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The Potential Role of GH-RH in Treating Alzheimer's


Written by Dr. Welsh, Published on 03 July 2013

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Growth Hormone-Releasing Hormone Shown to Increase Cognitive Health

Regular injections of Growth Hormone-Releasing Hormone have been clinically shown to boost cognitive capacity for both mildly impaired patients and perfectly healthy older individuals.

GH-RH Alzheimer's Treatment

In a recent clinical trial, both healthy and slightly impaired participants were injected with GH-RH in an attempt to quantify the potential cognitive benefits of the hormone. The study took place over the course of 5 months, and was aggressively controlled and randomized in order to ensure the quality of the results. Subjects that were treated with GH-RH were found to have significantly improved mental performance in comparison to recipients of placebo. The primary researcher in this study was Dr. Laura Baker, representative of the U. Washington Medical School. The study was recently released in the Archives of Neurology.

Baker and her associates were able to pinpoint the general areas of the mind which receive the most promising benefits of GH-RH Hormone Therapy. Improved mental faculties were the result of an overall increase in the patients' ability to organize, prioritize, and execute mental processes. The primary area which seemed to improve was verbal but the treatment did not seem to have a beneficial affect upon the patients' ability to remember, visually.

GH-RH, HGH, and IGF-1

Growth Hormone-Releasing Hormone is one of the most important hormones released by the hypothalamus. GH-RH is responsible for the proper release of Human Growth Hormone by the pituitary, which has a stimulative and restorative effect upon the body in numerous different ways. Although we have known how HGH affects metabolic properties regarding fat and muscle in the body, we are just beginning to more fully comprehend how Human Growth Hormone affects the brain and other complex organs.

After Human Growth Hormone is secreted as a result of GH-RH stimulation, HGH cycles through the blood stream to the liver, where it is processed into IGF-1 and other important hormones known as Growth Factors. Although most HGH is converted into IGF-1, HGH does have direct stimulative affects on many tissues on its own.

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Growth Hormones Have a Powerful Effect Upon the Brain

In the brain, GH-RH, IGF-1, and HGH all have beneficial effects upon the health of brain tissue. No where does this seem more clear than in the case of patients suffering from Alzheimer's. As our knowledge of this dreaded disease becomes more fully fleshed out, more and more evidence points to the hypothesis that Alzheimer's could be considered a third form of diabetes, a type of metabolism disorder that effects not the blood sugar, but the composition of the brain itself.

Alzheimer's Correlated with IGF-1 Deficiency

There is growing evidence that Alzheimer's is correlated with decreased levels of these three important and interconnected hormones. New research suggests that it is possible to restore hormone balance with Recombinant Hormones that are functionally identical to GH-RH such as Sermorelin and Tesamorelin, in order to reduce the risk of cognitive decline and safeguard mental capacity in patients that are either at high risk of Alzheimer's, or are experiencing mild symptoms of the disorder.

Alzheimer's GH-RH Study Specifics

In order to explore the hypothesis, Baker and her associates gathered a group of 152 men and women between the ages of fifty-five and eighty-seven. Sixty-six of these patients were already experiencing mild symptoms of cognitive decline. One set of patients received Tesamorelin Injections, while the second group received imitation placebo injections. All shots were delivered subcutaneously just beneath the skin.

The injection period was designed to last a total of twenty weeks. In the end, 137 of the subjects completed the study, seventy-six control patients, and sixty-one experimental patients. At the beginning of the study, patients underwent cognitive examination, and changes in cognitive ability were measured at three different intervals during and after the study.

The cognitive tests administered were normal assessments of cognitive capacity. After Tesamorelin injections began, Cognition was evaluated after ten weeks, after twenty weeks, and then ten weeks after GH-RH Injection Therapy ceased. At the same time that cognitive evaluations took place, researchers also conducted blood diagnostics in order to find out the level of each of the three considered hormones (IGF-1, GH-RH, and HGH) that was circulating through the blood stream.

GH-RH Benefits both the Healthy Mind and the Cognitively Impaired Mind

As they examined the data, Baker and her fellow researchers discovered that Tesamorelin had the capacity to increase serum levels of IGF-1 by an average of 2.17 times the level active in the blood stream before treatment. This finding was well within the range of significance, and restored the patients' IGF-1 Levels to physiologically normal volume. This proved that the Tesamorelin had a physiologically appropriate affect on the hormone balance of the patients.

After evaluating the physiological expectations of therapy, the researchers then statistically evaluated the cognitive benefits of therapy. All but one of the 152 patients were evaluated cognitively, and signs of mental improvement in the experimental group were found to be significant. Interestingly enough, the increase in cognitive capacity benefited both the control group and the experimental group.

At the end of the study period, the 137 patients that finished the trial were evaluated in the same manner. Cognitive testing showed an even clearer statistical improvement after a full twenty weeks of treatment.

Tesamorelin GH-RH was shown to produce benefits in multiple aspects of physiological health. As a whole, the experimental group experienced an overall increase in their overall executive ability, while also experiencing significant gains in their ability to conceive of language and abstraction, but the GH-RH Replacement did not seem to affect visual representative memory.

GH-RH Burns Fat, Builds Muscles, and Builds Strong Minds

Outside of mental evaluation, GH-RH Injections also burned fat and increased muscle mass, leading to a reduction in fat-muscle ratio of 7.4% in all patients injected with GH-RH. Among patients exhibiting signs of cognitive decline, GH-RH Administration boosted fasting insulin by thirty-five percent. This increase was well within the healthy range of insulin production, however.

GH-RH Side-Effects Minor

Most negative events that occurred during the study were minor in nature, but they did occur at a higher rate among patients receiving Tesamorelin. Sixty-eight percent of experimental patients experienced at least some minor issue during treatment, whereas the placebo group only experienced these problems thirty-six percent of the time.

Large Scale GH-RH Trial Coming Soon

Although the results of this study are incredibly promising, the researchers are quick to remind their audience that a larger study is needed in order to more fully explore causality, although the treatment is clearly beneficial. They say that longer and bigger studies are necessary in order to more fully confirm the ability of GH-RH to beneficially safeguard mental health into old age.

GH-RH Hormone Replacement Therapy May Be Best Hope for Alzheimer's Care

This study shows that GH-RH injections have the capacity to increase cognitive ability in both the mentally healthy and those experiencing mild cognitive decline as a result of early Alzheimer's or other neurological conditions. GH-RH Research may very well be the beginning of a new era of Alzheimer's treatment that can improve health outcomes and extend quality of life and mental acuity much longer than was previously possible for these patients.

Alzheimer's is one of the most devastating and cognitively incapacitating diseases in the world, and the quicker we improve treatment options, the quicker that countless patients across the globe can experience a life less addled by the debilitating disease.

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