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BREAST CANCER: SEPARATING FACT FROM FICTION


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 14 December 2016

Breast Cancer is probably the most talked-about form of cancer today. Millions upon millions of dollars are donated from regular people just like you into research that will help patients overcome breast cancer, and treatments that save lives all over the country. In spite of all the money spent on Breast Cancer Awareness, a lot of people are still woefully ill-informed about the truths of Breast Cancer, and their knowledge regarding breast cancer is largely the result of hearsay and hypotheses put forth in the past that have now become outdated. Let's talk about some of these myths now, and separate the fact from the fiction.

Fiction: Breast Cancer is Primarily Hereditary, and women are only at high risk if they have a family history of breast cancer.

Many people believe that breast cancer is for the most part a genetic condition, and that risk is carried down from parents to daughters. In reality, it is believed that only between five and ten percent of breast cancer cases are the result of genetic mutations acquired from the mother or father.

Of course, having one of these mutations can significantly increase your risk of breast cancer. For example, women that have particular BRCA mutations are eighty percent likely to experience breast cancer at some point in their lives.

Just because you have a family history doesn't mean that you are definitely going to get cancer, however. Having a daughter, sister, or mother with breast cancer, for example, doubles cancer risk. If you have two close family members with the condition, your risk increases by three times compared to average.

Out of all breast cancer cases, only around twenty to thirty percent have immediate relatives that have experienced the condition in their lives. This means that the majority of women do not experience breast cancer as a result of direct hereditary risk passed down from their relatives.

Truth: Although genetic heritage does play a role, it is not the only factor which determines breast cancer risk, and most women that get breast cancer don't express genetic predisposition.

Fiction: If someone in your family has had Breast Cancer, you will inevitably get Breast Cancer yourself.

If someone in your family has experienced Breast Cancer in the past, this is vital information that your physician needs to know. In addition to knowing that you have a history, it's also important for your physician to know how many women in your family have experienced the condition in the past. Although Breast Cancer risk increases significantly when your family has a prior history of the condition, this doesn't mean that you will definitely get breast cancer in the future.

There are ways to establish your risk, including genetic testing and counseling. One of the issues with how Breast Cancer risk is evaluated these days is that not enough women get these tests done. In fact, the percentage of women that actually receive this analysis is in the single digits! As with many other conditions, patients simply aren't open enough with their doctors, and many doctors don't readily recommend such procedures without prompting.

If your genetic evaluation says that you are at an elevated risk of Breast Cancer, this can completely change the way that your physician handles your Breast Cancer Prevention and Monitoring. For example, women at high risk benefit from earlier screening, both in the form of mammograms and MRI scanning. Breast Cancer, when caught early, has a very high rate of successful treatment, and by catching it early, it can be removed and treated before it has the chance to significantly risk your health. There are even preventative treatments available, ranging from surgery to pharmaceuticals that can be used to mitigate your breast cancer risk, dependent on your risk level.

Truth: Women with a family history shouldn't think of breast cancer as inevitable, but they should take the steps to ensure their health and safety. With proper care and screening, Breast Cancer can usually be prevented or defeated before it reaches its more dangerous stages.

Fiction: Women without a history or genetic disposition toward breast cancer have nothing they can do to mitigate their potential risk for the condition.

Some variables of Breast Cancer risk are incontrovertible. There's nothing you can do about your age, or your family history. There's nothing you can do to change when you enter puberty or reach menopause. On the other hand, there are a variety of factors that you do have the power to mitigate, and you can take an active role in your breast cancer prevention. The following are three factors to think about in particular: Activity Level, Body Composition, and Alcohol Consumption.

Activity Level - A sedentary lifestyle has been scientifically shown to increase Breast Cancer risk. Studies have shown that women that get a lot of physical activity every day have a 25% reduced breast cancer risk as compared to their counterparts that are largely sedentary. The ideal level of cardiovascular exercise in order to mitigate breast cancer risk is between 45 minutes and an hour per day, although less activity also promotes breast health. Ideally, women should undergo fairly vigorous exercise, such as swimming, cycling, or jogging. As little as 75 minutes of light cardio per week has the potential to reduce the risk of breast cancer by around 18%, however.

