HOW DOES THE HUMAN BODY PRODUCE HUMAN GROWTH HORMONE?
Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D.. Published on September 4th, 2019
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HGH Deficiency with Age
How
does Human Growth Hormone Work?
HGH is
the primary hormone responsible for human growth, but how does it
actually physically function within the body? In this article we will
explain the endocrine processes which occur which both spur the
secretion of Growth Hormone and also the effects of HGH after it has
been released.
What
Are Hormones?
Hormones
are very similar to neurotransmitters in purpose, although they
function quite differently. Neurotransmitters send information and
messages via electrical current from neuron to neuron in order to
deliver them throughout the body. Hormones send messages or produce
change via the blood stream, circulating throughout the body to
target tissues and organs to produce an effect.
When a target molecule makes contact with a related hormone, it
produces a particular and unique response. There is also a third
category of messengers known as chemical messengers, which produce
change via the circulation of inorganic chemicals within the body.
The most common of these is Nitric Oxide, which is innately important
to male sexual performance.
GH-RH
Stimulates Growth Hormone Release
HGH is
stimulated by a hormone known as Growth Hormone-Releasing Hormone.
This hormone is an extended-chain polypeptide. There are a few
different variations of GH-RH, but they all produce the same
physiological effect upon the body,. They vary in length between
thirty-seven and forty-four peptides.
There is
also a medical form of GH-RH known as Sermorelin, which is
functionally identical to GH-RH, but only contains a chain of
twenty-nine amino acids. Most hormones released by the brain have an
effect upon multiple areas of the organ, but GH-RH only acts upon the
pituitary gland.
GH-RH is
released by the Hypothalamus, which is often referred to as the
control center of the brain. The particular region of the
Hypothalamus from which GH-RH is secreted is known as the Arcuate
Nucleus. The Hypothalamus controls the release of numerous different
hormones throughout the body in response to a variety of signals sent
from the body to the brain.
HGH
Released during Exercise and Sleep
The body
secretes GH-RH during periods of intense physical activity, as well
as during sleep. Moderate emotional stress can also increase GH-RH
release, but long-term, sustained stress contributes to GH-RH
Decline. GH-RH flows from the Hypothalamus to the Pituitary via a
pathway known as the Hypophyseal Portal System.
Early in life and during puberty, Human Growth Hormone stimulates
physiological growth throughout the body, most notably in the
skeletal system. The change in height that occurs during puberty is
almost completely the result of high levels of HGH that flow through
the body during this period.
More
about the Hypothalamus
The hypothalamus has a number of different and highly important
purposes as the regulation center of the brain. This organ is located
just underneath the center of the brain, attached to the thalamus
from below. The hypothalamus is responsible for a number of different
vital functions, including metabolism and temperature regulation.
In addition to this, the hypothalamus is directly in control of the
proper function of the testes and ovaries, as well as the adrenal
gland, meaning that the organ is in control of both aggression and
sex. The Hypothalamus is also the central mediator of the endocrine
system, releasing precursor hormones which spur the function of
various organs throughout the body, including the pituitary gland.
HGH,
the Pituitary, and Negative Feedback
Human
Growth Hormone is released as a result of the direct stimulation of
Growth-Hormone Releasing Hormone upon the Anterior Pituitary Gland.
HGH Production is limited via a few particular Negative-Feedback
Mechanisms.
One
hormone known as Somatostatin is the primary hormone which slows down
the production of Growth Hormone. Somatostatin is produced by organs
throughout the body, including the stomach, pancreas, intestines, and
the hypothalamus. The hypothalamus releases Somatostatin via the
Periventricular Nucleus.
When the
body receives signals to limit HGH Production, Somatostatin flows
throughout the body to the brain, where it attaches to receptors
within the anterior pituitary known as Somatotrophs. The Somatotrophs
are tiny organs attached to the anterior pituitary whose only job is
to secrete and release Human Growth Hormone. Because of this, HGH is
often referred to by the scientific term, Somatotrophin, because it
stimulates the function of the Somatotrophs.
HGH
Release Limited by Growth Factors
HGH
Production is also limited by the presence of Insulin-like Growth
Factors which are directly produced by the liver as a result of
Growth Hormone Production. When the brain senses these Growth
Factors, it sends a message to the body that there is a sufficient
level of Growth Hormone Released into the body.
HGH and
Ghrelin
Another
hormone which stimulates the release of Growth Hormone-Releasing
Hormone is known as Ghrelin. Ghrelin primarily plays a role in
digestion, sending the message to the brain that the stomach is full.
