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CAN SERMORELIN ACETATE IMPROVE MEMORY AND COGNITION?


Written by Dr. Welsh, Published on March 2nd, 2017
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Sermorelin Acetate and Mental Health

One of the most life-changing aspects of the aging process is cognitive decline. The thought of losing one's memory or losing one's capacity to think critically isnnn particularly unnerving. Some of the most devastating conditions related to aging are the result of changes within the brain. Two of the worst are Dementia and Alzheimer's.

New research suggests that there are ways to maintain a strong and healthy mind throughout one's life, and that cognitive decline is not strictly a factor of age, but largely an effect of underlying, chronic health issues. As more and more data is analyzed, it appears that the worst aspects of cognitive decline can be avoided for healthy patients that are not predisposed to conditions such as Alzheimer's.

Even for men and women genetically predisposed to diseases like Alzheimer's, there is a ton of promise on the horizon for effective treatments that may eventually be able to prevent these diseases. It is exceedingly likely that, in the next years and decades, a cure for Alzheimer's will be found.

Today, medical experts are quickly learning the mechanisms which precipitate the mental decline associated with Alzheimer's, and using this information, they will likely be able to come up with an effective preventative treatment.

New JAMA Article Explores a Method to Slow Down Cognitive Decline in Aging Patients

Even though Alzheimer's will only affect a certain percentage of Americans, the threat of cognitive decline hangs over us all, and scientists are doing everything they can to provide us with the tools and information we need to forestall such decline. A recent study released in the Journal of the American Medical Association shows one treatment that displays real promise for slowing or stopping cognitive decline.

What is Sermorelin Acetate?

Sermorelin Acetate is a medical hormone treatment. Although the hormone is synthetic, it is designed to completely imitate the biological function of a vital hormone produced by the human hypothalamus. Sermorelin is the medical form of a hormone known as Growth Hormone-Releasing Hormone, also referred to as GH-RH.

GH-RH is a very important hormone which is actually a precursor to a polypeptide which most people have heard about: Human Growth Hormone. GH-RH is produced by the Hypothalamus and delivered to the pituitary gland in order to stimulate the production of Growth Hormone. After the Pituitary gets the signal, it starts cranking out pulses of Human Growth Hormone, which circulate through the body, providing numerous benefits.

Sermorelin Acetate is functionally identical to Growth Hormone-Releasing Hormone, meaning that although the two molecules do not share the same physiological structure, they both have the same exact effect upon the human body. Sermorelin Acetate has a very similar biological construction to GH-RH: They actually share the same initial 29 amino acids. Due to a biological quirk, the remaining amino acid chain that composes GH-RH is junk, meaning that it serves no biological purpose.

Because of this, biologists isolated the active portion of GH-RH in order to streamline the synthetic form of the hormone for reasons of cost and efficiency. Because Sermorelin is functionally identical, there is no reason to spend the time and money replicating the non-functional portion of the strand.

So, What Does Sermorelin Acetate and GH-RH Have to Do with the Brain?

After Human Growth Hormone is intercepted by the liver, it is converted into another group of hormones known as Insulin-Like Growth Factors. These hormones represent the most active iteration of Human Growth Hormone. Although HGH does directly stimulate some physiological changes, most of the benefits caused by GH-RH and Human Growth Hormone are manifested by these Growth Factors.

The most influential and abundant Growth Factor is Insulin-Like Growth Factor-1. This hormone causes changes throughout the body. It increases adipose fat metabolism, it encourages muscle development, and it encourages the maintenance of bone mineral density.

In the last decade, researchers have discovered another important function of IGF-1: Insulin-Like Growth Factor-1 helps maintain healthy cognitive function throughout the lifespan. So, through a grand chain of events, the release of Growth Hormone-Releasing Hormone by the hypothalamus contributes directly to overall cognitive health.

Symptoms of Cognitive Decline

For this reason, it appears that Sermorelin Acetate Injections may be a valid treatment option for patients that are concerned about cognitive decline, or feel that they are experiencing symptoms related to cognitive decline, including:

Fuzzy Memory - Are you having trouble remembering things clearly?

Reduced Working Memory - Do you feel that you sometimes have trouble thinking about complex concepts, or juggling ideas?

Cognitive Fatigue - Do you often find yourself mentally drained?

Changes in Attention Span - Is it hard to sustain focus when switching between tasks?

These are all symptoms associated with Age-Related Cognitive Decline. Because of the gradual nature of these mental issues, most patients don't notice these changes taking place until they have already experienced a significant level of decline.