Body fat percentage has been strongly correlated to the risk of breast cancer in women (and men). This is even more true after Menopause. As you experience your regular periods, the ovaries are primarily responsible for the production of Estrogen, whereas adipose fat tissue produces much less. After a woman's Ovaries stop producing Estrogen at menopause, however, the body primarily relies on fat cells to produce the hormone. The amount of Estrogen that a woman produces via her body fat correlates completely with the amount of body fat she carries. Abnormally high Estrogen Levels increase breast tissue activity, which further correlates to breast cancer risk.

Alcohol Consumption - It is well documented that Alcohol suppresses Testosterone production in men by increasing the rate at which Testosterone is converted into Estrogen. Alcohol consumption also leads to an increase in breast cancer risk as well, as a result of increasing Estrogen levels in the blood stream. Specifically, each drink that a women consumes daily is associated with an increased risk of Breast Cancer of between ten and twelve percent. In addition, high levels of Alcohol consumption are also associated with other cancers such as liver, esophagus, throat, and mouth cancer.

For women that drink alcohol, the American Cancer Society suggests no more than one per day. To minimize Breast Cancer risk associated with Alcohol, it's best to not drink at all.

Truth - Lifestyle factors play a major role in cancer risk, and by improving your lifestyle, you can reduce the odds of experiencing Breast Cancer in the future.

Fiction - Injuring your breast can cause breast cancer.

Many women are under the mistaken notion that hurting one's breast can cause breast cancer. There is no evidence that bruising breast tissue can cause breast cancer. The reason that this myth first began to circulate is likely because bruising or pain in the particular area of the breast occasionally brings existing cancers to the notice of patient or physician. In these cases, the tumor has existed for awhile, but simply hasn't been noticed.

Truth - You can't get cancer from breast bruises.

Fiction - Breast Cancer is a disease which only occurs to women.

In reality, both sexes can get breast cancer. The reason why so many people think that men can't get breast cancer is because it is far more rare than female breast cancer. In fact, women get breast cancer at a rate which is a hundred times that of their male counterpart. On average, only around 2,200 men in the United States get breast cancer, whereas 230,000 women experience the disease. The mortality rates differ similarly: 400 males die each year from the condition, whereas 40,000 women die from breast cancer.

That men are not made aware of male breast cancer can be to the detriment of their health. Because they don't understand that men can get breast cancer, they frequently recognize the lumps, but simply ignore them until they become impossible to ignore, a point at which the danger of the cancer has grown dramatically and the outlook becomes far more grim.

Women have a higher incidence of breast cancer for a couple of important reasons. First, most cancers respond to progesterone and/or estrogen, feeding off of the hormones to grow. Since men don't produce nearly as much, their risk is significantly lower. Also, men have fewer breast cells than women, meaning that there are fewer possible cells to malfunction.

Truth - Although men experience breast cancer at a much lower rate, they should still see their doctor if they sense any breast tissue abnormalities.

Fiction - The ideal way to catch breast cancer is with monthly self-exams

Not too long ago, it was recommended that women give themselves monthly evaluations to check for breast lumps and other abnormalities, but this is no longer the recommended protocol of the American Cancer Society. They discovered that these examinations increased the rate of false positives while also not being all too effective at discovering real cancer. Instead, the current suggestion is simply to have knowledge of one's body, and be aware of any abnormal changes take place. The majority of women discover Breast Cancer during their normal routine, and an emphasis on awareness during routine appears to provide the best detection results.

Of course, women that are still interested in performing these monthly exams still may do so if they wish, but it is important that they learn how to perform the exams with maximum accuracy, as taught by their physician, if they wish to perform the self-exam in an optimal fashion.

