ANDROGEN TESTOSTERONE HORMONE INJECTIONS
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TESTOSTERONE HELPS MODULATE IMMUNE ACTIVITY IN THE DIGESTIVE SYSTEM
Written by , Article reviewed and edited by Dr. Fine M.D.
Published on 13 May 2021
Our bodies depend on the immune system for survival. The immune system is critical to protect against diseases and other foreign invaders. Unfortunately, the human immune system is also prone to over-activity. Millions in America deal with auto-immune disorders, which range from frustrating to life-threatening. While women are more likely to experience auto-immune issues, individuals of both sexes frequently experience these health problems.
Gender Differences in Chronic Inflammation
Jonathan Busada of West Virginia University is interested in exploring the mechanisms which lead to inflammation and how sexual differences cause men and women to experience inflammation differently. Women, in particular, are more prone to stomach inflammation than men. In his research, he found that androgens likely help to protect against problematic gut inflammation. This research was revealed in the medical journal Gastroenterology.
Busada is specifically concerned with how inflammation influences the onset of stomach cancer. In most cases, stomach cancer results from chronic inflammation of the gut. Busada explains that there is a difference between healthy immunity and an overactive immune system. The immune system is designed to protect the body, but it can do more harm than good when it goes into overdrive.
This sort of research helps scientists understand the difference between a healthy immune response and destructive inflammation and what factors lead the body down the path of harm. Busada's work shows that Testosterone is a powerful force to reign in inflammation and help the immune system perform its duties more efficiently and effectively.
Animal Research Tests the Effects of Testosterone on Inflammation
Busada explored the effects of both Testosterone and Glucocorticoids on stomach inflammation, with a focus on Testosterone. This study focused on animal research with mice. Glucocorticoids are adrenal hormones secreted by mammals. Cortisol is an example of a human glucocorticoid and is the most influential. Mice do not produce Cortisol but produce biologically similar hormones which serve the same purpose. Glucocorticoids are made in the same way by both men and women but can be influenced by sex hormone activity.
Professor Busada first worked with mice that produced neither Testosterone nor Glucocorticoids. Researchers found that without the influence of these hormones, inflammation rates remained equal between male and female mice. When treated with Testosterone, on the other hand, inflammation disappeared. This research showed that female mice only have natural inflammation protection via glucocorticoids. In contrast, the male rats were protected further from inflammation due to the benefits of Testosterone, in addition to glucocorticoids.
Women at Increased Risk of Autoimmune Disorders
This research helps to explain why women are more at risk for auto-immune conditions than men. It's estimated that women experience 80% of Auto-Immune Disorders. Women have triple the chances of experiencing rheumatoid arthritis and have more than twice the risk of celiac disease, as examples.
Stomach cancer is of particular concern because it's one of the most deadly forms of cancer in the world today—third behind colorectal cancer (2nd) and lung cancer (1st). Treating stomach inflammation can help patients across the globe mitigate their risk of stomach cancer, and Testosterone Therapy may be a tool at doctors' disposal.
Testosterone as Anti-Inflammatory
There's a chance that specialized Testosterone or Androgen treatments could help women improve their resistance to inflammation. This also shows the importance of being tested for Low-T, as waning Testosterone Levels in men can have an adverse impact on the functional performance of the immune system. While women are more prone to stomach inflammation, men are at greater risk of stomach cancer which is largely encouraged by inflammation.
This research lays the groundwork for our understanding of how stomach inflammation is impacted by androgen activity. Further study will give medical professionals the knowledge and tools that they need to create effective therapies. For now, the results offer more evidence regarding the importance of Endocrine Balance for a healthy immune system.
A recent Chinese study provides evidence that Hypertension is associated with suppressed Total Testosterone, Free Testosterone, and SHBG Levels in older men. The results were released in a recent edition of the Journal of the American Heart Association. Clinical evidence shows that both Elevated Testosterone and Low Testosterone are potentially threatening risk factors for dangerous cardiovascular events.
