 of 6Part 1: Suzanne Somers on hormone therapy for menopause
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hormones and hormone replacement therapyHormones and Hormone Replacement Therapy
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dr. hotze talks about a natural solution for depression.Dr. Hotze talks about a natural solution for depression.
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testosterone replacement therapyTestosterone Replacement Therapy
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video: truth about steroidsVideo: Truth About Steroids
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Beneficial HGH
controlling your blood pressure naturallyControlling Your Blood Pressure Naturally
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eight tricks to relieve inflammationEight Tricks to Relieve Inflammation
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a medical doctor tries human growth hormone in 1992A Medical Doctor Tries Human Growth Hormone in 1992
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my own experience with human growth hormone (case study)My Own experience with Human Growth Hormone (case study)
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hgh cell regenerationHGH Cell Regeneration
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hgh sleep: keep young and healthy with deep sleepHGH Sleep: Keep Young and Healthy With Deep Sleep
HGH Illegal/Scams
performance enhancing drugs banned from the olympics and sportsPerformance Enhancing Drugs Banned From the Olympics and Sports
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hgh spraysHGH Sprays
exercise to increase your hgh production!Exercise to Increase your HGH Production!
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buying hgh from mexico is illegalBuying HGH From Mexico is Illegal
side effects of hghSide Effects of HGH
hgh in sports todayHGH in Sports Today
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drugs banned from sportsDrugs Banned From Sports
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hgh scamsHGH Scams
hgh sprays (scam): what is a nanogram? the quantity of a nano gramHGH Sprays (Scam): What is a NanoGram? The Quantity of a Nano Gram
testing olympians hgh giving unfair advantage in sports performanceTesting Olympians HGH Giving Unfair Advantage in Sports Performance
boca raton trainer sentenced for role in prescription drug schemeBoca Raton trainer sentenced for role in prescription drug scheme
braves schafer talks about his suspension over hghBraves' Schafer talks about his suspension over HGH
hgh scams: different hgh scams and things to watch for onlineHGH Scams: Different HGH Scams and things to watch for online
hgh honesty a hallmark of indians pitcher byrds first bookHGH Honesty a hallmark of Indians Pitcher Byrds first book
hgh pills and spraysHGH Pills and Sprays
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hgh tested on chinese prisoners for chinese olympicsHGH Tested on Chinese Prisoners for Chinese Olympics

Immortality Medicine
ten ways to live ten years longerTen Ways to Live Ten Years Longer
eighteen suggestions for a longer and happier lifeEighteen Suggestions for a Longer and Happier Life
hgh decline and aging, factors for increasing hghHGH Decline and Aging Factors for increasing HGH
andropause: male menopause, its just a matter of time. try testosterone, hgh or sermorelinAndropause: Male Menopause it's just a matter of time. Try Testosterone HGH or Sermorelin
get motivated to exercise and increase your hgh levels naturallyGet Motivated to Exercise and Increase Your HGH Levels naturally
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the a4m: the future of anti-aging, hrt and longevity medicineThe A4M: The Future of Anti-Aging HRT and Longevity Medicine
cancer breakthrough as dna code crackedCancer breakthrough as DNA code cracked
a medical doctor tries human growth hormone in 1992A Medical Doctor Tries Human Growth Hormone in 1992
chemical pollution is destroying masculinityChemical Pollution Is Destroying Masculinity
what is andropause?What is Andropause?
natural hormone replacement abc news 13Natural Hormone Replacement ABC NEWS 13
introduction to human growth hormoneIntroduction to Human Growth Hormone
will human growth hormone prove to be the first anti-aging medication?Will Human Growth Hormone Prove to be the First Anti-Aging Medication?
hgh injections treating polio virus and post polio syndromeHGH injections treating Polio Virus and Post Polio Syndrome
exercise to increase your hgh production!Exercise to Increase your HGH Production!
l-carnitine: improves cognitive function in centenariansL-Carnitine: Improves Cognitive Function in Centenarians
restrict your calories 30% and live 30% longer?Restrict your calories 30% and live 30% longer?