If a woman feels a lump or recognizes any breast abnormalities, it is vital to talk to one's physician as soon as possible. Even if you have recently had a mammogram performed, it's still possible that the exam missed a potential cancer. It's important to not only engage in self-examination, but also to undergo Mammogram, because often, Breast Cancer tumors can be recognized before they are felt, and the earlier that Breast Cancer is treated, the more likely it can be safely removed and treated completely.

Truth - There's nothing wrong with monthly breast exams, but regular, breast awareness is more than sufficient to recognize potential breast cancer.

Fiction - Finding lumps is the only indication of Breast Cancer

All women understand that breast cancer can lead to tumors, which are referred to as lumps, but many women are unaware of other symptoms which are indicative of Breast Cancer which can be recognized, other than lumps. For example, unnatural breast discharge, scaliness and redness of the breast or nipple, pain and extreme sensitivity, dimpling, and irritation can all be signs of Breast Cancer. Some women may even experience an inversion of the nipple.

In fact, one rare but particularly dangerous type of breast cancer, known as Inflammatory Breast Cancer, is characterized by swelling, thickened skin, and redness, rather than lumps. Never assume that changes in breast health are benign or simply caused by infection. Visit a physician as soon as you can.

Truth - Lumps are the most commonly recognized symptom, but different cancers have different symptoms, and you should always take the proper precautions and make an appointment with a medical professional at the first sign of breast trouble.

Fiction - Mammograms Are Barely Worth the Time

Some women, unfortunately, have lost their faith in the effectiveness of the mammogram. In reality, mammograms are quite effective at recognizing breast cancer, with a success rate of between 80% and 90%. There's no data which can accurately reflect how Mammograms mitigate mortality risk, but there is near universal agreement that Mammograms save women's live on a regular basis. The general consensus is that when women turn forty, they should start getting yearly Mammograms.

Truth - Mammograms are an effective means to monitor for breast cancer.

Fiction - Deodorants Can Cause Breast Cancer

There are websites and emails which claim that Deodorants and Antiperspirants have the ability to cause breast cancer, by inhibiting immune function by blocking the lymph nodes. By inhibiting immune function, they supposedly increase toxin concentrations in the breast tissue There is next to no evidence that suggests that this is even a possibility.

One major study surveyed whether women with and without breast cancer used deodorant, in an attempt to see if there was any correlation with the use of such products and breast cancer. No significant connection was found. Shaving also had no notable impact on breast cancer rate.

Truth - Antiperspirants have absolutely zero noted connection with Breast Cancer.


SIX QUESTIONS YOU SHOULD ASK YOURSELF BEFORE YOUR TRIP TO THE DOCTOR


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 26 December 2017

Six Questions You Should Ask Yourself Before Your Trip to the Doctor

We all know how frustrating it can be to feel unwell and not understand why. Sometimes it can even be difficult for your doctor to help. Your physician is obviously very smart, that's how he got through med school, of coursebut he or she doesn't know everything, or may not be able to diagnose your condition effectively without some help from you. Getting the help that you need from your doctor is a group project, whether you realize it or not. In order to get the best possible care, you need to come to your doctor armed with knowledge, and able to describe to your physician what problems that you are dealing with as completely as possible.

In this article, we are going to discuss some underlying issues which may be impacting your health and wellness without you fully realizing it. By understanding more about your body and what affects you negatively, you will improve your doctor's ability to give you accurate treatment, or test for chronic conditions which may be suppressing your otherwise good health.

Most doctors focus on a particular set of questions when they assess your health, whether it is during a physical, or other assessment of your health. They will discuss your activity level, and your diet. They will ask you how much water you drink. They will also ask likely ask if you experience feelings of stress and anxiety. Because there are so many questions to ask, there's no doubt that your doctor will skip over some questions which could seriously benefit you. The following are six questions that you should ask yourself before you go to the doctor, and if you find any of the answers unsatisfying, you should discuss them with your doctor. Most patients that suffer from chronic illness will have issues related to their answers to a few of these questions.

