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HOME > GROWTH HORMONE THERAPY > MACIMORELIN A NEW DIAGNOSTIC TOOL FOR DIAGNOSING ADULT GROWTH HORMONE DEFICIENCY



MACIMORELIN A NEW DIAGNOSTIC TOOL FOR DIAGNOSING ADULT GROWTH HORMONE DEFICIENCY


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 22 July 2021

Adult growth hormone deficiency is not the easiest condition to test for and diagnose accurately. Doctors cannot just take a blood sample and see how much growth hormone is in your blood because growth hormone is released in pulses throughout the day. Thus, the concentration in the blood stream will vary widely over the course of 24 hours. In addition, other symptoms need to be taken into consideration, such as decreased muscle mass and chronic fatigue.

Doctors will take a blood sample and test for the concentration of insulin-like growth factor-1 (IGF-1) which is a protein that is produced via growth hormone stimulation by the liver and other tissues. In addition, doctors would diagnose adult-onset growth hormone deficiency via an insulin tolerance test (IST) or glucagon stimulation test (GST). These tests involve the use of a needle, which many people are not fans of, and thankfully, there is a new diagnostic test available that involves ZERO needles. The new product is Macrilen (macimorelin acetate), developed by Aeterna Zentaris, and is taken orally in order to make administration of the drug easier for patients and providers, alike.

Macimorelin Acetate: Oral Formulation for Ease of Diagnosis

In 2017, macimorelin acetate was approved by the Food and Drug Administration as a method of diagnosing growth hormone deficiency. Technically, macimorelin acetate is a synthetic growth hormone secretagogue receptor agonist. The acetate salt causes the release of growth hormone from the pituitary gland. Chemically, macimorelin acetate is known as: D-Tryptophanamide, 2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]-acetate. Good luck wrapping your head around that and prayers to the scientists who study and work with this stuff!

As stated previously, the diagnosis of adult-onset growth hormone deficiency can be challenging and it needs to be confirmed with a growth hormone stimulation test (GHST). This test, GHST, is labor intensive and can cause severe hypoglycemia. Because of this, the test itself is not recommended for many patients. Macimorelin acetate seems to be a much better form of testing because it is an orally active growth hormone secretagogue and once taken, the stimulated growth hormone levels can then be tested via a blood test afterwards. Simple as that!

How to Take Macimorelin for Adult-Onset Growth Hormone Diagnosis

In order to take macimorelin acetate to find out whether you are suffering from adult-onset growth hormone deficiency, you first need to get the go-ahead from your doctor. He or she needs to know whether you have ever had a hormone, thyroid or hypothalamus disorder before, and whether or not you are pregnant or breastfeeding.

One week before your growth hormone test, stop taking any growth hormone medication, if you are currently taking anything. Macimorelin acetate oral administration requires a fasting period of 8 hours prior to the test, with no food or drink except water.

Only one dose of macimorelin acetate is given and it will be mixed in with a drink that you must consume within 30 seconds. Your blood will then be drawn at 30 minutes, 45 minutes, 60 minutes and 90 minutes later.

Side Effects of Macimorelin

The side effects of taking macimorelin acetate are minimal. However, there is always the risk of an allergic reaction. Tell your doctor immediately if you experience hives, swelling of the face, lips, tongue or throat and/or you have difficulty breathing.

Other serious side effects include and should be reported right away: light-headedness, slow heartbeats, shortness of breath or fast/pounding heartbeats in conjunction with dizziness like you might pass out.

Common side effects include:

  • headache; dizziness
  • nausea, hunger, diarrhea
  • increased sweating/feeling hot
  • feeling tired
  • changes in sense of taste
  • symptoms that are similar to a cold: stuffy nose, sore throat, sinus pain

A Simple Diagnostic Tool Available Now

Despite the possible, but rare side effects, macimorelin acetate is a simple and effective way to diagnose adult-onset growth hormone deficiency. In addition, you are super safe because youll be in the doctors office for a long time after the dose is taken in order to take blood tests. You can report any adverse side effects to the doctor right away and get treated right away.

The treatment of adult-onset growth hormone deficiency is fairly straight-forward and simple, especially when overseen by a qualified hormone specialist or endocrinologist. And now, the diagnosis of the condition is easier than ever before!

Typically, growth hormone deficiency is treated with growth hormone injections or sermorelin acetate injections. The patient can choose which treatment is best for them based on personal preference, finances, safety concerns, etc.

Hormone Imbalance is Simple to Treat Once Diagnosed

The occurrence of adult-onset growth hormone deficiency is on the rise, especially in the United States. This is due to the fact that as we age, its much easier for our hormones to become imbalanced and certain lifestyle factors certainly play a role in this. If you havent been taking care of your health properly over the last 30-60 years or so, you may be paying the price now with hormone imbalance, including adult-onset growth hormone deficiency.

The only way to know for sure is to get tested. See if those annoying symptoms such as increased belly fat, low libido, chronic fatigue and/or low muscle mass are due to hormone imbalance. Contact our clinic to get tested as soon as possible! Give us a call today! We will answer any questions you might have about macimorelin acetate as a diagnosis tool and hormone replacement therapy (HRT) in general.


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