Displays the Benefits of Resveratrol
have recently come to the conclusion that Resveratrol has the ability
to produce significant benefits in regard to Anti-Aging, as well as
overall health and wellness. A recent study conducted by Harvard
medical scientists confirms a long-standing hypothesis that
Resveratrol is an incredibly beneficial supplemental nutrient. One of
the most well known sources of Resveratrol is red wine, although red
grapes confer the benefit as well, in addition to dark chocolate and
Increases SIRT-1 Release
of research was conducted in early March of 2013, and illuminates the
process by which Resveratrol interacts with the human physiology.
Researchers found that Resveratrol works by increasing the secretion
of a hormone known as SIRT-1. SIRT-1 is a hormone which is
intricately linked to cellular efficiency and longevity. SIRT-1 also
increases the body's resistance to disease by increasing the rate of
addition to discovering how Resveratrol is able to stimulate hormone
production, scientists also discovered the exact genetic link which
causes Resveratrol to produce its stimulative effects. The
researchers also hypothesize that a number of pharmaceuticals now in
the process of clinical assessment may be able to stimulate these
same benefits in regard to longevity.
Optimistic about Resveratrol
research team responsible for this discovery is incredibly excited
and optimistic about the findings of the study. The lead researcher,
Dr. David Sinclair, explains that Resveratrol achieves something that
he has yet to witness from any other drug. The rate at which
Resveratrol increases mitochondria metabolism is absolutely
Sinclair is a genetics professor at Harvard Med School. He is also a
scientific consultant, as well as one of the founders, of Sirtris, a
company related to the pharmaceutical giant GlaxoSmithKline. Sinclair
goes on to say that there are very few drugs that have the capacity
to increase cellular metabolism, and that most drugs that interact at
this level actually block or depress this form of metabolism.
is an Anti-Oxidant as Well as a Phytoalexin
Western Scientists are just beginning to learn about Resveratrol, it
is a chemical which is present in nature, most commonly in cocoa and
grapes. In countries such as China and Japan, Resveratrol has been
used as an herbal treatment for centuries. Resveratrol belongs to a
potent class of compounds known as antioxidants that preserve
cellular health at the molecular level, safeguarding the cells from
outside damage, as well as damage caused by internal processes of
not only has Antioxidant capabilities, it also produces
anti-inflammatory and immune-strengthening benefits. Resveratrol
belongs to a classification known as Phytoalexin, which is a group of
microscopic compounds which prevent microbes from establishing
presence on plants. In addition to this, Phytoalexins have the
capacity to increase the resiliency of plants, preserving them from
dangers such as environmental change, infection, and excess sunlight.
Benefits of Resveratrol
has been found to be connected to a number of different preservative
benefits in human beings, safeguarding the body against both diabetes
and obesity while having an immensely positive effect upon the
cardiovascular system. In regard to the heart and the blood stream,
Resveratrol has been proven to alleviate excess blood clotting,
normalize LDL Cholesterol levels, and open up blood vessels, reducing
blood pressure. Resveratrol also seems to have a stimulative effect
upon Nitric Oxide production.
Controversy: Was Early Resveratrol Research Falsified?
studies in the past pointed to the potential benefits of Resveratrol,
earlier researchers were accused of falsifying results in order to
make Resveratrol look more beneficial than it actually is. In early
2013, rumors began to fly that Dr. Dipak Das, the author of a number
of studies regarding Resveratrol was serially fluffing up the
results. The results of this study vindicate Dr. Das, and provide
further evidence that Resveratrol produces specific benefits in ways
that have not been replicated anywhere else in nature.
two primary sources of conflict in regard to Dr. Das' study. The
first conflict was primarily in regard to the data itself. Many
researchers question whether Resveratrol was actually increasing the
release of SIRT-1 directly, or if some other conflicting influence
was actually producing the displayed benefit.
conflict inferred something more sinister. Some scientists were so
awed by the level of SIRT-1 stimulation, that they did not believe
that the results could be produced without outside tampering. They
believed that the vastly increased SIRT-1 activation was the result
of researcher manipulation rather than a natural biological process.