Am I Suffering from Digestive Issues?

Most people don't think about it, or even look at it, but your poop says a lot about what your body is going through, and whether your body is effectively taking in nutrients through your diet. Each cell within your body thrives as a result of the calories and nutrients that you intake. For better or worse, you are completely composed of the nutrients that you take into your diet.

Sometimes it isn't enough for you just to eat well, however. Sometimes, the body has issues taking in nutrients effectively because of issues related directly to how your body is digesting food, or how your stomach and intestines are absorbing nutrients. There are many symptoms that are associated with poor digestive health, including bloating, gas, cramping, diarrhea, and constipation.

It may sound a little weird, but taking the time to look to your poop after you go number two can go a long way in helping you (and your doctor) understand your digestive health. And because your food is what makes you, your digestive health can provide insight into your overall health and wellness.

There are many examples of health issues which can impact your digestive health. The following is a list of some of the more common causes:

  • Chronic Stress

  • Poor Diet

  • Food Sensitivity

  • Suppressed Digestive Enzymes

  • Poor Bacteria Balance

  • Parasites

For patients that are having issues with digestive health, this is one of the most important things to fix as soon as possible, because most digestive problems can be easily treated, and provide significant benefits to the patient.

Am I Eating the Wrong Foods?

Another important part of good nutrition is eating a good diet. Your doctor will likely talk to you about dieting with regard to your weight, but is less likely to get into the specifics of your diet. There are many food sensitivities that people suffer from without even realizing it that can negatively impact health. Some of the more common allergies and sensitivities include nuts, eggs, corn, soy, and dairy. Many people also suffer from gluten allergy which is also a reaction to wheat products.

Often, it's difficult to find the root cause of your food problems. This is because it can take as long as a few days for foods you eat to cause problems, and by then, it's difficult to link the cause to the effect. Also, symptoms may lead to digestive problems, but frequently, the issues can be fatigue or other problems not directly related to noticeable digestive problems. These foods may also lead to widespread or acute inflammation, limiting the optimal function of your kidneys or liver, or slowing down your healing processes.

Food sensitivities are a known health issue, but there isn't a whole lot of implementation because the science is still relatively new. The best way to assess how your diet affects your health is through a combination of selectively eliminating foods from your diet and having your blood tested for specific allergic sensitivities.

How Well Do I Sleep?

Everyone understands that sleep is important, but most people don't understand exactly why. Most of your body's rejuvenative processes are functioning at their peak while you are asleep. If you aren't sleeping well, then you are going to have issues not only with fatigue, but with your body's ability to maintain itself. Human Growth Hormone is one of the mechanisms by which the body promotes healing, and this hormone is produced in its greatest quantities during deep sleep. If you don't sleep steadily through the night, or you toss and turn, this inhibits your healing processes, as well as your memory and cognitive function.

When you don't sleep well, this also leads you to take shortcuts throughout the day in order to keep yourself awake and active. Many people rely heavily on sugar and caffeine, which can both cause issues when used in excess. Too much caffeine can lead to anxiety and jitters and make it even harder to fall asleep.

By talking to a doctor about your sleeping habits, you may be able to uncover what issues are preventing you from sleeping well. Perhaps it could be chronic anxiety or even sleep apnea.

Am I Being Exposed to Chemicals in My Home or at Work?

Our bodies have some mechanisms to get rid of many toxins, but if we are exposed to too much, this can be a serious health hazard. There are many ways that you can be exposed to toxins. Not too long ago, lead was widely used in a variety of products, before we realized exactly how dangerous lead was. There are still products like that. We may not be exposed to them as heavily and they may not be as potently toxic, but they still can lead to issues. For example, there are many forms of plastic which are not designed to be exposed to hot water, like that in a dishwasher, and leech toxic chemicals without you even realizing it.