Sermorelin Acetate Study Specifics

What led the researchers to study Sermorelin Acetate in this way?

This is not the first study that has sought to illuminate the link between Growth Hormone-Releasing Hormone and Cognitive Health. Since the turn of the century, there have been a number of studies that have established this link between mental health and GH-RH. This study, in particular, was declined to analyze the effects of Sermorelin Acetate upon neurotransmitters responsible for cognitive health.


This study was conducted at the University of Washington Medical School, by a group which specializes in clinical research and clinical implications.

How was this Sermorelin Acetate Study Designed?

This study was double-blind, meaning that neither doctor or patient had any prior knowledge to which patients were experimental participants and which were control patients. The pools were also randomized in order to maximize the predictive potential of the data.

This research was conducted as a part of a much larger study regarding the effects of Sermorelin Acetate and GH-RH upon human patients.


In total, there were thirty patients which participated in the study. These patients ranged from fifty-five to eighty-seven years of age. Out of the thirty participants, seventeen were showing signs of memory issues, referred to specifically as Mild Cognitive Impairment. All thirty participants completed the study in its entirety.

How was this Sermorelin Study Conducted?

In this study, the experimental group received injections of a form of Sermorelin Acetate known as Tesamorelin. Tesamorelin is a product of Theratechnologies, which did not finance this study. Experiemental subjects injected 1 milligram/deciliter of Tesamorelin GH-RH once daily.


These injections were administered Subcutaneously, meaning that the injections were delivered just beneath the skin, but above muscle tissue. Both Sermorelin and Human Growth Hormone injections are delivered in this fashion, using small needles which can also be used to inject Insulin.

Rather than injecting Tesamorelin Growth Hormone-Releasing Hormone, control patients Subcutaneously injected a placebo solution.

Both groups administered injections one half hour before bedtime daily over the course of five months.

At three periods, all participants underwent MRI imaging and spectroscopy in order to examine the physiological effects of treatment. These scans took place at the beginning of the study, after ten weeks, and finally at the conclusion of the study after twenty weeks. In addition to this, Patients underwent quantitative memory testing. They also received blood diagnostic testing after their period of fasting. Both before and after treatment was completed, patients underwent tests for insulin sensitivity.

What were the Results of this Sermorelin Study?

After twenty weeks of Tesamorelin Injections, levels of GABA were shown to increase. GABA is one of the most critical hormones related to memory and cognition. Researchers believe that GABA concentration in the parts of the brain associated with memory has a direct effect upon a patient's ability to create and recall memories.

Another hormone, known as NAAG, was found to increase as well. Although much less is known about this hormone, researchers have made a clear connection between NAAG concentration in the Frontal Cortex and a patient's capacity to remember events in the past, also known as episodic memory.

A third hormone, Myo-Inositol, was found to decrease in concentration in an area known as the Posterior Cingulate. Abnormally high levels of Myo-Inositol in this area of the brain is strongly associated with both Age-Related Cognitive Decline and Alzheimer's Disease.

The new baseline after GH-RH Treatment was actually very similar to the biological balance of chemicals in the brain associated with a healthy older adults not experiencing the effects of cognitive decline. Glutamate levels were found to be unchanged.

As a direct result of the GH-RH Injection, IGF-1 levels in the brain were shown to increase. Increased IGF-1 levels were causally linked to increased levels of GABA activity in the brain. Healthy IGF-1 Levels were also shown to be correlated with lower levels of Myo-Inositol.

GH-RH Intervention had a significant, positive effect upon the mental faculties of the participating patients. Also, Tesamorelin Injections did not contribute to changes in Insulin Sensitivity. Glucose levels were not affected by this treatment.

GH-RH Study Conclusions

This study provides powerful evidence that Sermorelin Acetate Therapy can slow down or prevent Age-Related Cognitive Decline. GH- RH Injections were capable if boosting GABA Levels in all relevant parts of the brain, while increasing the concentration of Frontal Cortex NAAG and MI in the Posterior Cingulate.

This was the first study of its kind that reveals exactly how GH-RH Administration can positively affect cognitive health. By utilizing Magnetic Resonance Imaging, researchers have shown that Sermorelin Acetate can be one of the most effective tools in maintaining a sharp and healthy mind.

The results of this study are incredibly promising for individuals that have a family history of Age-Related Cognitive Decline. This is just another reason to think about both Sermorelin Acetate Hormone Replacement Therapy and Human Growth Hormone Replacement Therapy as you grow older.

Number of words:1631

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