Resveratrol Study Resolves Controversy
Harvard Resveratrol Study, researchers came to the conclusion that
high levels of Resveratrol are likely to be incredibly beneficial in
preserving the health of aging men and women. Dr. Sinclair explains
that he and his staff had worked for six years in order to prove that
Resveratrol does indeed increase SIRT-1 production, and that they had
their first confirmation in 2006, using laboratory mice in order to
show proof of benefit.
2006, the goal of research went from proving the impact of
Resveratrol, to uncovering the underlying genetic component which
causes Resveratrol to activate within the human body. Surprisingly,
the conclusion that the researchers came to was incredibly clean cut.
Does Resveratrol Work?
process of attempting to showcase the link between SIRT-1 and
Resveratrol, researchers found that Resveratrol was chemically very
similar to a few different natural amino acids, including Tryptophan,
which is common in certain meats and food products such as turkey.
After discovering a potential link between Tryptophan and
Resveratrol, they attempted to activate SIRT-1 molecules in a
laboratory setting in order to more fully establish the link. They
making this link, Dr. Sinclair and his research team studied two
thousand separate mutations of the SIRT-1 gene in order to find out
exactly in what manner Resveratrol functioned. As they studied these
various mutations, they discovered one form of mutated gene which did
not respond to Resveratrol stimulation.
pinpointed the location of Resveratrol activation, they were able to
go into normal genes and turn off that single gene in an otherwise
perfectly normal genetic code. Scientists cultured skin and muscle
cells that had the gene for Resveratrol turned off. Then, they tested
the culture with Resveratrol and other pharmaceuticals which impacted
the same gene. In control cells, Resveratrol produced its
hypothesized stimulatory function. Experimental cells no longer
benefited from Resveratrol exposure.
Sinclair's Resveratrol Study Answers Many Questions
Sinclair says that this was the experiment that connected all of the
dots. After conducting this experiment, it became perfectly clear
that Resveratrol does in fact stimulate SIRT-1 secretion. Now that
the researchers have made the connections, this paves the way for
further scientific study in order to look at how Resveratrol
stimulates SIRT-1 production, and re-engineer the hormone in order to
produce an even stronger stimulative effect.
is not only interested in producing a more robust and stimulative
form of Resveratrol. He wants to learn more about the benefits of
Resveratrol, and commit to further scientific study in order to
examine the capacity of Resveratrol to benefit healthy individuals.
Research Enlightens Our Understanding of Aging
Resveratrol Treatment is very near on the horizon, and the benefits
seem to be astounding. These findings in regard to Resveratrol
provide further evidence that the aging process is more complicated,
and less inevitable, than we previously imagined. Every year, it is
going to get easier to break the threshold of 100 years. Although
some aspects of aging are irreversible, it is becoming clear that
more and more conditions which were once thought to simply be the
result of aging, are actually the result of hormone imbalance and
other medical issues which are actually damaging health.
One day we
may even find that the majority of aging symptoms are the result of
malfunctions of this sort. The process of evolution was not designed
to produce an Ageless Man, but it is becoming clear that there are
numerous ways that we can chemically and biologically alter our
personal physiology in order to alter and prolong the normal common
track of human life and existence.
Scientists are Intrigued by the Possibilities of Resveratrol
many in the scientific community that share Dr. Sinclair's enthusiasm
about Resveratrol. Dr. Leonard Guarente, another Sirtris science
consultant, and MIT biologist, believes that Resveratrol is the real
deal. He believes that Resveratrol research and development will
inevitably lead to profoundly beneficial results (and financial
success for those who invest in Resveratrol).
findings of this study are so clear and certain, that they are even
converting former skeptics and detractors into believers. Dr. Brian
Kennedy, CEO and President of the Buck Institute for Research on
Aging, was once incredibly skeptical in regard to initial Resveratrol
research, because he did not believe that positive results in yeast
would carry over into human physiology. Now that early research has
been supported, and it has been shown that Resveratrol indeed
activates human cells, Dr. Kennedy has changed his mind about
Resveratrol, and is optimistic that further research will yield real
becoming increasingly clear that in spite of how different we seem,
living organisms share an immense and awe-inspiring level of