Also, your makeup or even your soap or shampoo may contain ingredients which irritate your skin and cause adverse reactions which impact your health. The human body can metabolize or otherwise get rid of certain levels of most toxins, but if you are overexposed, this can inhibit your body's healing processes. There are many products that put men at risk in particular. These are known as Endocrine Disrupting Chemicals, and they have the ability to disrupt the body's Testosterone Levels, which can suppress health and vitality.

Of course, other EDCs can stimulate high levels of cortisol or imbalance hormones in other ways. Many people are also very sensitive to molds. If you have been feeling chronically under the weather lately it may pay to give your house a thorough cleaning and look for ways to reduce your exposure to potentially harmful chemicals.

Do I Have a Healthy Level of Self-Esteem?

Psychological health and physical health are intricately related. If you aren't feeling good about yourself, this can have a devastating effect upon your health and wellness. People that are down on themselves are less likely to take care of themselves, and more likely to feel stress and sadness which prevent them both from living up to their potential and being optimally healthy.

Studies have clearly shown that people with positive attitudes and positive self-worth are more likely to live longer than their pessimistic and self-defeating peers. A big aspect of negative thinking is that you make yourself feel inferior and not up to the task of living your life. As a result, you have a tendency to stress out about things way more than you should, preventing the stress from allowing you to live your life. Stress is a physiological response, largely mediated by the release of cortisol. Cortisol and other adrenal hormones activate what is known as the Fight-or-Flight Response.

Stress is designed to be a short term change of physiological priorities designed to help you overcome high pressure situations, but when you feel long term stress, you overload yourself and your body's protective and rehabilitative processes go into decline.

Take stock of your life. If you experience any of the following characteristics in excess, then you need to take steps to reevaluate yourself and your life to accentuate the positive:

  • Self-Deprivation

  • Addiction

  • Chronic Tendency to Sell Yourself Short

  • Perfectionism

  • Beating Yourself Up Over Mistakes

  • Hanging on to Bad Memories

If you have severe issues with the characteristics above, you would likely benefit from therapy. There are clinical ways to overcome mood disorders, depression, and chronic anxiety, whether they be through therapeutic means, medication, or a combination of both.

How is My Social Life?

Whether you are an introvert or an extrovert, human beings thrive when they make meaningful relationships with others. If you are not fostering close relationships with those around you, you are putting both your psychological and your physical health at risk. People with close friends are more likely to live longer and be happier for a number of reasons. They tend to be less stressed because they have someone to talk to. If they are having trouble and need help, they have someone to reach out to. People with friends simply have more protection from the forces in the world which attempt to break them down.

That doesn't mean that all relationships are healthy, however. A bad relationship with someone you are very close to can be absolutely destructive. If you have a boyfriend or girlfriend, it's important to understand what makes a healthy relationship and understanding when its time to work to make things better and when it's time to cut your losses and run. If you are in a rough marriage, it may be time for counseling. Sometimes people simply surround themselves with the wrong friends. Perhaps they are good and loyal, but they have a tendency to get you into bad or severely unhealthy situations. If you have trouble with drinking, for example, hanging out with your drinking buddies all the time is obviously going to be bad for your health.

Take the time to take stock of your relationships with those around you. Try to take steps to improve your relationships with those that you want to keep and work on maintaining more distance or being more honest with those that put you in an unhealthy place. By making the concerted effort to surround yourself with nurturing people, or people that can promote good in your life, you will be healthier and happier in the long run.

In Order to Stay Healthy, It's Important to Keep Your Whole Being in Mind

The human body is incredibly complex, which is exactly why you need to work with your doctor to get the best treatment and/or health advice possible. He or she can only do so much without your input, but with just a few questions or comments from you, you could totally change and improve the quality of your healthcare.

It's not necessarily your doctor's intention, but he or she is primarily interested in treating the symptoms of the conditions which you are experiencing, but may not be able to figure out the root cause of your chronic problems without help from you. Being and staying healthy is both physical and mental. In order to optimize your health and wellness, you must take steps to improve your quality of life in addition to your simple physical state. By living a conscientious lifestyle, you can live a longer and happier life.

