Hormone-Releasing Hormone Shown to Increase Cognitive Health
injections of Growth Hormone-Releasing Hormone have been clinically
shown to boost cognitive capacity for both mildly impaired patients
and perfectly healthy older individuals.
recent clinical trial, both healthy and slightly impaired
participants were injected with GH-RH in an attempt to quantify the
potential cognitive benefits of the hormone. The study took place
over the course of 5 months, and was aggressively controlled and
randomized in order to ensure the quality of the results. Subjects
that were treated with GH-RH were found to have significantly
improved mental performance in comparison to recipients of placebo.
The primary researcher in this study was Dr. Laura Baker,
representative of the U. Washington Medical School. The study was
recently released in the Archives of Neurology.
her associates were able to pinpoint the general areas of the mind
which receive the most promising benefits of GH-RH Hormone Therapy.
Improved mental faculties were the result of an overall increase in
the patients' ability to organize, prioritize, and execute mental
processes. The primary area which seemed to improve was verbal but
the treatment did not seem to have a beneficial affect upon the
patients' ability to remember, visually.
HGH, and IGF-1
Hormone-Releasing Hormone is one of the most important hormones
released by the hypothalamus. GH-RH is responsible for the proper
release of Human Growth Hormone by the pituitary, which has a
stimulative and restorative effect upon the body in numerous
different ways. Although we have known how HGH affects metabolic
properties regarding fat and muscle in the body, we are just
beginning to more fully comprehend how Human Growth Hormone affects
the brain and other complex organs.
Human Growth Hormone is secreted as a result of GH-RH stimulation,
HGH cycles through the blood stream to the liver, where it is
processed into IGF-1 and other important hormones known as Growth
Factors. Although most HGH is converted into IGF-1, HGH does have
direct stimulative affects on many tissues on its own.
Hormones Have a Powerful Effect Upon the Brain
brain, GH-RH, IGF-1, and HGH all have beneficial effects upon the
health of brain tissue. No where does this seem more clear than in
the case of patients suffering from Alzheimer's. As our knowledge of
this dreaded disease becomes more fully fleshed out, more and more
evidence points to the hypothesis that Alzheimer's could be
considered a third form of diabetes, a type of metabolism disorder
that effects not the blood sugar, but the composition of the brain
Correlated with IGF-1 Deficiency
growing evidence that Alzheimer's is correlated with decreased levels
of these three important and interconnected hormones. New research
suggests that it is possible to restore hormone balance with
Recombinant Hormones that are functionally identical to GH-RH such as
Sermorelin and Tesamorelin, in order to reduce the risk of cognitive
decline and safeguard mental capacity in patients that are either at
high risk of Alzheimer's, or are experiencing mild symptoms of the
GH-RH Study Specifics
to explore the hypothesis, Baker and her associates gathered a group
of 152 men and women between the ages of fifty-five and eighty-seven.
Sixty-six of these patients were already experiencing mild symptoms
of cognitive decline. One set of patients received Tesamorelin
Injections, while the second group received imitation placebo
injections. All shots were delivered subcutaneously just beneath the
injection period was designed to last a total of twenty weeks. In the
end, 137 of the subjects completed the study, seventy-six control
patients, and sixty-one experimental patients. At the beginning of
the study, patients underwent cognitive examination, and changes in
cognitive ability were measured at three different intervals during
and after the study.
cognitive tests administered were normal assessments of cognitive
capacity. After Tesamorelin injections began, Cognition was evaluated
after ten weeks, after twenty weeks, and then ten weeks after GH-RH
Injection Therapy ceased. At the same time that cognitive evaluations
took place, researchers also conducted blood diagnostics in order to
find out the level of each of the three considered hormones (IGF-1,
GH-RH, and HGH) that was circulating through the blood stream.
Benefits both the Healthy Mind and the Cognitively Impaired Mind
examined the data, Baker and her fellow researchers discovered that
Tesamorelin had the capacity to increase serum levels of IGF-1 by an
average of 2.17 times the level active in the blood stream before
treatment. This finding was well within the range of significance,
and restored the patients' IGF-1 Levels to physiologically normal
volume. This proved that the Tesamorelin had a physiologically
appropriate affect on the hormone balance of the patients.
evaluating the physiological expectations of therapy, the researchers
then statistically evaluated the cognitive benefits of therapy. All
but one of the 152 patients were evaluated cognitively, and signs of
mental improvement in the experimental group were found to be
significant. Interestingly enough, the increase in cognitive capacity
benefited both the control group and the experimental group.
At the end
of the study period, the 137 patients that finished the trial were
evaluated in the same manner. Cognitive testing showed an even
clearer statistical improvement after a full twenty weeks of
GH-RH was shown to produce benefits in multiple aspects of
physiological health. As a whole, the experimental group experienced
an overall increase in their overall executive ability, while also
experiencing significant gains in their ability to conceive of
language and abstraction, but the GH-RH Replacement did not seem to
affect visual representative memory.
Burns Fat, Builds Muscles, and Builds Strong Minds
mental evaluation, GH-RH Injections also burned fat and increased
muscle mass, leading to a reduction in fat-muscle ratio of 7.4% in
all patients injected with GH-RH. Among patients exhibiting signs of
cognitive decline, GH-RH Administration boosted fasting insulin by
thirty-five percent. This increase was well within the healthy range
of insulin production, however.
negative events that occurred during the study were minor in nature,
but they did occur at a higher rate among patients receiving
Tesamorelin. Sixty-eight percent of experimental patients experienced
at least some minor issue during treatment, whereas the placebo group
only experienced these problems thirty-six percent of the time.
Scale GH-RH Trial Coming Soon
the results of this study are incredibly promising, the researchers
are quick to remind their audience that a larger study is needed in
order to more fully explore causality, although the treatment is
clearly beneficial. They say that longer and bigger studies are
necessary in order to more fully confirm the ability of GH-RH to
beneficially safeguard mental health into old age.
Hormone Replacement Therapy May Be Best Hope for Alzheimer's Care
shows that GH-RH injections have the capacity to increase cognitive
ability in both the mentally healthy and those experiencing mild
cognitive decline as a result of early Alzheimer's or other
neurological conditions. GH-RH Research may very well be the
beginning of a new era of Alzheimer's treatment that can improve
health outcomes and extend quality of life and mental acuity much
longer than was previously possible for these patients.
is one of the most devastating and cognitively incapacitating
diseases in the world, and the quicker we improve treatment options,
the quicker that countless patients across the globe can experience a
life less addled by the debilitating disease.