hgh in forefront to remain youngHGH in Forefront to remain young
testosterone basicsTestosterone Basics
side effects of hghSide Effects of HGH
some of the symptoms of decreased human growth hormone Some of the Symptoms of Decreased Human Growth Hormone
anti-ageing clinics distribute human growth hormoneAnti-ageing clinics distribute human growth hormone
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growing life spans and life expectancyGrowing Life Spans and Life Expectancy
sleep and hgh go hand in handSleep and HGH go hand in hand
geneticists discover a way to extend lifespans to 800 yearsGeneticists Discover a Way to Extend Lifespans to 800 Years
theories on agingTheories on Aging
flax seed oil: longevity and anti-aging medicineFlax Seed Oil: Longevity and Anti-Aging Medicine
hgh declines with agingHGH Declines with Aging
knowing two languages can postpone dementiaKnowing two languages can postpone dementia
hgh sleep: keep young and healthy with deep sleepHGH Sleep: Keep Young and Healthy With Deep Sleep
Testosterone
testosterone overviewTestosterone Overview
clomiphene low-testosterone andropause treatmentClomiphene Low-Testosterone Andropause Treatment
low-t quizLow-T Quiz
supplementing testosterone with hcgSupplementing Testosterone with HCG
top tips for boosting testosteroneTop Tips For Boosting Testosterone
testosterone replacement therapy is safe for the heartTestosterone Replacement Therapy is Safe for the Heart
testosterone patchesTestosterone Patches
subtle effects of low-tSubtle Effects of Low-T
testosterone deficiency and erectile dysfunctionTestosterone Deficiency and Erectile Dysfunction
natural testosterone restorationNatural Testosterone Restoration
the connection between low-t and infertilityThe Connection Between Low-T and Infertility
coping and overcoming low testosteroneCoping And Overcoming Low Testosterone
chemicals and testosterone productionChemicals And Testosterone Production
testosterone and prostate healthTestosterone and Prostate Health
axiron testosterone sprayAxiron Testosterone Spray
intramuscular injection information and proceduresIntramuscular Injection Information and Procedures
testosterone deficiency beneficial to aging menTestosterone Deficiency Beneficial to Aging Men
bio-identical testosterone prescriptionsBio-Identical Testosterone Prescriptions
testosterone shows promise in treating obesity and diabetesTestosterone Shows Promise in Treating Obesity and Diabetes
japanese study shows restorative benefits of testosteroneJapanese Study Shows Restorative Benefits of Testosterone
sleep and testosterone are linkedSleep and Testosterone are linked
andropause: male menopause, its just a matter of time. try testosterone, hgh or sermorelinAndropause: Male Menopause it's just a matter of time. Try Testosterone HGH or Sermorelin
low testosterone leads to frailtyLow Testosterone Leads to Frailty
low testosterone means a higher risk of cardiac problemsLow Testosterone Means a Higher Risk of Cardiac Problems
low testosterone might mean poor sleepLow Testosterone might mean poor sleep
some general thoughts on testosteroneSome General Thoughts on Testosterone
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testosterone enanthateTestosterone Enanthate
video: truth about steroidsVideo: Truth About Steroids
testosterone propionateTestosterone Propionate
testosterone cypionateTestosterone Cypionate
low testosterone affects a third of young men with type 2 diabetesLow testosterone affects a third of young men with type 2 diabetes
reuters: high testosterone appears to keep men aliveReuters: High testosterone appears to keep men alive
testosterone levels and making moneyTestosterone Levels And Making Money
injectable testosterone, testosterone cream, aging and anti-aging benefits of trtInjectable Testosterone Testosterone Cream Aging and Anti-Aging Benefits of TRT
the testosterone factorThe Testosterone Factor

HRT Overview
preventing testicular shrinkage with hcgPreventing Testicular Shrinkage with HCG
anastrozole research studyAnastrozole Research Study
hormone replacement therapy with pellet implantsHormone Replacement Therapy with Pellet Implants
estrogen hormone replacement therapy and alzheimers diseaseEstrogen Hormone Replacement Therapy and Alzheimers Disease
estrogen hormone replacement therapy may diminish alzheimers disease riskEstrogen Hormone Replacement Therapy May Diminish Alzheimers Disease Risk
do you qualify for hrt?Do you qualify for HRT?
hgh testimonials and reviewsHGH Testimonials And Reviews
a medical doctor tries human growth hormone in 1992A Medical Doctor Tries Human Growth Hormone in 1992
natural hormone replacement abc news 13Natural Hormone Replacement ABC NEWS 13
my own experience with human growth hormone (case study)My Own experience with Human Growth Hormone (case study)
hgh is illegal if bought outside of the 50 united statesHGH is illegal if bought outside of the 50 United States
getting started with an hgh programGetting Started with an HGH Program
introduction to human growth hormoneIntroduction to Human Growth Hormone
hgh dosageHGH Dosage
how to age rapidly or notHow to age rapidly or not
dr. hotze talks about a natural solution for depression.Dr. Hotze talks about a natural solution for depression.
