CAN SERMORELIN ACETATE IMPROVE MEMORY AND COGNITION?
Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D.. Published on September 4th, 2019
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Hormone Replacement Therapy
Sermorelin
Sermorelin
Acetate and Mental Health
One of the
most life-changing aspects of the aging process is cognitive decline.
The thought of losing one's memory or losing one's capacity to think
critically isnnn particularly unnerving. Some of the most devastating
conditions related to aging are the result of changes within the
brain. Two of the worst are Dementia and Alzheimer's.
New
research suggests that there are ways to maintain a strong and
healthy mind throughout one's life, and that cognitive decline is not
strictly a factor of age, but largely an effect of underlying,
chronic health issues. As more and more data is analyzed, it appears
that the worst aspects of cognitive decline can be avoided for
healthy patients that are not predisposed to conditions such as
Alzheimer's.
Even for
men and women genetically predisposed to diseases like Alzheimer's,
there is a ton of promise on the horizon for effective treatments
that may eventually be able to prevent these diseases. It is
exceedingly likely that, in the next years and decades, a cure for
Alzheimer's will be found.
Today,
medical experts are quickly learning the mechanisms which precipitate
the mental decline associated with Alzheimer's, and using this
information, they will likely be able to come up with an effective
preventative treatment.
New
JAMA Article Explores a Method to Slow Down Cognitive Decline in
Aging Patients
Even
though Alzheimer's will only affect a certain percentage of
Americans, the threat of cognitive decline hangs over us all, and
scientists are doing everything they can to provide us with the tools
and information we need to forestall such decline. A recent study
released in the Journal of the American Medical Association shows one
treatment that displays real promise for slowing or stopping
cognitive decline.
What is
Sermorelin Acetate?
Sermorelin
Acetate is a medical hormone treatment. Although the hormone is
synthetic, it is designed to completely imitate the biological
function of a vital hormone produced by the human hypothalamus.
Sermorelin is the medical form of a hormone known as Growth
Hormone-Releasing Hormone, also referred to as GH-RH.
GH-RH is a
very important hormone which is actually a precursor to a polypeptide
which most people have heard about: Human Growth Hormone. GH-RH is
produced by the Hypothalamus and delivered to the pituitary gland in
order to stimulate the production of Growth Hormone. After the
Pituitary gets the signal, it starts cranking out pulses of Human
Growth Hormone, which circulate through the body, providing numerous
benefits.
Sermorelin
Acetate is functionally identical to Growth Hormone-Releasing
Hormone, meaning that although the two molecules do not share the
same physiological structure, they both have the same exact effect
upon the human body. Sermorelin Acetate has a very similar biological
construction to GH-RH: They actually share the same initial 29 amino
acids. Due to a biological quirk, the remaining amino acid chain that
composes GH-RH is junk, meaning that it serves no biological purpose.
Because of
this, biologists isolated the active portion of GH-RH in order to
streamline the synthetic form of the hormone for reasons of cost and
efficiency. Because Sermorelin is functionally identical, there is no
reason to spend the time and money replicating the non-functional
portion of the strand.
So,
What Does Sermorelin Acetate and GH-RH Have to Do with the Brain?
After
Human Growth Hormone is intercepted by the liver, it is converted
into another group of hormones known as Insulin-Like Growth Factors.
These hormones represent the most active iteration of Human Growth
Hormone. Although HGH does directly stimulate some physiological
changes, most of the benefits caused by GH-RH and Human Growth
Hormone are manifested by these Growth Factors.
The most
influential and abundant Growth Factor is Insulin-Like Growth
Factor-1. This hormone causes changes throughout the body. It
increases adipose fat metabolism, it encourages muscle development,
and it encourages the maintenance of bone mineral density.
In the
last decade, researchers have discovered another important function
of IGF-1: Insulin-Like Growth Factor-1 helps maintain healthy
cognitive function throughout the lifespan. So, through a grand chain
of events, the release of Growth Hormone-Releasing Hormone by the
hypothalamus contributes directly to overall cognitive health.
Symptoms
of Cognitive Decline
For this
reason, it appears that Sermorelin Acetate Injections may be a valid
treatment option for patients that are concerned about cognitive
decline, or feel that they are experiencing symptoms related to
cognitive decline, including:
Fuzzy
Memory - Are you having trouble remembering things clearly?
Reduced
Working Memory - Do you feel that you sometimes have trouble
thinking about complex concepts, or juggling ideas?
Cognitive
Fatigue - Do you often find yourself mentally drained?
Changes
in Attention Span - Is it hard to sustain focus when switching
between tasks?
These are
all symptoms associated with Age-Related Cognitive Decline. Because
of the gradual nature of these mental issues, most patients don't
notice these changes taking place until they have already experienced
a significant level of decline.