Since Human Growth Hormone is a metabolite, Ghrelin Release is
directly correlated with HGH Production.
It is also
theorized that Ghrelin increases the release of GH-RH while also
limiting the release of Somatostatin. Although scientists are
well-versed in the effects of Ghrelin upon hunger, they are less
certain regarding the direct manner by which Ghrelin effects GH-RH
and Growth Hormone Release.
How is
Human Growth Hormone Released?
HGH is
secreted by the pituitary gland in short and brief intervals known as
pulses. These pulses occur both during the day and at night, but the
pituitary is most active while we are asleep. The highest volume of
Growth Hormone Secretion occurs in the initial deep phase of sleep
which happens about one hour into the sleep cycle.
The second
highest volume of Human Growth Hormone is released during vigorous
physical activity, in order to spur the metabolism and increase the
amount of energy available to the muscles. From this point on, both
Endogenous Growth Hormone and Injected Bio-Identical Somatropin
function in the same way.
Once HGH
hits the blood stream, it is no longer influenced by the brain,
outside of reverse feedback mechanisms and sensitivities that may
arise at the level of target organs.
HGH and
the Liver
Although
Human Growth Hormone has the capacity to directly stimulate many
different target tissues, the majority of HGH circulates through the
liver, where it is processed into hormones known as Insulin-Like
Growth Factors, the most common of which, by far, is IGF-1. Human
Growth Hormone slows down the rate at which the liver absorbs glucose
while also encouraging a process known as gluconeogenesis.
Gluconeogenesis
is an internal chemical process which converts proteins into fuel for
the body. This is one reason why HGH is so beneficial for weight loss
and muscle development. By converting protein into energy, the body
burns many more calories than it would during otherwise normal
physiological processes.
Role of
IGF-1 and HGH in the Human Body
IGF-1 and
Human Growth Hormone stimulate target tissues all over the human
body. Every one of the significant organs of the body have receptors
for these hormones, even the brain. The bodily tissues that have the
highest number of IGF-1 and HGH receptors are the muscles, cartilage,
and bones, explaining why these organs are the most sensitive to both
Human Growth Hormone and HGH Deficiency.
In the
bones, IGF-1 stimulates the function of osteoblasts, organs within
the bones that are responsible for the recycling and reconstruction
of new bone tissue, which prevents osteoporosis. In the soft
cartilage of the bones, IGF-1 is utilized by organs known as
chondrocytes in order to stimulate the development of new and healthy
cartilage tissue.
Human
Growth Hormone also has the capacity to stimulate the development of
muscle tissue, because it increases the amount of energy available to
the muscles in order to respond to exercise, while also increasing
the efficiency of the bodies ability to cultivate muscle growth
during sleep.
Human
Growth Hormone and IGF-1 also encourage the metabolism and breakdown
of adipose fat deposits across the body, increasing the rate at which
the body burns fat while also providing increased energy and reducing
fatigue.
How is
Human Growth Hormone Metabolized?
HGH is
processed primarily by the kidneys and the liver. The liver can
metabolize 3-4 IU of Human Growth Hormone every 5-7 hours. Because of
this, most Hormone Specialists suggest that Somatropin Users inject
their medication in a pattern which replicates the body's normal
pattern of hormone release.
Purposefully
injecting an overdose of Human Growth Hormone significantly increases
the risk of unwanted side-effects, and these side-effects very likely
will outweigh the minor increase in benefit that the patient
experiences. Whatever HGH the body does not use is broken down
directly into component amino acids which are released through
urination.
Human
Growth Hormone only stays in the system for a brief period of time,
no more than three to four hours. IGF-1, on the other hand, is
detectable in the blood for a slightly longer period of time, but no
longer than a few days. Because of how quickly the hormones cycle
through the body, it is incredibly difficult to detect Human Growth
Hormone or IGF-1 use unless drug tests are taken very soon after an
injection is administered, making it a very tempting choice for
athletes subject to drug testing.
HGH for
Growth Hormone Deficiency
HGH Hormone Replacement is also highly sought after because of its
ability to alleviate the effects of Age-Related Human Growth Hormone
Deficiency. HGH Production naturally declines with age, beginning in
the late twenties and early thirties, and as the decline continues,
it can increase the risk of numerous health complications throughout
the body.
Many men and women across the world choose Hormone Replacement with
Bio-Identical Somatropin in order to alleviate the symptoms of the
aging process which take place as a result of moderate-to-enhanced
Growth Hormone Deficiency.
Number of words: 1618
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