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HOW MUCH DOES TESTOSTERONE CONTROL MEN'S BEHAVIOR?


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 07 October 2020
While Testosterone is undeniably critical to male physiology, it's essential to understand the wide range of effects that Testosterone has on men. Testosterone clearly impacts the way that men act and think in a variety of ways. It's correlated with increased assertiveness and confidence as well as increased aggression, for example. There's no doubt that Testosterone has some effect on male behavior, but it's also possible that Testosterone is somewhat of a red herring when it comes to many factors that differentiate men and women psychologically. Testosterone, unlike most hormones, has a very particular mystical aura surrounding its effects. Along with confidence and assertiveness, the quintessentially male hormone is also associated with increased promiscuity, athletic prowess, and willingness to take risks.

Testosterone and the Endocrine System

Testosterone is one of a number of Steroid Hormones, along with progesterone, Estrogen, and others. Cholesterol is the foundation of Testosterone. While Testosterone is dominant in men, it's also produced in much smaller amounts by women. Testosterone is just one actor in the endocrine system, and the human body functions at its peak when all of these hormones are in proper alignment. Just like women need some Testosterone, men require some level of Estrogen for health and fertility. These Hormones do more than just promote sexual function, however. They also support liver function, cardiovascular health, and bone structure, just to name a few key influences.

Testosterone and Psychology

While Testosterone is linked with several traits associated with toxic masculinity, it's quite possible that the hormone gets a bad wrap. Early research in the late 19th and early 20th century clearly correlated Testosterone with aggression in animals. As we've learned more about how Testosterone works over the last century, it's clear that our actions and circumstances influence Testosterone Production. There are feedback mechanisms at play. While Testosterone increases the tendency toward aggression, our free will certainly play a role as well. Numerous recent studies have begun to explore the link between Cortisol and Testosterone. Cortisol is the body's primary stress hormone and is built from the same component parts as Testosterone. It's theorized by many that Testosterone is produced in anticipation of aggression and competition, just as Cortisol is released in response to stress. Testosterone also appears to act as a sorting mechanism for dominance. Studies have shown that success in competition leads to temporarily increased Testosterone, while defeat is correlated with a drop in Testosterone. This is true not only for competitors, but for fans! This is one area that is very different for men and women. Among men, success and competition have the potential to create a feedback loop that induces ongoing aggression. In women, this is not the case.

Self Control and Testosterone

So it's clear that Testosterone induces aggression, but can nurture mitigate the negative risks associated with Testosterone? One study shows that Cognitive Behavioral Therapy during adolescence can help boys and men control how their bodies and brains respond to confrontation. Therapy reduced aggression during adulthood and also produced less Testosterone during provocation. Men release Testosterone in response to situations that suggest the need for aggression, but cognitive processes can keep the mind in control of the emotions. Interestingly enough, studies show that women and men both have a similar capacity for anger. The differences lie in the way that anger is expressed. Men are far more likely to respond with physical aggression than women. It's believed that Testosterone makes men more likely to convert anger into force and action than women. In the end, it's important to understand that Testosterone is not in the driver seat of male psychology. Men ultimately have control over our actions, and our choices and willpower can keep the potential negative consequences of Testosterone in check. Testosterone is just a tool, and men must wield that tool thoughtfully.

TESTOSTERONE SHOCK THERAPY MAY BE AN EFFECTIVE PROSTATE CANCER TREATMENT


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 23 August 2020
Testosterone Therapy is popular among American Men, but it's not for everyone. For example, Testosterone exacerbates Prostate Cancer. Almost 200,000 men are diagnosed with Prostate Cancer each year. Researchers continue to search for innovative ways to treat Prostate Cancer effectively. A study from 2016 investigates a treatment method that may seem counterintuitive—Testosterone Shock Therapy. One patient in this study experienced complete remission resulting from treatment.

Testosterone Normally Makes Prostate Cancer Worse

Under normal circumstances, Testosterone exacerbates Prostate Cancer, but a high-dose of Testosterone appears to kill the Prostate Tumor. In order to eliminate Prostate Cancer cells, researchers alternated between delivering high doses and extremely low doses of Testosterone. This treatment is also known as Bipolar Androgen Therapy. Intriguingly, researchers do not currently fully understand how this works, but the results are readily apparent. The long-term goal is to learn the mechanisms behind this new treatment and figure out how best to include Testosterone Shock Therapy, among other treatment options.