Testosterone, Aging, Diabetes, and Cardiovascular Disease
Testosterone Levels naturally drop as an element of the male aging process. While this decline is natural, the body still requires a certain level of Testosterone to promote optimized health. On the other hand, there is also significant evidence that cardiovascular disease and diabetes both result in significantly reduced Testosterone Levels resulting from the conditions themselves. Many health conditions suppress Testosterone, which creates a negative feedback loop where Low-T exacerbates the existing disorder, further dropping Testosterone Production.
For that reason, researchers continue to take steps to identify ideal Testosterone Levels as a factor of age. Millions of men can undoubtedly benefit from Testosterone Therapy, but it's essential to identify the high and low Testosterone Thresholds which provide the maximum benefit for the least risk.
Chinese Study Evaluates Correlation between Testosterone and Hypertension
In order to broaden our knowledge of how Testosterone interacts with Cardiovascular outcomes, Chinese researchers conducted a broad study that included 6296 participants, selected between the years of 2013 and 2016. Patients were evaluated clinically, provided basic patient information, and filled out health questionnaires.
During clinical evaluation, doctors obtained a number of data points, including levels of Free Testosterone, Total Testosterone, Luteinizing Hormone, and SHBG, along with blood pressure. In the end, the scientists used data collected from 5786 of the original 6296. The collection of patients were an average of 55 years old, and 37.2% suffered from clinical Hypertension.
When looking at all of this data together, researchers were able to make some critical observations. Hypertensive patients were more likely to have lower SHBG, Free Testosterone, and Total Testosterone. SHBG is responsible for the transport of Testosterone for use by the body. Total Testosterone refers to all bound and unbound Testosterone in the bloodstream. Free Testosterone is biologically active Testosterone readily available for use by cells.
Healthy Testosterone Levels Associated with Strong Hearts
Using advanced statistical analysis, researchers were able to determine that Total Testosterone was most strongly correlated with cardiovascular risk. Testosterone is critical to male cardiovascular health because it plays a vital role in vascular constriction and relaxation. Impaired Testosterone Levels had the worst effects on patients under 65 with a BMI less than 24. Patients that smoked and/or had a family history of high blood pressure were most likely to have suppressed Testosterone and high blood pressure.
On the other hand, elevated Luteinizing Hormone Levels were associated with an increased risk of Hypertension. High Luteinizing Hormone Levels combined with Testosterone Deficiency is the physiological marker for Primary Hypogonadism and is considered to be a big risk factor for Cardiovascular Disorder. Hormone Balance is one of the keys to good health. Both Low-T and abnormally high Testosterone lead to increased cardiovascular risk. This is why getting appropriate treatment for Low-T is so important.
GETTING TO THE BOTTOM OF LOW-T UNDER-REPORTED SOURCES OF TESTOSTERONE DEFICIENCY
Written by , Article reviewed and edited by Dr. Fine M.D.
Published on 05 May 2021
While Testosterone Therapy is the go-to medical treatment for Low-T, it's essential to recognize the potential causes of Hormone Imbalance and suppression. In many cases, Bio-Identical Testosterone can be combined with lifestyle changes and other interventions to overcome the symptoms of Testosterone Deficiency.
Most people understand that Testosterone is intricately linked to sexual function and libido. Many understand that Low-T contributes to feelings of fatigue and exhaustion. The majority of folks don't recognize the truly widespread effects of Low-T, however. Testosterone also preserves bone mineral density and muscle mass, preserves cognitive function, protects against depression, and more.
Low-T Likely More Prevalent Than Ever
Testosterone Deficiency is an increasingly common concern among men, and for good reason. It's increasingly understood that Low-T has been under-diagnosed for a long time, and we're just now becoming appropriately vigilant. A recent study involving 1400 patients revealed that 25% of participants clinically suffered from Low Testosterone. It's believed that this number could increase by 38% in 2025.
It's clear that Testosterone Deficiency is a huge problem for men, and the problem isn't going away without sufficient medical/social intervention. Societal factors, lifestyle choices, environment, and genetics all play a combined role, which is increasing the prevalence of Low-T.
