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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on September 4th, 2019
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How does Human Growth Hormone Work?

HGH is the primary hormone responsible for human growth, but how does it actually physically function within the body? In this article we will explain the endocrine processes which occur which both spur the secretion of Growth Hormone and also the effects of HGH after it has been released.

What Are Hormones?

Hormones are very similar to neurotransmitters in purpose, although they function quite differently. Neurotransmitters send information and messages via electrical current from neuron to neuron in order to deliver them throughout the body. Hormones send messages or produce change via the blood stream, circulating throughout the body to target tissues and organs to produce an effect.

When a target molecule makes contact with a related hormone, it produces a particular and unique response. There is also a third category of messengers known as chemical messengers, which produce change via the circulation of inorganic chemicals within the body. The most common of these is Nitric Oxide, which is innately important to male sexual performance.

GH-RH Stimulates Growth Hormone Release

HGH is stimulated by a hormone known as Growth Hormone-Releasing Hormone. This hormone is an extended-chain polypeptide. There are a few different variations of GH-RH, but they all produce the same physiological effect upon the body,. They vary in length between thirty-seven and forty-four peptides.

There is also a medical form of GH-RH known as Sermorelin, which is functionally identical to GH-RH, but only contains a chain of twenty-nine amino acids. Most hormones released by the brain have an effect upon multiple areas of the organ, but GH-RH only acts upon the pituitary gland.

GH-RH is released by the Hypothalamus, which is often referred to as the control center of the brain. The particular region of the Hypothalamus from which GH-RH is secreted is known as the Arcuate Nucleus. The Hypothalamus controls the release of numerous different hormones throughout the body in response to a variety of signals sent from the body to the brain.

HGH Released during Exercise and Sleep

The body secretes GH-RH during periods of intense physical activity, as well as during sleep. Moderate emotional stress can also increase GH-RH release, but long-term, sustained stress contributes to GH-RH Decline. GH-RH flows from the Hypothalamus to the Pituitary via a pathway known as the Hypophyseal Portal System.

Early in life and during puberty, Human Growth Hormone stimulates physiological growth throughout the body, most notably in the skeletal system. The change in height that occurs during puberty is almost completely the result of high levels of HGH that flow through the body during this period.

More about the Hypothalamus

The hypothalamus has a number of different and highly important purposes as the regulation center of the brain. This organ is located just underneath the center of the brain, attached to the thalamus from below. The hypothalamus is responsible for a number of different vital functions, including metabolism and temperature regulation.

In addition to this, the hypothalamus is directly in control of the proper function of the testes and ovaries, as well as the adrenal gland, meaning that the organ is in control of both aggression and sex. The Hypothalamus is also the central mediator of the endocrine system, releasing precursor hormones which spur the function of various organs throughout the body, including the pituitary gland.

HGH, the Pituitary, and Negative Feedback

Human Growth Hormone is released as a result of the direct stimulation of Growth-Hormone Releasing Hormone upon the Anterior Pituitary Gland. HGH Production is limited via a few particular Negative-Feedback Mechanisms.

One hormone known as Somatostatin is the primary hormone which slows down the production of Growth Hormone. Somatostatin is produced by organs throughout the body, including the stomach, pancreas, intestines, and the hypothalamus. The hypothalamus releases Somatostatin via the Periventricular Nucleus.

When the body receives signals to limit HGH Production, Somatostatin flows throughout the body to the brain, where it attaches to receptors within the anterior pituitary known as Somatotrophs. The Somatotrophs are tiny organs attached to the anterior pituitary whose only job is to secrete and release Human Growth Hormone. Because of this, HGH is often referred to by the scientific term, Somatotrophin, because it stimulates the function of the Somatotrophs.

HGH Release Limited by Growth Factors

HGH Production is also limited by the presence of Insulin-like Growth Factors which are directly produced by the liver as a result of Growth Hormone Production. When the brain senses these Growth Factors, it sends a message to the body that there is a sufficient level of Growth Hormone Released into the body.

HGH and Ghrelin

Another hormone which stimulates the release of Growth Hormone-Releasing Hormone is known as Ghrelin. Ghrelin primarily plays a role in digestion, sending the message to the brain that the stomach is full. Since Human Growth Hormone is a metabolite, Ghrelin Release is directly correlated with HGH Production.

