Doctor Gary Wittert recently put up
advertisements in order to recruit overweight males of the baby
boomer generation for a clinical research trial. Amazingly, he was
gathered over 800 applications in a single day. What was Doctor
Wittert studying that garnered such fervent interest in potential
participants? Every patient involved in the study would receive a
battery of Testosterone injections at no cost to them.
Who is Dr. Wittert?
Dr. Wittert is a medical professor at
the Australian University of Adelaide. The doctor and his collegiate
fellows hypothesize that Testosterone may be able to Adult-Onset
Diabetes. Testosterone has now been studied for generations, and it
is clear that Testosterone Injections provide numerous medical
benefits—especially in those who suffer from Low Testosterone, also
known as Testosterone Deficiency.
Testosterone Injections clearly boost
muscle mass and strength, and Testosterone has been used as a means
to enhance mood and sex drive in deficient men for years now, but
there continue to be alternate uses for the hormone which are
uncovered on a near annual basis. Adult-Onset Diabetes is a worldwide
phenomenon which seems to most heavily effect first world countries.
There is evidence that more than 300 million men and women across the
globe struggle with Type-Two Diabetes.
What Does Testosterone HRT Do?
Testosterone is the primary male
hormone produced by the body, though Testosterone also plays a lesser
role in feminine physiology as well. Testosterone, which has been
vilified in the past, is becoming more appreciated as a legitimate
medical therapy, and current research trends suggest that it is
inevitable that the hormone will become far more mainstream as a
Hormone Replacement Therapy Treatment Option as news about its
impressive benefits continues to grow.
In the past, testosterone has primarily
been used as a means to enhance libido and as a means to increase
athletic performance. Lance Armstrong recently admitted to using
Performance Enhancing Testosterone as a tool to help him win his
multiple Tour de France championships, for example. But ideas about
this vital hormone continue to expand its viability as a mainstream
therapy for common illnesses and medical conditions.
If the results of this diabetes study
prove that Testosterone Injections can prevent diabetes in obese men,
the hormone will quickly become one of the most prescribed medical
treatments in the world.
Wittert Study May Fully Legitimize
Testosterone HRT to the Public
Stuart Roberts is a Sydney healthcare
specialist for Bell Potter Securities, and he believes that this
hypothesis, if proven true, may change the way that the world thinks
about Testosterone HRT. He says that the Wittert Trial may be the
study that truly legitimizes Testosterone from a consumer
perspective.
He believes that there is largely a
bias against Testosterone because outsiders often feel that
Testosterone usage is something to laugh and joke about. He also
feels that the drug will likely become more widespread in its usage
because Testosterone is not prohibitively expensive to manufacture
and distribute, so insurance companies and health care systems will
likely be very open to covering its usage as a non-elective means of
healthcare.
The Wittert Testosterone Trial was
recently presented at the International Congress of Andrology, making
it a subject of great debate within the Australian medical community.
What is Testosterone?
Testosterone is the primary male sex
hormone, which is produced primarily in the Testes, but also in the
adrenal glands of both men and women. Testosterone is ultimately
responsible for all sexual characteristics which differentiate the
male body from the female body. Testosterone can be bio-synthetically
manufactured, and many companies include AbbVie Incorporated, Eli
Lilly and Company, and Bayer AG, provide trademark forms of
Testosterone in order to treat and alleviate Testosterone Hormone
Deficiency.
Testosterone is an incredibly potent
and profitable hormone therapy. In the United States, sales of
prescription Testosterone truly exploded in the last decade, growing
by over ten times from just over $200 million in revenue in 2001 to
well over $2 billion in 2012. One reason for this is that
Testosterone gels and patches are becoming more trusted and
widespread in their usage.
Previously, Injectable HGH was the
primary means of administering the Testosterone Hormone. These new
and easy-to-use topical formulas are causing the market for
Testosterone to expand exponentially. Market analyses conducted April
2012 by California-based Global Industry Analyst Incorporated provide
evidence that Net Sales of Testosterone are expected to net $5
billion annually by year 2017.