Bipolar Androgen Therapy Helps Patients Grapple With Prostate Cancer

Patients underwent three phases of alternating High/Low Testosterone exposure. This pattern overloads Prostate Cancer Cells then starves them. It's hypothesized that this alternating pattern helps kill off the cells faster than simply cutting them off from their fuel source. Each Testosterone Cycle consisted of a single injection of High-Dosage Testosterone every four weeks. During this same period, they received medication to shut down the natural production of Testosterone. The easiest way to monitor Prostate Cancer activity is by measuring Prostate Specific Antigen (PSA) Levels. The higher that PSA Levels are beyond baseline, the more aggressive the tumor. Among patients in the experiment, 47 men experienced lower PSA Count due to Testosterone Shock Treatment. The one lucky patient with total remission had PSA Levels fall to zero for at least 22 treatment cycles. Shock Treatments helped many patients stabilize their Prostate Cancer, halting its progression. It's clear that this treatment can help at least some patients significantly reduce the mortality risk associated with Prostate Cancer.

Bipolar Androgen Therapy Alternative to Androgen Deprivation Therapy

For decades, it's been supposed that Testosterone is the primary reason that Prostate Cancer gets out of hand. Indeed, treatments that shut down Testosterone Production or block Testosterone Activity have proven useful and effective. It's believed that Bipolar Androgen Therapy works because it interrupts the proliferation of Prostate Cancer Cells by disrupting cellular division. The alternating feast/famine Testosterone Cycle appears to breakdown the DNA of these rogue cells.

TESTOSTERONE AND OTHER SEX HORMONES IMPACT ASTHMA RESPONSE DEPENDENT ON SEX


Written by Dr. Welsh, Article reviewed and edited by Dr. Fine M.D..
Published on 21 July 2020


Many conditions affect men and women differently. One of these conditions is asthma. It has long been known that pre-pubertal males tend to have more issues with asthma than females of the same age, but the underlying reasons why have not been so clear.

Recently, researchers from Johns Hopkins have explored the effects of Testosterone concerning asthma. It's critical to understand how men and women differ physiologically because it leads to different risks and different factors that impact potential treatment options.

While this study was conducted in mice, its results are hypothesized to be transferrable to humans. The research was published via the Journal of Immunology last October. While women are less likely to experience asthma than men in adulthood, Testosterone activated inflammation receptors in the lungs in response to exposure to an allergen known as ovalbumin. Obviously, these results give some mixed messages.

Asthma Risk Dependent on Age and Sex

Asthma is an interesting condition because its prevalence changes among males and females depending on age. Prior to puberty, boys are more liable to have issues with asthma than girls. After puberty, however, the situation changes. Then girls and women are more likely to have asthma. This is a clear example of how sex hormones lead to wellness-related sex differences. By exploring the mechanisms behind these differences, we can improve asthma diagnosis and treatment protocols.

A previous study investigated how Estrogen effected lung inflammation in mice. They found that Estrogen triggers inflammation. As we mentioned earlier, post-pubertal girls and women have a much higher incidence of asthma than men of the same age. This data led researchers to hypothesize that Testosterone would provide benefits against lung inflammation. For example, while still in experimental phases, male hormones have been prescribed as a successful treatment for women with asthma.

Mouse Testosterone Asthma Study

In order to learn more about how Testosterone impacts asthma, researchers needed mice that couldn't produce their own sex hormones. By using castrated mice, they could precisely control hormone levels using Testosterone Implants, which slowly and steadily release hormones.

Researchers also had to simulate asthmatic allergic reaction in the mice, because mice don't normally experience allergic asthma. Researchers aerosolized albumin to trigger a lung reaction similar to what humans experience when they have an asthma attack.

Testosterone and Lung Inflammation

Lung Inflammation is triggered by specific immune cells known as Alveolar Macrophages. These microscopic phagocytes absorb and break down debris in the lungs. They also trigger inflammatory activity, including the cascade of symptoms associated with an asthma attack. Researchers expected Testosterone to protect against lung inflammation in the mice.

What they discovered was more complicated. While Testosterone suppressed most markers of inflammation, it activated lung inflammation, specifically in Alveolar Macrophages. Researchers then bred male/female mice without Testosterone Receptors in their Alveolar Macrophages. Here, they discovered a critical sex-difference. Male mice had less inflammation when these receptors were deactivated. Female mice saw no such change. This means that in male mice, Testosterone is more intricately involved in how irritants trigger asthma response.

This provides evidence for why Testosterone can help women with asthma, but those results are sex-specific. This research highlights that a person's individual characteristics are very important to consider when deliberating upon treatment options.

In the future, research like this will likely lead to treatment options that differ for men and women. While an asthma attack looks the same in males and females, the mechanisms which trigger the attack clearly differ, which provides different opportunities for ideal treatment. Antihistamines and Steroids are the go-to treatment for asthma, but males with severe asthma may benefit more from an alternative form of therapy.


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