It is also theorized that Ghrelin increases the release of GH-RH while also limiting the release of Somatostatin. Although scientists are well-versed in the effects of Ghrelin upon hunger, they are less certain regarding the direct manner by which Ghrelin effects GH-RH and Growth Hormone Release.

How is Human Growth Hormone Released?

HGH is secreted by the pituitary gland in short and brief intervals known as pulses. These pulses occur both during the day and at night, but the pituitary is most active while we are asleep. The highest volume of Growth Hormone Secretion occurs in the initial deep phase of sleep which happens about one hour into the sleep cycle.

The second highest volume of Human Growth Hormone is released during vigorous physical activity, in order to spur the metabolism and increase the amount of energy available to the muscles. From this point on, both Endogenous Growth Hormone and Injected Bio-Identical Somatropin function in the same way.

Once HGH hits the blood stream, it is no longer influenced by the brain, outside of reverse feedback mechanisms and sensitivities that may arise at the level of target organs.

HGH and the Liver

Although Human Growth Hormone has the capacity to directly stimulate many different target tissues, the majority of HGH circulates through the liver, where it is processed into hormones known as Insulin-Like Growth Factors, the most common of which, by far, is IGF-1. Human Growth Hormone slows down the rate at which the liver absorbs glucose while also encouraging a process known as gluconeogenesis.

Gluconeogenesis is an internal chemical process which converts proteins into fuel for the body. This is one reason why HGH is so beneficial for weight loss and muscle development. By converting protein into energy, the body burns many more calories than it would during otherwise normal physiological processes.

Role of IGF-1 and HGH in the Human Body

IGF-1 and Human Growth Hormone stimulate target tissues all over the human body. Every one of the significant organs of the body have receptors for these hormones, even the brain. The bodily tissues that have the highest number of IGF-1 and HGH receptors are the muscles, cartilage, and bones, explaining why these organs are the most sensitive to both Human Growth Hormone and HGH Deficiency.

In the bones, IGF-1 stimulates the function of osteoblasts, organs within the bones that are responsible for the recycling and reconstruction of new bone tissue, which prevents osteoporosis. In the soft cartilage of the bones, IGF-1 is utilized by organs known as chondrocytes in order to stimulate the development of new and healthy cartilage tissue.

Human Growth Hormone also has the capacity to stimulate the development of muscle tissue, because it increases the amount of energy available to the muscles in order to respond to exercise, while also increasing the efficiency of the bodies ability to cultivate muscle growth during sleep.

Human Growth Hormone and IGF-1 also encourage the metabolism and breakdown of adipose fat deposits across the body, increasing the rate at which the body burns fat while also providing increased energy and reducing fatigue.

How is Human Growth Hormone Metabolized?

HGH is processed primarily by the kidneys and the liver. The liver can metabolize 3-4 IU of Human Growth Hormone every 5-7 hours. Because of this, most Hormone Specialists suggest that Somatropin Users inject their medication in a pattern which replicates the body's normal pattern of hormone release.

Purposefully injecting an overdose of Human Growth Hormone significantly increases the risk of unwanted side-effects, and these side-effects very likely will outweigh the minor increase in benefit that the patient experiences. Whatever HGH the body does not use is broken down directly into component amino acids which are released through urination.

Human Growth Hormone only stays in the system for a brief period of time, no more than three to four hours. IGF-1, on the other hand, is detectable in the blood for a slightly longer period of time, but no longer than a few days. Because of how quickly the hormones cycle through the body, it is incredibly difficult to detect Human Growth Hormone or IGF-1 use unless drug tests are taken very soon after an injection is administered, making it a very tempting choice for athletes subject to drug testing.

HGH for Growth Hormone Deficiency

HGH Hormone Replacement is also highly sought after because of its ability to alleviate the effects of Age-Related Human Growth Hormone Deficiency. HGH Production naturally declines with age, beginning in the late twenties and early thirties, and as the decline continues, it can increase the risk of numerous health complications throughout the body.

Many men and women across the world choose Hormone Replacement with Bio-Identical Somatropin in order to alleviate the symptoms of the aging process which take place as a result of moderate-to-enhanced Growth Hormone Deficiency.

Number of words: 1618

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