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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 09 October 2018

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Human Growth Hormone May Improve Physical Therapy Outcomes in the Elderly

Human Growth Hormone Replacement Therapy has been shown to both increase Bone Mineral Density and Increase Lean Muscle in elderly patients. New evidence shows that HGH Hormone Replacement may offer another benefit: Increased healing capacity.

Dr. Robert Costa, professor of molecular genetics and biochemistry at the University of Illinois at Chicago, says that he and his staff have discovered that Human Growth Hormone has the ability to switch on a gene that is responsible for tissue to regenerate and heal more quickly. This function of HGH may help to explain one critical factor of the aging process: The older that we get, the harder that it is to recover from injury or tissue damage.

Aging is the Result of Ongoing Physical Breakdown

It is believed that one of the ways that the body physiologically ages is through a slow process of degradation, resulting from the body's reduced ability to heal efficiently. HGH Levels appear to have a distinct correlation with the speed at which our bodies can heal. Dr. Costa explains that the gene Foxm1b plays a critical role in the human body's ability to undergo repair. Foxm1b is turned on directly by Human Growth Hormone secretion, and as the body releases less HGH, Foxm1b loses its ability to efficiently restore tissue to a healthy state after damage or injury.

HGH Study in Hepatology

The study in which Dr. Costa participated in was released in the medical journal Hepatology. Although this study was conducted with animals, there is sufficient evidence to extrapolate the results of this animal research to human patients. Dr. Costa's study revolved around liver regeneration in both young and aging mice. The study compared two month old mice with twelve month old mice in regard to their capacity to recover from tissue damage in the liver.

The reason why the liver was chosen for this study is because of a particular unique trait: The liver can completely restore itself simply from a collection of mature liver cells. No other organ in the human body can completely rebuild itself with such a sparse set of resources.

The Importance of Foxm1b

Foxm1b is an important gene which plays a role in every aspect of the development of all mammalian cells. Foxm1b is active within all cells upon cell division, throughout the development of the cell, and until the cell finally surrenders to apoptosis at the end of its life cycle. Early in life, the Foxm1b gene is highly active, but as mammals age, the gene becomes less and less responsive.

Foxm1B Activation Heals Organs

In earlier research, scientists added the human form of Foxm1b into aging mice with livers which had been partially destroyed. Humans and mice have Foxm1b genes that are functionally identical, and serve nearly the exact same set of purposes within the body. Researchers found that adding the Foxm1b gene to damaged livers increased the speed at which the liver recovered from damage. The rate at which recovery occurred was similar to that of younger mice.

Upon further analysis, the study also showed exactly how the Foxm1b regulates the health and function of cells throughout the lifespan, encouraging them to undergo the process of cellular division more efficiently and more quickly.

The Correlation between HGH Exposure and Foxm1b Activation

In this study, the goal was to test the effect of HGH upon the rate at which cell division occurs in aging organisms. The previous study already made it clear that activated Foxm1b has the ability to increase regenerative capacity, and researchers hypothesized that Human Growth Hormone may have the capability to activate dormant Foxm1b cells, thus encouraging increased healing capacity later in the aging process.

What is the Role of HGH?

Human Growth Hormone is one of the most important hormones which regulate health and function throughout the lifespan. Earlier in life, HGH is recognized primarily for its ability to spur growth and adolescent development, but later in life, the role of Growth Hormone is primarily to maintain optimal health balance and regulate cellular metabolism.

As the aging process continues, the body is less able to self-regulate and repair itself, and this is believed to be at least partially the result of declining levels of Human Growth Hormone released by the Human Pituitary.

HGH Makes Cells Regenerate More Quickly

Dr. Costa says that there is evidence in the body of endocrinological research that HGH Hormone Replacement Therapy likely has the capacity to increase rates of cellular regeneration in aging patients. This is one of the primary reasons why changes in physical composition occur as a result of HGH Injections.

Increased cellular metabolism leads to increased lean muscle mass, increased bone mineral density, and stronger skin, because the body is repairing and replacing dying cells quickly and more effectively. Dr. Costa claims that the ultimate goal of his study is to discover how Human Growth Hormone functions at the molecular level, in order to uncover new medical purposes for HGH Replacement Therapy.

Foxm1b HGH Study Results

The results of the study were fairly dramatic. When the year old mice were administered HGH Injection, multiple tests showed that Foxm1b drastically increased in activity. In addition to this, other proteins and enzymes responsible for the process of cell division also became more active as well. At the organ level, the mice experienced physiological regeneration as a result of Human Growth Hormone Stimulation.