Sermorelin
Acetate Study Specifics
What
led the researchers to study Sermorelin Acetate in this way?
This is not the first study that has sought to illuminate the link
between Growth Hormone-Releasing Hormone and Cognitive Health. Since
the turn of the century, there have been a number of studies that
have established this link between mental health and GH-RH. This
study, in particular, was declined to analyze the effects of
Sermorelin Acetate upon neurotransmitters responsible for cognitive
health.
This study was conducted at the University of Washington Medical
School, by a group which specializes in clinical research and
clinical implications.
How was
this Sermorelin Acetate Study Designed?
This study
was double-blind, meaning that neither doctor or patient had any
prior knowledge to which patients were experimental participants and
which were control patients. The pools were also randomized in order
to maximize the predictive potential of the data.
This
research was conducted as a part of a much larger study regarding the
effects of Sermorelin Acetate and GH-RH upon human patients.
In total, there were thirty patients which participated in the study.
These patients ranged from fifty-five to eighty-seven years of age.
Out of the thirty participants, seventeen were showing signs of
memory issues, referred to specifically as Mild Cognitive Impairment.
All thirty participants completed the study in its entirety.
How was
this Sermorelin Study Conducted?
In this study, the experimental group received injections of a form
of Sermorelin Acetate known as Tesamorelin. Tesamorelin is a product
of Theratechnologies, which did not finance this study. Experiemental
subjects injected 1 milligram/deciliter of Tesamorelin GH-RH once
daily.
These injections were administered Subcutaneously, meaning that the
injections were delivered just beneath the skin, but above muscle
tissue. Both Sermorelin and Human Growth Hormone injections are
delivered in this fashion, using small needles which can also be used
to inject Insulin.
Rather
than injecting Tesamorelin Growth Hormone-Releasing Hormone, control
patients Subcutaneously injected a placebo solution.
Both
groups administered injections one half hour before bedtime daily
over the course of five months.
At three
periods, all participants underwent MRI imaging and spectroscopy in
order to examine the physiological effects of treatment. These scans
took place at the beginning of the study, after ten weeks, and
finally at the conclusion of the study after twenty weeks. In
addition to this, Patients underwent quantitative memory testing.
They also received blood diagnostic testing after their period of
fasting. Both before and after treatment was completed, patients
underwent tests for insulin sensitivity.
What
were the Results of this Sermorelin Study?
After
twenty weeks of Tesamorelin Injections, levels of GABA were shown to
increase. GABA is one of the most critical hormones related to memory
and cognition. Researchers believe that GABA concentration in the
parts of the brain associated with memory has a direct effect upon a
patient's ability to create and recall memories.
Another
hormone, known as NAAG, was found to increase as well. Although much
less is known about this hormone, researchers have made a clear
connection between NAAG concentration in the Frontal Cortex and a
patient's capacity to remember events in the past, also known as
episodic memory.
A third
hormone, Myo-Inositol, was found to decrease in concentration in an
area known as the Posterior Cingulate. Abnormally high levels of
Myo-Inositol in this area of the brain is strongly associated with
both Age-Related Cognitive Decline and Alzheimer's Disease.
The new
baseline after GH-RH Treatment was actually very similar to the
biological balance of chemicals in the brain associated with a
healthy older adults not experiencing the effects of cognitive
decline. Glutamate levels were found to be unchanged.
As a
direct result of the GH-RH Injection, IGF-1 levels in the brain were
shown to increase. Increased IGF-1 levels were causally linked to
increased levels of GABA activity in the brain. Healthy IGF-1 Levels
were also shown to be correlated with lower levels of Myo-Inositol.
GH-RH
Intervention had a significant, positive effect upon the mental
faculties of the participating patients. Also, Tesamorelin Injections
did not contribute to changes in Insulin Sensitivity. Glucose levels
were not affected by this treatment.
GH-RH
Study Conclusions
This study
provides powerful evidence that Sermorelin Acetate Therapy can slow
down or prevent Age-Related Cognitive Decline. GH- RH Injections
were capable if boosting GABA Levels in all relevant parts of the
brain, while increasing the concentration of Frontal Cortex NAAG and
MI in the Posterior Cingulate.
This was
the first study of its kind that reveals exactly how GH-RH
Administration can positively affect cognitive health. By utilizing
Magnetic Resonance Imaging, researchers have shown that Sermorelin
Acetate can be one of the most effective tools in maintaining a sharp
and healthy mind.
The
results of this study are incredibly promising for individuals that
have a family history of Age-Related Cognitive Decline. This is just
another reason to think about both Sermorelin Acetate Hormone
Replacement Therapy and Human Growth Hormone Replacement Therapy as
you grow older.
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