Testosterone Perceived as Distilled
Manhood
Testosterone is not only becoming more
popular in the United States, its prescription use is expanding
rapidly in Australia as well. There are arguments as to why
Testosterone use is growing as quickly as it is in the country. One
Sydney University Medical Professor, David Handelsman, remains
skeptical. The doctor is a specialist on male reproductive health. He
believes that Testosterone Injections are commonly provided for
patients as a nebulous means of Longevity Therapy.
Handelsman believes that those who view
Testosterone as a type of Fountain of Youth are mischaracterizing the
effects of the drug. He feels that the primary reason that
Testosterone is becoming so popular is because of the means by which
it is marketed. Testosterone is widely linked to sexual prowess and
ability in advertisement—a strategy that has long been shown to
capture the male attention span. The doctor believes that men
generally view Testosterone as a means to indefinitely post-pone the
aging process as a means to restore their lost youth.
Although the doctor has the right to be
skeptical, it is clear through research regarding Testosterone
Replacement Therapy that, although Testosterone can’t make you 20
years old again, it can help slow down the aging process and extend
the good years of life greatly while also improving medical outcomes
in numerous ways for patients who suffer from Low-T.
Testosterone Deficiency Global
Pandemic
It is clear that Testosterone
Deficiency is a common medical condition that effects the lives of
many men across the world. According to U.S. National Institute of
Health Research, there are around five million males in America that
suffer from diagnosable Testosterone Deficiency in America today.
This number may not seem that high at first glance, but it should be
noted that Testosterone Deficiency primarily effects males over the
age of thirty, and is far more common among this subset of the
American population than in females or younger males.
A slightly older European clinical
study discovered that an average of 20% of men over the age of fifty
experience modest-to-major symptoms of Testosterone Deficiency, and
this does not include patients for whom the symptoms of Testosterone
Deficiency are more insipid, such as those who suffer from
Adult-Onset Diabetes.
Although Testosterone Deficiency is
treated more widely in America, outside of the United States only
about two percent of underlying Low-T cases get treated, according to
a representative from the London Centre for Men’s Health.
In America and across the world,
knowledge about the symptoms of Low Testosterone are quickly becoming
general knowledge as information about Hormone Deficiency
disseminates across the internet, but there are still millions upon
millions around the world who do not understand this disorder or
don’t know how to obtain treatment.
Testosterone Enhances Muscle
Testosterone Hormone Replacement
Therapy has been used in some form or fashion for the last 80 years
as a means to treat male patients with particular medical afflictions
like Klinefelter’s syndrome. One of the primary symptoms of
Klinefelter’s syndrome is Low Testosterone, which leads to issues
such as reduced muscular strength, low libido, poor cognitive
function, fatigue, and increased incidence of osteoporosis.
Healthy individuals eventually took
notice of the beneficial effects of Testosterone , and beginning in
the 1950s, sports athletes began to utilize Testosterone Injections
in order to bolster their performance. Lance Armstrong is just the
most recent of a long list of successful as well as not-so-prominent
athletes who have taken advantage of performance enhancers such as
Testosterone, blood doping, and EPO. At first, Testosterone was only
available via Injection, but as procedural methods have become more
advanced, Testosterone is now available via a number of methods,
including patches, gels, injections. The latest method of
administration is via tablets of gum called troches.
Professor Handelsman says that
Testosterone Replacement is becoming more and more popular every day.
He says that in his experience, there are no individuals that have
used Testosterone Replacement Therapy that have been uncomfortable
with the effects of the treatment. In addition to improving physical
performance, it also elevates the mood and improves mental
well-being.
Testosterone Known for Side-Effects
when Used Improperly
Although Testosterone can be
administered carefully and safely, there is some risk involved. This
risk is primarily manifested toward the side-effects of abuse,
however. When males take too much testosterone for too long, they can
develop a number of issues, such as hair loss, gynecomastia (increase
in breast size), testicular shrinkage and reduced sperm count, liver
disease, impotence, acne, and increased aggression. Handelsman says
that individuals who choose to abuse Testosterone for personal
enhancement can sometimes become erratic and can become violent and
aggressive even without requisite negative stimuli.