The damaged livers repaired more quickly as a result of treatment, healing at a rate which was comparable to that of healthy, youthful mice. The rate of efficiency of cellular division reached its peak after only 2 short days, and the liver was completely rehabilitated after only a single week. As opposed to aging mice in the experimental group, control mice which were not administered HGH did not experience total regeneration until at least one month after the damage occurred.

This means that, in the case of mice, HGH Hormone Replacement has the capacity to increase the rate at which liver rehabilitation takes place by over 400%. Of course, mice have metabolic processes which are much faster than our own (and thus, live shorter lifespans), but this study is proof of concept. Human Growth Hormone HRT can, and likely does, have the capacity to increase rate of healing in aging patients.

In mice that did not receive supplemental HGH, the Foxm1b gene stayed relatively dormant, limiting the rate at which cellular regeneration could take place. Without the rapid increase in cell regeneration spurred by Human Growth Hormone, the liver could only repair itself at a slow and limited pace.

Foxm1B Deactivation Blunts the Effect of HGH

Further testing examined the function of HGH upon Foxm1b activation from the opposite perspective. In a second group of mice, the rodents were genetically altered so that their livers contained Foxm1b genes that were totally inactivated. In this second experiment, mice acted physiologically according to Dr. Costa's hypothesis. When the Foxm1b gene is inactivated, it prevents HGH injections from having any appreciable effect upon cellular metabolism and physiological recovery.

Dr. Costa explains that the results of the research conducted by his academic team show that Foxm1b is a necessary ingredient which is required to encourage the regeneration of the liver after damage occurs. There is also strong reason to believe that Human Growth Hormone Replacement Therapy has the capability to increase the rate of physiological response in other tissues throughout the body as well.

Future Research will Improve our Knowledge of Foxm1b

Although Dr. Costa finds the results of his study promising, he still urges caution regarding the use of Human Growth Hormone Replacement Therapy. He explains that his study only explores the short term benefits of HGH Injection, but does not offer any information regarding the long term benefits or consequences of Human Growth Hormone Usage.

This study increases our knowledge of the mechanisms by which Human Growth Hormone can benefit the body at a molecular level, but Dr. Costa encourages further research and evaluation to take place before his data can be extrapolated fully to human patients.

Human Growth Hormone May Be Useful in Encouraging Physical Rehabilitation in Aging Patients

In the future, many are confident that HGH Injections can be utilized in elderly patients to increase physiological healing capacity and resiliency. There is hope that Human Growth Hormone can be used in urgent care situations in order to increase the speed of the healing process in order to more fully preserve the health of the elderly patient.

The Future of HGH Hormone Replacement Therapy

Perhaps in the future, a combination of therapies will become available in order to preserve health into old age. Since older patients tend to be more sensitive to Human Growth Hormone, it may be found that Sermorelin Acetate Injections can be a long-term solution to Age-Related HGH Deficiency which minimizes the risk of overdose and side-effects, while Growth Hormone Injections can be utilized in a rehabilitation setting to increase the effectiveness of the healing process while also stimulating cellular metabolism more directly.

Although Human Growth Hormone cannot be prescribed as an Anti-Aging Solution, in the future, as our knowledge of the benefits of the hormone become more complete, many restrictions on the use of the hormone will likely be lifted, and HGH can be utilized more fully as a tool of health optimization.

HGH May Be Beneficial in the Physical Rehabilitation Outcomes of Patients of All Ages

Although this study is primarily concerned with the concept of Human Growth Hormone as a tool to improve rehabilitation outcomes for older patients with low levels of innate Human Growth Hormone, there are also studies which show that Human Growth Hormone has the potential to benefit adults of all ages that are going through the process of physical rehabilitation and therapy.

In the case of cartilage repair, for example, it appears that Human Growth Hormone and IGF-1 have the capability to restore healthy cartilage tissue, minimizing pain and limited range of movement which is sometimes associated with cartilage surgery and damage. In addition to this, HGH Hormone Injections may also benefit patients that have recently undergone surgery, whether they are suffering from HGH Deficiency or not. Side-effects of Human Growth Hormone use are primarily associated with long-term use at abusive levels.

There are some that hypothesize that patients of all ages may be able to directly benefit from short term therapy using Human Growth Hormone in order to spur tissue regeneration and shorten downtime from injury or surgery.

Time will only tell, but it appears that in future years, HGH will find increased acceptance as a medical treatment, and medical professionals will gradually uncover more and greater benefits of HGH Hormone Replacement Therapy as a legitimate medical treatment.

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