hrt, hormone replacement therapyHRT Hormone Replacement Therapy
will human growth hormone prove to be the first anti-aging medication?Will Human Growth Hormone Prove to be the First Anti-Aging Medication?
hgh on 60 minutesHGH on 60 Minutes
hgh injections treating polio virus and post polio syndromeHGH injections treating Polio Virus and Post Polio Syndrome
hgh igf-1 growth factor stimulates rapid extension of key motor neurons in brainHGH IGF-1 Growth Factor Stimulates Rapid Extension Of Key Motor Neurons In Brain
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study shows new method of growth hormone dosing improves heightStudy Shows New Method Of Growth Hormone Dosing Improves Height
how to lose weight with human growth hormoneHow To Lose Weight With Human Growth Hormone
video: truth about steroidsVideo: Truth About Steroids
hgh therapyHGH Therapy
testosterone basicsTestosterone Basics
anti-ageing clinics distribute human growth hormoneAnti-ageing clinics distribute human growth hormone
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Diet Science
the ideal balanced diet the reality of healthy eatingThe Ideal Balanced Diet The Reality of Healthy Eating
the role of magnesium for good healthThe Role of Magnesium for Good Health
how safe is msg?How Safe is MSG?
xylitol alternative low-calorie sweetenerXylitol Alternative Low-Calorie Sweetener
how to increase lean muscle mass and strengthHow to increase lean muscle mass and strength
insomnia guideInsomnia Guide
the importance and purpose of stressThe Importance and Purpose of Stress
alcohol appears to impact sperm qualityAlcohol Appears to Impact Sperm Quality
a pound of muscle vs a pound of fat the truth about weight lossA Pound of Muscle vs a Pound of Fat The Truth about Weight Loss
hidden sources of sugar in common foodsHidden Sources of Sugar in Common Foods
how is sleep apnea diagnosed and treatedHow Is Sleep Apnea Diagnosed and Treated
what is sleep apnea and how does it impact healthWhat is Sleep Apnea and How Does It Impact Health
twenty simple weight loss tips that can change your lifeTwenty Simple Weight Loss Tips that Can Change Your Life
consumers of processed meat put themselves at riskConsumers of Processed Meat Put Themselves At Risk
four reasons why healthy sleep encourages weight lossFour Reasons Why Healthy Sleep Encourages Weight Loss
sixteen common foods than increase cancer riskSixteen Common Foods than Increase Cancer Risk
should you consider intermittent fastingShould You Consider Intermittent Fasting
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the truth about the zone dietThe Truth About the Zone Diet
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the truth about the realage dietThe Truth About the RealAge Diet
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nine more natural ways to relieve anxietyNine More Natural Ways to Relieve Anxiety
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twelve ways to control cravingsTwelve Ways to Control Cravings
what makes vitamin c so important to health and longevity?What Makes Vitamin C So Important to Health and Longevity?
metabolism boosting tips for losing weight and feeling greatMetabolism Boosting Tips for Losing Weight and Feeling Great
poor sleeping habitsPoor Sleeping Habits
amazing health benefits of l-citrulline and watermelonAmazing Health Benefits of L-Citrulline and Watermelon
get motivated to exercise and increase your hgh levels naturallyGet Motivated to Exercise and Increase Your HGH Levels naturally
chemical pollution is destroying masculinityChemical Pollution Is Destroying Masculinity
how to age rapidly or notHow to age rapidly or not
how to lose weight with human growth hormoneHow To Lose Weight With Human Growth Hormone
anti-aging cell regeneration and longevity recommendationsAnti-Aging Cell Regeneration And Longevity Recommendations
dont eat before you sleep increase hghDon't Eat Before you Sleep Increase HGH
l-carnitine: improves cognitive function in centenariansL-Carnitine: Improves Cognitive Function in Centenarians
restrict your calories 30% and live 30% longer?Restrict your calories 30% and live 30% longer?
vitamin-d longevity vitaminVitamin-D Longevity Vitamin
whats the healthiest diet?What's the Healthiest Diet?
what is a nutraceutical?What is a Nutraceutical?
flax seed oil: longevity and anti-aging medicineFlax Seed Oil: Longevity and Anti-Aging Medicine
knowing two languages can postpone dementiaKnowing two languages can postpone dementia
mind, not matter, rules, leading thinker saysMind Not Matter Rules Leading Thinker Says
healthy living can add 14 years to your lifeHealthy Living can add 14 years to your life


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