Testosterone can also lead to other
medical issues when administered at dosages which are too high. One
Testosterone Study performed by Shalender Bhasin with a grant
provided by the United States National Institute on Aging was ended
prematurely because it was discovered that the patients using the
therapy had increased risk of hypertension and heart attacks.
Australian government medical advisor
Carolyn Allan says that Normal Testosterone Levels can be somewhat
difficult to track. They can change dependent upon the particular
Testosterone Test, the time that the test is administered, the age of
the participants sampled and their current state of health.
What is a Healthy Testosterone
Level?
For youthful adult males who are
perfectly healthy, a normal Testosterone Level ranges between eight
and twenty seven nanomolars/liter. Although there is a wide range of
what is considered healthy, it is physiologically normal for Serum
Testosterone Levels to drop by one to two percent each year after the
age of thirty.
There is some debate as to the exact
reason why Testosterone levels begin to decline at such a steady
rate. Although many say that dropping Testosterone levels are
innately tied to the aging process, there are others that believe
that Testosterone levels may decline not because of aging, but
because of medical abnormalities which develop as a result of the
aging process.
UCLA Medical Professor Ronald Swerdloff
says that the medical community understands that certain medical
conditions are correlated with particular levels of Testosterone
deficiency. He says that individuals who have Testosterone Levels
below eight nanomolars are most likely to suffer from the symptoms of
erectile dysfunction and will often need Testosterone treatments in
order to restore physical sexual ability.
Serum Testosterone Measurements of
below 10 nanomolars are linked to increased risk of osteoporosis and
overall bone degeneration. Patients that have Testosterone Levels
below 15 Nanomolars are at an increased risk of fatigue and libido
issues related to Low-T. In addition to this, they are also more
likely to struggle with obesity and increased levels of unhealthy
adipose fat tissue.
German Testosterone Study
A recent study released at a German
Medical conference proves the hypothesis that Low Testosterone Levels
are associated with increased obesity risk. The study provided strong
evidence that Testosterone HRT had the ability to help obese males
meet and beat their weight loss goals. It was also shown that the
Administration of Testosterone helps men keep the weight off as well.
The study was broad in scope, with 214 male participants.
These patients were followed and
monitored for a minimum of two years of Testosterone Treatments. 115
of the original patients continued to use Testosterone HRT and were
monitored for five full years. The researchers discovered that for
the majority of participants, blood pressure, blood-sugar, and
cholesterol levels all normalized in addition to improving the
patients’ ability to lose weight and retain their new, healthier
weight.
As a result of this study and others
like it, the Australian National Health and Medical Research Council
is granting more than $4.5 million in order to finance research which
will be able to hopefully prove that Testosterone is an effective and
safe means to encourage weight loss in obese patients.
Testosterone and Dieting
Today’s medical protocol for
encouraging patients to delay or prevent Type-2 diabetes is two-fold.
The first part of the strategy is to encourage patients to reduce
levels adipose fat, which has an innate tendency to raise insulin
levels. The second part of the plan is to increase activity levels in
order to encourage weight loss and promote proper hormone function
and metabolism.
This strategy is incredibly successful,
but it is not all-encompassing. Even when used successfully, diabetes
still occurs in almost one-third of at-risk patients inside a 5-year
window. The International Diabetes Foundation—the world’s
foremost authority on diabetes in the world, suggests that global
efforts to fight obesity are approaching half a trillion dollars.
Wittert, who is spearheading the
Testosterone Research Study that is gathering potential participants,
and his associates discovered that on top of the 800 males who
registered as potential subjects on day one, more than 3000 more
clicked the internet link which advertised the Testosterone Trial.
The ultimate goal of the scientists is
to build a patient pool of 1,500 men between the ages of 50 and 74
who are clinically diagnosed as pre-diabetic. In addition to this,
each participant must also be diagnosed with Low Testosterone and
must have a waist size of 37” or greater. Each of these
participants will be placed on a free Weight Watchers weight control
program. The group of participants will be divided into two groups.
The first group will receive Testosterone Injections, and the second
group will receive a placebo in order to control the experiment.