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CLOMIPHENE CITRATE INFORMATION AND GUIDE


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 07 August 2014

Clomiphene Information Guide

What is Clomiphene?

Clomiphene is a synthetic medication which has the ability to imitate the function of hormones produced by the human body known as Selective Estrogen Receptor Modulators (SERMs). In short, Clomiphene impacts the way that the hypothalamus registers Estrogen, in order to encourage the body to produce hormones related to ovulation in women and the production of Testosterone and sperm in men. There are three forms of Clomiphene available in the pharmaceutical market: Omifin, Clomid, and Androxal. Clomiphene is also available in generic form.

In the United States, the drug is named Clomiphene, but based on international standards, it is named Clomifene. This drug is taken orally, and, dependent upon the formulation, is a light yellow or white tablet.

Clomiphene and Female Fertility

Clomiphene was first used as a fertility treatment for women. There are two forms of infertility for which Clomiphene has proven exceptionally useful—oligoovulation and anovulation.

What is Oligoovulation?

Oligoovulation refers to ovulation which occurs irregularly or infrequently during the menstrual cycle. Under normal circumstances, women ovulate about two weeks into their menstrual cycle, but certain circumstances can get this release off track. In some cases, women only ovulate around once every fifty days or more, and under other circumstances, ovulation can simply occur at the wrong time of the cycle.

As a result of this irregularity, it is difficult for women to know exactly when conception is most possible. Clomiphene can help regulate this process, making ovulation occur more regularly and predictably.

What is Anovulation?

Anovulation is a condition in which the menstrual cycle occurs, but ovulation does not happen, which prevents the possibility of conception. Clomiphene is often used to encourage ovulation to take place in a normal fashion.

Clomiphene for General Infertility

There are strong clinical results for the use of Clomiphene for these purposes, but for fertility without known causes, the body of evidence is incomplete with regard to the effectiveness of Clomiphene Fertility Treatment.

However, there is evidence that Clomiphene can boost fertility in patients with unknown causes of infertility. Clinical studies have varied with regard to Clomiphene for this purpose. Under these circumstances, Clomiphene is shown to increase fertility to around a 5.6% chance of conception per menstrual cycle, an increase in fertility of 1.4%-4.3% dependent upon the study.

Clomiphene for Multi-Modal Fertility Treatment

Clomiphene Citrate is often combined with other forms of fertility treatment in order to further increase the odds of conception.

How is Clomiphene Prescribed for Women?

Generally, for female fertility treatment, Clomiphene Therapy begins at fifty milligrams per day for five days, beginning in the third, fourth, or fifth day of the menstrual cycle. In doing so, it encourages ovulation at a normalized and stable point of the menstrual cycle. In the week prior to ovulation, which will occur between the 15th and 18th day of the cycle, the couple should copulate frequently in order to optimize the chance of fertility success.

In many cases of feminine infertility, the physician will perform tests to monitor for the surge in Luteinizing Hormone which encourages ovulation and is spurred by Clomiphene, and these tests generally take place beginning on the day that the fifth dose of Clomiphene is taken, and are administered daily until ovulation occurs, as shown by affirmative Luteinizing Hormone Testing. If ovulation does not occur by the 18th day, the fertility doctor may force ovulation through a 10,000 IU dose of Human Chorionic Gonadotropin, if there is a follicle of sufficient size for implantation.

Interestingly enough, HCG triggering is not as effective at inducing pregnancy as monitoring and waiting for the natural release of Luteinizing Hormone.

How Is Ovulation Monitored?

There are a number of ways to keep track of cycling induced by Clomiphene Citrate:

  • Vaginal Ultrasound – Using ultrasound, it is possible to monitor the development of Ovarian Follicles necessary for implantation and which form preceding the release of the egg. Evidence of ovulation can also be obtained via ultrasound.