Hidden Contributors to Testosterone Deficiency
Obesity and Aging are the most commonly recognized causes of Low-T, but several other factors have a strong influence on Testosterone Balance. Several of these causes are well within our control to ameliorate.
Nutrition Deficiencies Can Lead to Low-T
Proper nutrition is critical to adequate Hormone Balance. A few of the most important vitamins and minerals associated with healthy Testosterone Levels are Zinc and Vitamins A/D. Americans tend to consume too many processed foods these days, which can limit the absorption of nutrients.
Even the healthy-foods that we choose to eat may not be as deeply nutritious as they were generations ago. Improper farming techniques, pesticides, and the exhaustion of land all deplete the nutrient levels of farm-fresh fruits and vegetables. Ethical food-sourcing provides higher quality fruits and veggies, not only in taste but in content. Even if you try to eat well, it's smart to add a quality multivitamin from a trusted supplier to round out your nutritional needs.
Chronic Stress Can Cause Testosterone Levels to Plummet
Stress has a powerful effect on Hormone Balance that is often overlooked. Cortisol is the human body's most potent stress hormone and is produced from the same basic parts as other hormones such as Testosterone and Estrogen. Both psychological and physiological stress are largely impacted by Cortisol. While the hormone is critical to daily function, chronic stress can have a devastating effect on your health and Hormone Balance. The more Cortisol that your body is making, the fewer components are available for the production of Testosterone. By taking steps to manage or control stress, you make your body less susceptible to Low-T.
Endocrine Disrupting Chemicals (EDCs) Impair Testosterone
There are a variety of chemicals that can disrupt your body's ability to produce Testosterone. These chemicals are known as EDCs. Some of the more common EDCs are BPA, phthalates, pesticides, phytoestrogens, dioxins, and PCBs. EDCs in Pesticides are another reason to look for responsibly-sourced, organic foods. It may also be smart to limit your consumption of foods from some plastic containers.
Make sure you do use plastics properlymany of which are intended for single-use or are not dishwasher-safe. Also, be aware of environmental sources of EDCs, including polluted water and anywhere that plastics are incinerated. Mold can also have a negative hormonal impact.
Many Common Medications Suppress Testosterone
When preparing to discuss Low-T with your doctor, consider any prescription or over-the-counter medications that you are currently taking. Furthermore, be aware that certain recreational drugs, such as opiates and alcohol, can severely disrupt Testosterone Production, tipping the axis toward Estrogen Production.
NSAIDs, including Ibuprofin and Aspirin, can harm Testosterone Levels if abused or used for an extended period. Antidepressants, statins, and prescription opiates can also contribute to symptoms of Low-T.
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NORDITROPIN VIALS OR PEN
Norditropin Pen System is activated with first usage and can be used for three weeks without any refrigeration, Pen will last 4 weeks with refrigeration after which potency might begin to degrade.
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Testosterone Therapy Benefits
Correctly performed testosterone therapy can be your ticket to
Three sided solution: Testosterone + HCG + Arimidex
If your doctor only prescribes testosterone by itself, you will
probably have a rough ride. The tendency is for you to feel
great the first couple months, while you increase testosterone
levels, followed by a slow deterioration, once your estrogen
High estrogen negates a lot of the positives from testosterone
therapy, resulting in the same symptoms of low testosterone you
had in the first place!
The solution is to add a drug called Arimidex. It's called an
aromatase inhibitor, which essentially blocks the conversion of
testosterone to estrogen. It has the effect of increasing
testosterone levels, while keeping your estrogen low.
Once you have your testosterone and estrogen solved, it's time
to stop the next inevitable decline? Shrinking testicles.
This is where HCG (human chorionic gonadotropin) comes in. It
prevents both infertility and testicle shrinkage. Your
testicles shrink because your body thinks it doesn't need to
make testosterone anymore.
For some, small testicles may seem like just a cosmetic
problem. But HGC does more than increase testicle size, it also
increases adrenal function, which can have positive effects on
well-being, libido, and energy.
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