Nebido Testosterone by Bayer
The control group which will receive
Testosterone will receive it via 1,000 mg doses of Nebido, a
long-acting form of Testosterone medication sold by the
pharmaceutical giant Bayer under the label Reandron in Australia.
Administration begins on the first day of the trial and each patient
will be delivered another dose of Nebido after six weeks, then they
will receive additional injections four times per year over the
course of two years. Males who suffer from cardiovascular issues or
prostate cancer are not eligible for the study. The study has
received funding from Sonofi, Eli Lilly, and Becton Dickinson and
Company
Although this trial is largely funded
by pharmaceutical companies, the study is completely led by the
investigating scientists, and the only influence that Bayer has on
the study is their donation of Testosterone Treatments.
Although Testosterone abuse has been
shown to increase risk of prostate cancer in some patients, there is
absolutely no evidence that this treatment will lead to any cancer
nor will it lead to prostate enlargement, medically known as
prostatic hyperplasia. Prostatic hyperplasia has been known to
increase the difficulty of fluid excretion.
Testosterone and Prostate Cancer
Although in the past there have been
worries that Testosterone Replacement Therapy could agitate existing
prostate cancers, there is no evidence that suggests that this is the
case. Even so, physicians and scientists remain cautious, because
there is no definitive proof that Testosterone HRT does not
exacerbate existing cancers of the prostate. Although there have been
studies that have tested for this potential, none of these studies
had a participant pool large enough to provide proper assurance that
patients who have Prostate cancer can be safely treated with
Testosterone Creams, Injections, and Patches.
Even though obesity and diabetes are
correlated with Low Testosterone, researchers are unsure as to
exactly how Testosterone levels effect risk of Type-2 Diabetes in
males who are pre-diabetic as a result of increasing insulin
sensitivity.
Participants in this Testosterone for
Diabetes Trial will be closely monitored for body composition,
muscular strength, and blood-sugar levels. In addition to this,
researchers will also take note of patients’ motivation levels in
regard to their weight control program. To ensure that the clinical
trial remains safe, an independent group will conduct tests and
monitor the program in order to make sure that the Testosterone
Replacement Program for Diabetes is not causing the subjects any risk
of harm.
Testosterone Trial is a Large
Undertaking
Dr. Handelsman says that this Diabetes
and Testosterone Clinical Trial is a massive effort, but is
clinically important to our understanding of both Testosterone
Hormone Replacement Therapy and potential treatment options regarding
diabetes. Handelsman is a senior fellow at the ANZAC Research
Institute, one of the 6 primary sites where this Testosterone for
Diabetic Prevention study will take place. As far as Handelsman
knows, there have been no clinical trials of this size and scope
about the effect of Testosterone on Diabetes anywhere around the
globe.
Putting the Testosterone Debate to
Rest
Although research seems to continue to
suggest potential benefits for Testosterone Injection Treatments, the
use of Testosterone HRT is still largely up for debate, says
Andrology Australia. This debate cannot ultimately be put to rest
until large studies such as this one have proven that Testosterone
Treatments are safe and effective. Most scientific data shows that
legitimate use of Testosterone Replacement Therapy is safe, but
patients and doctors should still be judicious with the therapy.
Any individual who seeks to gain
Anti-Aging Benefits from Testosterone should carefully weigh the
risks and rewards, Handelsman tells reporters. For more than 30
years, Testosterone HRT was routinely utilized in order to relieve
the symptoms of menopause, but analysis of long-term clinical
outcomes showed that Testosterone raised the risk of stroke and heart
attack for menopausal and post-menopausal women.
Today, Testosterone HRT is still used
as a treatment for Menopause alleviation, but treatment strategies
have change to adapt to this new knowledge. Testosterone is now
delivered in combination with estrogen and progesterone in order to
reduce the risk of negative effects. In addition to this,
Testosterone dosages have been adjusted in order to minimize negative
impact as well.
The story of Testosterone for Menopause
is why clinical research is so important. Large-scale clinical trials
can uncover potential issues before they reach the market, decreasing
the risk of Testosterone Replacement Therapy by ensuring that
physicians have all the data that they need in order to provide the
treatment responsibly.
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