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Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on September 4th, 2019
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Hormone Replacement Therapy


Serostim Approved by the Food and Drug Administration as a Treatment for HIV-Related Cachexia

Serostim is the only Human Growth Hormone Medical Treatment approved by the FDA for the treatment of muscle wasting associated with the HIV Virus. Serostim has been shown in increase muscle mass and stabilize and increase healthy weight while also reducing fatigue and increasing endurance for physical activity.

Serostim History

Seventeen years ago, Serostim was fast-tracked for approval by the Food and Drug Administration. Any drugs which offer new and unique treatment options for patients with a severe and critical ailment can qualify for this streamlined version of the FDA-Approval Process. After being placed in this approval track, Serono (the creator of Serostim Bio-Identical HGH) began a large-scale study in order to fully evaluate the usefulness and safety profile of Serostim HGH for HIV-Wasting.

This medical trial was double blind in nature and controlled by placebo. In addition to this, the large-scale trial also involved numerous independent medical facilities. The results of this trial corroborated with initial small-scale trials which hinted at the beneficial usefulness of Serostim for this purpose.

FDA-Facilitated HGH Research showed that Serostim was able to both stimulate the production of lean muscle as well as significantly reduce fatigue in patients suffering from HIV-Related Wasting. In addition to quantitative benefits related to Serostim HGH, patients also felt that the benefits provided by Serostim were significantly qualitatively beneficial as well.

Muscle Atrophy Among Worst Symptoms of HIV and AIDS

Lean muscle wasting is one of the most detrimental symptoms of the HIV virus, and Serostim has been proven to alleviate or reverse the affects of this devastating condition. Stronger muscles and decreased fatigue give the body more resources to fight off other symptoms associated with the HIV Virus, increasing overall health outcomes for those that suffer from HIV.

Although Antiretroviral medications have the ability to alleviate many of the debilitating symptoms of the HIV Virus, it is clear that Serostim provides an additional benefit that Antiretroviral Drugs alone cannot produce alone. Combining these HIV Drugs with Serostim allows patients to live a healthier life that is closer to normal.

Pitfalls of Cachexia Due to HIV

HIV-Related Wasting Disease is a disorder which becomes progressively worse over time without treatment. The negative effects of lean muscle atrophy degrade the human body over time and rapidly increase mortality rates over time without treatment. HIV Wasting is a Metabolism Disease which leads the body to burn organ and muscle tissue for energy. This process is a physiological response to negative stimuli associated with the HIV-Virus.

Even though the human body still has stores of usable fat, the HIV Virus tricks the body into burning vital muscle tissue rather than fat tissue. Because of this, patients suffering from HIV-Related Cachexia have a viciously imbalanced body-fat percentage, as the body burns structural muscle rather than emergency fat. Lean muscle is a blanket term which refers to a number of types of tissue throughout the body, including organ tissue, the muscles themselves, and blood cells within the cardiovascular system.

Decreased Lean Muscle Mass vastly increases the risk of extreme physiological exhaustion, illness, and infection, which can overwhelm the weakened immune system of an HIV patient and vastly decrease both their life quality as well as their long term odds of survival. Serostim was designated as an Orphan Drug Treatment for HIV-Related Muscle Wasting by the Food and Drug Administration in 1991.

HGH-AIDS Study Protocol

The final seal approval for Serostim Human Growth Hormone Replacement Therapy was granted as a result of a dose-variable, double-blind, randomized large scale medical study which was funded directly to assess the benefits of Serostim HGH Treatments. This clinical trial included 757 participants which all suffered from Wasting as a result of HIV or AIDS.

Subjects were not limited to the United States, and international medical facilities and patients also participated. Patients were either provided Serostim Growth Hormone Injections on a daily basis, or were provided injections daily, half of which were Serostim, half of which were placebo. A third group was injected with a placebo on a daily basis, and served as a complete control.

HGH-AIDS Research Results

All groups received injections for an identical period of time and then were physiologically assessed at the end of an initial treatment period. Researchers found that patients that received daily HGH Injections had significantly increased levels of lean muscle in comparison to the other subset of patients which only received a half-dose.

Both of these groups of patients benefited significantly in comparison to a third group which simply received placebo injections. In both experimental groups, patients could perceive the benefits of Serostim Subcutaneous Injections in their everyday life.

All of the patients that completed the first three months of the controlled clinical trial maintained treatment beyond the initial phase of clinical study. Of the 646 patients that completed the initial study, 548 remained in treatment for an extra three months. Among all of these patients, the benefits of Serostim on muscle mass maintenance continued to accrue.

As of today, Serostim Recombinant HGH Therapy is the only HGH Treatment that the Food and Drug Adminsitration has granted approval for the treatment of HIV-Related Cachexia. The dose recommended by the FDA is 0.1 Milligram per Kilogram each day. For patients that weigh more than fifty five kilograms, the maximum dose is six milligrams of Serostim per day. Patients that are at increased risk of side effect should be prescribed half of a normal dose per week provided every other day.

HGH Caused Relatively Few Side-Effects

For the most part, Serostim produces very few side effects. The most reported side-effects of treatment were edema, as well as non-severe joint and muscle pain. Any side-effects are directly related to the size of the dose, and side-effects eventually subsided either as treatment continued, or with a reduction in dose size.

In a very small minority of patients, issues related to glucose tolerance occurred, including the exacerbation of insulin sensitivity or the uncovering of underlying Type-Two Diabetes. In some of these latter patients, Insulin treatments either had to be initiated or adjusted as a result of treatment. Patients with HIV-Wasting Disease with a history of Diabetes or insulin sensitivity should be closely monitored during HGH Treatment.

HGH High-Dosage AIDS Treatment

It should be noted that the Human Growth Hormone Dosage used to treat HIV-Related Cachexia is significantly higher than that used to therapeutically treat Adult-Onset Human Growth Hormone Deficiency. Generally, the dose used in order to treat HGH Deficiency is between one and two IU per day, which is far less than the six milligrams per day generally prescribed to patients dealing with severe Cachexia.

Human Growth Hormone has an amazing capacity to stimulate the maintenance and development of lean muscle tissue in at-risk patients, and in the future, there is no doubt that Human Growth Hormone Replacement Therapy will be found highly beneficial for a number of other medical disorders as well.

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