  • Luteinizing Hormone Testing – Luteinizing Hormone Levels increase in the days preceding ovulation, or are artificially increased to induce ovulation.

  • Estradiol Levels – These levels are generally tested four to six days after the last Clomiphene Dose, and can also provide evidence of impending ovulation.

  • Progesterone Levels – Between seven and nine days past ovulation, Progesterone Levels should be a minimum of ten nanograms per milliliter for optimal chances of fertilization.

  • Testing for Active Sperm – Tests can be conducted in the days preceding ovulation to make sure there is sufficient active sperm present for a reasonable chance at successful conception.

  • By Inducing Consecutive Menstrual Cycles – By administering the Clomiphene monthly, this further encourages a healthy and normal menstrual cycle. Clomiphene treatment can be administered five of every thirty days, to produce a stable pattern. If ovulation does not occur in a cycle, the dose of Clomiphene administered is often increased by fifty milligrams per cycle over the course of six months. When used as a fertility treatment, Clomiphene is only recommended as a six month maximum course of treatment.

Side-Effects of Clomiphene for Female Fertility

Most women experience no significant side-effects resulting from Clomiphene Citrate Fertility Treatment. The most reported side-effect of Clomiphene is an enlargement of the ovaries. This occurs in less than ten percent of patients treated, and is completely reversible.

All other side effects occur in less than ten percent of patients. The most common among these side effects are:

  • Abdominal Discomfort

  • Abnormal Bleeding from the Uterus

  • Hot Flashes

  • Headaches

  • Temporary Changes in Vision, including Scotoma (blind spots), Photophobia (light sensitivity), Floaters, Diplopia (double vision), and Blurred Vision

A very small percentage of patients, less than one percent, experience the following symptoms:

  • Ovarian Hyperstimulation

  • Reversible Hair Loss (Alopecia)

  • Hepatitis

  • Hypertriglyceridemia (elevated triglyceride levels)

Like many other forms of fertilization treatment, Clomiphene increases the likelihood of triplets and twins resulting from the release of multiple eggs (ten percent of patients that conceive using Clomiphene have twins).

Potential Long Term Risks of Clomiphene Therapy for Women

There is limited research that provides inconclusive evidence that the use of clomiphene for more than twelve months can elevate the risk of Ovarian Cancer. It may be that long term use of Clomiphene only impacts patients that don't become pregnant over the course of a year, which is why the therapy is generally only recommended for six months for women.

There have been no studies that have reproduced these risks, so there are many that believe that Ovarian Cancer risk is not affected by Clomiphene.

Clomiphene Does Not Lead to Neonatal Complications

There are no signs that suggest that Clomiphene increases the risk of Genetic Abnormalities as compared to the normal process of conception. Clomiphene also does not lead to increased risk of spontaneous abortion.

How Does Clomiphene Work?

Clomiphene works by reducing the ability of Estrogen to activate receptor-sites on the Hypothalamus. When the Hypothalamus receives stimulus from circulating Estrogen, it reduces signals from the production of Luteinizing Hormone by the Pituitary Gland. There is a similar pharmaceutical, known as Zuclomifine that acts in the same manner, but for a long a longer period of time. Although Clomiphene affects the release of steroid hormones, Clomiphene is not itself a steroid.

How Do Normal Women Reach Ovulation?

When women experience normal menstrual cycles, Progesterone and Estrogen Levels increase significantly, as released by the Corpus Luteum. This inhibits the production of Luteinizing Hormone, Follicle-Stimulating Hormone, and Gonadotropin-Releasing Hormone from the anterior pituitary and the Hypothalamus.

It is during this period where fertilization occurs, and if the body doesn't experience fertilization in the days after ovulation takes place, the Corpus Luteum breaks down because it does not receive Human Chorionic Gonadotropin signaling. HCG is released after fertilization to encourage stable Estrogen and Progesterone levels.

When used as a fertility treatment, Clomiphene is administered orally in the early stage of the menstrual cycle. During this period, levels of Follicle Stimulating Hormone increase quickly, which leads to the production of follicles in the uterus. The follicles then produce Estrogen which circulates through the blood stream. Clomiphene increases the production of Follicle Stimulating Hormone by reducing the negative feedback mechanism caused by Estrogen upon the receptors on the Hypothalamus, causing the Hypothalamus to produce quick pulses of Gonadotropin-Releasing Hormone.

As Follicle-Stimulating Hormone Levels increase, this causes the ovaries to produce more follicles, which spurs ovulation as they rupture. When using Clomiphene, ovulation generally occurs six or seven days after the last dose of Clomiphene is taken.

Clomiphene Chemistry

Clomiphene is a combination of two isomers of the same compound, Zuclomiphene and Enclomiphene. These are the active ingredients, which both have the capability of encouraging the production of Estrogen while also inhibiting the activity of negative feedback mechanisms which discourage the production of Estrogen by the female body.

In men, Clomiphene encourages the production of Testosterone by inhibiting negative feedback mechanisms, because the precursor hormones which lead to the production of Estrogen in females lead to the production of Testosterone in males.

Clomiphene Off-Label Uses

Clomiphene has proven to be highly effective for males that are experiencing Andropause, or other forms of primary hypogonadism which slow down the production of Gonadotropin-Releasing Hormone, Luteinizing Hormone, and Follicle-Stimulating Hormone.

As a result of its high effectiveness and lower incidence of side-effects, many patients and physicians prefer Clomiphene to Bio-Identical Testosterone for many patients suffering from Low-T. This is primarily because Clomiphene is cheaper than Testosterone while also being easier to administer, since it is taken orally.

Another reason why many patients prefer Clomiphene is because Clomiphene Testosterone Restoration sustains fertility during treatment while also preserving the normal form and function of the testes. With Bio-Identical Testosterone Therapy, the testes slowly lose their ability to produce sufficient levels of sperm for fertility, although this can be prevented by combining HCG Injections with Testosterone to maintain the body's production of Luteinizing Hormone, necessary for natural Testosterone and Sperm Production.

It is important to note, however, that Clomiphene has not been approved by the FDA for male use. This is not because of any inherent issue with the therapy, but because there is no profit motive for pharmaceutical companies to lobby the FDA for approval, because Clomiphene is available in generic form, and most patients use Bio-Identical Testosterone in spite of its disadvantages, as a result of a number of factors, including branding distribution. Enclomiphene, one of the two isomers that comprise Clomiphene, is in the process of clinical testing for male patients, and is also known as Androxal.fffff

Use of Clomiphene as a Performance Enhancing Drug

Clomiphene is often used by men that abuse Testosterone in order to counteract the effects of the conversion of Testosterone into Estrogen. Steroid and Testosterone Abuse is generally conducted in cycles which last months, in which the user takes breaks to help encourage normal physiological function. Clomiphene is generally used between cycles in order to prevent gynecomastia and other side-effects of Steroid Abuse. This also simultaneously encourages the male body to produce its own Testosterone more quickly after a cycle.

Because of these uses, Clomiphene is included among Testosterone, Human Growth Hormone, and many other drugs on the list of banned PEDs in various international athletic leagues and competitions.

The History of Clomiphene

Clomiphene was first used in the 1960s as a medical treatment. At first it was used for women suffering from abnormal ovulation, and was later approved for use for women that had trouble ovulating at all.

In 1989, Clomiphene was also approved as a method to ascertain fertility in female patients. It was discovered that women that were capable of pregnancy would gain Bone Mineral Density via their use of the drug, while women that were unable to conceive and bear children would not experience this change in bone mass.

How to Buy Prescription Clomiphene

If you are interested in finding Clomiphene online, we can help. We have a staff of qualified clinical professionals and we can help you discover if you may be a candidate for treatment!


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